Trophoblast Fusion,Placental Function,Preeclampsia,Obstetric Endocrine Disorders (Obesity & Diabetes)
Manu Vatish has been at Warwick Medical School since 2003. He is clinically trained having done preclinical medicine at Oxford. He then intercalated a D.Phil studying ion transport across the human placenta. This was a basic science project investigating regulation of transport across brush border and basal membrane vesicles from the syncytiotrophoblast. Clinical studies were completed at Cambridge. He is trained as an obstetrician specializing in high-risk pregnancy (maternal medicine) and leads a research group examining placental function in preeclampsia, obesity and diabetes. He was awarded the Fulbright Distinguished Scholar award in 2008-9 which allowed him to spend a year at Albert Einstein College of Medicine under the mentorship of Professor Jeffrey Pessin. Here, he developed a Fluorescent Activated Cell Sorting assay for trophoblast fusion. A Churchill Fellowship in 2011 allowed him to utilize this to uncover the role of key molecules involved in energy sensing being involved in the fusion process.
- Adaikalakoteswari, Antonysunil, Vatish, Manu, Alam, Mohammad T., Ott, Sascha, Kumar, Sudhesh, Saravanan, P., 2017. Low vitamin B12 in pregnancy is associated with adipose-derived circulating miRs targeting PPAR? and insulin resistance. The Journal of Clinical Endocrinology & Metabolism, 102 (11), pp. 4200-4209
- Bari, Muhammad Furqan, Ngo, Sherry, Bastie, Claire C., Sheppard, Allan M., Vatish, Manu, 2016. Gestational diabetic transcriptomic profiling of microdissected human trophoblast. Journal of Endocrinology, 229 (1), pp. 47-59
- Adaikalakoteswari, Antonysunil, Finer, Sarah, Voyias, Philip D., McCarthy, Ciara M., Vatish, Manu, Moore, Jonathan D., Smart-Halajko, Melissa, Bawazeer, Nahla M., Al-Daghri, Nasser M., McTernan, P. G., Kumar, Sudhesh, Hitman, Graham A., Saravanan, Ponnusamy, Tripathi, Gyanendra, 2015. Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes. Clinical Epigenetics, 7 (1), pp. 1-14
- Deller, Robert C., Vatish, Manu, Mitchell, Daniel E., Gibson, Matthew I., 2015. Glycerol free cryopreservation of red blood cells enabled by ice recrystallization inhibiting polymers. Biomaterials Science and Engineering, 1 (9), pp. 789-794
- Raeburn, Jaclyn, Chen, Lin, Awhida, Salmah, Deller, Robert C., Vatish, Manu, Gibson, Matthew I., Adams, Dave J., 2015. Using molecular rotors to probe gelation. Soft matter, 11 (18), pp. 3706-3713
- Bari, Muhammad F., Weickert, Martin O., Sivakumar, Kavitha, James, Sean G., Snead, David R. J., Tan, Bee K., Randeva, Harpal S., Bastie, Claire C., Vatish, Manu, 2014. Elevated soluble CD163 in gestational diabetes mellitus : secretion from human placenta and adipose tissue. PLoS One, 9 (Number7)
- Deller, Robert C., Vatish, Manu, Mitchell, Daniel A., Gibson, Matthew I., 2014. Synthetic polymers enable non-vitreous cellular cryopreservation by reducing ice crystal growth during thawing. Nature Communications, 5
- McCloskey, Conor, Rada, Cara, Bailey, Elizabeth, McCavera, Samantha, Berg, Hugo van den, Atia, Jolene, Rand, D. A., Shmygol, Anatoly, Chan, Yi-Wah, Quenby, Siobhan, Brosens, Jan J., Vatish, Manu, Zhang, Jie, Denton, Jerod S., Taggart, Michael J., Kettleborough, Catherine, Tickle, David, Jerman, Jeff, Wright, Paul, Dale, Timothy et al (Select to open full list), 2014. The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy. EMBO Molecular Medicine, 6 (9), pp. 1161-1174
- Piya, Milan K., Harte, A. L., Sivakumar, Kavitha, Tripathi, Gyanendra, Voyias, Philip D., James, S., Sabico, Shaun, Al-Daghri, Nasser M., Saravanan, Ponnusamy, Barber, T. M., Kumar, Sudhesh, Vatish, Manu, McTernan, P. G., 2014. The identification of irisin in human cerebrospinal fluid : influence of adiposity, metabolic markers, and gestational diabetes. AJP : Endocrinology and Metabolism, 306 (5), pp. E512-E518
