Steve Royle

Stephen Royle

Stephen Royle

I am Professor at Warwick Medical School and my lab is part of the Centre for Mechanochemical Cell Biology. Following training at the University of Cambridge and the MRC Laboratory of Molecular Biology, I started my own research group at Liverpool in 2006. I moved the lab to Warwick in 2013 as a Senior Cancer Research UK Fellow and Associate Professor in WMS.

Pubmed | Lab webpage | Google scholar | ORCiD | Addgene

Plain English

My lab is working on how human cells do two really important jobs. First, how cells divide, a process called mitosis. Second, how cells bring in nutrients from the outside, a task named endocytosis. Our work is driven by a fascination with the basic cell biology underlying mitosis and endocytosis; and also by a desire to understand diseases that are caused when cells make mistakes when doing these jobs.

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Stephen Royle

Stephen Royle

Pubmed | Lab webpage | Google scholar | ORCiD | Addgene

Plain English

Technical Summary

We are interested in two processes fundamental to eukaryotic cellular life: mitosis and membrane trafficking. The lab are working to understand how these processes operate at the molecular level in the hope of identifying new strategies to prevent tumour formation and propagation in cancer and to inhibit cellular infection.

The mitotic spindle is a tiny machine whose purpose is to accurately segregate the chromosomes during cell division. We are trying to understand how the microtubules of the mitotic spindle are stabilised by non-motor proteins, and how stability is altered in cancer.

Clathrin-mediated endocytosis is the main route of entry into mammalian cells and it controls numerous cellular processes from cell motility and signalling to synaptic transmission and organelle identity. We are trying to understand the molecular mechanisms of this process, and how it is controlled by the cell cycle.

Publications:

Please see my ORCiD profile or my lab webpage for an up-to-date list of publications.