Abstract: To accomplish cell division, proteins required for chromosome segregation must be recruited to chromatin and many transcription factors are displaced. The cell may also retain markers on chromosomes that can “remember” whether genes are active or inactive so that they can be returned to their original states once cell division is complete. My laboratory seeks to understand how these events are controlled in location and time. In particular, we study how chromatin modifications help determine where and when key regulatory factors can bind to chromosomes. Specifically, we are interested in how histone kinases such as Haspin and Aurora B control cell division in human cells.