Publications - 2009

• Selective inhibition of carotenoid cleavage dioxygenases: phenotypic effects on shoot branching M. J. Sergeant, J-J. Li, C. Fox, N. Brookbank, D. Rea, T. D. H. Bugg, J. Biol. Chem. (2009), 284, 5257-5264.
• Investigation of acid/base catalysis in the extradiol and intradiol catechol dioxygenase reactions using a broad specificity mutant enzyme and model chemistry. M. Brivio, J. Schlosrich, M. Ahmad, C. Tolond and T. D. H. Bugg, Org. Biomol. Chem. (2009), 7, 1368-1373.
• Inhibition of lipid II:alanyl tRNA ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors E. Cressina, A.J. Lloyd, G. De Pascale, B.J. Mok, S. Caddick, D.I. Roper, C.G. Dowson, and T.D.H. Bugg, Bio-Org. Med. Chem, 17, 3443-3455 (2009).
• In vitro biosynthesis of bacterial peptidoglycan using D-Cys-containing precursors: fluorescent detection of transglycosylation and transpeptidation V. Vinatier, C.B. Blakey, D. Braddick, B.R.G. Johnson, S.D. Evans, and T.D.H. Bugg. Chem. Commun., 4037-4039 (2009).
• Oxygenases get to grips with polypeptides T.D.H. Bugg, Structure, 17, 913-914 (2009).
• Pseudomonas aeruginosa MurE amide ligase: enzyme kinetics and peptide inhibitor C. Paradis-Bleau, A. Lloyd, F. Sanschagrin, H. Maaroufi, T. Clarke, A. Blewett, C.G. Dowson, D.I. Roper, T.D.H. Bugg, and R.C. Levesque, Biochem. J., 421, 263-272 (2009).