Job Title
Professor
Department
WMS - Health Sciences
Phone
+44 24 76865329
Web Link
Research Interests
Sara mainly pursues 2 themes of research:
- Understanding and prevention of adverse metabolic programming: The PRiDE study explored the role of one-Carbon metabolites (specifically Folic acid and Vitamin B12) in early pregnancy on the risk of Gestational Diabetes and cardio-metabolic risk of the offspring (). His STRiDE study proposed a novel, early pregnancy composite risk score for GDM using HbA1c across three populations (India, Kenya and UK) (). Completed early pregnancy cohort studies in Malaysia and Thailand with a view to move the Diabetes in Pregnancy field towards population specific approaches. In collaboration with other Diabetes Pregnancy leading experts in the UK, he also completed MAGIC study on the use of CGM in early pregnancy, GDM and birth outcomes. He is actively involved in mechanistic studies delineating the molecular mechanisms of nutritional imbalance in mothers and the effect on children.
- Application of research evidence into clinical practice: For example, how best to implement the multi-factorial intervention in Diabetes, in particular in South Asian diabetes. He also actively pursues on developing and implementing "systems" that drives and delivers high quality of individualised, integrated care in diabetes at low cost.
His other on going projects are:
- Health inequalities in South Asians and other BAME population - Role of diet, lifestyle, behaviour & psychological aspects in Diabetes.
- PEAPOD study: Effect of maternal nutrition and offspring body composition growth trajectory
- Generating population specific, evidence-based guidelines for Low and Middle Income Countries (STRiDE and STRiDE sollow-up study)
- Research capacity building in India and other Low and Middle Income Countries (iDTP - international Doctoral Training Partnership)
- RADIANT study - Role of co-developed short video prompt for improving the screening post-GDM pregnancy in UK multi-ethnic population (NIHR funded, in collboration with Birmingham)
- PEEPO study - Role of adverse maternal health on Educational attainment in the offspring (Nuffield Foundation funded project)
- RADIANT study - Role of co-developed short video prompt for improving the screening post-GDM pregnancy in UK multi-ethnic population (NIHR funded, in collboration with Birmingham)
- Research capacity building in India and other Low and Middle Income Countries (iDTP - international Doctoral Training Partnership)
- Generating population specific, evidence-based guidelines for Low and Middle Income Countries (STRiDE and STRiDE sollow-up study)
- PEAPOD study: Effect of maternal nutrition and offspring body composition growth trajectory
Biography
Prof Ponnusamy Saravanan (known as Sara) completed his specialist training in Bristol & Exeter. For his PhD, he conducted the world's largest clinical trial on the effects of combined T4/T3 (thyroid hormone replacement), in Bristol. His thyroid work was instrumental in changing the combined guidelines issued by American Association of Clinical Endocrinologists & American Thyroid Association. Prof Saravanan widened his research expertise to pursue his longterm passion to understand the mechanisms of Gestational Diabetes (GDM), its ethnic variations and long term impact. He is a passionate advocate for the "primordial prevention" of metabolic disorders, emphasising the importance of nutrition and metabolic health in young women during pregnancy. He has successfully completed several large-scale, impactful studies funded by the Medical Research Council (MRC), including: PRiDE study (UK; n=4,750): Low B12 and high Folate levels in early pregnancy increases subsequent risk of developing GDM. STRiDE study (India and Kenya; n=3,070 and 4,104): Proposed a novel, early pregnancy composite risk score for GDM using HbA1c across three populations (India, Kenya and UK). Partnered with other leading experts, he completed early pregnancy studies in Malaysia (n=5,200), and Thailand (TaRGET; n=4,260). In addition, MAGIC study (UK) explored the role of CGM in early pregnancy. These studies aim to address critical unanswered questions in the fields of metabolic disorders in pregnancy and the prevention of non-communicable diseases (NCDs) in young mothers and their children. His clinical work focuses on patients who are at high risk of Cardiovascular disorders, complex thyroid problems and