Bugg Group Publications

“Bioconversion kinetics and valorisation of oil palm empty fruit bunches for biomethane production and lignin derived compounds” I.Nurika, E.N. Shabrina, N. Azizah, S. Suhartini, T.D.H. Bugg, G.C. Barker, Chem. Eng. Journal, 227, 110053 (2026).
“4-Aryl-2-aminoimidazole analogues of bromoageliferin with antimicrobial activity against Acinetobacter baumannii show in vitro inhibition of translocase MraY on the peptidoglycan biosynthesis pathway” R. Murphy, J.A. Fairbairn. B.W.A. Baileeves, P.J. Stansfeld, T.D.H. Bugg, Bio-Org. Med. Chem. Lett., 136, 130597 (2026).
“Enzyme-catalysed synthesis of pyridines from biomass-derived feedstocks” V. Sodré, G.M.M. Rashid, B. Yotzova and T.D.H. Bugg, Org. Biomol. Chem., 24, 5326-5332 (2026).

2025

“Bioconversion of a lignin-derived biphenyl dimer into the strategic building block 5-carboxyvanillic acid in Pseudomonas putida KT2440” H. Gómez-Álvarez, C. del Cerro-Sánchez, P. Iturbe, V. Rivero-Buceta, J. Nogales, T.D.H. Bugg, and E. Díaz, Green Chem., 27, 3197-3206 (2025).
“Antimicrobial triazinedione inhibitors of the translocase MraY-protein E interaction site: synergistic effects with bacitracin imply a new mechanism of action” J.A. Fairbairn, R.V. Kerr, N-K.A. Pierre-White, A. Jacovides, B.W.A. Baileeves, P.J. Stansfeld, G. Bringmann, A.T. Merritt, and T.D.H. Bugg, RSC Med. Chem., 16, 1641-1653 (2025).
“Assay methods and colorimetric screens for lignin-degrading microbes and lignin-oxidising enzymes” T.D.H. Bugg, M. Ahmad, C.R. Taylor, M. Konstantopoulou, and G.M.M. Rashid, Methods Enzymol., 716, 105-123 (2025).
“Dye-decolorizing peroxidase DyP1B from Pseudomonas fluorescens: expression, reconstitution and reaction with polymeric lignin substrates”
R. Rahmanpour and T.D.H. Bugg, Methods Enzymol., 716, 125-141 (2025).
“Glycolate oxidase from Rhodococcus jostii RHA1: an accessory enzyme for lignin bioconversion with bacterial DyP-type peroxidases.” A. Alruwaili and T.D.H. Bugg, Methods Enzymol., 716, 263-283 (2025).
“Assessing iron reductase activity: methodologies for fungal degradation of lignocellulose” I. Nurika, T.D.H. Bugg, G.C. Barker, D.C. Eastwood, Methods Enzymol., 716, 403-416 (2025).
“Degradation of brown coal and 1-methylnaphthalene by a Micrococcus luteus isolate: investigation of a novel aromatic degradation gene cluster containing paa genes” P. Iriani, G.G. Allison and T.D.H. Bugg, J. Appl. Microbiol., 136, lxaf153 (2025).
“Scaling up the bioconversion of lignin to 2,4-pyridinedicarboxylic acid with engineered Pseudomonas putida for bio-based plastics production” J. Seeger, S. Müller, H. Gómez-Álvarez, G.M.M. Rashid, T.D.H. Bugg, E. Diaz & R. Takors, Biotech. Bioeng., 122, 2770-2780 (2025).
“MreB filaments in the elongasome modulate E. coli membrane curvature” B.W.A. Baileeves, A.D.Q. Hoang, T.D.H. Bugg, and P.J. Stansfeld, Biophys. J., 124, 3583-3595 (2025).
“The mhqPOD gene cluster in lignin-degrading Paenibacillus sp. encodes a pathway for degradation of lignin-derived 5,5’-di(dehydrovanillic acid) (DDVA)” C. Fanitsios, R. Millar, M. Clegg, B. Dharsi, R.I. Horne, J.A. Fairbairn, E.M.H. Wellington, T.D.H. Bugg, FEMS Microbiol. Lett., 372, fnaf128 (2025).

2024

“Engineered co-culture for consolidated production of phenylpropanoids directly from aromatic-rich biomass” M. Chacόn, E. Percival, T.D.H. Bugg, and N. Dixon, Bioresource Technol., 391, 129935 (2024).
“Chemical logic of enzymatic lignin degradation” T.D.H. Bugg, Chemical Communications, 60, 804-814 (2024).
“Overexpression of endogenous multi-copper oxidases mcoA and mcoC in Rhodococcus jostii RHA1 enhances lignin bioconversion to 2,4-pyridine-dicarboxylic acid” G.M.M. Rashid, V. Sodré, J. Luo, and T.D.H. Bugg, Biotech. Bioeng., 121, 1366-1370 (2024).
“Ether bond cleavage of a phenylcoumaran -5 lignin model compound and polymeric lignin catalysed by a LigE-type etherase from Agrobacterium sp.” G.M.M. Rashid, G.N. Rivière, B. Cottyn-Boitte, A. Majira, L. Cézard, V. Sodré, R. Lam, J.A. Fairbairn, S. Baumberger, and T.D.H. Bugg, ChemBioChem, 25, e202400132 (2024).
“Expression, assay and inhibition of 9-cis-epoxycarotenoid cleavage dioxygenase (NCED) from Solanum lycopersicum and Zea mays” P.J. Harrison, J.O. Chandler, A.J. Thompson, and T.D.H. Bugg, Methods Enzymology, 704, 291-312 (2024).
“Sustainable production of aromatic chemicals from lignin using enzymes and engineered microbes” V. Sodré and T.D.H. Bugg, Chem. Commun., 60, 14360-14375 (2024).

