Job Title
Associate Professor (Teaching Focussed)
Department
WMS - Biomedical Sciences
Phone
02476 151 202
Email
Research Interests
The overall research interest of the lab is the regulation of nutrient sensing pathways in health and disease, with an emphasis on the metabolic changes related to obesity and type 2 diabetes. We have uncovered that Fyn tyrosine kinase is a nutrient-sensor regulating whole body energy homeostasis in conditions of excess (obesity) or deprivation (caloric restriction) of nutrient availability. Specific interests include: 1. Exploring how Fyn regulates adipose tissue development and differentiation, also investigating the relevance of Fyn function in obese individuals 2. Examining how Fyn relays nutritional signals between mother and foetus in pregnancies complicated with obesity and/or gestational diabetes.
Biography
I am an Associate Professor in Metabolic Biochemistry. Following a Ph.D at INSERM in the Centre of Biochemistry at Nice-Sophia-Antipolis (France), I moved as a Post-Doctoral fellow then as a Research Instructor at the State University of New York (USA). In 2010, I started my own lab at Albert Einstein College of Medicine (AECOM) in New York, supported by the National Institutes of Health. I held a joint appointment at AECOM and Warwick Medical School from 2011 to 2015 before permanently moving to Warwick Medical School.
- Uehara, Ryota, Yamada, Eijiro, Okada, Shuichi, Bastie, Claire C., Maeshima, Akito, Ikeuchi, Hidekazu, Horiguchi, Kazuhiko, Yamada, Masanobu, 2023. Fyn Phosphorylates Transglutaminase 2 (Tgm2) and modulates autophagy and p53 expression in the development of diabetic kidney disease. Cells, 12 (8)
- Gill, Manjot, Motta-Mejia, Carolina, Kandzija, Neva, Cooke, William, Zhang, Wei, Cerdeira, Ana Sofia, Bastie, Claire C., Redman, Christopher, Vatish, Manu, 2019. Placental syncytiotrophoblast-derived extracellular vesicles carry active NEP (neprilysin) and are increased in preeclampsia. Hypertension, 73 (5), pp. 1112-1119
- Shibusawa, Ryo, Yamada, Eijiro, Okada, Shuichi, Nakajima, Yasuyo, Bastie, Claire C., Maeshima, A., Kaira, K., Yamada, Masanobu, 2019. Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death. Scientific Reports, 9 (1)
- Gill, Manjot, Motta-Mejia, Carolina, Kandzija, Neva, Cooke , William, Zhang, Wei, Cerdeira, Ana Sofia, Bastie, Claire C., Redman, Christopher W., Vatish, Manu, 2019. Placental syncytiotrophoblast-derived extracellular vesicles carry active NEP (Neprilysin) and are increased in preeclampsia. Hypertension, 73 (5), pp. 1112-1119
- Kandzija, Neva, Zhang, Wei, Motta-Mejia, Carolina, Mhlomi, Vuyane, McGowan-Downey, Jennifer, James, Tim, Cerdeira, Ana Sofia, Tannetta, Dionne, Sargent, Ian, Redman, Christopher W., Bastie, Claire C., Vatish, Manu, 2019. Placental extracellular vesicles express active dipeptidyl peptidase IV ; levels are increased in gestational diabetes mellitus. Journal of Extracellular Vesicles, 8 (1)
- Shibusawa, Ryo, Yamada, Eijiro, Okada, Shuichi, Nakajima, Y., Bastie, Claire C., Yamada, Masanobu, 2018. The impact of short-term professional continuous glucose monitoring on glycemic control via lifestyle Improvement. Diabetes Technology & Therapeutics, 9, pp. 628-631
- Yamada, Eijiro, Okada, Shuichi, Nakajima, Yasuyo, Bastie, Claire C., Tagaya, Yuko, Osaki, Aya, Shimoda, Yoko, Shibusawa, Ryo, Saito, Tsugumichi, Ozawa, Atsushi, Yamada, Masanobu, 2018. Assessment of factors determining an HbA1c concentration =7.5% in patients with type 1 diabetes. Journal of Diabetes, 10 (2), pp. 140-147