won NHS innovation award for individualised care in South Asians. Founder-Director of the international Doctoral Training Program (iDTP) at Warwick with a view to generate research capacity in LMICs. So far, supported 21 clinical fellows/students to complete PhD/MDs and helped 8 allied health professionals/nurses/midwives to pursue their career in research. He has successfully completed 28 studies across 7 countries and collaborates with many more. He serves as a Non-Executive Director for the local mental health trust (CWPT) () and is the Editor in Chief of the prestigious Royal College of Physician's journal, Clinical Medicine. Published >150 papers so far, in various international journals, including NEJM, Lancet, Lancet Diabetes and Endo, BMJ, Plos Medicine, Diabetes Care, Diabetologia and JAMA Ophthalmology. Publications: https://scholar.google.com/citations?user=Y_nIzcQAAAAJ
- Ram, Uma, Thirunavukkarasu, Mathangi, Shyam, Krishna, Ghebremichael?Weldeselassie, Yonas, Sukumar, Nithya, Saravanan, Ponnusamy, 2024. Effects of treating subclinical hypothyroidism in pregnancy in India : are we treating too many for little gain? A retrospective cohort study. International Journal of Gynecology & Obstetrics, 164 (2), pp. 677-683
- Zayed, Mohammed G., Karsan, Waseem, Peto, Tunde, Saravanan, Ponnusamy, Virgili, Gianni, Preiss, David, 2024. Diabetic retinopathy and quality of life : a systematic review and meta-analysis. JAMA Ophthalmology, 142 (3), pp. 199-207
- Khunti, Kamlesh, Sukumar, Nithya, Waheed, Ghazala, Gillies, Clare, Dallosso, Helen, Brough, Chris, Davies, Melanie J., Fitzpatrick, Claire, Gray, Laura J., Highton, Patrick, Rowlands, Alex, Schreder, Sally, Yates, Tom, Saravanan, Ponnusamy, 2023. Structured group education programme and accompanying mHealth intervention to promote physical activity in women with a history of gestational diabetes : a randomised controlled trial. Diabetic Medicine, 40 (7)
- Parkhi, Durga, Periyathambi, Nishanthi, Ghebremichael-Weldeselassie, Yonas, Patel, Vinod, Sukumar, Nithya, Siddharthan, Rahul, Narlikar, Leelavati, Saravanan, Ponnusamy, 2023. Prediction of postpartum prediabetes by machine learning methods in women with gestational diabetes mellitus. iScience, 26 (10)
- Mclennan, Niamh?Maire, Lindsay, Robert, Saravanan, Ponnusamy, Sukumar, Nithya, White, Sara L., von Dadelszen, Peter, Burden, Christy, Hunt, Kathryn, George, Priya, Hirst, Jane E., Lattey, Katherine, Lee, Tara T. M., Murphy, Helen R., Scott, Eleanor M., Magee, Laura A., Reynolds, Rebecca M., 2023. Impact of COVID?19 on gestational diabetes pregnancy outcomes in the UK : a multicentre retrospective cohort study. BJOG: An International Journal of Obstetrics & Gynaecology
- Scott, Eleanor M., Murphy, Helen R., Myers, Jenny, Saravanan, Ponnusamy, Poston, Lucilla, Law, Graham R., 2023. MAGIC (maternal glucose in pregnancy) understanding the glycemic profile of pregnancy, intensive CGM glucose profiling and its relationship to fetal growth : an observational study protocol. BMC Pregnancy and Childbirth, 23 (1)
- 'Thirumoorthy, C., 'Deepa, M., 'Srikumar, B. N., 'Hannah, W., 'Venkatesan, U., 'Nikhil, P.J., 'Hemavathy, S., 'Binukumar, B., 'Anjana, R. M., 'Ram, Uma, 'Balasubramanyam, M., 'Saravanan, P., 'Mohan, V., 'Gokulakrishnan, K., 2022. 'Altered levels of neurobiological biomarkers at the interface of depression and gestational diabetes mellitus in Asian Indian women. Neuropeptides, 93
- 'Hannah, Wesley, 'Bhavadharini, Balaji, 'Beks, Hannah, 'Deepa, Mohan, 'Anjana, Ranjit Mohan, 'Uma, Ram, 'Martin, Erik, 'McNamara, Kevin, 'Versace, Vincent, 'Saravanan, Ponnusamy, 'Mohan, Viswanathan, 2022. 'Global burden of early pregnancy gestational diabetes mellitus (eGDM) : a systematic review. Acta diabetologica, 59, pp. 403-427
- 'Varadhan, Lakshminarayanan, 'Saravanan, Ponnusamy, 'Ali, Sarah N., 'Hanif, Wasim, 'Patel, Vinod, 2022. 'Informing and empowering patients and clinicians to make evidence-supported outcome-based decisions in relation to SGLT2 inhibitor therapies : the use of the novel Years of Drug administration (YoDa) concept. Clinical Drug Investigation, 42 (2), pp. 113-125
- 'Crasto, W., 'Altaf, Q -A., 'Selvaraj, D. R., 'Jack, B., 'Patel, Vinod, 'Nawaz, S., 'Murthy, N., 'Sukumar, Nithya, 'Saravanan, Ponnusamy, 'Tahrani, A. A., 2022. 'Frequency rhythmic electrical modulation system (FREMS) to alleviate painful diabetic peripheral neuropathy : a pilot, randomised controlled trial (The FREMSTOP study). Diabetic medicine : a journal of the British Diabetic Association, 39 (3)