2023

“Periplasmic expression of Pseudomonas fluorescens peroxidase Dyp1B and site-directed mutant enzymes enhances lignin oxidation activity in Pseudomonas putida KT2440” A. Ehibhatiomhan, R.R. Pour, S. Farnaud, T.D.H. Bugg, and S. Mendel-Williams, Enz. Microb. Technol. 162, 110147 (2023).
“Elucidation of microbial lignin degradation pathways using synthetic isotope-labelled lignin” A. Alruwaili, G.M.M. Rashid, V. Sodré, J. Mason, Z. Rehman, A. Menaketh, D. Cheung, S.P. Brown, and T.D.H. Bugg, RSC Chem. Biol., 4, 47-55 (2023).
“Enhancement of the ligninolytic activity of Lysinibacillus sphaericus by the addition of MnSO₄ and its impact on subsequent methane production from oil palm empty fruit bunches (OPEFB)” I.Nurika*, Y.I. Aristya, N. Azizah, N.M. Sabrina Sunyoto, S. Suhartini, T.D.H. Bugg, and G.C. Barker, Bioresource
Technol. Reports., 22, 101394 (2023).
“Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenase CntA catalytic site” M. Quareshy, M. Shanmugam, A.D. Cameron, T.D.H. Bugg, and Y. Chen, FEBS Journal, 290, 2939-2953 (2023).
“Pharmaceutical applications of lignin-derived chemicals and lignin-based materials: linking lignin source and processing with clinical indication”
P. Karagoz, S. Khiawjan, M.P.C. Marques, S. Santzouk, T.D.H. Bugg, G.J. Lye, Biomass Conversion and Biorefinery, s133399-023-03745-5 (2023).
“Application of Rhodococcus jostii RHA1 glycolate oxidase as an efficient accessory enzyme for lignin conversion by bacterial Dyp peroxidase enzymes” A. Alruwaili, G.M.M. Rashid, and T.D.H. Bugg, Green Chemistry, 25, 3549-3560 (2023).
“Metatranscriptomic analysis of the gut microbiome of black soldier fly larvae bred on varying lignocellulose-rich fiber diets unveils key lignocellulolytic enzymes” E.G. Kariuki, C. Kibet, J.C. Paredes, G.Mboowa, O. Mwaura, J. Njogu, D. Masiga, T.D.H. Bugg, and C.M. Tanga, Frontiers in Microbiology, 14, 1120224 (2023).
“Sustainable biosynthetic pathways to value-added products from hydroxycinnamic acids” R. Tramontina, I. Ciancaglini, E.K.B. Roman, M.G. Chacon, T.L.R. Correa, N. Dixon, T.D.H. Bugg and F.M. Squina, Appl. Microb. Biotechnol, 107, 4165-4185 (2023).
“Engineering of Rhodococcus jostii RHA1 for utilisation of carboxymethylcellulose” R. Yasin, G.M.M. Rashid, I. Ali, and T.D.H. Bugg, Heliyon, 9, e19511 (2023).

2022

“Bioconversion of lignin-derived aromatics into the building block pyridine 2,4-dicarboxylic acid by engineering recombinant Pseudomonas putida strains” H. Gómez-Álvarez, P. Iturbe, V. Rivero-Buceta, P. Mines, T.D.H. Bugg, J. Nogales, E. Díaz, Bioresource Technol., 346, 126638 (2022).
“Application of ligninolytic bacteria to the enhancement of lignocellulose breakdown and methane production from oil palm empty fruit bunches (OPEFB)” I. Nurika, E.N. Shabrina, N. Azizah, S. Suhartini, T.D.H. Bugg, G.C. Barker, Bioresource Technol. Reports, 17, 100951 (2022).
“Merging plastics, enzymes and microbes: highlights from an International Workshop” D.J. Jiménez, B. Öztürk , R. Wei, T.D.H. Bugg, C.V. Amaya-Gómez, F.S. Galan, J.L. Castro-Mayorga, J.F. Saldarriaga, & N.A. Tarazona, Appl. Environ. Microbiol., 88, e00721-22 (2022).

2021

“Metabolic engineering of Rhodococcus jostii RHA1 for production of pyridine-dicarboxylic acids from lignin” E.M. Spence, L. Calvo-Bado, P. Mines, and T.D.H. Bugg, Microb. Cell Fact., 20, 15 (2021).
“Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition and inter-subunit electron transfer” M. Quareshy, M. Shanmugam, T.D.H. Bugg, A. Cameron, and Y. Chen, J. Biol. Chem, 296, 100038 (2021).
“Light-activated electron transfer and catalytic mechanisms of carnitine oxidation by Rieske-type oxygenase from human microbiota” M. Shanmugam, M. Quareshy, A. Cameron, T.D.H. Bugg, and Y. Chen, Angew. Chem. Intl. Ed., 60, 4529-4534 (2021).
“Enhanced biocatalytic degradation of lignin using combinations of lignin-degrading enzymes and accessory enzymes”
G.M.M. Rashid, T.D.H. Bugg, Catalysis Sci. Technol., 11, 3568-3577 (2021).
“Assessment strategy for bacterial lignin depolymerisation: Kraft lignin and synthetic lignin bioconversion with Pseudomonas putida” E. Rouches, H. Gómez-Alvarez, A. Majira, Z. Martin-Moldes, J. Nogales, E. Diaz, T.D.H. Bugg, S. Baumberger, Bioresource Technol. Reports 15, 100742 (2021).
“Microbial hosts for metabolic engineering of lignin bioconversion to renewable chemicals” T.D.H. Bugg, J.J. Williamson, and F. Alberti, Renew. Sust. Energy Rev. 152, 111674 (2021).
“Peptidomimetic analogues of Arg-Trp-x-x-Trp motif targeting interaction site of translocase MraY with bacteriophage phiX174 lysis protein E”
R.V. Kerr, J.A. Fairbairn, A.T. Merritt, and T.D.H. Bugg, Bio-Org. Med. Chem., 52, 116502 (2021).

2020

"Biochemical characterization of Serpula lacrymans iron reductase enzymes in lignocellulose breakdown" Nurika, D.C. Eastwood, T.D.H. Bugg, and G.C. Barker, J. Ind. Microbiol. Biotechnol., 47, 145-154 (2020).
"Bacterial enzymes for lignin depolymerisation: new biocatalysts for generation of renewable chemicals from biomass" T.D.H. Bugg, J.J. Williamson, G.M.M. Rashid, Curr. Opin. Chem. Biol., 55, 26-33 (2020).
"Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass" R. Tramontina, J. Galman, S.R. Derrington, T.D.H. Bugg, N.J. Turner, F.M. Squina, N. Dixon, Green Chemistry, 22, 144-152 (2020).
“Functional genomic analysis of bacterial lignin degraders: diversity in mechanisms of lignin oxidation and metabolism”
R.S. Granja-Travez, G.F. Persinoti, F.M. Squina, and T.D.H. Bugg, Appl. Microbiol. Biotechnol., 104, 3305-3320 (2020).
“Extracellular alpha/beta-hydrolase from Paenibacillus species shares structural and functional homology to tobacco salicylic acid binding protein 2” R.C. Wilkinson, R. Rahmanpour, S. Jamshidi, V. Fülöp, and T.D.H. Bugg, J. Struct. Biol., 210, 107496 (2020).
“Production of substituted styrene bioproducts from lignin and lignocellulose using engineered Pseudomonas putida KT2440”
J.J. Williamson, N. Bahrin, E.M. Hardiman, and T.D.H. Bugg, Biotechnology J., 15, 1900571 (2020).
“Exploring the lignolytic potential of soil-derived lignocellulolytic microbial consortia by a gene-centric metagenomics approach”
L.A. Diaz, T.D.H. Bugg, and D.J. Jiménez, Microbial Ecology, 80, 885-896 (2020).
“The hydroxyquinol degradation pathway in Rhodococcus jostii RHA1 and Agrobacterium species is an alternative pathway for degradation of protocatechuic acid and lignin degradation fragments” E.M. Spence, H.T. Scott, L. Dumond, L. Calvo-Bado, S. Di Monaco, J.J. Williamson, G.F. Persinoti, F.M. Squina, and T.D.H. Bugg, Appl. Environ. Microbiol., 86, e01561-20 (2020).

