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Dr Andrew D McAinsh

 

Title   

Professor
 

Contact   

WMS - Cell and Development Biology
University of Warwick
Coventry
CV4 7AL
Tel: +44 (0)2476 151168
Email: A.D.McAinsh@warwick.ac.uk
WebLink: http://www.mechanochemistry.org/mcainsh/

Research Interests

Cell division is fundamental to the existence of life. A key part of this process involves the accurate separation of the chromosomes into the two daughter cells - a process called mitosis. Errors in chromosome segregation drive chromosomal instability, aneuploidy and cancer development. Dr. McAinsh's lab of graduate students, postdoctoral fellows and technicians are focused on understanding the mechanisms by which kinetochores power chromosome segregation and how the mitotic spindle is self-assembled and positioned during mitosis in human cells. Approaches in the McAinsh lab include live-cell microscope-based assays, computational image analysis and in vitro reconstitution.

Biography

Andrew McAinsh is a Professor of Cell Biology at Warwick Medical School and holds a Wellcome Trust Senior Investigator Award and Royal Society Wolfson Merit Award. Following a PhD at Cambridge with Steve Jackson and a postdoc at the Massachusetts Institute of Technology with Peter Sorger, where he was Jane Coffin Childs Fellow, he established his independent laboratory in 2005 at the Marie Curie Research Institute. He moved to Warwick in 2009 and is also supported by grants from the BBSRC and MRC.

Research Projects

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Publications

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Post Graduate Supervision

  • Gripping and regulating kinetochore microtubules Date of Completion:2016
  • Molecular analysis of kinetochore-microtubule dynamics and mitotic spindle positioning Date of Completion:2012
  • Biochemical Characterisation of the S. pombe Kinesin-14 Klp2 Date of Completion:2009
  • Chromosome Navigation: finding the way to the spindle equator Date of Completion:2013
  • Mechanical deformations in kinetochores during directed chromosome motion Date of Completion:2015
  • Chromosome Congression by CENP-E and CENP-Q Dependent Pathways Date of Completion:2013

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