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Prof Victor Zammit

Job Title
Professor of Metabolic Biochemistry
Department
WMS - Translational Medicine
Phone
024 76522798
Research Interests

The overall research interest of the laboratory is the regulation of fatty acid metabolism in health and disease, with particular emphasis on the changes related to insulin resistance and type-2 diabetes.

Specific interests include:

  • The role of fatty acids in the control of insulin secretion, and disruption of insulin signalling
  • Structure-function relationships of carnitine palmitoyltransferase 1 (CPT 1) and acetyl-CoA carboxylase 2 (ACC-2) with particular reference to the role of malonyl-CoA in the regulation of the intracellular content of long-chain acyl-CoA esters and products of their metabolism to complex lipids, in relation to the aetiology of insulin resistance and apoptosis
  • The role of different diacylglycerol acyltransferases in the control, and cellular trafficking, of triacylglycerol in lipoprotein-secretory tissues
  • The effects on acute hepatic insulin sensitivity of recurrent high-glycaemic intake
  • Grima, Joseph N., Gatt, Ruben, Zammit, Victor A., Williams, Jennifer J., Evans, Kenneth E., Alderson, Andrew, Walton, Richard I., 2007. Natrolite: a zeolite with negative Poisson's ratios. 28th International Conference on the Physics of Semiconductors, Vienna, Austria, 2006, Published in Journal of Applied Physics
Title Funder Award start Award end
Role of alternative pathways of triglyceride synthesis in muscle insulin resistance in humans at risk of type-2 diabetes Diabetes UK 01 Aug 2016 30 Nov 2019
Visiting Researcher Agreement - Dr S-O Park Kangwon National University 01 Sep 2017 31 Jan 2018
Dyslipidaemia and Hepatic Steatosis: Distinct Roles of DGAT2 and DGAT1 in Hepatocytes and Enterocytes MRC 01 Apr 2013 31 Mar 2017
Amendment 1: Case studentship Haja Wurie - Determination of the intracellular localisation of the DGAT enzymes and the effects on metabolic function in different cell types AstraZeneca UK Limited 18 May 2009 30 Sep 2011
The Role of Strutural Motifs Within the Transmembrane Domains of Cardiac CPT1B Determining its Distinctive Oligomerisation and Kinetic Characteristics British Heart Foundation 01 Sep 2008 31 Aug 2011
BHF ACC2 Pilot Study: A pilot study to test the hypothesis that in cardiomyocytes ACC-2 association with mitochondria is reversible and controlled by factors tha affect cardiac fatty acid oxidation. British Heart Foundation 01 Mar 2010 28 Feb 2011
Use of Pancreatic beta cells for the study of the role of CPT 1 activity in the control of insulin secretion Royal Society 04 Aug 2010 25 Aug 2010
Determination of the intracellular localisation of the DGAT enzymes and the effects on metabolic function in different cell types AstraZeneca 01 Oct 2006 30 Sep 2009
Role of DGAT 1 and 2 expression in cardiac muscle triglyceride synthesis and secretion British Heart Foundation 01 Jan 2006 31 Dec 2008
Do conserved motifs in the transmembrane domains of CPTI from liver and muscle propmote oligomerizationin situ? Diabetes UK 01 Apr 2007 31 Mar 2008
Do conserved motifs in the transmembrane domains of CPTI from liver and muscle promote oligomerization in situ? Diabetes UK 01 Jul 2007 31 Mar 2008
MOLECULAR DETERMINANTS OF THE DISTINCTIVE KINETIC CHARACTERISTICS OF THE HUMAN M-CPT 1 ISOFORM British Heart Foundation 01 Jan 2005 31 Jul 2006
MOLECULAR DETERMINANTS OF ACETYL-COA CARBOXYLASE-2 British Heart Foundation 01 Jan 2005 28 Feb 2006