2019

"Characterisation of thiamine diphosphate-dependent 4-hydroxybenzoylformate decarboxylase enzymes from Rhodococcus jostii RHA1 and Pseudomonas fluorescens Pf-5 involved in degradation of aryl-C2 lignin degradation fragments" Z. Wei, R.C. Wilkinson, G.M.M. Rashid, D. Brown, V. Fülöp and T.D.H. Bugg, Biochemistry, 58, 5281-5293 (2019).
"Mechanism of action of nucleoside antibacterial natural products" T.D.H. Bugg, R.V. Kerr, J. Antibiotics, 72, 865-876 (2019).
"Protein engineering of Pseudomonas fluorescens peroxidase Dyp1B for oxidation of phenolic and polymeric lignin substrates"R. Rahmanpour, A. Ehibhatiomhan, Y. Huang, B. Ashley, G.M. Rashid, S. Mendel-Williams, and T.D.H. Bugg, Enz. Microb. Technol., 123, 21-29 (2019).

2018

"Characterisation of multi-copper oxidase CopA from Pseudomonas putida KT2440 and Pseudomonas fluorescens Pf-5: involvement in bacterial lignin oxidation" R.S. Granja-Travez & T.D.H. Bugg, Arch. Biochem. Biophys. 660, 97-107 (2018).
“Sphingobacterium sp. T2 manganese superoxide dismutase catalyses the oxidative demethylation of polymeric lignin via generation of hydroxyl radical” G.M.M. Rashid, X. Zhang, R.C. Wilkinson, V. Fülöp, B. Cottyn, S. Baumberger, and T.D.H. Bugg, ACS Chem. Biol., 13, 2920-2929 (2018).
"Genome sequence of Lysinibacillus sphaericus, a lignin-degrading bacterium isolated from municipal solid waste soil" G.F. Persinoti, D. Paixao, T.D.H. Bugg, and F.M. Squina, Genome Announcements, 6:e00353-18 (2018).
"Structural and functional characterisation of a multi-copper oxidase CueO from lignin-degrading bacterium Ochrobactrum sp. reveal its activity towards lignin model compounds and lignosulfonate" R.S. Granja-Travez, R.C. Wilkinson, G.F. Persinoti, F.M. Squina, V. Fülöp, and T.D.H. Bugg, FEBS Journal, 285, 1684-1700 (2018).
"Lignolytic-consortium omics analyses reveal novel genomes and pathways involved in lignin modification and valorization" E.C. Moraes, T.M. Alvarez, G.F. Persinoti, G. Tomazetto, L.B. Brenelli, D.A.A. Paixão, G.C. Ematsu, J.A. Aricetti, C. Caldana, N. Dixon, T.D.H. Bugg, F.M. Squina, Biotechnology for Biofuels, 11:75 (2018)
"Structural and functional characterisation of multi‐copper oxidase CueO from lignin‐degrading bacterium Ochrobactrum sp. reveal its activity towards lignin model compounds and lignosulfonate" Rommel Santiago Granja‐Travez, Rachael C. Wilkinson, Gabriela Felix Persinoti, Fabio M. Squina, Vilmos Fülöp, Timothy D. H. Bugg, FEBS, [doi: 10.1111/febs.14437] (2018)

2017

"Esterase EstK from Pseudomonas putida mt‐2: An Enantioselective Acetylesterase with activity for Deacetylation of Xylan and Poly (vinylacetate)." R. Millar, R. Rahmanpour, E.W.J. Yuan, C. White, and T.D. Bugg, Biotechnology and Applied Biochemistry, [doi: 10.1002/bab.1536], (2017)
“Identification of an extracellular bacterial flavoenzyme that can prevent re-polymerisation of lignin fragments” R. Rahmanpour, L.D.W. King & T.D.H. Bugg, Biochem. Biophys. Res. Commun.. 482, 57-61, [doi 10.1016/j.bbrc.2016.10.144], (2017)
“Synthesis of sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis” A.T. Tran, E.E. Watson, V. Pujari, T. Conroy, L.J. Dowman, A.M. Giltrap, A. Pang, W-R. Wong, R.G. Linington, J. Saunders, S.A. Charman, N.P. West, T.D.H. Bugg, J. Tod, C.G. Dowson, D.I. Roper, D.C. Crick, W.J. Britton, R.J. Payne, Nature Comm. 14414 [doi 10.1038/ncomms14414], (2017)
“Promotion of germination using hydroxamic acid inhibitors of 9-cis-epoxycarotenoid dioxygenase” S.Z. Awan, J.O. Chandler, P.J. Harrison, M.J. Sergeant, T.D.H. Bugg and A.J. Thompson, Frontiers Plant Sci., 8, article 357, [doi 10.3389/fpls.2017.00357], (2017)

2016

"Bacterial Enzymes for Lignin Oxidation and Conversion to Renewable Chemicals." T.D.H. Bugg, R. Rahmanpour, and G.M.M Rashid. Production of Biofuels and Chemicals from Lignin. Springer Singapore, 2016. 131-146.
"Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage ϕX174 lysis protein E, and cationic antibacterial peptides." T.D. Bugg, M.T. Rodolis, A. Mihalyi, and S. Jamshidi, Bioorganic & medicinal chemistry, [doi:10.1016/j.bmc.2016.03.018], (2016)
"Structure of Thermobifida fusca DyP-type peroxidase and activity towards Kraft lignin and lignin model compounds." R. Rahmanpour, D. Rea, S. Jamshidi, V. Fülöp, and T.D. Bugg, Archives of biochemistry and biophysics 594, 54-60. (2016)
"O₂‐independent demethylation of trimethylamine N‐oxide by Tdm of Methylocella silvestris" Y. Zhu, A.Z. Ksibe, H. Schäfer, C.A. Blindauer, T.D. Bugg and Y. Chen, FEBS J., [doi:10.1111/febs.13902] (2016)
"An investigation of the chemocatalytic and biocatalytic valorisation of a range of different lignin preparations: the importance of β-O-4 content" C.S. Lancefield, G.M. Rashid, F. Bouxin, A. Wasak, W.C. Tu, J.P. Hallett, S. Zein, J. Rodriguez, S.D. Jackson, N.J. Westwood, and T.D. Bugg, ACS Sustainable Chem. Eng., [doi: 10.1021/acssuschemeng.6b01855] (2016)

