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Ultrafast & Terahertz Photonics: Publications

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Effect of transdermal drug delivery patches on the stratum corneum: in vivo inspection with a handheld terahertz probe

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A.I. Hernandez-Serrano, X. Ding, G. Costa, G. Nurumbetov, D.M. Haddleton and E. Pickwell-MacPherson
Biomedical Optics Express 15, 3064 (May 2024)

Wed 15 May 2024, 07:25 | Tags: 2024, biomedical, MacPherson, THz spectroscopy

Terahertz probe for real time in vivo skin hydration evaluation

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A.I. Hernandez-Serrano, X. Ding, J. Young, G. Costa, A. Dogra, J. Hardwicke and E. Pickwell-MacPherson
Advanced Photonics Nexus 3, 016012 (Feb 2024)

Fri 12 Apr 2024, 07:02 | Tags: 2024, biomedical, highlight, MacPherson, THz spectroscopy

Spectroscopic insight on impact of environment on natural photoprotectants

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A. Whittock, X. Ding, X. Ramirez Barker, N. Auckloo, R. Sellers, J.M. Woolley V. Krishnan, C. Marine, C. Corre, E. Pickwell-MacPherson and V.G. Stavros
Chem. Sci. 14, 6763 (June 2023)

Wed 28 Jun 2023, 08:00 | Tags: 2023, biomedical, MacPherson, THz spectroscopy

The 2023 terahertz science and technology roadmap

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A. Leitenstorfer, ..., E. Pickwell-MacPherson, ... and J. Cunningham
J. Phys. D: Appl. Phys. 56, 223001 (April 2023)


Quantitative evaluation of transdermal drug delivery patches on human skin with in vivo THz-TDS

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X. Ding, G. Costa, A. I. Hernandez-Serrano, R.I. Stantchev, G. Nurumbetov, D.M. Haddleton, and E. Pickwell-MacPherson
Bio. Opt. Express 14, 1146 (Feb 2023)

Tue 06 Jun 2023, 22:02 | Tags: 2023, biomedical, MacPherson, THz spectroscopy

Terahertz (THz) biophotonics technology: Instrumentation, techniques, and biomedical applications

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X. Chen, H. Lindley-Hatcher, R. I. Stantchev, J. Wang, K. Li, A. I. Hernandez-Serrano, Z. D. Taylor, E. Castro-Camus and E. Pickwell-MacPherson
Chem. Phys. Rev. 3, 011311 (June 2022)

Wed 01 Jun 2022, 09:45 | Tags: 2022, biomedical, MacPherson, review, THz spectroscopy

Real time THz imaging—opportunities and challenges for skin cancer detection

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H. Lindley-Hatcher, R. I. Stantchev, X. Chen, A. I. Hernandez-Serrano, J. Hardwicke and E. Pickwell-MacPherson
Appl. Phys. Lett. 118, 230501 (June 2021)

Thu 10 Jun 2021, 12:30 | Tags: 2021, biomedical, MacPherson, review, THz imaging, THz spectroscopy

Evaluation of in vivo THz sensing for assessing human skin hydration

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H. Lindley-Hatcher, A. I. Hernandez-Serrano, J. Wang, J. Cebrian, J. Hardwicke and E. Pickwell-MacPherson
J. Phys. Photonics 3, 014001 (December 2020)

Mon 14 Dec 2020, 13:00 | Tags: 2020, biomedical, MacPherson, THz spectroscopy

Exploiting Complementary Terahertz Ellipsometry Configurations to Probe the Hydration and Cellular Structure of Skin In Vivo

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X. Chen, Q. Sun, J. Wang, H. Lindley-Hatcher, E. Pickwell-MacPherson
Adv. Photonics Res. 2000024 (November 2020) [ pdf ] [ ref ]

Tue 10 Nov 2020, 10:00 | Tags: 2020, biomedical, MacPherson, THz spectroscopy

Evaluation of transdermal drug delivery using terahertz pulsed imaging

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J. Wang, H. Lindley-Hatcher, K. Liu, E. Pickwell-MacPherson
Biomedical Optics Express 11 4484 (August 2020) [ pdf ] [ ref ]

Thu 24 Sep 2020, 10:01 | Tags: 2020, biomedical, MacPherson, THz imaging

A Robust Protocol for In Vivo THz Skin Measurements

H. Lindley-Hatcher, A. I Hernandez-Serrano, Q. Sun, J. Wang, J. Cebrian, L. Blasco, E. Pickwell-MacPherson
J Infrared Milli Terahz Waves 40 980 (August 2019) [ pdf ] [ ref ]

MethodThis work presents an experimental setup to control the way in which pressure interferes with the repeatability of in vivo THz skin measurements. By integrating a pressure sensor circuit into our THz system, it is possible to identify which measurements were taken within a previously specified pressure range. The live response of the pressure sensor helps to acquire data within the desired pressure leading to greater consistency of data between measurements. Additionally, a protocol is proposed to help achieve repeatable results and to remove the effects of the natural variation of the skin through the course of the day. This technique has been shown to be able to quantify the changes induced in the skin following the application of a moisturising skin product and shows the measured result to be significantly different from natural skin variation. This research therefore prepares the way for further studies on the effectiveness of different skin products using in vivo THz measurements.

Wed 28 Aug 2019, 09:00 | Tags: 2019, MacPherson, THz spectroscopy, biomedical

Utilizing multilayer structures to enhance terahertz characterization of thin films ranging from aqueous solutions to histology slides

Q. Sun, K. Liu, X. Chen, X. Liu, A. I Hernandez-Serrano, E. Pickwell-MacPherson
Optics Letters 44 2149 (April 2019) [ pdf ] [ ref ]

GeometryWe propose a multilayer geometry to characterize thin-film samples in reflection terahertz time domain spectroscopy. Theory indicates that this geometry has higher sensitivity compared to ordinary transmission or reflection geometries when characterizing both low- and high-absorption samples. Pure water and water–ethanol mixtures are measured to verify the characterization accuracy of the proposed geometry and its capability to measure trace liquids. Paraffin-embedded oral cancer tissue is imaged to further show how the proposed geometry enhances the sensitivity for solid low-absorptive films.

Wed 17 Apr 2019, 17:00 | Tags: 2019, MacPherson, THz components, THz spectroscopy, biomedical

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