- Shivashri, Chockalingam, Hannah, Wesley, Deepa, Mohan, Ghebremichael-Weldeselassie, Yonas, Anjana, Ranjit Mohan, Uma, Ram, Mohan, Viswanathan, Saravanan, Ponnusamy, 2022. Prevalence of prediabetes and type 2 diabetes mellitus in south and southeast Asian women with history of gestational diabetes mellitus : Systematic review and meta-analysis. PLoS One, 17 (12)
- Periyathambi, Nishanthi, Parkhi, Durga, Ghebremichael-Weldeselassie, Yonas, Patel, Vinod, Sukumar, Nithya, Siddharthan, Rahul, Narlikar, Leelavati, Saravanan, Ponnusamy, 2022. Machine learning prediction of non-attendance to postpartum glucose screening and subsequent risk of type 2 diabetes following gestational diabetes. PLoS One, 17 (3)
- Fan, Hei Man, Mitchell, Alice L., Bellafante, Elena, McIlvride, Saraid, Primicheru, Laura I., Giorgi, Mirko, Eberini, Ivano, Syngelaki, Argyro, Lövgren-Sandblom, Anita, Jones, Peter, McCance, David, Sukumar, Nithya, Periyathambi, Nishanthi, Weldeselassie, Yonas, Hunt, Katharine F., Nicolaides, Kypros H., Andersson, David, Bevan, Stuart, Seed, Paul T., Bewick, Gavin A. et al (Select to open full list), 2022. Sulfated progesterone metabolites that enhance insulin secretion via Trpm3 are reduced in serum from women with gestational diabetes mellitus. Diabetes, 71 (4), pp. 837-852
- Boachie, Joseph, Adaikalakoteswari, Antonysunil, Goljan, Ilona, Samavat, Jinous, Cagampang, Felino R., Saravanan, Ponnusamy, 2021. Intracellular and tissue levels of vitamin B12 in hepatocytes are modulated by CD320 receptor and TCN2 transporter. International Journal of Molecular Sciences, 22 (6)
- Boachie, Joseph, Adaikalakoteswari, Antonysunil, Ga?zquez, Antonio, Zammit, Victor A., Larque?, Elvira, Saravanan, Ponnusamy, 2021. Vitamin B12 induces hepatic fatty infiltration through altered fatty acid metabolism. Cellular Physiology and Biochemistry, 55 (3), pp. 241-255
- Mohan, Mohapradeep, Perry, Benjamin Ian, Saravanan, Ponnusamy, Singh, Swaran P., 2021. COVID-19 in people with schizophrenia : potential mechanisms linking schizophrenia to poor prognosis. Frontiers in Psychiatry, 12
- Bagias, Christos, Sukumar, Nithya, Weldeselassie, Yonas, Oyebode, Oyinlola, Saravanan, Ponnusamy, 2021. Cord blood adipocytokines and body composition in early childhood : a systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 18 (4)
- Saravanan, Ponnusamy, Sukumar, Nithya, Adaikalakoteswari, Antonysunil, Goljan, Ilona, Venkataraman, Hema, Gopinath, Amitha, Bagias, Christos, Yajnik, Chittaranjan S., Stallard, Nigel, Ghebremichael-Weldeselassie, Yonas, Fall, Caroline, 2021. Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes : a prospective UK cohort study (PRiDE study). Diabetologia, 64, pp. 2170-2182
- Raja, Umar Yousaf, Saravanan, Ponnusamy, 2021. Dapagliflozin : the outcome of use as add-on therapy in real-life clinical setting - an audit. JPMA. The Journal of the Pakistan Medical Association, 71 (9), pp. 2214-2216
- Adaikalakoteswari, Antonysunil, Wood, Catherine, Mina, Theresia H., Webster, Craig, Goljan, Ilona, Weldeselassie, Yonas, Reynolds, Rebecca M., Saravanan, Ponnusamy, 2020. Vitamin B12 deficiency and altered one-carbon metabolites in early pregnancy is associated with maternal obesity and dyslipidaemia. Scientific Reports, 10
- Sukumar, Nithya, Saravanan, Ponnusamy, 2019. Investigating vitamin B12 deficiency. BMJ
- Samavat, Jinous, Cantini, Giulia, Lorubbio, Maria, Degl'Innocenti, Selene, Adaikalakoteswari, Antonysunil, Facchiano, Enrico, Lucchese, Marcello, Maggi, Mario, Saravanan, Ponnusamy, Ognibene, Agostino, Luconi, Michaela, 2019. Seminal but not serum levels of holotranscobalamin are altered in morbid obesity and correlate with semen quality : a pilot single centre study. Nutrients, 11 (7)
- Pramodkumar, Thyparambil Aravindakshan, Jayashri, Ramamoorthy, Gokulakrishnan, Kuppan, Velmurugan, Kaliyaperumal, Pradeepa, Rajendra, Venkatesan, Ulagamathesan, Saravanan, Ponnusamy, Uma, Ram, Anjana, Ranjit Mohan, Mohan, Viswanathan, 2019. 1,5 Anhydroglucitol in gestational diabetes mellitus. Journal of Diabetes and its Complications, 33 (3), pp. 231-235
- Sukumar, Nithya, Dallosso, Helen, Saravanan, Ponnusamy, Yates, Tom, Telling, Carol, Shorthose, Karen, Northern, Alison, Schreder, Sally, Brough, Christopher, Gray, Laura J, Davies, Melanie J, Khunti, Kamlesh, 2018. Baby Steps - a structured group education programme with accompanying mobile web application designed to promote physical activity in women with a history of gestational diabetes: study protocol for a randomised controlled trial.. Trials, 19 (1)
