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Mrs Karoline Freeman

Job Title
Senior Research Fellow
WMS - Health Sciences
Research Interests

Karoline's research interests are in health technology assessment and evidence for decision making. She is particularly interested in test evaluations with a methodological focus on the transferability of evidence such as test accuracy data between populations.


Karoline joined Warwick Evidence in October 2012 as a clinical effectiveness reviewer. She has contributed to a range of multiple technology appraisals, diagnostic assessment reports, and a clinical guideline. Health technologies under evaluation included drugs (aspirin for the primary prevention of cardiovascular disease and cancer), devices (hip replacement interventions for osteoarthritis), surgical procedures (laser treatment for diabetic retinopathy) and tests. Karoline has developed a particular interest in test evaluations including an assay for guiding dose adjustment in patients receiving chemotherapy for colorectal cancer, assays for the monitoring of drugs in Crohn's disease patients, and pathogen panel tests for patients with gastroenteritis. Karoline has collaborative links with the CLAHRC West Midlands and contributes to reviews of screening tests for the UK National Screening Committee. Prior to joining Warwick Evidence, Karoline has worked as a research fellow in the field of health technology assessment in health services research at Warwick Medical School for 6 years. She took part in a socio-economic evaluation of emerging prenatal genetic tests within the EU funded SAFE International Network of Excellence and has undertaken systematic reviews on integrated working with the voluntary sector in children`s services, patient safety in ambulance services and Do Not Attempt Cardiopulmonary Resuscitation (DNACPR) decisions.

Title Funder Award start Award end
TAR 3 - Production of Technology Assessment Reviews (TAR) National Institute for Health Research (NIHR DoH) 01 Apr 2022 31 Mar 2027
NIHR HS&DR Stage 2: Adapting Breast Cancer Screening to MAximise Mortality Benefit and Minimise Overdiagnosis harm (Adapt-MAMMO) National Institute for Health Research (NIHR DoH) 01 Jan 2021 31 Dec 2023
SLOANE atypia National Institute for Health Research (NIHR DoH) 01 Dec 2021 30 Nov 2022
NIHR DRF 2016 - Karoline Freeman: What is the role of faecal calprotectin testing for the differentiation between IBS and IBD in primary care? National Institute for Health Research (DoH) 01 Oct 2016 30 Sep 2020
UKNSC Tender Public Health England 01 Oct 2015 30 Sep 2018
Tyrosinemia Review (part of NSC framework agreement) Public Health England 01 Oct 2015 31 Dec 2016
Therapeutic communication in black and minority ethnic populations: a synthesis of the evidence base: Via QMUL The Human Tissue Authority (HTA) 01 Jan 2012 30 Jun 2013
Extension to: Health econometrics study to inform the Detection & Identification of Infectious Agents (DIIA) Innovation Platform. Technology Strategy Board 01 Dec 2010 01 Mar 2012
Improvement of Medication use in Older Residents (IMOR) Project BUPA Foundation 01 Jan 2010 31 Dec 2010
Extension to Health Econometrics Study to inform the Detection and Identification of Infectious Agents (DIIA) innnovation platform Technology Strategy Board 01 Apr 2010 31 Jul 2010