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Dr Nikola Chmel

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Prof Peter Scott
Professor of Chemistry
Deputy Head of Faculty of Science
Head of Research Ctte Chemistry

BSc(Salford), DPhil(Oxon), DSc (Warwick), CChem, FRSC

tel +44 24 7652 3238
fax +44 24 7657 2710
skype peter.scott.1965

Research Group Site

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Research Summary
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Metallo-organic chemistry, particularly the design of self-assembling chiral systems; their applications as medicines for challenging diseases (superbugs, cancer), catalysts for enantioselective transformations of organic molecules, and materials for high-technology products (magnetism and conductivity)...more (group site)


Selected Publications
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Associate Professor


N Chmel profile picture Nikola Chmel is working on method development in spectroscopy for applications in complex biomolecular systems; circular and linear dichroism; fluorescence; dynamic light scattering; and vibrational spectroscopy.

N dot Chmel at warwick dot ac dot uk

024 765 23234

Office M3.09 (Senate House)

Biophysical Chemistry Group

Groups at Warwick


Affiliations

  • Head of Postgraduate Taught Studies, Department of Chemistry
  • Director of MSc and Management Board Member, Analytical Science Centre for Doctoral Training (AS CDT)
  • Director of Postgraduate Certificate in Transferable Skills in Science, Faculty of Science, Engineering and Medicine
  • Committee Member, Analytical Biosciences Group of the Royal Society of Chemistry

Biography

    • 2019-present Associate Professor, Department of Chemistry, University of Warwick
    • 2014-2019 Senior Teaching Fellow, Department of Chemistry, University of Warwick
    • 2011-2014 Research Fellow, Molecular Organisation and Assembly in Cells (MOAC), University of Warwick
    • 2010-2011 Warwick Knowledge Transfer Fellow, University of Warwick/Starna UK
    • 2007-2010 PhD in Chemistry, Department of Chemistry, University of Warwick

    I am working on the following projects at the moment:

    • Standards for circular dichroism spectroscopy

      In collaboration with Starna UK and Jasco UK we have developed new standards for circular dichroism spectroscopy. We are currently testing the prototype calibration kits and we expect them to be commercially available within the next few months.

    • Orientation of small molecules in membranes

      The aim of this project is to develop protocols for determining orientation of small molecules in lipid membranes using a mixture of methods, including linear dichroism, Raman and FT/IR.

    • Determination of trace impurities in formulated materials

      The aim of this project is to develop new methodologies to look at trace impurities in formulated products. This project is sponsored by Pfizer.

    Method development in spectroscopy for applications in complex biomolecular systems; circular and linear dichroism; fluorescence; dynamic light scattering; and vibrational spectroscopy.

    I teach the following modules:

    Undergraduate:

    • CH162 Introduction to Physical Chemistry (Tutorials)
    • CH3F2 Advanced Analytical Chemistry

    Postgraduate:

    • CH911 Chromatography and Separation Science
    • CH913 Team Research Project: Real World Analysis
    • CH915 Techniques in Quantitative and Qualitative Analysis
    • CH921 Frontier Techniques in Analytical Science
    • CH932 Introduction to Chemistry and Biochemistry

    Transferable Skills:

    • CH948 Warwick Interdisciplinary Transferable Skills
    • CH950 Doctoral Skills 1
    • CH951 Doctoral Skills 2
    • CH952 Doctoral Skills 3
    • CH955 Decision-Making and Leadership
    • CH956 Scientific Research Skills I


    I am co-supervising the following PhD students:

    • Katie Wood, The role of adaptor proteins in the dynamics of clathrin coat formation and disassembly
    • Marco Pinto, Protein structure and function: analytical methods to characterise protein structure, protein-protein interactions and their functions

    At the moment I am unable to accept any further applications, but if you get in touch I'll see if a member of my team might be able to help.