- Venkataraman, Hema, Saravanan, Ponnusamy, 2018. Medicalising pregnancy with new diagnostic criteria for gestational diabetes mellitus: do we need more evidence?. Diabetologia, 61 (8), pp. 1886-1888
- Sukumar, Nithya, Bagias, Christos, Goljan, Ilona, Weldeselassie, Yonas, Gharanei, Seley, Tan, Bee K., Holst, Jens J., Saravanan, Ponnusamy, 2018. Reduced GLP-1 Secretion at 30 Minutes After a 75-g Oral Glucose Load Is Observed in Gestational Diabetes Mellitus: A Prospective Cohort Study. Diabetes, 67 (12), pp. 2650-2656
- Sukumar, Nithya, Bagias, Christos, Goljan, Ilona, Weldeselassie, Yonas, Gharanei, Seley, Tan, Bee K., Holst, Jens J., Saravanan, Ponnusamy, 2018. Reduced GLP-1 secretion at 30 minutes after a 75-g oral glucose load is observed in gestational diabetes mellitus : a prospective cohort study. Diabetes, 67 (12), pp. 2650-2656
- Wang, J., Moore, D., Subramanian, A., Cheng, K. K., Toulis, K. A., Qiu, X., Saravanan, Ponnusamy, Price, M. J., Nirantharakumar, K., 2018. Gestational dyslipidaemia and adverse birthweight outcomes : a systematic review and meta-analysis. Obesity Reviews, 19 (9), pp. 1256-1268
- Al-Musharaf, Sara, Fouda, Mona A., Turkestani, Iqbal Z., Al-Ajlan, Abdulrahman, Sabico, Shaun, Alnaami, Abdullah M., Wani, Kaiser, Hussain, Syed Danish, Alraqebah, Buthaynah, Al-Serehi, Amal, Alshingetti, Naemah M., Al-Daghri, Nasser, McTernan, Philip G, Wimalawansa, Sunil J., Saravanan, Ponnusamy, 2018. Vitamin D deficiency prevalence and predictors in early pregnancy among Arab women. Nutrients, 10 (4)
- Al-Musharaf, Sara, Fouda, Mona A., Turkestani, Iqbal Z., Al-Ajlan, Abdulrahman, Sabico, Shaun, Alnaami, Abdullah M., Wani, Kaiser, Hussain, Syed Danish, Alraqebah, Buthaynah, Al-Serehi, Amal, Alshingetti, Naemah M., Al-Daghri, Nasser, McTernan, Philip G, Wimalawansa, Sunil J., Saravanan, Ponnusamy, 2018. Vitamin D Deficiency Prevalence and Predictors in Early Pregnancy among Arab Women. Nutrients, 10 (4)
- Sailesh, S., Randeva, Harpal S., Callaghan, C. J. O., O'Hare, J. Paul, Philip, Sam, Saravanan, Ponnusamy, Patel, Vinod, 2018. The THOR effect : thyroid hormone offsets retinopathy. Journal of Endocrinology and Thyroid Research, 3 (1)
- Daly, Barbara, Toulis, Konstantinos A., Thomas, Neil, Gokhale, Krishna, Martin, James, Webber, Jonathan, Keerthy, Deepi, Jolly, Kate, Saravanan, Ponnusamy, Nirantharakumar, Krishnarajah, 2018. Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions : a population-based cohort study. PLoS Medicine, 15 (1)
- Nørgaard, Kirsten, Sukumar, Nithya, Rafnsson, Snorri B, Saravanan, Ponnusamy, 2018. Efficacy and safety of rapid-acting insulin analogs in special populations with type 1 diabetes or gestational diabetes : Systematic Review and Meta-Analysis. Diabetes therapy, 9 (3), pp. 891-917
- Pastakia, Sonak D., Njuguna, Benson, Onyango, Beryl Ajwang', Washington, Sierra, Christoffersen-Deb, Astrid, Kosgei, Wycliffe K., Saravanan, Ponnusamy, 2017. Prevalence of gestational diabetes mellitus based on various screening strategies in western Kenya : a prospective comparison of point of care diagnostic methods.. BMC Pregnancy and Childbirth, 17 (1)
- Mohan, Viswanathan, Bhavadharini, Balaji, Mahalakshmi, Manni Mohanraj, Deepa, Mohan, Harish, Ranjani, Ranjit, Unnikrishnan, Anjana, Ranjt Mohan, Malanda, Belma, Kayal, Arivudainambi, Belton, Anne, Saravanan, Ponnusamy, Uma, Ram, 2017. Elevated glycated hemoglobin predicts macrosomia among Asian Indian pregnant women (WINGS-9). Indian Journal of Endocrinology and Metabolism, 21 (1), pp. 184-189
- Toulis, K A., Hanif, W., Saravanan, P., Willis, B. H., Marshall, T., Kumarendran, B., Gokhale, K., Ghosh, S., Cheng, K. K., Narendran, P., Thomas, G. N., Nirantharakumar, K., 2017. All-cause mortality in patients with diabetes under glucagon-like peptide-1 agonists : a population-based, open cohort study. Diabetes & Metabolism, 43 (3), pp. 211-216
- Rogne, Tormod, Tielemans, Myrte J., Chong, Mary Foong-Fong, Yajnik, Chittaranjan S., Krishnaveni, Ghattu V., Poston, Lucilla, Jaddoe, Vincent W. V., Steegers, Eric A. P., Joshi, Suyog, Chong, Yap-Seng, Godfrey, Keith M., Yap, Fabian, Yahyaoui, Raquel, Thomas, Tinku, Hay, Gry, Hogeveen, Marije, Demir, Ahmet, Saravanan, Ponnusamy, Skovlund, Eva, Martinussen, Marit P. et al (Select to open full list), 2017. Associations of maternal Vitamin B12 concentration in pregnancy with the risks of preterm birth and low birth weight : a systematic review and meta-analysis of individual participant data. American Journal of Epidemiology, 185 (3), pp. 212-223
