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Dr Karoline Freeman

Job Title
Associate Professor (Quantitative analysis of brea
WMS - Health Sciences
Research Interests

My research interests are methods for test evaluation, evidence synthesis for policy, health technology assessment and health data science.


I am a Senior Research Fellow in Screening and Test Evaluation at Warwick Medical School. I graduated from the University of Birmingham with a BSc in Biological Sciences. I completed a MSc in Evidence Based Health Care and Health Technology Assessment at the University of Birmingham and a PhD in Health Sciences (NIHR doctoral fellowship) at the University of Warwick. In 2022 I undertook an NIHR Development and Skills Enhancement Fellowship in Health Data Science with a focus on causal inference methods for the analysis of observational data. In my PhD I combined routine data with published evidence to assess the transferability of test accuracy data from secondary care to primary care with the aim of translating evidence into practice. My current research focuses on test evaluations using systematic review methods and routine data to produce high quality evidence to inform national policy advisers on test use and changes to screening programmes. As part of my work for Warwick Screening I lead the analysis of the Sloane atypia data with outcomes expected to inform recommendations on the management of women with atypia detected through routine breast screening. Prior to that I led the evidence review on artificial intelligence for image analysis in breast cancer screening for the UK National Screening Committee (UK NSC). My work as a clinical effectiveness reviewer for Warwick Evidence involves producing health technology assessments for the National Institute for Health and Care Excellence (NICE). I was the lead systematic reviewer on three Diagnostic Assessment Reports including an assay for guiding dose adjustment in patients receiving chemotherapy for colorectal cancer, assays for the monitoring of drugs in Crohn's disease patients, and pathogen panel tests for patients with gastroenteritis. For an overview of other review topics I have been involved in please refer to my publication list. I am co-leader of the postgraduate Health Screening module which is a collaboration between Warwick Medical School and the UK National Screening Committee, and I am a member of the NHS breast screening research, innovation and development advisory committee (RIDAC) contributing to the advice on the feasibility of research using national breast screening programme data.

Title Funder Award start Award end
TAR 3 - Production of Technology Assessment Reviews (TAR) National Institute for Health Research (NIHR DoH) 01 Apr 2022 31 Mar 2027
SLOANE atypia National Institute for Health Research (NIHR DoH) 01 Dec 2021 31 Dec 2023
NIHR HS&DR Stage 2: Adapting Breast Cancer Screening to MAximise Mortality Benefit and Minimise Overdiagnosis harm (Adapt-MAMMO) National Institute for Health Research (NIHR DoH) 01 Jan 2021 31 Dec 2023
NIHR DRF 2016 - Karoline Freeman: What is the role of faecal calprotectin testing for the differentiation between IBS and IBD in primary care? National Institute for Health Research (DoH) 01 Oct 2016 30 Sep 2020
UKNSC Tender Public Health England 01 Oct 2015 30 Sep 2018
Tyrosinemia Review (part of NSC framework agreement) Public Health England 01 Oct 2015 31 Dec 2016
Therapeutic communication in black and minority ethnic populations: a synthesis of the evidence base: Via QMUL The Human Tissue Authority (HTA) 01 Jan 2012 30 Jun 2013
Extension to: Health econometrics study to inform the Detection & Identification of Infectious Agents (DIIA) Innovation Platform. Technology Strategy Board 01 Dec 2010 01 Mar 2012
Improvement of Medication use in Older Residents (IMOR) Project BUPA Foundation 01 Jan 2010 31 Dec 2010
Extension to Health Econometrics Study to inform the Detection and Identification of Infectious Agents (DIIA) innnovation platform Technology Strategy Board 01 Apr 2010 31 Jul 2010