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Purpose:
There is a lack of clarity about what constitutes Science, Technology, Engineering, Arts and Mathematics (STEAM) education and what the arts contribute. In this paper the authors discuss a distinct model, theorised from a five-year study of a particular, innovative STEAM education project (The Imagineerium), and developed by the researchers through working with primary school teachers in England within a second project (Teach-Make). The paper examines how teachers implemented this model, the Trowsdale art-making model for education (the TAME), and reflected on its value and positive impact on their planning and pedagogy.
Design/methodology/approach
The paper draws on two studies: firstly, a five-year, mixed methods, participative study of The Imagineerium and secondly a participative and collaborative qualitative study of Teach-Make.
Findings:
Study of The Imagineerium showed strong positive educational outcomes for pupils and an appetite from teachers to translate the approach to the classroom. The Teach-Make project showed that with a clear curriculum model (the TAME) and professional development to improve teachers' planning and active pedagogical skills, they could design and deliver "imagineerium-like" schemes of work in their classrooms. Teachers reported a positive impact on both their own approach to supporting learning, as well as pupil progression and enjoyment.
Originality/value:
The paper argues that the TAME, a consolidation of research evidence from The Imagineerium and developed through Teach-Make, offers both a distinctive and effective model for STEAM and broader education, one that is accessible to, valued by and manageable for teachers.
During this PhD, a modular, robust, pipeline has been developed for sequencing, assembling, and annotating fungal genomes. The pipeline can use short and long-read sequencing as inputs, alongside RNA sequencing. This has been used to create the foundations from which work on identifying the biosynthetic gene clusters for a number of natural products has been conducted. Within this thesis 8 organisms have been sequenced, assembled, and annotated using this pipeline. Four in collaboration with the John Innes Centre, 3 in collaboration with both the Universiti Kebangsaan Malaysia and Malaysian Agricultural Research and Development Institute, and one genome for a strain of Hohenbuehelia atrocaerulea - a known producer of the anticancer antibiotic pleurotin.
Pleurotin was first discovered in 1947. During the 'Golden age' of antibiotic discovery, it has not been utilised industrially to date as was not from an organism that could be fermented easily at scale as well as being toxic to human cells and unstable. Several intermediates are proven, and a predicted metabolic pathway developed. Attempts to create the chemical synthetically had failed to produce it stereo-selectively until recently, and continue to fail to efficiently produce it.
The annotated genome for Hohenbuehelia atrocaerulea was the basis for comparative proteomic and transcriptomic work in this thesis, enabling the identification of a putative pleurotin producing biosynthetic gene cluster (BGC).
Saccharomyces cerevisiae and Aspergillus oryzae strains were selected as heterologous hosts for the putative BGC. Having faster culturing times, simpler growth requirements, and having GRAS status (generally regarded as safe). The putative BGC was expressed heterologously to discover biosynthetic intermediates to pleurotin and to gather further evidence to contribute to the eventual characterisation of the entire pleurotin pathway, while developing a base strain for eventual optimisation for pleurotin production in the future.
Metabolites from these strains have been detected, and NMR spectroscopy conducted on one of these which was purified (3-farnesyl-4-hydroxy-benzoic acid), a known precursor to pleurotin, not present in untransformed heterologous hosts.
Purpose
This study aims to examine how different uses of performance measurement systems (PMS) enable or hinder organizational ambidexterity (OA), intended as the simultaneous pursuit of exploitation and exploration.
Design/methodology/approach
Following a qualitative research design, we gathered data through semi-structured interviews, observations and reviews of documents at four departments of an automotive firm.
Findings
We contribute to operations management research and practice by demonstrating how PMS, which are typically associated with exploitation, can also foster exploration and enable organizations to become ambidextrous. Specifically, we show how PMS can be structured and used in more agile ways and, in relation to innovation, we identify which PM practices should be introduced and with what effects and those that should be avoided. We also contribute to organization theory by highlighting how a single management tool can promote the achievement of both exploration and exploitation.
Practical implications
In investigating PMS uses and their effects, we identify several positive practices. For example, we show how managers can use PMS more effectively and how targets could be deployed to stimulate creativity and innovation. We also emphasize the need for managers to opt more often for team incentives rather than individual ones to encourage the collaboration needed for OA.
Originality/value
We provide in-depth insight into how PM tools affect an organization's ability to pursue exploitation and exploration, thus contributing to research in operations, innovation and organization theory.
A novel benzotrifuranyl COF with excellent photovoltaic properties and low exciton binding energy was successfully constructed and used for efficient photolysis of water.
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