- Meshaka, Riwa, Jeffares, Stephen, Sadrudin, Farah, Huisman, Nicole, Saravanan, Ponnusamy, 2017. Why do pregnant women participate in research? A patient participation investigation using Q-Methodology. Health Expectations, 20 (2), pp. 188-197
- Venkataraman, Hema, Ram, Uma, Craik, Sam, Arungunasekaran, Anuradhai, Seshadri, Suresh, Saravanan, Ponnusamy, 2017. Increased fetal adiposity prior to diagnosis of gestational diabetes in South Asians : more evidence for the ?thin?fat' baby. Diabetologia, 60 (3), pp. 399-405
- Sarwar, Komil N., Cliff, Phoebe, Saravanan, Ponnusamy, Khunti, Kamlesh, Nirantharakumar, Krishnarajah, Narendran, Parth, 2017. Comorbidities, complications and mortality in people of South Asian ethnicity with type 1 diabetes compared with other ethnic groups : a systematic review. BMJ Open, 7 (7)
- Adaikalakoteswari, Antonysunil, Vatish, Manu, Alam, Mohammad T., Ott, Sascha, Kumar, Sudhesh, Saravanan, P., 2017. Low vitamin B12 in pregnancy is associated with adipose-derived circulating miRs targeting PPAR? and insulin resistance. The Journal of Clinical Endocrinology & Metabolism, 102 (11), pp. 4200-4209
- Al-Daghri, Nasser, Rahman, Shakilur, Sabico, Shaun, Yakout, Sobhy, Wani, Kaiser, Al-Attas, Omar, Saravanan, Ponnusamy, Tripathi, Gyanendra, McTernan, P. G., Alokail, Majed, 2016. Association of Vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects. Nutrients, 8 (9)
- Sukumar, Nithya, Venkataraman, Hema, Wilson, Sean, Goljan, Ilona, Selvamoni, Selvin, Patel, Vinod, Saravanan, Ponnusamy, 2016. Vitamin B12 status among pregnant women in the UK and its association with obesity and gestational diabetes. Nutrients, 8 (12)
- Sukumar, Nithya, Rafnsson, Snorri B., Kandala, Ngianga-Bakwin, Bhopal, Raj, Yajnik, Chittaranjan S., Saravanan, Ponnusamy, 2016. Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight : a systematic review and meta-analysis. The American Journal of Clinical Nutrition, 103 (5), pp. 1232-1251
- Sukumar, Nithya, Adaikalakoteswari, Antonysunil, Venkataraman, Hema, Maheswaran, Hendramoorthy, Saravanan, Ponnusamy, 2016. Vitamin B12 status in women of childbearing age in the UK and its relationship with national nutrient intake guidelines : results from two National Diet and Nutrition Surveys. BMJ Open, 6 (8)
- Adaikalakoteswari, Antonysunil, Finer, Sarah, Voyias, Philip D., McCarthy, Ciara M., Vatish, Manu, Moore, Jonathan D., Smart-Halajko, Melissa, Bawazeer, Nahla M., Al-Daghri, Nasser M., McTernan, P. G., Kumar, Sudhesh, Hitman, Graham A., Saravanan, Ponnusamy, Tripathi, Gyanendra, 2015. Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes. Clinical Epigenetics, 7 (1), pp. 1-14
- Antonysunil, Adaikalakoteswari, Vatish, Manu, Lawson, Alexander, Wood, Catherine, Sivakumar, Kavitha, McTernan, P. G., Webster, Craig, Anderson, Neil, Yajnik, Chittaranjan S., Tripathi, Gyanendra, Saravanan, Ponnusamy, 2015. Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white caucasians living in the UK. Nutrients, 7 (4), pp. 2401-2414
- Wilson, Andrew, O'Hare, J. Paul, Hardy, Ainsley, Raymond, Neil T., Szczepura, Ala, Crossman, Richard, Baines, Darrin L., Khunti, Kamlesh, Kumar, Sudhesh, Saravanan, Ponnusamy, 2014. Evaluation of the clinical and cost effectiveness of intermediate care clinics for diabetes (ICCD) : a multicentre cluster randomised controlled trial. PLoS One, 9 (4)
- Antonysunil, Adaikalakoteswari, Jayashri, Ramamurthy, Sukumar, Nithya, Venkataraman, Hema, Pradeepa, Rajendra, Gokulakrishnan, Kuppan, Anjana, Ranjit, McTernan, P. G., Tripathi, Gyanendra, Patel, Vinod, Kumar, Sudhesh, Mohan, Viswanathan, Saravanan, Ponnusamy, 2014. Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovascular Diabetology, 13 (1), pp. 1-7
- Finer, Sarah, Saravanan, Ponnusamy, Hitman, G., Yajnik, Chittaranjan S., 2014. The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity. Diabetic Medicine, 31 (3), pp. 263-272
- Piya, Milan K., Harte, A. L., Sivakumar, Kavitha, Tripathi, Gyanendra, Voyias, Philip D., James, S., Sabico, Shaun, Al-Daghri, Nasser M., Saravanan, Ponnusamy, Barber, T. M., Kumar, Sudhesh, Vatish, Manu, McTernan, P. G., 2014. The identification of irisin in human cerebrospinal fluid : influence of adiposity, metabolic markers, and gestational diabetes. AJP : Endocrinology and Metabolism, 306 (5), pp. E512-E518