2015

“Lignocellulose degradation mechanisms from across the Tree of Life” S.M. Cragg, G.T. Beckham, N.C. Bruce, T.D.H. Bugg, D.L. Distel, P. DuPree, A. Etxabe Green, B.S. Goodell, J. Jellison, J. McGeehan, S.J. McQueen-Mason, K. Schnorr, P. Walton, J.E.M. Watts, and M. Zimmer, Curr. Opin. Chem. Biol., 29, 108-119 (2015)
“Identification of manganese superoxide dismutase from Sphingobacterium sp. T2 as a novel bacterial enzyme for lignin oxidation” G.M.M. Rashid, C.R. Taylor, Y. Liu, X. Zhang, D. Rea, V. Fülöp & T.D.H. Bugg, ACS Chem Biol., 10, 2286–2294 (2015).
“Enzymatic conversion of lignin into renewable chemicals” T.D.H. Bugg, R. Rahmanpour., Curr. Opin. Chem. Biol., 29, 10-17 (2015).
“Biochemical characterization and selective inhibition of β-carotene cis-trans-isomerase D27 and carotenoid cleavage dioxygenase CCD8 on the strigolactone biosynthetic pathway” P.J. Harrison, S. Newgas, F. Descombes, S.A. Shepherd, A.J. Thompson & T.D.H. Bugg, FEBS Journal., 282, 3986–4000 (2015).
“Biocatalytic conversion of lignin to aromatic dicarboxylic acids in Rhodococcus jostii RHA1 by re-routing aromatic degradation pathways” Z. Mycroft, M. Gomis, P. Mines, P. Law & T.D.H. Bugg, Green Chem., 17, 4974-4979(2015).
“Characterisation of Dyp-type peroxidases from Pseudomonas fluorescens Pf-5: oxidation of Mn(II) and polymeric lignin by Dyp1B” R. Rahmanpour & T.D.H. Bugg, Arch. Biochem. Biophys., 574, 93-98 (2015).
“Chemical intervention in bacterial lignin degradation pathways: development of selective inhibitors for intradiol and extradiol catechol dioxygenases” P.D. Sainsbury, Y. Mineyeva, Z. Mycroft, and T.D.H. Bugg, Bioorg. Chem., 60, 102-109 (2015).

2014

“Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B” A. Mihalyi, S. Jamshidi, J. Slikas, and T.D.H. Bugg, Bio-Org. Med. Chem., 22, 4566-4571 (2014).
“Mechanism of action of the uridyl peptide antibiotics: an unexpected link to a protein-protein interaction site in translocase MraY” M.T. Rodolis, A. Mihalyi, C. Ducho, K. Eitel, B. Gust, R.J.M. Goss, and T.D.H. Bugg, Chem Commun., 50, 13023- 13025 (2014)
“Lead structures for new antibacterials: stereocontrolled synthesis of a bioactive muraymycin analogue” A.P. Spork, M. Büschleb, O. Ries, D. Wiegmann, S. Boettcher, A. Mihalyi, T.D.H. Bugg, and C. Ducho, Chem. Eur. J., 20, 15292-15297 (2014).
“Observation of the time-course for peptidoglycan lipid II polymerization by Staphylococcus aureus monofunctional transglycosylase” D. Braddick, S. Sandhu, D.I. Roper, M.J. Chappell and T.D.H. Bugg, Microbiology, 160, 1628-1636 (2014).
“How to break the rules of dioxygen activation” T.D.H. Bugg, Chemistry & Biology, 21, 168-169 (2014).
“Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota" Y. Zhu, E. Jameson, M. Crosatti, H. Schäfer, K. Rajakumar, T.D.H. Bugg, and Y. Chen, Proc. Natl. Acad. Sci. USA, 111, 4268-4273 (2014).
“Periodic root branching in Arabidopsis requires synthesis of an uncharacterized carotenoid derivative" J.M. Van Norman, J. Zhang, C.I. Cazzonelli, B.J. Pogson, P.J. Harrison, T.D.H. Bugg, K.X. Chan, A.J. Thompson and P.N. Benfey, Proc. Natl. Acad. Sci. USA, 111, E1300-E1309 (2014).
“Identification of a novel inhibition site in translocase MraY based upon the site of interaction with lysis protein E from bacteriophage phiX174” M.T. Rodolis, A. Mihalyi, A. O’Reilly, J. Slikas, D.I. Roper, R.E.M. Hancock, and T.D.H. Bugg, ChemBioChem, 15, 1300-1308 (2014).
“Phytotoxic effects of selected N-benzyl-benzoylhydroxamic acid metallo-oxygenase inhibitors: investigation into mechanism of action” M. J. Sergeant, P. J. Harrison, R. Jenkins, G. R. Moran, T. D. H. Bugg & A. J. Thompson, N. J. Chem, 37, 3461 (2013).

2013

Enzymology of the Carotenoid Cleavage Dioxygenases: Reaction Mechanisms, Inhibition & Biochemical Roles. Harrison, P.J., Bugg, T.D.H. Arch Biochem Biophys. doi: 10.1016/j.abb.2013.10.005 (2013)
Breaking Down Lignin to High-Value Chemicals: The Conversion of Lignocellulose to Vanillin in a Gene Deletion Mutant of Rhodococcus jostii RHA1 . Sainsbury, P. D., Hardiman, E. M., Ahmad, M., Otani, H., Seghezzi, N., Eltis, L. D., & Bugg, T. D. H. ACS Chemical Biology Volume 8, Issue 10, pages 2151–2156 (2013)
Assembly in vitro of Rhodococcus jostii RHA1 encapsulin and peroxidase DypB to form a nanocompartment Rahman Rahmanpour, Timothy DH Bugg FEBS Journal Volume 280, Issue 9, pages 2097–2104 (2013)

2012

Detection of Staphylococcus aureus cell walls by enzyme-linked immunoassay using antibodies prepared from a semi-synthetic peptidoglycan precursor S. Sandhu, J. A. Schouten, J. Thompson, M. Davis and T.D.H. Bugg, Analyst, 137, 1130-1136 (2012).
Isolation of bacterial strains able to metabolise lignin from screening of environmental samples C.R. Taylor, E.M. Hardiman, M. Ahmad, P. Sainsbury, P.R. Norris, T.D.H. Bugg, Journal of Applied Microbiology, 113, 521-30 (2012).