- Markovic, Danijela, Bari, Muhammad F., Lu, Buyu, Vatish, Manu, Grammatopoulos, Dimitris, 2013. Corticotropin-releasing hormone intereacts with interleukin-1 beta to regulate prostaglandin H synthase-2 expression in human myometrium during pregnancy and labor. Journal of Clinical Endocrinology & Metabolism, 98 (7), pp. 2864-2875
- Sivakumar, Kavitha, Bari, Muhammad F., Adaikalakoteswari, A., Guller, S., Weickert, Martin O., Randeva, Harpal S., Grammatopoulos, Dimitris, Bastie, Claire C., Vatish, Manu, 2013. Elevated fetal adipsin/acylation-stimulating protein (ASP) in obese pregnancy : novel placental secretion via Hofbauer cells. The Journal of Clinical Endocrinology & Metabolism, 98 (10), pp. 4113-4122
- Sivakumar, Kavitha, Tan, Bee K., Bari, Muhammad F., Vatish, Manu, Randeva, Harpal S., 2013. Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes. PLoS One, 8 (6)
- Lee, T. -W. A., Kwon, H., Zong, H., Yamada, Eijiro, Vatish, Manu, Pessin, J. E., Bastie, Claire C., 2013. Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation. Diabetes, 62 (5), pp. 1537-1546
- Bari, Muhammad F., Brown, Helen, Nicholson, Andrew G., Kerr, Keith M., Gosney, John R., Wallace, William A., Soomro, Irshad, Muller, Salli, Peat, Danielle, Moore, Jonathan D., Ward, Lesley A., Freidin, Maxim B., Lim, Eric, Vatish, Manu, Snead, David R. J., 2013. BAI3, CDX2 and VIL1 : a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas. Histopathology, 64 (4), pp. 547-556
- Markovic, Danijela, Bari, Muhammad F., Lu, B., Vatish, Manu, Grammatopoulos, Dimitris, 2013. Corticotropin-releasing hormone interacts with interleukin-1 to regulate prostaglandin H synthase-2 expression in human myometrium during pregnancy and labor. Journal of Clinical Endocrinology & Metabolism, 98 (7), pp. 2864-2875
- Deller, Robert C., Congdon, Thomas, Sahid, Mohammed A., Morgan, Michael, Vatish, Manu, Mitchell, Daniel A., Notman, Rebecca, Gibson, Matthew I., 2013. Ice recrystallisation inhibition by polyols : comparison of molecular and macromolecular inhibitors and role of hydrophobic units. Biomaterials Science, 1 (5), pp. 478-485
- Qin, Cheng, Shi, Nongnong, Gu, Mei, Zhang, Hang, Li, Bin, Shen, Jiajia, Mohammed, Atef, Ryabov, Eugene V., Li, Chunyang, Wang, Huizhong, Liu, Yule, Osman, Toba, Vatish, Manu, Hong, Yiguo, 2012. Involvement of RDR6 in short-range intercellular RNA silencing in Nicotiana benthamiana. Scientific Reports, Vol.2 (No.467)
- Vatish, Manu, Tesfa, Lydia, Grammatopoulos, Dimitris, Yamada, Eijiro, Bastie, Claire C., Pessin, Jeffrey E., 2012. Inhibition of Akt activity and calcium channel function coordinately drive cell-cell fusion in the BeWO choriocarcinoma placental cell line. PLoS ONE, Vol.7 (No.1)
- Delidaki, Maria, Gu, Mei, Hein, Anna Caroline, Vatish, Manu, Grammatopoulos, Dimitris, 2011. Interplay of cAMP and MAPK pathways in hCG secretion and fusogenic gene expression in a trophoblast cell line. Molecular and Cellular Endocrinology, Vol.332 (No.1-2), pp. 213-220
- Li, Chunyang, Gu, Mei, Shi, Nongnong, Zhang, Hang, Yang, Xin, Osman, Toba, Liu, Yule, Wang, Huizhong, Vatish, Manu, Jackson, Stephen D., Hong, Yiguo, 2011. Mobile FT mRNA contributes to the systemic florigen signalling in floral induction. Scientific Reports, Vol.1 (No.73), pp. 1-7
- Vatish, Manu, Steer, P. J., Blanks, Andrew M., Hong, M., Thornton, Steven, 2010. Diurnal variation is lost in preterm deliveries before 28 weeks of gestation. BJOG - An International Journal of Obstetrics & Gynaecology, Vol.117 (No.6), pp. 765-767
- Gould, Phillip S., Gu, Mei, Liao, Jianqin, Ahmad, Shakil, Cudmore, Melissa J., Ahmed, Asif, Vatish, Manu, 2010. Upregulation of Urotensin II receptor in preeclampsia causes in vitro placental release of soluble vascular endothelial growth factor receptor 1 in hypoxia. Hypertension, Vol.56 (No.1), pp. 172-178