- Lee, James D., Saravanan, Ponnusamy, Varadhan, Lakshminarayanan, Morrissey, John R., Patel, Vinod, 2014. Quality of diabetes care worldwide and feasibility of implementation of the Alphabet Strategy : GAIA project (Global Alphabet Strategy Implementation Audit). BMC health services research, 14 (467), pp. 1-12
- Harte, A. L., Tripathi, G. N., Piya, Milan K., Barber, Thomas, Clapham, J. C., Al-Daghari, N., Al-Disi, Dara, Kumsaiyai, Warunee, Saravanan, Ponnusamy, Fowler, Anne E., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G., 2013. NFêB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status and TNFá. Obesity, 21 (11), pp. 2322-2330
- Makura, Caroline BT, Nirantharakumar, Krishnarajah, Girling, Alan J, Saravanan, Ponnusamy, Narendran, Parth, 2013. Effects of physical activity on the development and progression of microvascular complications in type 1 diabetes : retrospective analysis of the DCCT study. BMC Endocrine Disorders, 13 (1)
- Harte, A. L., Tripathi, Gyanendra, Piya, Milan K., Barber, T. M., Clapham, John C., Al-Daghri, Nasser, Al-Disi, Dara, Kumsaiyai, Warunee, Saravanan, Ponnusamy, Fowler, Anne E., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G., 2013. NF?B as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status, and TNFa. Obesity research, 21 (11), pp. 2322-23300
- Panicker, Vijay, Saravanan, Ponnusamy, Vaidya, Bijay, Evans, Jonathan, Hattersley, Andrew T., Frayling, Timothy M., Dayan, Colin M., 2013. Common variation in the DIO2Gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. The Journal of Clinical Endocrinology & Metabolism, 94 (5), pp. 1623-1629
- Armstrong, Natalie, Baines, Darrin L., Baker, Richard H., Crossman, Richard, Davies, Melanie, Hardy, Ainsley, Khunti, Kamlesh, Kumar, Sudhesh, O'Hare, J. Paul, Raymond, Neil T., Saravanan, Ponnusamy, Stallard, Nigel, Szczepura, Ala, Wilson, Andrew, 2012. A cluster randomized controlled trial of the effectiveness and cost-effectiveness of Intermediate Care Clinics for Diabetes (ICCD) : study protocol for a randomized controlled trial. Trials, Vol.13 (No.1)
- Harte, A. L., Varma, Madhusudhan C., Tripathi, Gyanendra, McGee, K. C., Al-Daghri, Nasser M., Al-Attas, Omar S., Sabico, Shaun, O'Hare, J. Paul, Ceriello, Antonio, Saravanan, Ponnusamy, Kumar, Sudhesh, McTernan, P. G., 2012. High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects. Diabetes Care, Vol.35 (No.2), pp. 375-382
- Schisano, Bruno, Harte, Alison L., Lois, Konstantinos, Saravanan, Ponnusamy, Al-Daghri, Nasser M., Al-Attas, Omar S., Knudsen, Lotte B., McTernan, P. G., Ceriello, Antonio, Tripathi, Gyanendra, 2012. GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress. Regulatory Peptides, Vol.174 (No.1-3), pp. 46-52
- Kyrou, Ioannis, Osei-Assibey, G., Williams, Nerys R., Thomas, R., Halder, L. (Louise), Taheri, S., Saravanan, Ponnusamy, Kumar, Sudhesh, 2011. Self-reported disability in adults with severe obesity. Journal of Obesity, Vol.2011 (No.918402)
- Rafnsson, Snorri B., Saravanan, Ponnusamy, Bhopal, Raj S., Yajnik, Chittaranjan S., 2011. Is a low blood level of vitamin B12 a cardiovascular and diabetes risk factor? A systematic review of cohort studies. European Journal of Nutrition, Vol.50 (No.2), pp. 97-106
- Osei-Assibey, G., Kyrou, Ioannis, Kumar, Sudhesh, Saravanan, Ponnusamy, Matyka, Krystyna, 2010. Self-reported psychosocial health in obese patients before and after weight loss. Journal of Obesity, Vol.2010 (No.372463)
- Saravanan, Ponnusamy, Yajnik, C. S., 2010. Role of maternal vitamin B12 on the metabolic health of the offspring : a contributor to the diabetes epidemic?. The British Journal of Diabetes & Vascular Disease, 10 (3), pp. 109-114
- Panicker, Vijay, Saravanan, Ponnusamy, Vaidya, Bijay, Evans, Jonathan, Hattersley, Andrew T., Frayling, Timothy M., Dayan, Colin M., 2009. Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. Journal of Clinical Endocrinology & Metabolism, Vol.94 (No.5), pp. 1623-1629
- Panicker, Vijay, Cluett, Christie, Shields, Beverley, Murray, A. (Anna), Parnell, Kirstie S., Perry, John R. B., Weedon, Michael N., Singleton, Andrew, Hernandez, Dena, Evans, Jonathan, Dr., Durant, Claire, Ferrucci, Luigi, Melzer, David, Saravanan, Ponnusamy, Visser, Theo J., Ceresini, Graziano, Hattersley, Andrew T., Vaidya, Bijay, Dayan, Colin M., Frayling, Timothy M., 2008. A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. Journal of Clinical Endocrinology and Metabolism, 93 (8), pp. 3075-3081
