1992-1995 Wellcome Trust Research Fellow, University of Sheffield, UK<br>1995-1996 Royal Society Traveling Research Fellow, UBC,Vancouver, Canada<br>1996-1997 Izaak Walton Killam Research Fellow, UBC, Vancouver, Canada<br>1997-2001 Diabetes UK, RD Lawrence Research Fellow, King's College London<br>1998 EASD/Bayer & Peter Baker Traveling Research Fellow, Uppsala, Sweden<br>2001-2005 Lecturer in Cellular Signalling, University of Warwick, UK<br>2001-2004 Honorary Lecturer, King's College London <br>2005-2010 Senior Lecturer Molecular Physiology, University of Warwick, UK<br>2010-present Reader in Diabetes & Endocrinology, University of Warwick, UK<br><br><br>My Research interests include elucidating sub-cellular mechanism that regulate insulin insulin secretion and action. A common avenue for both projects is the role of cell-to-cell communication in synchronising Ca2+-transients and function between cells of both the nephron and pancreatic islet.<br><p><b>Research Theme: <a href="http://www2.warwick.ac.uk/fac/sci/lifesci/research/themes/cellbiology//">Cell Biology</a></b>
I joined the University of Warwick in 2001 following an RD Lawrence Research Fellowship (Diabetes UK:1998-2001) tenured at King's College London. I was awarded an Honorary Lectureship in the School of Biomedical Sciences KCL (2001-2004) and I was a recipient of the Paul Langerhans Research Fellowship for Research on the Physiology and Pathophysiology of the pancreatic beta-cell (EASD: 2001). I spent 3years at the University of British Columbia (UBC), Vancouver as a Royal Society Travelling Research Fellow and Honorary Fellow of the Izaak Walton Killam Memorial Foundation (1995-1998), and received a Travelling Research Fellowship to study at the University of Uppsala, Sweden (EASD/Bayer & Peter Baker). I'm currently Associate Professor (READER) within the School of Life Sciences and help deliver numerous modules, including: Molecular Endocrinology (BS252), Pharmacology (BS261) and Physiology & Metabolism (BS129). I have been External Assessor for the MSc Programme in Biomedicine & Molecular Science Research, KCL (2005-2009) and been involved in the recent Periodic Reviews for the Peninsula College of Medicine and Dentistry Graduate program (2012). I have been a member of the Research Advisory Boards for Diabetes UK (DUK: 2005-2012), the Diabetes Research & Wellness Foundation (DRWF: 2010-present) and the European Foundation for the Study of Diabetes (EFSD: 2012-present) and I am the Warwick representative to the Physiological Society (2009-present).
- Hills, Claire E., Bland, Rosemary, Squires, Paul E.. SGK1 in the kidney: disrupted sodium transport in diabetes and beyond. Asia-Pacific Journal of Endocrinology, Vol.1 (No.1), pp. 27-34
- Siamantouras, Eleftherios, Hills, Claire E., Squires, Paul E., Liu, Kuo-Kang, 2016. Quantifying cellular mechanics and adhesion in renal tubular injury using single cell force spectroscopy. Nanomedicine : Nanotechnology, Biology, and Medicine, 12 (4), pp. 1013-1021
- Siamantouras, Eleftherios, Hills, Claire E., Squires, Paul E., Liu, Kuo-Kang, 2015. Nanomechanical investigation of soft biological cell adhesion using atomic force microscopy. Cellular and Molecular Bioengineering, 8 (1), pp. 22-31
- Siamantouras, Eleftherios, Hills, Claire E., Younis, Mustafa Y. G., Squires, Paul E., Liu, Kuo-Kang, 2014. Quantitative investigation of calcimimetic R568 on beta cell adhesion and mechanics using AFM single-cell force spectroscopy. FEBS Letters, 588 (7), pp. 1173-1178
- Hills, Claire E., Kerr, Michael I., Wall, Mark J., Squires, Paul E., 2013. Visfatin reduces gap junction mediated cell-to-cell communication in proximal tubule-derived epithelial cells. Cellular Physiology & Biochemistry, 32 (5), pp. 1200-1212
- Hills, Claire E., Jin, Tianrong, Siamantouras, Eleftherios, Liu, Kuo-Kang, Jefferson, Kieran P., Squires, Paul E., 2013. 'Special K' and a loss of cell-to-cell adhesion in proximal tubule-derived epithelial cells : modulation of the adherens junction complex by ketamine. PLoS One, 8 (8)