- Shibusawa, Ryo, Yamada, Eijiro, Okada, Shuichi, Nakajima, Yasuyo, Bastie, Claire C., Yamada, Masanobu, 2018. The Impact of Short-Term Professional Continuous Glucose Monitoring on Glycemic Control Via Lifestyle Improvement. Diabetes Technology & Therapeutics, 20 (9), pp. 628-631
- Yamada, Eijiro, Okada, Shuichi, Nakajima, Yasuyo, Bastie, Claire C., Vatish, Manu, Tagaya, Yuko, Osaki, Aya, Shimoda, Yoko, Shibusawa, Ryo, Saito, Tsugumichi, Okamura, Takashi, Ozawa, Atsushi, Yamada, Masanobu, 2017. HBA1C and mean glucose derived from short term continuous glucose monitoring (CGM) assessment do not correlate in patients with HBA1C >8. Endocrine Practice
- Yamada, Eijiro, Okada, Shuichi, Nakajima, Yasuyo, Bastie, Claire C., Tagaya, Yuko, Osaki, Aya, Shimoda, Yoka, Shibusawa, Ryo, Saito, Tsugumichi, Ozawa, Atsushi, Yamada, Masanobu, 2017. Effect of carbohydrate counting using bolus calculators on glycemic control in type 1 diabetes patients during continuous subcutaneous insulin infusion. Journal of Diabetes Investigation, 8 (4), pp. 496-500
- Tarabra, Elena, An Lee, Ting-Wen, Zammit, Victor A., Vatish, Manu, Yamada, Eijiro, Pessin, Jeffrey E., Bastie, Claire C., 2017. Differential activation of Fyn kinase distinguishes saturated and unsaturated fats in mouse macrophages. Oncotarget
- Yamada, Eijiro, Okada, Shuichi, Nakajima, Yasuyo, Bastie, Claire C., Tagaya, Yuko, Osaki, Aya, Shimoda, Yoko, Shibusawa, Ryo, Saito, Tsugumichi, Ozawa, Atsushi, Yamada, Masanobu, 2016. Effect of carbohydrate counting using bolus calculators on glycemic control in type 1 diabetes patients during continuous subcutaneous insulin infusion. Journal of Diabetes Investigation, 8 (4), pp. 496-500
- Bari, Muhammad Furqan, Ngo, Sherry, Bastie, Claire C., Sheppard, Allan M., Vatish, Manu, 2016. Gestational diabetic transcriptomic profiling of microdissected human trophoblast. Journal of Endocrinology, 229 (1), pp. 47-59
- Yamada, Eijiro, Okada, Shuichi, Bastie, Claire C., Vatish, Manu, Nakajima, Yasuyo, Shibusawa, Ryo, Ozawa, Atsushi, Pessin, Jeffrey E., Yamada, Masanobu, 2016. Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy. Oncotarget
- Bari, Muhammad F., Weickert, Martin O., Sivakumar, Kavitha, James, Sean G., Snead, David R. J., Tan, Bee K., Randeva, Harpal S., Bastie, Claire C., Vatish, Manu, 2014. Elevated soluble CD163 in gestational diabetes mellitus : secretion from human placenta and adipose tissue. PLoS One, 9 (Number7)
- Apontes, Pasha, Liu, Zhongbo, Su, Kai, Benard, Outhiriaradjou, Youn, Dou Y., Li, Xisong, Li, Wei, Mirza, Raihan H., Bastie, Claire C., Jelicks, Linda A., Pessin, Jeffrey E., Muzumdar, Radhika H., Sauve, Anthony A., Chi, Yuling, 2014. Mangiferin stimulates carbohydrate oxidation and protects against metabolic disorders induced by high-fat diets. Diabetes, 63 (11), pp. 3626-3636
- Yamada, Eijiro, Bastie, Claire C., 2014. Disruption of fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase. PLoS ONE, 9 (2)
- Sivakumar, Kavitha, Bari, Muhammad F., Adaikalakoteswari, A., Guller, S., Weickert, Martin O., Randeva, Harpal S., Grammatopoulos, Dimitris, Bastie, Claire C., Vatish, Manu, 2013. Elevated fetal adipsin/acylation-stimulating protein (ASP) in obese pregnancy : novel placental secretion via Hofbauer cells. The Journal of Clinical Endocrinology & Metabolism, 98 (10), pp. 4113-4122
