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The Gibson group (in collaboration with Alison Rodger) investigate how stimuli responsive polymers can be used to modulate lipophilicity and hence trigger membrane interactions, when heated. These findings suggest that stimuli responsive materials can help overcome a key challenge with polymer/nanoparticle drug delivery: the conjugate must be both water soluble to be dispersable in the circulation, but also lipophilic to enable effecient cell membrane penetration.

The work is puiblished in Macromolecular Rapid Communications as part of the special issue "Polymer Science the Next Generation".

Read the paper here http://dx.doi.org/10.1002/marc.201100873

Read more about the Gibson groups' work at the interface of medicine/biology/materials science here.