- Palmer, Julie, Vatish, Manu, Tidy, J. A. (John A.), 2009. Epithelial ovarian cancer in pregnancy : a review of the literature. BJOG : an international journal of obstetrics and gynaecology, Vol.116 (No.4), pp. 480-491
- Gu, Mei, Pritlove, D. C., Boyd, C. A. R., Vatish, Manu, 2009. Placental expression of 2,3 Bisphosphoglycerate mutase in IGF-II knock out mouse : correlation of circulating maternal 2,3 Bisphosphoglycerate and fetal growth. Placenta, Vol.30 (No.10), pp. 919-922
- Ladds, Graham, Zervou, Sevasti I., Vatish, Manu, Thornton, Steven, Davey, John, 2009. Regulators of G protein signalling proteins in the human myometrium. European Journal of Pharmacology, Vol.610 (No.1-3), pp. 23-28
- Patel, Pushpa, Vatish, Manu, Heptinstall, John, Wang, Rui, Carson, Ray J., 2009. The endogenous production of hydrogen sulphide in intrauterine tissues. Reproductive Biology and Endocrinology, Vol.7 (No.10)
- Zhang, Junlong, Zhang, F. (Fang), Didelot, Xavier, Bruce, Kimberley D., Cagampang, Felino R., Vatish, Manu, Hanson, Mark A., Lehnert, Hendrik, Ceriello, Antonio, Byrne, Christopher D., 2009. Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring. BMC Genomics, Vol.10 (No.478)
- Gaymer, C., Whalley, H., Achten, Juul, Vatish, Manu, Costa, Matthew L., 2009. Midfoot plantar pressure significantly increases during late gestation. The Foot, Vol.19 (No.2), pp. 114-116
- Vatish, Manu, Yamada, Eijiro, Pessin, Jeffrey E., Bastie, Claire C., 2009. Fyn kinase function in lipid utilization : a new upstream regulator of AMPK activity?. Archives of Physiology and Biochemistry, Vol.115 (No.4), pp. 191-198
- Kou, Baijun, Ni, Jinsong, Vatish, Manu, Singer, Donald R. J., 2008. Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis. Microcirculation, 15 (3), pp. 251-267
- Chatterjee, Jayanta, Gullam, Joanna E., Vatish, Manu, Thornton, Steven, 2007. The management of preterm labour. Archives of Disease in Childhood. Fetal and Neonatal Edition, Vol.92 (No.2), pp. F88-F93
- Kou, Baijun, Vatish, Manu, Singer, Donald R. J., 2007. Effects of Angiotensin II on human endothelial cells survival signalling pathways and its angiogenic response. Vascular Pharmacology, Vol.47 (No.4), pp. 199-208
- Lewandowski, K. C., Stojanovic, N., Press, M., Tuck, S. M., Szosland, K., Bienkiewicz, M., Vatish, Manu, Lewinski, A., Prelevic, G. M., Randeva, Harpal S., 2007. Elevated serum levels of visfatin in gestational diabetes: a comparative study across various degrees of glucose tolerance. Diabetologia, Vol.50 (No.5), pp. 1033-1037
- Markovic, Danijela, Vatish, Manu, Gu, Mei, Slater, Donna, Newton, Rob, Lehnert, Hendrik, Grammatopoulos, Dimitris, 2007. The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium : putative role of interleukin-1ß. Endocrinology, Vol.148 (No.7), pp. 3205-3213
- Chen, J., Tan, B., Karteris, E. M., Zervou, S., Digby, J., Hillhouse, Edward W., Vatish, Manu, Randeva, Harpal S., 2006. Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines. Diabetologia, Vol.49 (No.6), pp. 1292-1302
- Randeva, Harpal S., Vatish, Manu, Tan, Bee K., Qureshi, Z, Lewandowski, Krzysztof C., O'Hare, J. Paul, 2006. Raised plasma adiponectin levels in type 1 diabetic pregnancies. Clinical Endocrinology, 65 (1), pp. 17-21
- Pritlove, D. C., Gu, Mei, Boyd, C. A. R., Randeva, Harpal S., Vatish, Manu, 2006. Novel placental expression of 2,3-bisphosphoglycerate mutase. Placenta, Vol.27 (No.8), pp. 924-927
- Bari, M. F., Nicholson, A. G., Kerr, K. M., Gosney, J. R., Freidin, M. B., Moore, J. D., Vatish, Manu, Snead, David R. J., 2012. Biomarkers for the classification of highly malignant neuroendocrine lung carcinoma. XXIXth Congress of the International Academy of Pathology, Cape Town, South Africa, 30 Sep- 5 Oct 2012, Published in Histopathology
