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Research by Clinical Area: Gastrointestinal Diseases

CAPACITY - Studying Chronic Constipationcapacity

Development of a UK evidence based pathway for the management of chronic constipation in adults.

CapaCiTY involves an NIHR-funded programme of research providing trial-based evidence for patients with chronic symptoms who fail to respond to more basic care. A suite of multicentre trials will assess types of investigation, specialist nurse-led bowel retraining, anal irrigation and surgery. A common outcome framework will assess changes in symptoms, patient acceptability, quality-of-life and cost. Findings will be synthesised to develop national guidance and a treatment pathway for appropriate care.

The study is being managed by the Pragmatic Clinical Trials Unit at Barts Health NHS Trust and Queen Mary University of London, with further details on the Trial website.

Publications

Emmett C, Close H, Mason J, Taheri S, Stevens N, Eldridge S, Norton C, Knowles C, Yiannakou Y. Low-volume versus high-volume initiated trans-anal irrigation therapy in adults with chronic constipation: study protocol for a randomised controlled trial. Trials 2017;18:151

Norton C, Emmanuel A, Stevens N, Scott SM, Grossi U, Bannister S, Eldridge S, Mason JM, Knowles CH. Habit training versus habit training with direct visual biofeedback in adults with chronic constipation: study protocol for a randomised controlled trial. Trials 2017;18:139

HE: James Mason PI: Charles Knowles Funder: NIHR PGfAR