- Saravanan, Ponnusamy, Patel, Vinod, O'Hare, J., Kumar, Sudhesh, 2016. Integrated diabetes care : Coventry and Warwickshire approach. In Simmons, David; Wenzel , Helmut; Zgibor , Janice C. (eds.), Integrated Diabetes Care : A Multidisciplinary Approach, Heidelberg, Springer International Publishing, pp. 147-168
- Saravanan, Ponnusamy, Wood, C., Anderson, N., 2010. B12 deficiency is more common than folate deficiency in early pregnancy: do we need to consider B12 fortification?. 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), Stockholm, Sweden, September 20-24, 2010, Published in Diabetologia, pp. S151-S152
- Bhalerao, Abhir, Patanaik, Amiya, Anand, Sarabjot Singh, Saravanan, Ponnusamy, 2008. Robust detection of microaneurysms for sight threatening retinopathy screening. 6th Indian Conference on Computer Vision, Graphics and Image Processing, Bhubaneswar, India, Dec 16-19 2008, Published in Sixth Indian Conference on Computer Vision, Graphics & Image Processing, ICVGIP 2008, pp. 520-527
- Bhalerao, Abhir, Anand, Sarabjot Singh, Saravanan, Ponnusamy, 2008. Retinal fundus image constrast normalization using mixture of gaussians. 42nd Asilomar Conference on Signals, Systems and Computers, Pacific Grove, CA, Oct 26-29, 2008, Published in Asilomar Conference on Signals, Systems and Computers. Conference Record, pp. 647-650
- 'Bick, Debra, 'Ram, Uma, 'Saravanan, Ponnusamy, 'Temmerman, Marleen, 2022. 'New global WHO postnatal guidance is welcome but misses the long-term perspective. The Lancet, Lancet Publishing Group, pp. 1578-1580
- Saravanan, Ponnusamy, 2010. Psychological well-being on thyroid hormone replacement.
| Title | Funder | Award start | Award end |
|---|---|---|---|
| Supplement Award to Role of vitamin B12 and folate imbalance on Gestational Diabetes (GDM) and metabolic risk of the offspring. See Proposal 49867 PEAPOD for Clinical Fellows | George Eliot Hospital NHS Trust | 01 Feb 2017 | 22 Feb 2026 |
| George Elliot Hospitsl NHS Trust: RCF funding: Evaluation of West Midlands Regional Familial Hypercholesterolemia Service. | George Eliot Hospital NHS Trust | 01 Oct 2021 | 31 Dec 2024 |
| Novo Nordisk agreement for international research and doctoral training studentships | Novo Nordisk A/S | 01 Feb 2019 | 31 Jan 2024 |
| MRC Population & Systems Medicine lead by Univ of Leeds:entitled "MICA: Understanding the glycemic profile of pregnancy: intensive CGM glucose profiling and its relationship to fetal growth", | MRC | 05 Oct 2020 | 04 Oct 2023 |
| MnCA agreement linked to award on 65610 for Medical and Life Sciences Research Fund:Contribution of energy EXPEnditure to post-paRTum weight retention in women following GDM pregnancy (EXPERT-GDM): Pilot studyMedical and Life Sciences Research Fund:Contribution of energy EXPEnditure to post-paRTum weight retention in women following GDM pregnancy (EXPERT-GDM): Pilot study | University Hospitals Coventry and Warwickshire NHS Trust | 01 Mar 2022 | 31 Mar 2023 |
| CoA Role of HbA1c and 50g GCT in early detection and prediction of Gestational Diabetes and associated maternal and fetal complications in Thailand linked to | UK Research and Innovation | 01 Apr 2021 | 31 Mar 2022 |
| Co-Sponsorship Agreement with George Eliot for WCPRS studentship - link to 55104 | George Eliot Hospital NHS Trust | 01 Jul 2019 | 30 Jun 2021 |
| Role of HbA1c and 50g GCT in early detection and prediction of gestational diabetes and associated maternal and fetal complications in Thailand | MRC | 01 Apr 2018 | 31 Mar 2021 |
| WMS: WCPRS with BHR Pharmaceutical Ltd | BHR Pharmaceutical Ltd | 01 Oct 2017 | 31 Mar 2021 |
| Freeze dried broccoli as a dietary intervention to reduce cardiometabolic risk in post-partum GDM women. | Novo Nordisk UK Research Foundation | 01 Nov 2016 | 31 Jan 2020 |
| Gestational hyperglycaemia in Malaysia: early screening and intervention | MRC | 03 Jan 2017 | 31 Dec 2019 |
| Risk stratification of gestational diabetes in India and Kenya. | MRC | 14 Jul 2015 | 31 Jul 2019 |
| Role of Vitamin B12 on obesity and diabetes | The Sir Jules Thorn Charitable Trust | 01 Jun 2016 | 31 May 2019 |
| Clinical RF funding - PEAPOD PRiDE | George Eliot Hospital NHS Trust | 01 Mar 2016 | 01 Apr 2019 |
| The role of vitamin D deficiency in pregnant women and its association with gestational diabetes mellitus and impact on inflammation | King Saud University | 30 Sept 2013 | 30 Sept 2017 |
