His research background is in mucosal immunology, and his early work was based on the role of macrophage cytokines in intertinal and lung inflammation. THis work contributed to the introduction of anti-TNF therapy in Crohn's disease, and also provided the first demonstration of the role of inflammatory cytokines in lung disease affecting preterm infants.His particular interests in food allergies include food-sensitive enteropathy and non lgE-mediated allergy. His recent work has shown evidence of impaired development of regulatory immune responses in allergic children, and future studies are planned to look at early infectious exposures to the intestinal flora as possible causes of impaired immunological priming. His additional work has focussed on the role of intestinal inflammation in childhood malnutrition disorders, and in the molecular basis of protein-losing enteropathy.
Simon Murch is Professor of Paediatrics and Child Health at Warwick Medical School. Before taking up this post, he was Senior Lecturer in Paediatric Gastroenterology at the Royal Free and University College School of Medicine, London. His clinical interests include paediatric inflammatory bowel disease, coeliac disease, food allergy and complex inherited enteropathies. He was the leader of the international IBD Working Group for the World Congress of Paediatric Gastroenterology in 2004, and has been a member of national and international working groups in paediatric food allergy.
- 'Allen, Hilary I., 'Pendower, Ursula, 'Santer, Miriam, 'Groetch, Marion, 'Cohen, Mitchell, 'Murch, Simon, 'Williams, Hywel C., 'Munblit, Daniel, 'Katz, Yitzhak, 'Gupta, Neeraj, 'Adil, Sabeen, 'Baines, Justine, 'de Bont, Eefje G. P. M., 'Ridd, Matthew, 'Sibson, Victoria L., 'McFadden, Alison, 'Koplin, Jennifer J., 'Munene, Josephine, 'Perkin, Michael R., 'Sicherer, Scott H. et al (Select to open full list), 2022. 'Detection and management of milk allergy : Delphi consensus study. Clinical & Experimental Allergy, 52 (7), pp. 848-858
- Alam, Mohammad T., Amos, Gregory C. A., Murphy, Andrew, Murch, Simon, Wellington, E. M. H., Arasaradnam, Ramesh P., 2020. Microbial imbalance in inflammatory bowel disease patients at different taxonomic levels. Gut Pathogens, 12
- Coad, Jane, Toft, Alex, Lapwood, Susie, Manning, Joseph, Hunter, Mark, Jenkins, Huw, Sadlier, Clare, Hammonds, Julie, Kennedy, Ailsa, Murch, Simon, Widdas, David, 2016. Blended foods for tube-fed children : a safe and realistic option? A rapid review of the evidence. Archives of Disease in Childhood
- Jones, Kelsey D. J., Hünten-Kirsch, Barbara, Laving, Ahmed M. R., Munyi, Caroline W., Ngari, Moses, Mikusa, Jenifer, Mulongo, Musa M., Odera, Dennis, Nassir, H. Samira, Timbwa, Molline, Owino, Moses, Fegan, Greg, Murch, Simon, Sullivan, Peter B., Warner, J. O. (John O.), Berkley, James A., 2014. Mesalazine in the initial management of severely acutely malnourished children with environmental enteric dysfunction : a pilot randomized controlled trial. BMC Medicine, 12 (1)
- Salvestrini, Camilla, Lucas, Mark, Lionetti, Paolo, Torrente, Franco, James, Sean G., Phillips, Alan D., Murch, Simon, 2014. Matrix expansion and syncytial aggregation of syndecan-1+ cells underpin villous atrophy in coeliac disease. PLoS One, 9 (9)
- Papadopoulou, A., Koletzko, S., Heuschkel, R., Dias, J. A., Allen, K. J., Murch, Simon, Chong, S., Gottrand, F., Husby, S., Lionetti, P., Mearin, M. L., Ruemmele, F. M., Schappi, M. G., Staiano, A., Wilschanski, M., Vandenplas, Y., 2014. Management guidelines of eosinophilic esophagitis in childhood. Journal of Pediatric Gastroenterology and Nutrition, 58 (1), pp. 107-118