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2011

Bacterial cell wall assembly: still an attractive target T.D.H. Bugg, D. Braddick, C.G. Dowson and D. I. Roper, Trends in Biotechnology, 29, 167-173 (2011).
The emerging role for bacteria in lignin degradation and bio-product formation T.D.H. Bugg, M. Ahmad, E.M. Hardiman and R. Singh, Current Opinion in Biotechnology, 22, 394-400 (2011)
Identification of DypB from Rhodococcus jostii RHA1 as a Lignin Peroxidase M. Ahmad, J.N. Roberts, E.M. Hardiman, R. Singh, L.D. Eltis and T.D.H. Bugg, Biochemistry, 50, 5096–5107 (2011).
Characterization of Dye-Decolorizing Peroxidases from Rhodococcus jostii RHA1 J. N. Roberts, R. Singh, J.C. Grigg, M.E.P. Murphy, T.D.H. Bugg, and L.D. Eltis, Biochemistry, 50, 5108–5119 (2011).
Pathways for degradation of lignin in bacteria and fungi. T.D.H. Bugg, M. Ahmad, E. M. Hardiman and R. Rahmanpour. Natural Products Report, (2011), 28 (12), 1883 - 1896
Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis. J.G Hattersley, J. Pérez-Velázquez, M.J. Chappell, D. Bearup, D. Roper, C. Dowson, T.D.H. Bugg, N.D. Evans, Comput Methods Programs Biomed., 104., 70-80 (2011).

2010

Biomimetic formation of 2-tropolones via dioxygenase-catalysed ring expansion of substituted cyclohexa-2,4-dienones M. Xin and T.D.H. Bugg,ChemBioChem, 11, 272-276 (2010).
Antimicrobial nucleoside antibiotics targetting cell wall assembly: recent advances in structure-function studies and nucleoside biosynthesis M. Winn, R.J.M. Goss, K. Kimura, T.D.H. Bugg, Natural Product Reports, 27, 279-304 (2010).
Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimicsA.E. Trunkfield, S.S. Gurcha, G.S. Besra, and T.D.H. Bugg, Bio-Organic and Medicinal Chemistry, 18, 2651-2663 (2010).
Development of novel assays for lignin degradation: comparative analysis of bacterial and fungal lignin degraders M. Ahmad, C.R. Taylor, D. Pink, K. Burton, D. Eastwood, G.D. Bending and T.D.H. Bugg, Molecular Biosystems, 6, 815-821 (2010).
Does abscisic acid affect strigolactone biosynthesis? J.A. López-Ráez, W. Kohlen, T. Charnikhova, P. Mulder, A. Undas, M.J. Sergeant, F. Verstappen, T.D.H. Bugg, A.J. Thompson, C. Ruyter-Spira, H. Bouwmeester, New Phytologist, 187, 343-354 (2010).

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2009

Selective inhibition of carotenoid cleavage dioxygenases: phenotypic effects on shoot branching M. J. Sergeant, J-J. Li, C. Fox, N. Brookbank, D. Rea, T. D. H. Bugg, J. Biol. Chem. (2009), 284, 5257-5264.
Investigation of acid/base catalysis in the extradiol and intradiol catechol dioxygenase reactions using a broad specificity mutant enzyme and model chemistry. M. Brivio, J. Schlosrich, M. Ahmad, C. Tolond and T. D. H. Bugg, Org. Biomol. Chem. (2009), 7, 1368-1373.
Inhibition of lipid II:alanyl tRNA ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors E. Cressina, A.J. Lloyd, G. De Pascale, B.J. Mok, S. Caddick, D.I. Roper, C.G. Dowson, and T.D.H. Bugg, Bio-Org. Med. Chem, 17, 3443-3455 (2009).
In vitro biosynthesis of bacterial peptidoglycan using D-Cys-containing precursors: fluorescent detection of transglycosylation and transpeptidation V. Vinatier, C.B. Blakey, D. Braddick, B.R.G. Johnson, S.D. Evans, and T.D.H. Bugg. Chem. Commun., 4037-4039 (2009).
Oxygenases get to grips with polypeptides T.D.H. Bugg, Structure, 17, 913-914 (2009).
Pseudomonas aeruginosa MurE amide ligase: enzyme kinetics and peptide inhibitor C. Paradis-Bleau, A. Lloyd, F. Sanschagrin, H. Maaroufi, T. Clarke, A. Blewett, C.G. Dowson, D.I. Roper, T.D.H. Bugg, and R.C. Levesque, Biochem. J., 421, 263-272 (2009).

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2008

Kinetic Characterization of Lipid II-Ala: Alanyl-tRNA Ligase MurN from Streptococcus pneumoniae using semi-synthetic aminoacyl-lipid II substrates G. De Pascale, A. J. Lloyd, J. A. Schouten, A. M. Gilbey, D. I. Roper, C. G. Dowson & T. D. H. Bugg, Journal of Biological Chemistry (2008), 283, 34571-34579.
Crystal Structure and Functional Assignment of YfaU, a Metal Ion Dependent Class II Aldolase from Escherichia coliK12. D. Rea, R. Hovington, J. F. Rakus, J. A. Gerlt, V. Fulop, T. D. H. Bugg, D. I. Roper, Biochemistry (2008), 47(38), 9955-9965.
Evidence from Mechanistic Probes for Distinct Hydroperoxide Rearrangement Mechanisms in the Intradiol and Extradiol Catechol Dioxygenases. M. Xin, T. D. H. Bugg, Journal of the American Chemical Society (2008), 130(31), 10422-10430.
Identification of a novel β-replacement reaction in the biosynthesis of 2,3-diaminobutyric acid in peptidylnucleoside mureidomycin A. W.-H. Lam, K. Rychli, T. D. H. Bugg, Organic & Biomolecular Chemistry (2008), 6(11), 1912-1917.
Non-heme iron-dependent dioxygenases: unravelling catalytic mechanisms for complex enzymatic oxidations. T. D. H. Bugg, S. Ramaswamy, Current Opinion in Chemical Biology (2008), 12(2), 134-40.
Evolution of peptidoglycan biosynthesis under the selective pressure of antibiotics in Gram-positive bacteria. J.-L. Mainardi, R. Villet, T. D. H. Bugg, C. Mayer, M. Arthur, FEMS Microbiology Reviews (2008), 32(2), 386-408.
The biosynthesis of peptidoglycan lipid-linked intermediates. A. Bouhss, A. E. Trunkfield, T. D. H. Bugg, D. Mengin-Lecreulx, FEMS Microbiology Reviews (2008), 32(2), 208-233.
Characterization of tRNA-dependent Peptide Bond Formation by MurM in the Synthesis of Streptococcus pneumoniae Peptidoglycan. A. J. Lloyd, A. M. Gilbey, A. M. Blewett, G. De Pascale, A. El Zoeiby, R. C. Levesque, A. C. Catherwood, A. Tomasz, T. D. H, Bugg, D. I. Roper, C. G. Dowson, Journal of Biological Chemistry (2008), 283(10), 6402-6417.
Synthesis of gem-difluorinated nucleoside analogues of the liposidomycins and evaluation as MraY inhibitors. X.-H. Xu, A. E. Trunkfield, T. D. H. Bugg, F.-L. Qing, Organic & Biomolecular Chemistry (2008), 6(1), 157-161.
Catalytic promiscuity in the alpha/beta-hydrolase superfamily: hydroxamic acid formation, C--C bond formation, ester and thioester hydrolysis in the C--C hydrolase family. C. Li, M. Hassler, T. D. H. Bugg, ChemBioChem (2008), 9(1), 71-76.
Native E. coli inner membrane incorporation in solid-supported lipid bilayer membranes. C. E. Dodd, B. R. G. Johnson, L. J. C. Jeuken, T. D. H. Bugg, R. J. Bushby, S. D. Evans, Biointerphases (2008), 3(2), FA59-FA67.

