A recent paper by the GibsonGroup in Chem Commun has been highlighted in the RSC Magazine 'Chemistry World'. The Gibson Group have a research program focussed on mimicking the function of Antifreeze Proteins which are found in Polar fish species. These proteins can slow the rate of ice growth, which has been identified as a challenge in the cryopreservation of donor cells and tissue for transplantation. In this work they showed a facile route to new cryoprotective polymers, using cheap, commodity polymer starting materials. These polymers were shown to have ice growth inhibition activity and to signficantly reduce the ice-induced damage during red blood cell freeze/thaw storage. In a second paper, the group also reported signficantly enhanced cryopreservation using poly(vinyl alcohol).

Read the Chemistry World article here

Read the Chemical Communications article here; Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

Read our recent ACS Biomaterials Science and Enginneering paper here Glycerol Free Cryopreservation of Red Blood Cells Enabled by Ice Recrystallization Inhibiting Polymers