- Murch, Simon, Jenkins, H. Donald Brooke, Auth, M., Bremner, R., Butt, A., France, S., Furman, M., Gillett, P., Kiparissi, F., Lawson, M., McLain, B., Morris, M.-A., Sleet, S., Thorpe, M., 2013. Joint BSPGHAN and coeliac UK guidelines for the diagnosis and management of coeliac disease in children. Archives of Disease in Childhood, 98 (10), pp. 806-811
- Jenkins, H. R., Murch, Simon, Beattie, R. M., 2012. Diagnosing coeliac disease. Archives of Disease in Childhood, Vol.97 (No.5), pp. 393-394
- Edwards, Lindsey A., O'Neill, Colette, Furman, Mark A., Hicks, Susan, Torrente, Franco, Pérez-Machado, Miguel, Wellington, E. M. H., Phillips, Alan D., Murch, Simon, 2012. Enterotoxin-producing staphylococci cause intestinal inflammation by a combination of direct epithelial cytopathy and superantigen-mediated T-cell activation. Inflammatory Bowel Diseases, Vol.18 (No.4), pp. 624-640
- Edwards, Lindsey A., Bajaj-Elliott, Mona, Klein, Nigel, Murch, Simon, Phillips, Alan D., 2011. Bacterial-epithelial contact is a key determinant of host innate immune responses to enteropathogenic and enteroaggregative escherichia coli. PLoS One, Vol.6 (No.10)
- Amadi, Beatrice, Fagbemi, Andrew O., Kelly, Paul, Mwiya, Mwiya, Torrente, Franco, Salvestrini, Camilla, Day, Richard, Golden, Michael H., Eklund, Erik A., Freeze, Hudson H., Murch, Simon, 2009. Reduced production of sulfated glycosaminoglycans occurs in Zambian children with kwashiorkor but not marasmus. American Journal of Clinical Nutrition, Vol.89 (No.2), pp. 592-600
- Bode, Lars, Salvestrini, Camilla, Park, Pyong Woo, Li, Jin-Ping, Esko, Jeffrey D., Yamaguchi, Yu, Murch, Simon, Freeze, Hudson H., 2008. Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function. Journal of Clinical Investigation, Vol.118 (No.1), pp. 229-238
- Salvestrini, Camilla, McGrath, John A., Ozoemena, Linda, Husain, Khaled, Buhamrah, Eman, Sabery, Nasim, Leichtner, Alan, Rufo, Paul A., Perez-Atayde, Antonio, Orteu, Cate H., Torrente, Franco, Heuschkel, Robert B., Thomson, Michael A., Murch, Simon, 2008. Desquamative enteropathy and pyloric atresia without skin disease caused by a novel intracellular beta4 integrin mutation. Journal of pediatric gastroenterology and nutrition, Vol.47 (No.5), pp. 585-591
- Edwards, L., Hicks, S., Furman, M., O'Neill, C., Wellington, E. M. H., Torrente, F., Fitzhenry, R., Phillips, A., Murch, Simon, 2007. Seg/I producing Staphylococcus aureus induces intestinal epithelial cytopathy independent of T cell responses. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Annual Meeting, Barcelona, Spain, May 9-12, 2007, Published in Journal of Pediatric Gastroenterology and Nutrition, pp. 118-118
- Edwards, L. A., Murch, Simon, Klein, N., Bajaj-Elliott, M., Phillips, A. D., 2007. Probiotic and commensal bacteria differentially regulate intestinal epithelial cell innate defence gene expression. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Annual Meeting, Barcelona, Spain, May 9-12, 2007, Published in Journal of Pediatric Gastroenterology and Nutrition, pp. 138-138
- Hill, D. J., Murch, Simon, Rafferty, K., Wallis, P., Green, C. J., 2007. The efficacy of amino acid-based formulas in relieving the symptoms of cow's milk allergy: a systematic review. Clinical and Experimental Allergy, Wiley-Blackwell Publishing Ltd, pp. 808-822
Title | Funder | Award start | Award end |
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Predicting serious infection in children - the Warwick - Oxford Childrens Infection Study | University of Oxford | 01 Jan 2005 | 31 Dec 2005 |