- Yang, G. K., Squires, Paul E., Tian, Faming, Kieffer, T. J., Kwok, Y. N., Dale, Nicholas, 2012. Glucose decreases extracellular adenosine levels in isolated mouse and rat pancreatic islets. Islets, Vol.4 (No.1)
- Hills, Claire E., Younis, Mustafa Y. G., Bennett, Jeanette, Siamantouras, Eleftherios, Liu, Kuo-Kang, Squires, Paul E., 2012. Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function. Cellular Physiology and Biochemistry, Vol.30 (No.3), pp. 575-586
- Hills, Claire E., Siamantouras, Eleftherios, Smith, S. W., Cockwell, Paul, Liu, Kuo-Kang, Squires, Paul E., 2012. TGFß modulates cell-cell communication in early epithelial-to-mesenchymal transition. Diabetologia, Vol.55 (No.3), pp. 812-824
- Hills, Claire E., Bland, Rosemary, Squires, Paul E., 2012. Functional expression of TRPV4 channels in human collecting duct cells : implications for secondary hypertension in diabetic nephropathy. Experimental Diabetes Research, 2012
- Hills, Claire E., Squires, Paul E., 2011. The role of TGF-ß and epithelial-to mesenchymal transition in diabetic nephropathy. Cytokine & Growth Factor Reviews
- Stratton, Rebecca C., Squires, Paul E., Green, Anne K., 2010. 17ß-estradiol elevates cGMP and, via plasma membrane recruitment of protein kinase GIa, stimulates Ca2+ efflux from rat hepatocytes. Journal of Biological Chemistry, Vol.285 (No.35), pp. 27201-27212
- Hills, Claire E., Squires, Paul E., 2010. TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy. American Journal of Nephrology, Vol.31 (No.1), pp. 68-74
- Hills, Claire E., Bland, Rosemary, Bennett, Jeanette, Ronco, Pierre M., Squires, Paul E., 2009. TGF-beta 1 mediates glucose-evoked up-regulation of connexin-43 cell-to-cell communication in HCD-cells. Cellular Physiology and Biochemistry, Vol.24 (No.3-4), pp. 177-186
- Stratton, Rebecca C., Squires, Paul E., Green, Anne K., 2008. ANP stimulates hepatocyte Ca2+ efflux via plasma membrane recruitment of PKGIa. Biochemical and Biophysical Research Communications, Vol.368 (No.4), pp. 965-970
- Kitsou-Mylona, Isidora, Burns, Christopher J., Squires, Paul E., Persaud, Shanta J., Jones, Peter M., 2008. A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of Langerhans. Cellular Physiology and Biochemistry, Vol.22 (No.5-6), pp. 557-566
- Hills, Claire E., Squires, Paul E., Bland, Rosemary, 2008. SGK and disturbed renal sodium transport in diabetes. Journal of Endocrinology, Vol.199 (No.3), pp. 343-349
- Hodgkin, M. N., Hills, Claire E., Squires, Paul E., 2008. The calcium-sensing receptor and insulin secretion : a role outside systemic control 15 years on. Journal of Endocrinology, Vol.199 (No.1-4)
- Ramraeheya, Reshma D., Muller, Danu S., Squires, Paul E., Brereten, Helen, Sugden, David (Researcher in life sciences), Huang, Guo Cai, Amiel, Stephanie, Jones, Peter M., Persaud, Shanta J., 2008. Function and expression of melatonin receptors on human pancreatic islets. Journal of Pineal Research, 44 (3), pp. 273-279
- Holden, Neil S., Squires, Paul E., Kaur, Manminder, Bland, R. (Rosemary), Jones, Carol E., Newton, R. (Robert), 2008. Phorbol ester-stimulated NF-kappa B-dependent transcription : Roles for isoforms of novel protein kinase C. Cellular Signalling, 20 (7), pp. 1338-1348
- Rogers, Gareth J., Hodgkin, Matthew N., Squires, Paul E., 2007. E-cadherin and cell adhesion : a role in architecture and function in the pancreatic islet. Cellular Physiology and Biochemistry, 20 (6), pp. 987-994
- Green, Anne K., Stratton, Rebecca C., Squires, Paul E., Simpson, Alec W. M., 2007. Atrial natriuretic peptide attenuates elevations in Ca2+ and protects hepatocytes by stimulating net plasma membrane Ca2+ efflux. Journal of Biological Chemistry, Vol.282 (No.47), pp. 34542-34554
- Gray, Elizabeth, Muller, Dany, Squires, Paul E., Asare-Anane, Henry, Huang, Guo-Cai, Amiel, Stephanie, Persaud, Shanta J., Jones, Peter M., 2006. Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans : involvement of protein kinases. Journal of Endocrinology, 190 (3), pp. 703-710