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2007

Structure and Mechanism of HpcH: A Metal Ion Dependent Class II Aldolase from the Homoprotocatechuate Degradation Pathway of Escherichia coli. D. Rea, V. Fueloep, T. D. H. Bugg, D. I. Roper, Journal of Molecular Biology (2007), 373(4), 866-876.
Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae. E. Cressina, A. J. Lloyd, G. De Pascale, D. I. Roper, C. Dowson, T. D. H. Bugg, Bioorganic & Medicinal Chemistry Letters (2007), 17(16), 4654-4656.
Investigation of a general base mechanism for ester hydrolysis in C-C hydrolase enzymes of the α/β-hydrolase superfamily: a novel mechanism for the serine catalytic triad. J.–J. Li, T. D. H. Bugg, Organic & Biomolecular Chemistry(2007), 5(3), 507-513.

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2006

Directed evolution of a non-heme-iron-dependent extradiol catechol dioxygenase: identification of mutants with intradiol oxidative cleavage activity. J. Schlosrich, K. L. Eley, P. J. Crowley, T. D. H. Bugg, ChemBioChem (2006), 7(12), 1899-1908.
Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing D-cysteine at position 4 or 5. J. A. Schouten, S. Bagga, A. J. Lloyd, G. de Pascale, C. G. Dowson, D. I. Roper, T. D. H. Bugg, Molecular BioSystems (2006), 2(10), 484-491.
Catalytic role for arginine 188 in the C-C hydrolase catalytic mechanism for Escherichia coli MhpC and Burkholderia xenovorans LB400 BphD. C. Li, J.-J. Li, M. G. Montgomery, S. P. Wood, T. D. H. Bugg, Biochemistry (2006), 45(41), 12470-12479.
Evidence for a gem-Diol Reaction Intermediate in Bacterial C-C Hydrolase Enzymes BphD and MhpC from 13C NMR Spectroscopy. J.-J. Li, C. Li, C. A. Blindauer, T. D. H. Bugg, Biochemistry (2006), 45(41), 12461-12469.
Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins. T. D. H. Bugg, A. J. Lloyd, D. I. Roper, Infectious Disorders: Drug Targets (2006), 6(2), 85-106.
Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme. C. Paradis-Bleau, M. Beaumont, L. Boudreault, A. Lloyd, F. Sanschagrin, T. D. H. Bugg, R. C. Levesque, Peptides (2006), 27(7), 1693-1700.
Antibiotic action and peptidoglycan formation on tethered lipid bilayer membranes. M. J. Spencelayh, Y. Cheng, R. J. Bushby, T. D. H. Bugg, J.-J. Li, P. J. F. Henderson, J. O'Reilly, S. D. Evans, Angewandte Chemie, (2006), 45(13), 2111-2116.
Arene cis-dihydrodiol formation: from biology to application. D. R. Boyd, T. D. H. Bugg, Organic & Biomolecular Chemistry (2006), 4(2), 181-192.
Interaction of the transmembrane domain of lysis protein E from bacteriophage phiX174 with bacterial translocase MraY and peptidyl-prolyl isomerase SlyD. S, Mendel, J. M. Holbourn, J. A. Schouten, T. D. H. Bugg Microbiology (2006), 152(10), 2959-67.

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2005

Expression, purification and preliminary crystallographic analysis of 2,4-dihydroxy-hepta-2-ene-1,7-dioate aldolase (HpcH) from Escherichia coliC. D. Rea, V. Fulop, T. D. H. Bugg, D. I. Roper, Acta Crystallographica, Section F: Structural Biology and Crystallization Communications (2005), F61(9), 821-824.
Lactone synthesis activity in a site-directed mutant of an extradiol catechol dioxygenase enzyme. S. Mendel, A. Arndt, T. D. H. Bugg, Chemical Communications (2005), (5), 666-668.
The Structure of the C-C Bond Hydrolase MhpC Provides Insights into its Catalytic Mechanism. G. Dunn, M. G. Montgomery, F. Mohammed, A. Coker,J. B. Cooper, T. Robertson, J.-L. Garcia, T. D. H. Bugg, S. P. Wood, Journal of Molecular Biology (2005), 346(1), 253-265.
Catalytic Mechanism of C-C Hydrolase MhpC from Escherichia coli: Kinetic Analysis of His263 and Ser110 Site-directed Mutants. C. Li, M. G. Montgomery, F. Mohammed, J.-J. Li, S. P. Wood, T. D. H. Bugg, Journal of Molecular Biology (2005), 346(1), 241-251.
Stereochemistry of the reaction catalysed by 2-hydroxy-6-keto-6-phenyl-hexa-2,4-dienoic acid 5,6-hydrolase (BphD). J.-J. Li, T. D. H. Bugg,Chemical Communications (2005), (1), 130-132.
Regulation and manipulation of the biosynthesis of abscisic acid, including the supply of xanthophyll precursors. I. B. Taylor, T. Sonneveld, T. D. H. Bugg, A. J. Thompson, Journal of Plant Growth Regulation (2005), 24(4), 253-273.