    Recent Publications

    • Irshad, Z.; Chmel, N.; Adya, R.; et al. Hepatic VLDL secretion: DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2. J. Lipid Res., 2019, 60, 111-120
    • Roth, D.; Fitton, B. P; Chmel, N. P. et al. Spatial positioning of EB family proteins at microtubule tips involves distinct nucleotide-dependent binding properties. J Cell Sci. 2019, 132: jcs.219550
    • Wemyss, A. M.; Razmkhah K; Chmel N. P.; et al. Fluorescence detected linear dichroism of small molecules oriented on polyethylene film. Analyst, 2018, 143, 5805-5811
    • Wemyss, A. M.; Chmel, N. P.; Lobo, D. P.; et al. Fluorescence detected linear dichroism spectroscopy: A selective and sensitive probe for fluorophores in flow-oriented systems. Chirality, 2018, 30 (3), 227-237
    • Corujo, M. P.; Sklepari, M.; Ang, D. L.; et al. Infrared absorbance spectroscopy of aqueous proteins: Comparison of transmission and ATR data collection and analysis for secondary structure fitting. Chirality, 2018, 30 (8), 957-965.
    • Morrison, K. A.; Akram, A.; Mathews, A.; et al. Membrane protein extraction and purification using styrene-maleic acid (SMA) copolymer: effect of variations in polymer structure. Biochemical Journal, 2016, 473, 4349-4360
    • Pages, B. J.; Sakoff, J.; Gilbert, J.; et al., Multifaceted Studies of the DNA Interactions and In Vitro Cytotoxicity of Anticancer Polyaromatic Platinum(II) Complexes. Chemistry-a European Journal 2016, 22, 26, 8943-8954
    • Betanzos-Lara, S.; Chmel, N. P.; Zimmerman, M. T.; Barron-Sosa, L. R.; Garino, C.; Salassa, L.; Rodger, A.; Brumaghim, J. L.; Gracia-Mora, I.; Barba-Behrens, N., Redox-active and DNA-binding coordination complexes of clotrimazole. Dalton Trans. 2015, 44, 3673-3685
    • Razmkhah, K., Chmel, N. P., Gibson, M. I., Rodger, A., Oxidized polyethylene films for orienting polar molecule for linear dichroism spectroscopy. Analyst 2014, 139, 1372-1382
    • Howson, S. E.; Chmel, N. P.; Clarkson, G. J.; Deeth, R. J.; Simpson, D. H.; Scott, P., Jahn-Teller effects on [small pi]-stacking and stereoselectivity in the phenylethaniminopyridine tris-chelates Cu(NN’)32+. Dalton Trans. 2012, 41 (15), 4477-4483.
    • Chmel, N. P.; Scott, P.; Rodger, A., Considerations of Noise and Measurement Reproducibility of Circular Dichroism Measurements Using Na[CoIII(EDDS)]. Chirality 2012, 24, 699-705.
    • Chmel, N. P.; Clarkson, G. J.; Troisi, A.; Turner, S. S.; Scott, P., Chiral Semiconductor Phases: The Optically Pure D3[MIII(S,S-EDDS)]2 (D = TTF, TSF) Family. Inorg. Chem. 2011, 50 (9), 4039-4046.
    • Chmel, N. P.; Allan, L. E.; Becker, J. M.; Clarkson, G. J.; Turner, S. S.; Scott, P., TTF salts of optically pure cobalt pyridine amidates; detection of soluble assemblies with stoichiometry corresponding to the solid state. Dalton Trans. 2011, 40, 1722-1731.
    • Chmel, N. P.; Howson, S. E.; Allan, L. E. N.; Barker, J.; Clarkson, G. J.; Turner, S. S.; Scott, P., Organic-soluble optically pure anionic metal complexes PPh4[MIII(S,S-EDDS)]·2H2O (M = Fe, Co, Cr). Dalton Trans. 2010, 39 (11), 2919-2927.
    • Howson, S. E.; Allan, L. E. N.; Chmel, N. P.; Clarkson, G. J.; van Gorkum, R.; Scott, P., Self-assembling optically pure Fe(A-B)3 chelates. Chem Commun 2009, (13), 1727-1729.
    • Podgajny, R.; Chmel, N. P.; Balanda, M.; Tracz, P.; Gawel, B.; Zajac, D.; Sikora, M.; Kapusta, C.; Lasocha, W.; Wasiutynski, T.; Sieklucka, B., Exploring the formation of 3D ferromagnetic cyano-bridged CuII2+{CuII4[WV(CN)8]4-2[WIV(CN)8]2}·yH2O networks. J. Mater. Chem. 2007, 17 (31), 3308-3314.