- Hills, Claire E., Bland, Rosemary, Bennett, Jeanette, Ronco, Pierre M., Squires, Paul E., 2006. High glucose up-regulates ENaC and SGK1 expression in HCD-cells. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 18 (6), pp. 337-346
- Hills, Claire E., Bland, Rosemary, Wheelans, Dianne C., Bennett, Jeanette, Ronco, Pierre M., Squires, Paul E., 2006. Glucose-evoked alterations in connexin43-mediated cell-to-cell communication in human collecting duct: a possible role in diabetic nephropathy. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 291 (5), pp. F1045-F1051
- Squires, Paul E., Jones, Peter J., Younis, Mustafa Y. G., Hills, Claire E., 2014. The calcium-sensing receptor and beta-cell function. In Litwack, Gerald (ed.), The Pancreatic beta-cell, UK, Academic Press, pp. 249-267
- Squires, Paul E., Hills, Claire E., Ronco, Pierre, Bland, Rosemary, 2008. Functional expression of TRPV4 in human collecting duct (HCD) cells: a role in diabetic nephropathy. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, Sep 18-21, 2007, Published in Diabetologia, pp. S44-S45
- Squires, Paul E., Rogers, G. J., Hodgkin, M. N., 2006. E-cadherin-mediated cell adhesion : a role in islet architecture, cell-to-cell coupling and insulin secretion?. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen, Denmark, 14-17 Sep 2006, Published in Diabetologia, pp. 314-315
- Hills, Claire E., Bland, Rosemary, Ronco, P. M., Squires, Paul E., 2006. Deranged transcriptional regulation of SGK and ENaC : a link between hyperglycaemia and diabetic nephropathy. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen, Denmark, 14-17 Sep 200, Published in Diabetologia, pp. 654-655
- Hills, Claire E., Brunskill, Nigel J., Squires, Paul E., 2010. C-Peptide as a therapeutic tool in diabetic nephropathy. American Journal of Nephrology, Karger, pp. 389-397
- Hills, Claire E., Squires, Paul E., Bland, Rosemary, 2008. Serum and glucocorticoid regulated kinase and disturbed renal sodium transport in diabetes. Journal of Endocrinology, Society for Endocrinology, pp. 343-349
Title | Funder | Award start | Award end |
---|---|---|---|
Special K and urological complications of ketamine abuse | The Teresa Rosenbaum Golden Charitable Trust (Rosetrees Trust) | 01 Oct 2013 | 30 Sep 2016 |
Does reorganisation of the extracellular matrix promote a loss of phenotypic stability in diabetic nephropathy? | WPH Charitable Trust | 01 Mar 2014 | 29 Feb 2016 |
DUK Equipment Grant: AFM single-cell force spectroscopy: determining the functional role of cell-cell adhesion and membrane dynamics in diabetes | Diabetes UK | 01 Jan 2013 | 31 Dec 2015 |
The effect of TGF-beta on connexin-mediated signalling: a role in diabetic nephropathy. | Diabetes UK | 01 Oct 2011 | 30 Sep 2014 |
The importance of cell-to-cell contact in diabetic nephropathy: identifying potential novel targets for therapeutic intervention | WPH Charitable Trust | 01 Mar 2012 | 28 Feb 2014 |
The effect of TGF-beta on cell adhesion, cell coupling & cell communication: a role in diabetic nephropathy | European Foundation for the Study of Diabetes (EFSD) | 01 Oct 2011 | 31 May 2013 |
A role for C-peptide in alleviating diabetic nephropathy | Diabetes Research and Wellness Foundation | 01 Feb 2010 | 31 Jan 2011 |
The extracellular calcuim-sensing receptor and paracrine signalling in the islet | Diabetes UK | 01 Dec 2009 | 30 Nov 2010 |
Royal Society Conference Grant (42nd Annual Conference of EASD, Copenhagen) | Royal Society | 13 Sep 2006 | 17 Sep 2006 |
41st Annual Meeting of the European Association for the Study of Diabetes | Royal Society | 10 Sep 2005 | 15 Sep 2005 |
Renal regulation of sodium transport by tubular osmotic variation: a potential role in the development of hypertension asociated with Diabetes Mellitus | Diabetes Endocrine and Immersion Research Trust | 01 Jun 2003 | 31 May 2005 |
Regulation of sodium transport in ocular ciliary epithelium; a role in the development of diabetic glaucoma | Diabetes Endocrine and Immersion Research Trust | 01 May 2004 | 30 Apr 2005 |