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  1. F. Alberti, D. Leng, I. Wilkening, M. Tosin, L. Song, C. Corre, Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discovery, bioRxiv, 2018, DOI: 10.1101/265645
  2. C. Perry, J. Sargeant, L. Song, G. Challis, Relative stereochemical assignment of C33 and C35 in the antibiotic gladiolin, Tetrahedron, 2018,

  3. Banerjee, J. Soldevila, J. Wolny, C. Wootton, A. Habtemariam, I. Romero, F. Chen, G. Clarkson, I. Prokes, L. Song, P. O'Connor, V. Schunemann, P. Sadler. New activation mechanism for half-sandwich organometallic anticancer complexes, Chem Sci., 2018, 9, 3177-3188
  4. Z. Anderson, C. Hobson, R. Needley, L. Song, M. Perryman, P. Kerby, and D. Fox, NMR-based assignment of isoleucine vs allo-isoleucine stereochemistry. Org. Biomol. Chem., 2017, 15, 9372-9378

  5. D. Blessborn, K. Kaewkhao, L. Song, NJ White, NPJ Day, J Tarning, Quantification of the antimalarial drug pyronaridine in whole blood using LC-MS/MS-increased sensitivity resulting from reduced non-specific binding, J Pharm Biomed Anal. 2017, 146: 214-219
  6. L. Song, M. Jenner, J. Masschelein, C. Jones, M. Bull, S. Harris, R. Hartkoorn, A. Vocat, I. Romero-Canelón, P. Coupland, Paul, G. Webster, M. Dunn, R. Weiser, C. Paisey, S. Cole, J. Parkhill, E. Mahenthiralingam and G. L. Challis. Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis. J. Am. Chem. Soc. 2017, 139(23)7974-7981
  7. O. Tsypik, R. Makitrynskyy, A. Bera, L. Song, W. Wohlleben, V. Fedorenko, B. Ostash, Role of GntR Family Regulatory Gene SCO1678 in Gluconate Metabolism in Streptomyces coelicolor M145, BioMed Research International, 2017,
  8. Y. Inahashi, S. Zhou, M. Bibb, L. Song, M. Al-Bassam, M. Bibb and G. Challis. Watasemycin biosynthesis in Streptomyces venezuelae: thiazoline C-methylation by a type B radical-SAM methylase homologue. Chem. Sci. 2017, 8, 2823-2831
  9. M. Sotenko, S. Coles, G. Barker, L. Song, Y. Jiang, P. Longhurst, T. Romanova, O. Shuvaeva, K. Kirwan. Phytoremediation combined with biorefinery on the example of two agricultural crops grown on Ni soil and degraded by P. chrysosporium. Int. J. Phytoremediation., 2016, Dec 12:0
  10. L. Ray, T. Valentic, T. Miyazawa, D. Withall, L. Song, H. Osada, S. Takahashi, S. Tsai, G. Challis, Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics, Nat. Comm., 2016, 7, 13609.
  11. A. Thanapipatsiri, J. Gomez-Escribano, L. Song, M. Bibb, M. Al-Bassam, G. Chandra, A. Thamchaipenet, G. Challis and M. Bibb, Discovery of unusual biaryl polyketides by activation of a silent Streptomyces venezuelae biosynthetic gene cluster, ChemBioChem., 2016, 17, 2189-2198.
  12. I. Wilkening, S. Gazzola, E. Riva, J. Parascandolo, L. Song, M. Tosin. Second-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assembly. Chem. Comm., 2016, 52, 10392-10395.
  13. J. Sidda, V. Poon, L. Song, W. Wang, K. Yang, C. Corre. Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production super host Streptomyces M1152. Org. Biomol. Chem., 2016, 14(27), 6390-6393
  14. D. Zabala, J. W. Cartwright, D. M. Roberts, B. C. Law, L. Song, M. Samborskyy, P. F. Leadlay, J. Micklefield, and G. L. Challis. A flavin-dependent decarboxylase-dehydrogenase-monooxygenase assembles the warhead of α, β-epoxyketone proteasome inhibitors. J. Am. Chem. Soc. 2016, 137, 432-435.
  15. J. Parascandolo, J. Havemann, H. Potter, F. Huang, E. Riva, J. Connolly, I. Wilkening, L. Song, P. Leadlay, M. Tosin, Novel insights into 6-methylsalicylic acid bio-assembly via chemical probes, Angew. Chem. Int. Ed. 2016, 55(10), 3463-3467.