| Role of B12 and Folate on Differentiation of adipocytes and myocytes Agreement 8 | George Eliot Hospital NHS Trust | 01 Jul 2016 | 30 Jun 2017 |
| PRIDE extension costs | MRC | 01 Dec 2015 | 31 Mar 2017 |
| PEAPOD | Warwickshire Private Hospitals Charitable Trust | 31 Aug 2015 | 30 Aug 2016 |
| Role of B12 and Folate on Differentiation of adipocytes and myocytes | George Eliot Hospital NHS Trust | 01 Apr 2015 | 30 Jun 2016 |
| CRN strategic funding | Royal Wolverhampton Hospitals NHS Trust - New Cross Hospital | 26 Mar 2015 | 25 Mar 2016 |
| Role of B12 and Folate on differentiation of adipocytes and myocytes - extension 5 | George Eliot Hospital NHS Trust | 01 Apr 2014 | 31 Mar 2015 |
| Research Fellow Funding Additional Supplemental | George Eliot Hospital NHS Trust | 01 Mar 2012 | 31 Mar 2015 |
| Support for two 0.75FTE Research Fellows to work on the MRC Study | George Eliot Hospital NHS Trust | 01 Mar 2012 | 31 Mar 2015 |
| ICMR-MRC FULL application: Non-Communicable Disease Research Funding | MRC | 01 Nov 2011 | 31 Oct 2014 |
| RMRV0033 - Variation No. 4 - Role of B12/Folate on adipocyte and mycoyte differentiation | George Eliot Hospital NHS Trust | 06 Sept 2013 | 31 Mar 2014 |
| Funding for 0.5 FTE Amith Gopinath 2013/14 | Thames Valley Diabetes Local Research Network (TV DLRN) | 01 Apr 2013 | 31 Mar 2014 |
| Variation No. 2: Role of B 12 and folate on the diffemtia | George Eliot Hospital NHS Trust | 01 Nov 2012 | 30 Apr 2013 |
| Funding for GEH Host costs | Thames Valley Diabetes Local Research Network (TV DLRN) | 01 Feb 2013 | 31 Mar 2013 |
| Funding for 0.5WTE Amith Gopinath | Thames Valley Diabetes Local Research Network (TV DLRN) | 01 Apr 2012 | 31 Mar 2013 |
| Research nurse support at GEH - Via Warwick | Thames Valley Diabetes Local Research Network (TV DLRN) | 01 Apr 2012 | 31 Mar 2013 |
| FSF 2011/12 Full Time Research Nurse (support recruitment to MRC-GDM study) | Thames Valley Diabetes Local Research Network (TV DLRN) | 01 Feb 2012 | 31 Jan 2013 |
| Continuation of Thames Valley DLRN Funding 2010/11 FSF Funding (50% Band 5 Research Co-ordinator April 11 - March 12) | Thames Valley Diabetes Local Research Network (TV DLRN) | 05 Mar 2012 | 31 Dec 2012 |
| Extension - Role of B12 and folate on the differntiation | University Hospitals Coventry and Warwickshire NHS Trust | 01 Feb 2012 | 31 Dec 2012 |
| F&S funding for Project Manager supporting the PRiDE (MRC-GDM) study. | Thames Valley Diabetes Local Research Network (TV DLRN) | 09 Mar 2012 | 30 Sept 2012 |
| Funding for a Research Nurse for 2011/2012 | Thames Valley Diabetes Local Research Network (TV DLRN) | 05 Mar 2012 | 31 Aug 2012 |
| Supplement/Extension - Role of B12/Folate on adipocyte and mycoyte differentiation | George Eliot Hospital NHS Trust | 22 Jul 2011 | 29 Feb 2012 |
| FSF Funding (60% Research Nurse for 12 months) | Thames Valley Diabetes Local Research Network (TV DLRN) | 14 Dec 2010 | 13 Dec 2011 |
| Role of B12/ Folate on adipocyte and mycoyte differentialtion | George Eliot Hospital NHS Trust | 15 Jul 2010 | 05 Jul 2011 |
| Thames Valley DLRN Funding 2010/11FSF Funding (50% Band 5 Research Co-ordinator April 10 - March 11) | Thames Valley Diabetes Local Research Network (TV DLRN) | 01 Feb 2011 | 31 Mar 2011 |
| FSF Funding (50% Band 4 Research Co-ordinator April 09 - March 10) | Thames Valley Diabetes Local Research Network (TV DLRN) | 01 Feb 2011 | 31 Mar 2011 |
| Flexibility and sustanability funding 09/10 - support staff time | Thames Valley Diabetes Local Research Network (TV DLRN) | 02 Aug 2010 | 31 Dec 2010 |
| Role of B12 and folate on the differntiation of adipocytes and myoctes: A mechanism to prevent diabetes epidemic | University Hospitals Coventry and Warwickshire NHS Trust | 01 Jan 2010 | 31 Dec 2010 |
| Flexibility and sustainability: Diabetes specialist Nurse | National Institute for Health Research (DoH) | 02 Aug 2010 | 31 Aug 2010 |
| Flexability & Sustainability Finding for ICCD Project | Thames Valley Diabetes Local Research Network (TV DLRN) | 01 Mar 2009 | 31 Aug 2010 |
| Additional Funding for Supporting Recruitment to ICCD Project | Thames Valley Diabetes Local Research Network (TV DLRN) | 01 Mar 2009 | 30 Aug 2010 |
| To Develop an Affordable Ubiquitous Generic Method of Monitoring Chronic Disease in a Community Based Programme | Aston University | 15 Jun 2008 | 15 Dec 2008 |