This is fifteenth edition of the conference series, which was started in 1993. It has been held biennially since its second edition in 1994 (the 2020 edition has been postponed to 2021 due to Covid). The conference was initially known as "Heavy Quarks at Fixed Target", but in 2002 the the conference was renamed to "Heavy Quarks and Leptons". The previous editions of the conference are as follows:

• Yamagata 2018, Japan
• Virginia 2016, USA
• Mainz 2014, Germany
• Prague 2012, Czech Republic
• Frascati 2010, Italy
• Melbourne 2008, Australia
• Munich 2006, Germany
• San Juan 2004, Puerto Rico
• Vietri sul mare 2002, Italy
• Rio de Janeiro 2000, Brazil
• Batavia 1998, USA
• St. Goar 1996, Germany
• Charlottesville 1994, USA
• Frascati 1993, Italy