  16. C. Amaratunga, P. Lim, S. Suon, S. Sreng, S. Mao, C. Sopha, B. Sam, D. Dek, V. Try, R. Amato, D. Blessborn, L. Song, G. Tullo, M. Fay, J. Anderson, J. Tarning, R. Fairhurst. Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multi-site observational cohort study, Lancet Infectious Disease, 2016, 16(3), 357-365.
  17. N. Liu*, L. Song*, M. Liu*, F. Shang, Z. Anderson, D. Fox, G. L. Challis, Y. Huang, Unique post-translational ­oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264, Chem. Sci., 2016, 7(1), 482-488. (* Co-first author)
  18. B. Uytterhoeven, K. Appermans, L. Song, J. Masschelein, C. Michiels, R. Lavigne, Systematic analysis of the kalimantacin assembly line NRPS module using an adapted targeted mutagenesis approach, Microbiology Open, 2016, 5(2), 279-286.
  19. R. Leang, W. Taylor, D. Bouth, L. Song, J. Tarning, M. Char, S. Kim, B. Witkowski, V. Duru, A. Domergue, N. Khim, P. Ringwald, D. Menard, Evidence of falciparum malaria multidrug resistance to artemisinin and piperaquine in western Cambodia: dihydroartemisinin-piperaquine open-label multicenter clinical assessment. Antimicrob Agents Chemother., 2015, 59(8), 4719-4726.
  20. J. Gubbens, H. Zhu, G. Girard, L. Song, B. Florea, P. Aston, K. Ichinose, D. Filippov, Y. Choi, H. Overkleeft, G. Challis, G. van Wezel, Natural Product Proteomining, a Quantitative Proteomics Platform, Allows Rapid Discovery of Biosynthetic Gene Clusters for Different Classes of Natural Products. Chem. Biol., 2014, 21(6), 707-718.
  21. L. Song, L. Laureti, C. Corre, P. Leblond, B. Agile, G. L. Challis. Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonisation in stambomycin biosynthesis. J. Antibiotic, 2014, 67, 71-76.
  22. J. Sida, L. Song, V. Poon, M. Al-Bassam, O. Lazos, M. Buttner, G. Challis, C. Corre. Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster, Chem. Sci., 2014, 5 (1), 86-89.
  23. J. Suberu, P. Yamin, K. Leonhard, L. Song, S. Chemat, N. Sullivan, G. Barker, A. Lapkin . The effect of O-methylated flavonoids and other co-metabolites on the crystallization and purification of artemisinin. J. Biotechnol., 2014, 171, 25-33.
  24. J. Suberu, L. Song, N. Sullivan,S. Slade, G. Barker, A. Lapkin, A rapid method for the determination of artemisinin and its biosynthetic precursor in Artemisia annua L. crude extract. J. Pharm. Biomed. Anal., 2013, 84, 269-277.
  25. S. Kodani, J. Bicz, L. Song, R. Deeth, M. Ohnish-Kameyama,M. Yoshida, K. Ochi, and G. L. Challis. Structure and biosynthesis of scabichelin, a novel tris-hydroxamate siderophore produced by the plant pathogen Streptomyces scabies 87.22. Org. Biomol. Chem., 2013, 11, 4686-4694.
  26. Y. Zhao, J Woods, N. Farrer, K. Robinson, J. Pracharova, J. Kasparkova, O. Nokakova, H. Li, L. Salassa, A. Pizarro, G. Clarkson, L. Song, V. Brabec, P. Sadler, Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible light form novel DNA adducts, Chem. Eur. J., 2013, 19(29), 9578-9591.
  27. J. Gomez-Escribano*, L. Song*, M. Bibb, G.. Challis, Posttranslational β-methylation and macrolactamidination in the biosynthesis of the bottromycin complex of ribosomal peptide antibiotics, Chem. Sci, 2012, 3, 3522-3525. (* co-first author)
  28. S. Barry, J. Kers, E. Johnson, L. Song, P. Aston, B. Patel, S. Krasnoff, B. Crane, D. Gibson, R. Loria and G. Challis. Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis. Nat. Chem. Biol., 2012, 8, 814-816.
  29. A. Gerc*, L. Song*, G. L. Challis, N. R. Stanley-Wall, S. J. Coulthurst, Identification and characterisation of the althiomycin biosynthetic operon of Serratia marcescens Db10, PLoS ONE, 2012, 7(9), e44673 (* Co-first Author).