- Martinez-Lopez, Nuria, Athonvarangkul, Diana, Sahu, Srabani, Coletto, Luisa, Zong, Haihong, Bastie, Claire C., Pessin, Jeffrey E., Schwartz, Gary J., Singh, Rajat, 2013. Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO reports, 14 (9), pp. 795-803
- Lee, T. -W. A., Kwon, H., Zong, H., Yamada, Eijiro, Vatish, Manu, Pessin, J. E., Bastie, Claire C., 2013. Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation. Diabetes, 62 (5), pp. 1537-1546
- Tarabra, Elena, Yang, Yingjuan, Yang, Gong-She, Vaitheesvaran, Bhavapriya, Palacios, Gustavo, Kurland, Irwin J., Pessin, Jeffrey E., Bastie, Claire C., 2013. Alteration of de novo glucose production contributes to fasting hypoglycaemia in fyn deficient mice. PLoS One, 8 (11)
- Bastie, Claire C., Gaffney-Stomberg, E., Lee, T. -W. A., Dhima, E., Pessin, J. E., Augenlicht, L. H., 2012. Dietary cholecalciferol and calcium levels in a western-style defined rodent diet alter energy metabolism and inflammatory responses in mice. Journal of Nutrition, 142 (5), pp. 859-865
- Vatish, Manu, Tesfa, Lydia, Grammatopoulos, Dimitris, Yamada, Eijiro, Bastie, Claire C., Pessin, Jeffrey E., 2012. Inhibition of Akt activity and calcium channel function coordinately drive cell-cell fusion in the BeWO choriocarcinoma placental cell line. PLoS ONE, Vol.7 (No.1)
- Yamada, Eijiro, Bastie, Claire C., Koga, Hiroshi, Wang, Yichen, Cuervo, Ana Maria, Pessin, Jeffrey E., 2012. Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway. Cell Reports, Vol.1 (No.5), pp. 557-569
- Yamada, Eijiro, Pessin, Jeffrey E., Kurland, Irwin J., Schwartz, Gary J., Bastie, Claire C., 2010. Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metabolism, Vol.11 (No.2), pp. 113-124
- Yamada, Eijiro, Lee, Ting-Wen A., Pessin, Jeffrey E., Bastie, Claire C., 2010. Targeted therapies of the LKB1/AMPK pathway for the treatment of insulin resistance. Future Medicinal Chemistry, 2 (12), pp. 1785-1796
- Vatish, Manu, Yamada, Eijiro, Pessin, Jeffrey E., Bastie, Claire C., 2009. Fyn kinase function in lipid utilization : a new upstream regulator of AMPK activity?. Archives of Physiology and Biochemistry, Vol.115 (No.4), pp. 191-198
- Drover, V. A., Nguyen, D. V., Bastie, Claire C., Darlington, Y. F., Abumrad, N. A., Pessin, J. E., London, E., Sahoo, D., Phillips, M. C., 2008. CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. Journal of Biological Chemistry, Vol.283 (No.19), pp. 13108-13115
- Zong, H., Bastie, Claire C., Xu, J., Fassler, R., Campbell, K. P., Kurland, I. J., Pessin, J. E., 2008. Insulin resistance in striated muscle-specific integrin receptor 1-deficient mice. Journal of Biological Chemistry, Vol.284 (No.7), pp. 4679-4688
- Bastie, Claire C., Zong, Haihong, Xu, Jun, Busa, Bhavin, Judex, Stefan, Kurland, Irwin J., Pessin, Jeffrey E., 2007. Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. Cell Metabolism, 5 (5), pp. 371-381
- Lee, T. A., Kwon, H., Vatish, Manu, Yamada, Eijiro, Pessin, Jeffrey E., Bastie, Claire C., 2010. Fyn deficient mice are protected against high fat diet induced insulin resistance and adipose tissue inflammation despite low levels of regulatory T cells. 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), San Diego, CA, 19-22 Jun 2010, Published in Endocrine Reviews
| Title | Funder | Award start | Award end |
|---|---|---|---|
| A novel hyaluronic acid hydrogel as an extracellular matrix to improve fat graft survival in autologous fat transfer in breast cancer reconstruction | Medical and Life Sciences Research Fund | 01 Apr 2021 | 31 Aug 2021 |