Events in Physics
Robert Best, Cambridge
Interpreting single molecule folding experiments: insights from molecular simulation
A unique capability of single molecule experiments is the unambiguous resolution of conformational sub-states of biomolecules and their rates of interconversion. However, these experiments usually probe a single observable, such as a distance, and therefore specific structural information is limited. I will describe how coarse-grained molecular simulations can be used to fill in some of the details. First, I will show how coarse-grained models can be used to suggest structures for the misfolded states of titin polyproteins which are observed in single-molecule FRET experiments. The structures of the misfolds explain their unusual stability, and are also consistent with earlier measurements by AFM. Secondly, I will consider the analysis of folding kinetics in single molecule pulling experiments, focussing mainly on the interpretation of the one-dimensional models which are commonly used to interpret experimental kinetic data.
Academic Leave Diary
Physics Days
Research Group Events
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Open Funder Deadlines
UKRI - Daphne Jackson Fellowship
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UKRI Deadlines
Due to the implementation of a new UKRI funding system (TFS) there will be a fixed quarterly deadlines for some grants which would previously have been on open calls, this is to allow necessary system amendments and updates.
The first deadline after implementation will be 28th September 2023 and applies to those calls listed below:
EPSRC Post Doctoral Fellowship
EPSRC Working with overseas scientists