  30. J. Gomez-Escribano*, L. Song*, D.J.Fox, M. Bibb, G.L. Challis, Identification of the yellow-pigmented polyketide product of the cryptic cpk gene cluster of Streptomyces coelicolor M145, Chem. Sci, 2012,3(9), 2716-2720. (* co-first author)
  31. S. Lautru, L. Song, L. Demange, H. Galons, G. L. Challis and Jean-Luc Pernodet. A Sweet Origin for the Key Congocidine Precursor 4-Acetamidopyrrole-2-carboxylate. Angew. Chem Int. Ed., 2012, 51(30), 7454-7458
  32. Y. Fu, M. Romero, A. Habtemariam, M. Snowden, L. Song, G. Clarkson, B. Qamar, A. Pizarro, P. Unwin and P. Sadler, The Contrasting Chemical Reactivity of Potent Isoelectronic Iminopyridine and Azopyridine Osmium(II) Arene Anticancer Complexes, Chem. Sci., 2012, 3(8), 2485-2494.
  33. P. Milnes, M. McKee, J. Bath, L. Song , E. Stulz, A. Turberfield and R. O'Reilly, Sequence- specific synthesis of macromolecules using DNA-templated chemistry, Chem. Comm., 2012, 48,5614-5616.
  34. L. Song, L. Laureti, J.-P. Gomez-Escribano, D. Fox, V. Yeo, C. Corre, S. Huang, P. Leblond, B. Aigle, M. Bibb and G. L. Challis. Bacterial Genome Mining for Novel Natural Product Discovery. Planta Med., 2012, 78, 1030.
  35. S. Schmelz, C.H. Botting, L. Song, N. Kadi, G.L. Challis and J.H. Naismith. Structural basis for acyl acceptor specificity in the achrombactin biosynthetic enzyme AcsD. J. Mol. Biol., 2011, 412 (3)495-504.
  36. R. Seipke, L. Song, J. Bic, P. Laskaris, A. Yaxley, G. L. Challis, R. Loria, Expression of a pyochelin biosynthetic gene cluster in Streptomyces scabies 87022 is regulated by TetR- and AfsR- family regulatory proteins. Microbiology, 2011, 157, 2681-2693.
  37. L. Laureti*, L. Song*, S. Huang, C. Corre, P. Leblond, G.L. Challis and B. Aigle. A new class of bioactive macrolide discovered by activation of a silent polyketide synthase. Proc. Nat. Acad. Sci. USA. 2011,108(15), 6258-6263, (*co-first author)
  38. E. Mahenthiralingam, L. Song, A. Sass, J. White,C. Wilmot, A. Marchbank, O. Boaisha, J. Paine, D. Knight, G. Challis, Enacyloxins are products of an unusual hybrid modular polyketide synthase encoded by a cryptic Burkholderia ambifaria genomic island. Chem. Biol., 2011, 18(5), 665-677.
  39. R. Bunet, L. Song, M. V. Mendrea, C. Corre, L. Hotel, N Rouhler, X. Framboisier, P Leblond, G.L.Challis, B. Aigle. Characterisation and manipulation of the pathway specific regulator AlpW reveals Streptomyces ambofaciens a new producer of kinamycins. J. Bacteriol., 2011, 195, 1142-1153.
  40. P. Sydor, S. Barry, O. Odulate, F. Barona-Gomez, S. Haynes, C. Corre, L. Song, G. L. Challis, Antibiotic Oxidative Carbocyclizations Catalyzed by Rieske Oxygenase-Like Enzymes, Nat. Chem., 2011, 3, 388-392.
  41. S. Haynes, P. Sydor, C. Corre, L. Song, and G.L. Challis. Stereochemical elucidation of streptorubin B. J. Am. Chem. Soc.,2011, 133 (6), 1793-1798.
  42. P. Patel, L Song, G.L.Challis, Distinct extracytoplasmic siderophore binding proteins recognise ferrioxamines and ferricoelichelin in Streptomyces Coelicolor A3(2), Biochemistry, 2010, 49, 8033-8042.
  43. B. Aigle, R. Bunet, C. Corre,; A. Garenaux, L. Hotel, S. Huang, L. Laureti, S. Lautru, M/. Mendes, S. Nezbedova, H. Nguyen, L Song, J. Weiser, G. Challis, P. Leblond, J.Pernodet. Genome-guided exploration of Streptomyces ambofaciens secondary metabolism. Streptomyces, 2011, 179-194.
  44. Y. Chen, J. Scanlan, L Song, A. Crombie, M. Rahman, H. Schafer, C. Murrell, γ-glutamylmethylamide is essential in the metabolism of methylamine by Methylocella silvestris BL2. Appl. Environ Microbiol., 2010, 76(3), 4530-4537.