- Delidaki, Maria, Gu, Mei, Vatish, Manu, Grammatopoulos, Dimitris, 2010. Placental corticotropin releasing hormone : biological actions on trophoblast proliferation and differentiation. 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), San Diego, CA, 19-22 Jun 2010
- Lee, T. A., Kwon, H., Vatish, Manu, Yamada, Eijiro, Pessin, Jeffrey E., Bastie, Claire C., 2010. Fyn deficient mice are protected against high fat diet induced insulin resistance and adipose tissue inflammation despite low levels of regulatory T cells. 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), San Diego, CA, 19-22 Jun 2010, Published in Endocrine Reviews
- Lu, Nan, Wang, Jihong, Zhang, Chenghui, Vatish, Manu, Randeva, Harpal S., 2007. Uterine electromyography features extraction for classification of term and pre-term signals. International Conference on Complex Systems and Applications, Jinan, People's Republic of China, June 08-10, 2007, Published in Dynamics of Continuous Discrete and Impulsive Systems. Series B. Applications & Algorithims, pp. 1675-1679
- Kou, Baijun, Vatish, Manu, Singer, Donald R. J., 2006. Biphasic effects of angiotensin II on basal and vascular endothelial growth factor-stimulated Akt phosphorylation and expression in human umbilical vein endothelial cells. 21sth Scientific Meeting of the International-Society-of-Hypertension/5th Asian-Pacific Congress of Hypertension/29th Annual Scientific Meeting of the Japanese-Society-of-Hypertension, Fukuoka, JAPAN, OCT 15-19, 2006, Published in JOURNAL OF HYPERTENSION, pp. 186-186
- Kou, B., Ni, J., Vatish, Manu, Singer, Donald R. J., 2006. Effects of angiotensin II on basal and vascular endothelial growth factor stimulated vascular tube formation by human umbilical vein endothelial cells. World Congress of Cardiology, Barcelona, Spain, Sep 02-06, 2006, Published in European Heart Journal, pp. 4-4
- Kou, B., Ni, J., Vatish, Manu, Singer, Donald R. J., 2006. VEGF protects from apoptosis induced by oxidant stress and angiotensin II in HUVECs by PI-3K/Akt dependent and p-38 MAPK independent pathways. World Congress of Cardiology, Barcelona, Spain, Sep 02-06, 2006, Published in European Heart Journal, pp. 806-806
- Kou, Baijun, Vatish, Manu, Singer, Donald R. J., 2006. Effects of stretch stress on basal and ligand-modulated Akt phosphorylation in human umbilical vein endothelial cells. 21sth Scientific Meeting of the International-Society-of-Hypertension/5th Asian-Pacific Congress of Hypertension/29th Annual Scientific Meeting of the Japanese-Society-of-Hypertension, Fukuoka, JAPAN, OCT 15-19, 2006, Published in JOURNAL OF HYPERTENSION, pp. 46-46
- Kou, B., Vatish, Manu, Singer, Donald R. J., 2005. Effects of mechanical stretch and oxidant stress on vascular endothelial growth factor-mediated PKB/Akt expression in HUVEC. 27th Congress of the European-Society-of-Cardiology, Stockholm, SWEDEN, SEP 03-07, 2005, Published in EUROPEAN HEART JOURNAL, pp. 261-261
- Hillman, Sarah, Chant, Ian, Gu, M, Rose, Peter, Vatish, Manu, 2009. Tissue pathway factor inhibitor (TFPI) activity is elevated in pregnant patients at 20 weeks gestation who subsequently develop preeclampsia. Thrombosis and Haemostasis, Schattauer GmbH, pp. 778-780
- Vatish, Manu, Randeva, Harpal S., Grammatopoulos, Dimitris, 2006. Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia. Trends in Molecular Medicine, Elsevier Ltd. * Trends Journals, pp. 223-233
Title | Funder | Award start | Award end |
---|---|---|---|
Adipokines and Vasoactive Substances in Cardiovascular Medicine | Coventry General Charities | 01 Dec 2005 | 30 Nov 2010 |
Wellcome Trust Biomedical Vacation Scholarships: Miss Amy Irwin | Wellcome Trust | 01 Jul 2010 | 31 Aug 2010 |