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2004

Synthetic 6-aryl-2-hydroxy-6-ketohexa-2,4-dienoic acid substrates for C-C hydrolase BphD: investigation of a general base catalytic mechanism.D. M. Speare, S. M. Fleming, M. N. Beckett, J.-J. Li, T. D. H, Bugg, Organic & Biomolecular Chemistry (2004), 2(20), 2942-2950.
Acid-Base Catalysis in the Extradiol Catechol Dioxygenase Reaction Mechanism: Site-Directed Mutagenesis of His-115 and His -179 in Escherichia coli 2,3-Dihydroxyphenylpropionate 1,2-Dioxygenase (MhpB). S. Mendel, A. Arndt, T. D. H. Bugg, Biochemistry (2004), 43(42), 13390-13396.
Diverse catalytic activities in the αβ-hydrolase family of enzymes: activation of H₂O, HCN, H₂O₂, and O₂. T. D. H. Bugg, Bioorganic Chemistry (2004), 32(5), 367-375.
Phospho-N-acetyl-muramyl-pentapeptide translocase from Escherichia coli: catalytic role of conserved aspartic acid residues. A. J. Lloyd, P. E. Brandish, A. M. Gilbey, T. D. H. Bugg, Journal of Bacteriology (2004), 186(6), 1747-1757.
Expression, purification, crystallization and preliminary characterization of uridine 5'-diphospho-N-acetylmuramoyl l-alanyl-d-glutamate:lysine ligase (MurE) from Streptococcus pneumoniae 110K/70. A. M. Blewett, A. J. Lloyd, A. Echalier, V. Fueloep, C. G. Dowson, T. D. H. Bugg, D. I. Roper,Acta Crystallographica, Section D: Biological Crystallography (2004), D60(2), 359-361.
A fluorescent analogue of UDP-N-acetylglucosamine: application for FRET assay of peptidoglycan translocase II (MurG). J.-J. Li, T. D. H. Bugg,Chemical Communications (2004), 2), 182-183.

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2003

Multivalent Conjugates of Poly-g -D-glutamic Acid from Bacillus licheniformis with Antibody F(ab') and Glycopeptide Ligands. E. J. Prodhomme, A. L. Tutt, M. J. Glennie, T. D. H. Bugg, Bioconjugate Chemistry (2003), 14(6), 1148-1155.
Dioxygenase enzymes: catalytic mechanisms and chemical models. T. D. H. Bugg, Tetrahedron (2003), 59(36), 7075-7101.
Synthesis and activity of 5'-Uridinyl dipeptide analogues mimicking the amino terminal peptide chain of nucleoside antibiotic mureidomycin A. N. I.Howard, T. D. H. Bugg, Bioorganic & Medicinal Chemistry (2003), 11(14), 3083-3099.
Stereochemical and mechanistic aspects of dioxygenase-catalyzed benzylic hydroxylation of indene and chroman substrates. D. R. Boyd, N. D. Sharma, N. I. Bowers, R. Boyle, J. S. Harrison, K. Lee, T. D. H. Bugg, D. T. Gibson, Organic & Biomolecular Chemistry (2003), 1(8), 1298-1307.
A density functional investigation of the extradiol cleavage mechanism in non-heme iron catechol dioxygenases. R. J. Deeth, T. D. H. Bugg, Journal of Biological Inorganic Chemistry (2003), 8(4), 409-418.
Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis. K.-I. Kimura, T. D. H. Bugg, Natural Product Reports (2003), 20(2), 252-273.

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2002

2-Hydroxy-6-keto-nona-2,4-diene 1,9-dioic acid 5,6-hydrolase: evidence from ¹⁸O isotope exchange for gem-diol intermediate. T. D. H. Bugg, S. M. Fleming, T. A. Robertson, G. J. Langley, Methods in Enzymology (2002), 354, 106-118.
Enzyme Assays, 2nd Edition Edited by R. Eisenthal and M. J. Hanson. T. D. H. Bugg, University of Warwick, UK. Natural Product Reports (2002), 19(5), 673.
Hammett analysis of a C-C hydrolase-catalysed reaction using synthetic 6-aryl-2-hydroxy-6-ketohexa-2,4-dienoic acid substrates. D. M. Speare, P. Olf, T. D. H. Bugg, Chemical Communications (2002), (20), 2304-2305.
Biological Properties of N-Acyl and N-Haloacetyl Neuraminic Acids: Processing by Enzymes of Sialic Acid Metabolism, and Interaction with Influenza Virus. A. J. Humphrey, C. Fremann, P. Critchley, Y. Malykh, R. Schauer, T. D. H. Bugg, Bioorganic & Medicinal Chemistry (2002), 10(10), 3175-3185.
Directed evolution of intradiol and extradiol catechol dioxygenases. K. Eley, T. D. H. Bugg, P. Crowley, Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, August 18-22, 2002 (2002), BIOL-043.
Thioester analogues of peptidoglycan fragment MurNAc-L-Ala-g -D-Glu as substrates for peptidoglycan hydrolase MurNAc-L-Ala amidase. R. L. Harding, J. Henshaw, J. Tilling, T. D. H. Bugg, Journal of the Chemical Society, Perkin Transactions 1 (2002), (14), 1714-1722.

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2001

Extradiol Oxidative Cleavage of Catechols by Ferrous and Ferric Complexes of 1,4,7-Triazacyclononane: Insight into the Mechanism of the Extradiol Catechol Dioxygenases. G. Lin, G. Reid, T. D. H. Bugg, Journal of the American Chemical Society (2001), 123(21), 5030-5039.
Oxygenases: mechanisms and structural motifs for O₂ activation. T. D. H. Bugg, Current Opinion in Chemical Biology (2001), 5(5), 550-555.
Enhanced acid stability of a reduced nicotinamide adenine dinucleotide (NADH) analogue. P. H. Hentall, N. Flowers, T. D. H. Bugg, Chemical Communications (2001), (20), 2098-2099.
The development of mechanistic enzymology in the 20th century. T. D. H. Bugg, Natural Product Reports (2001), 18(5), 465-493.
Enzymes: Biochemistry, Biotechnology, Clinical Chemistry, by Trevor Palmer. T. D. H. Bugg, Natural Product Reports (2001), 18(4), 460.
Solving the riddle of the intradiol and extradiol catechol dioxygenases: how do enzymes control hydroperoxide rearrangements? T. D. H. Bugg, G. Lin, Chemical Communications (2001), (11), 941-952.
Solvolytic C-C Cleavage Reaction of 6-Acetoxycyclohexa-2,4-dienones: Mechanistic Implications for the Intradiol Catechol Dioxygenases. K. L.Eley, P. J. Crowley, T. D. H. Bugg, Journal of Organic Chemistry (2001), 66(6), 2091-2097.
Mechanistic studies of hydrolase enzymes on the aromatic degradation pathways of Escherichia coli. D. M. Speare, T. D. H. Bugg, Abstracts of Papers, 222nd ACS National Meeting, Chicago, IL, United States, August 26-30, 2001 (2001), BIOL-221.
Synthesis of novel inhibitors of phospho-N-acetylmuramylpentapeptide translocase (mraY). N. I. Howard, T. D. H. Bugg, Abstracts of Papers, 222nd ACS National Meeting, Chicago, IL, United States, August 26-30, 2001 (2001), BIOL-109.