  45. C. Corre, S. W. Haynes, N. Malet, L. Song and G. L. Challis A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically 13C-labelled glycerols, Chem. Comm., 2010, 46, 4079-4081.
  46. D. Oves-Costales, L. Song and G.L. Challis. Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA. Chem. Comm., 2009, 1389-1391.
  47. S. Schmelz, N. Kadi, S. McMahon, L. Song, D. Oves-Costales, M. Oke, H. Liu, K. Johnson, L.G. Carter, C.H. Botting, M.F. White, G.L. Challis and J.H. Naismith, AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. Nat. Chem. Biol., 2009, 5, 174-182.
  48. C. Corre, L. Song, S. O'Rourke, K.F. Chater and G.L. Challis. 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proc. Nat. Acad. Sci. USA 2008, 105, 17510-17515.
  49. N. Kadi, L. Song and G.L. Challis. Bisucaberin biosynthesis: An adenylating domain of the BibC multi-enzyme catalyzes cyclodimerization of N-hydroxy-N-succinylcadaverine. Chem. Comm., 2008, 5119-5121.
  50. Z. Mitchell, M.T.G. Holden, J. Parkhill, L. Song, G.L. Challis, C. Robinson, N. Davis-Poynter and A.S. Waller. A novel streptococcal integrative conjugative element involved in iron acquisition. Mol. Microbiol., 2008, 70, 1274-1292.
  51. D. Oves-Costales, N. Kadi, M.J. Fogg, L. Song, K.S. Wilson and G.L. Challis. Petrobactin biosynthesis: AsbB catalyses ATP-dependent condensation of spermidine with N8-citryl-spermidine and its N1-(3, 4-dihydroxybenzyl) derivative. Chem. Comm., 2008, 4034-4036.
  52. N. Kadi, S. Arbache, L. Song, D. Oves-Costales and G.L. Challis. Identification of a gene cluster that directs putrebactin biosynthesis in Shewanella species: PubC catalyzes ATP-dependent cyclodimerization of N-hydroxy-N-succinyl-putrescine. J. Am. Chem. Soc., 2008, 130, 10458-10459.
  53. S. Haynes, P. Sydor, A. Stanley, L. Song and G.L. Challis. Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis. Chem. Comm., 2008, 1865-1867.
  54. S. Mo, P. Sydor, C. Corre, M. Alhamadsheh, A. Stanley, S. Haynes, L. Song, K.A. Reynolds and G.L. Challis. Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chem. Biol., 2008, 15, 137-148.
  55. D. Oves-Costales, N. Kadi, M. Fogg, L. Song, K. Wilson, G.L. Challis, Enzymatic logic of anthrax stealth siderophore biosynthesis: AsbA catalyzes ATP-dependant condensation of citric acid and spermidine, J. Am. Chem. Soc., 2007, 129, 6017-6018.
  56. L. Song and P. Thornalley, Effects of storage, cooking and processing on glucosinolates and related metabolites in Brassica vegetables, Food and Chem. Toxicl., 2007, 45, 216-224.
  57. L. Song, F. Barona-Gomez, C. Corre, L. Xiang, D. W. Udwary, M. Austin, J. P. Noel, B. S. Moore and G. L. Challis, Type III polyketide synthase extender unit specificity in germicidin biosynthesis discovered by Streptomyces Coelicolor genome mining, J. Am. Chem. Soc., 2006, 128, 14754-14755.
  58. D. Dobler, N. Ahmad, L. Song, K. Eboigbodin, P. Thornalley, Increased dicarbonyl metabolism in endothelial cells in hyperglycemia induces anoikis and impairs angiogenesis by RGD and GFOGER motif modification, Diabetes, 2006, 55, 1961-1969.
  59. L. Song, R. Iori, P. Thornalley, Purification of major glucosinolates from Brassicaceae seeds and preparation of isothiocyanates and amine metabolites, J. Sci. Food and Agriculture. 2006, 86, 1271-1280.
  60. L. Song, J. Morrison, N. Botting, P. Thornalley, Analysis of glucosinolates, isothiocyanates and amines degradation products in vegetable extracts and blood plasma by LC-MS/MS, Analytical Biochemistry, 2005, 347, 234-243.
  61. G. McWalter, L. Higgins, L, McLellan, C. Henderson, L. Song, P. Thornalley, K. Itoh, M. Yamamoto, J. Hayes. Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferase, and glutathione cysteine ligase by broccoli seeds and isothiocyanates, J. Nutrition, 2004, 134, 3499s-3506s.