(1) Background: This exploratory study aims to explore the relationship between nonspecific chronic spinal pain (nCSP) and insomnia symptoms, by examining the interconnections, strengths, and directional dependence of the symptoms. In addition, we aim to identify the key symptoms of the nCSP–insomnia relationship and shed light on the bidirectional nature of this relationship. (2) Methods: This study is a secondary analysis of the baseline data (cross-sectional) from a randomized controlled trial, which examined the added value of Cognitive Behavioral Therapy for Insomnia (CBT-I) combined with cognition-targeted exercise therapy, conducted in collaboration with the Universiteit Gent and Vrije Universiteit Brussel (Belgium). One hundred and twenty-three nCSP patients with comorbid insomnia were recruited through the participating hospitals, advertisements, announcements in local newspapers, pharmacies, publications from support groups, and primary care. To explore the interconnections and directionality between symptoms and the strengths of the relationships, we estimated a regularized Gaussian graphical model and a directed acyclic graph. (3) Results: We found only one direct, but weak, link between sleep and pain, namely, between average pain and difficulties maintaining sleep. (4) Conclusions: Despite the lack of strong direct links between sleep and pain, pain and sleep seem to be indirectly linked via anxiety and depression symptoms, acting as presumable mediators in the network of nCSP and comorbid insomnia. Furthermore, feeling slowed down and fatigue emerged as terminal nodes, implying their role as consequences of the network.

Although many studies have examined the biochemical metabolic pathways by which an egg (egg yolk) lowers blood lipid levels, data on the molecular biological mechanisms that regulate and induce the partitioning of hepatic glycerolipids are missing. The aim of this study was to investigate in vivo monitoring in four study groups using an animal nutrition biomodel fitted with a jugular-vein cannula after egg yolk intake: CON (control group, oral administration of 1.0 g of saline), T1 (oral administration of 1.0 g of pork belly fat), T2 (oral administration of 1.0 g of smart-farm egg yolk), and T3 (oral administration of T1 and T2 alternately every week). The eggs induced significant and reciprocal changes in incorporating 14C lipids into the total glycerolipids and releasing 14CO2, thereby regulating esterification and accelerating oxidation in vivo. The eggs increased phospholipid secretion from the liver into the blood and decreased triacylglycerol secretion by regulating the multiple cleavage of fatty acyl-CoA moieties' fluxes. In conclusion, the results of the current study reveal the novel fact that eggs can lower blood lipids by lowering triacylglycerol secretion in the biochemical metabolic pathway of hepatic glycerolipid partitioning while simultaneously increasing phospholipid secretion and 14CO2 emission.

Context. From late September 2017 to January 2018, the Be X-ray binary (BeXB) Swift J0243.6+6124 underwent a giant outburst that was unprecedently bright. The reported X-ray luminosities were so high that the system was classified as an ultraluminous X-ray source (ULX). It was also the first BeXB pulsar to show radio jet emission. The source was not only bright in X-rays and radio, but also in the optical and ultraviolet (UV) wavelenghts as well.

Aims. In this work, we aim to understand the origin of the observed optical/UV fluxes simultaneous to the X-ray emission.

Methods. We studied the optical/UV light curves in comparison with the X-ray fluxes along the outburst. We considered the main mechanisms that can explain the optical/UV emission in X-ray binaries. Due to the tight correlation observed between the optical/UV and X-ray light curves, reprocessing of X-rays seems to be the most plausible explanation. We calculated the timescales of the light curve decays and studied the correlation indexes between the optical and X-ray emission. Finally, we built a physical model that considers the X-ray heating of the surface of the donor star, irradiation of the accretion disk, and emission from a viscously heated accretion disk, so that we could reproduce the observed optical/UV spectral energy distributions (SEDs) along the outburst. In our model, we considered the Be circumstellar disk to be co-planar to the orbit and then we neglected its irradiation in the current model. As an input for the model, we used as incident X-ray luminosities those calculated from the bolometric X-ray fluxes obtained from the spectral fit of the Swift/XRT and BAT observations.

Results. The timescales of the exponential decay of the outburst are between two and four times longer for the UV and optical light curves than for the X-ray light curve. The correlation index between the optical/UV and X-ray fluxes varies between optical/UV filters and when different X-ray bands are considered and is larger for the rise than for the decay phase of the outburst for the fluxes at redder wavelengths. The modelling of the SED shows that X-ray heating of the companion star surface is the main mechanism contributing to the UV emission and contributes significantly to the optical emission during the whole outburst. The X-ray irradiation of the accretion disk is necessary to reproduce the optical observed fluxes from MJD 58047 to 58120 and contributes significantly to the UV fluxes close to the peak of the outburst. As a first attempt, the fits yield an increasing value of the outer radius of the accretion disk along the outburst. An alternative interpretation points to variations in the geometry of the inner flow and the fraction of reprocessed X-ray emission during the outburst. On the other hand, variations in the geometry of the Be circumstellar disk could also play a role, but they have not been considered in the current model.

Conclusions. Reprocessing of X-rays via the X-ray heating of the Be star surface and as irradiation of the accretion disk is the main mechanism that can reproduce the observed optical/UV emission during the 2017−2018 giant outburst of Swift J0243.6+6124.