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2000

Catalytic Mechanism of a C-C Hydrolase Enzyme: Evidence for a Gem-Diol Intermediate, Not an Acyl Enzyme. S. M. Fleming, T. A. Robertson, G. J. Langley, T. D. H. Bugg, Biochemistry (2000), 39(6), 1522-1531.
Enzymatic Breakdown of Poly-g-D-glutamic Acid in Bacillus licheniformis: Identification of a Polyglutamyl g -Hydrolase Enzyme. E. C. King, A. J. Blacker, T. D. H. Bugg, Biomacromolecules (2000), 1(1), 75-83.
Use of trityl thiol for stereoselective thioester synthesis: a new preparation of (S)-thiolactic acid. R. L. Harding, T. D. H. Bugg, Tetrahedron Letters(2000), 41(15), 2729-2731.
A biomimetic model reaction for the extradiol catechol dioxygenases. G. Lin, T. D. H. Bugg, G. Reid, Chemical Communications (2000), (13), 1119-1120.
Elucidation of the catalytic mechanisms of the non-haem iron-dependent catechol dioxygenases: synthesis of carba-analogues for hydroperoxide reaction intermediates. C. J. Winfield, Z. Al-Mahrizy, M. Gravestock, T. D. H. Bugg, Journal of the Chemical Society, Perkin Transactions 1 (2000), (19), 3277-3289.

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1999

Bacterial peptidoglycan biosynthesis and its inhibition. T. D. H. Bugg, Comprehensive Natural Products Chemistry (1999), 3 41-294
Structure-function studies on nucleoside antibiotic mureidomycin A: synthesis of 5'-functionalized uridine models. C. A. Gentle, S. A. Harrison, M. Inukai, T. D. H. Bugg, Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1999), (10), 1287-1294.
Role of the enamide linkage of nucleoside antibiotic mureidomycin A: synthesis and reactivity of enamide-containing analogues. C. A. Gentle, T. D. H. Bugg, Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1999), (10), 1279-1286.

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1998

Substrate selectivity and biochemical properties of 4-hydroxy-2-keto-pentanoic acid aldolase from Escherichia coli. J. R. Pollard, D. Rialland, T. D. H. Bugg, Applied and Environmental Microbiology (1998), 64(10), 4093-4094.
Enzymic cleavage of aromatic rings: mechanistic aspects of the catechol dioxygenases and later enzymes of bacterial oxidative cleavage pathways. T. D. H. Bugg, C. J. Winfield, Natural Product Reports (1998), 15(5), 513-530.
Covalent modification in aqueous solution of poly-g -D-glutamic acid from Bacillus licheniformis. E. C. King, W. J. Watkins, A. J. Blacker, T. D. H. Bugg, Journal of Polymer Science, Part A: Polymer Chemistry (1998), 36(12), 1995-1999.
Purification, characterization and reaction mechanism of monofunctional 2-hydroxypentadienoic acid hydratase from Escherichia coli. J. R. Pollard, T. D. H. Bugg, European Journal of Biochemistry (1998), 251(1/2), 98-106.
Aminoalkylphosphinate inhibitors of D-Ala-D-Ala adding enzyme. D. J. Miller, S. M. Hammond, D. Anderluzzi, T. D. H. Bugg, Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1998), (1), 131-142.

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1997

Pre-Steady-State Kinetic Analysis of 2-Hydroxy-6-keto-nona-2,4-diene-1,9-dioic Acid 5,6-Hydrolase: Kinetic Evidence for Enol/Keto Tautomerization. I. M. Henderson, T. D. H. Bugg, Biochemistry (1997), 36(40), 12252-12258.
Purification, Characterization, and Stereochemical Analysis of a C-C Hydrolase: 2-Hydroxy-6-keto-nona-2,4-diene-1,9-Dioic Acid 5,6-Hydrolase.W. W. Y. Lam, T. D. H. Bugg, Biochemistry (1997), 36(40), 12242-12251.
Chemical and biochemical properties of 2-hydroxypentadienoic acid, a homolog of enolpyruvic acid. J. R. Pollard, I. M. Henderson, T. D. H. Bugg,Chemical Communications (1997), (19), 1885-1886.
Exploring the catalytic mechanism of the extradiol catechol dioxygenases. T. D. H. Bugg, J. Sanvoisin, E. L. Spence, Biochemical Society Transactions(1997), 25(1), 81-85.
Regiospecific ester hydrolysis by orange peel esterase: an undergraduate experiment. T. D. H. Bugg, A. M. Lewin, E. R. Catlin, Journal of Chemical Education (1997), 74(1), 105-107.

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1996

Catechol dioxygenases from Escherichia coli (MhpB) and Alcaligenes eutrophus (MpcI): sequence analysis and biochemical properties of a third family of extradiol dioxygenases. E. L. Spence, M. Kawamukai, J. Sanvoisin, H. Braven, T. D. H. Bugg, Journal of Bacteriology (1996), 178(17), 5249-5256.
Cis-Trans Isomerization of a Cyclopropyl Radical Trap Catalyzed by Extradiol Catechol Dioxygenases: Evidence for a Semiquinone Intermediate.E. L. Spence, G. J. Langley, T. D. H. Bugg, Journal of the American Chemical Society (1996), 118(35), 8336-83
Modes of action of tunicamycin, liposidomycin B, and mureidomycin A: inhibition of phospho-N-acetylmuramyl-pentapeptide translocase fromEscherichia coli. P. E. Brandish, K.-I. Kimura, M. Inukai, R. Southgate, J. T. Lonsdale, T. D. H. Bugg, Antimicrobial Agents and Chemotherapy (1996), 40(7), 1640-1644.
Slow binding inhibition of phospho-N-acetylmuramyl-pentapeptide-translocase (Escherichia coli) by mureidomycin A. P. E. Brandish, M. K.Burnham, J. T. Lonsdale, R. Southgate, M. Inukai, T. D. H. Bugg, Journal of Biological Chemistry (1996), 271(13), 7609-14.

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