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Prof Sebastien Perrier

Sebastien Perrier

Prof. Sébastien Perrier

Monash-Warwick Chair in Polymer Chemistry

Dipl Ing (ENSC Montpellier), MSc (Montpellier), PhD (Warwick), CChem, FRSC, FRACI



Research Summary

Our research focuses on the synthesis of macromolecules with highly controlled and pre-determinable structures using modern polymer and organic synthetic methods. We exploit supramolecular interactions to organise these molecules into nanostructured materials, for applications in nanomedicine (e.g. drug delivery, vaccines, antimicrobial materials - our materials are tested in house and in our group at the Monash Institute for Pharmaceutical Sciences (MIPS) in Melbourne, Australia), nanotechnology (e.g. components for optoelectronic applications), materials science (e.g. rheology modifiers) or chemistry (catalysis, processes, etc.).

Research projects in the group cover:

i/ fundamental understanding of polymerization mechanisms,

ii/ development of synthetic strategies to make functional polymeric architectures,

iii/ self-assembly via supramolecular interaction, and

iv/ engineering of nanostructured materials.

Selected Publications

Cobo, I.; Li, M.; Sumerlin, B. S.; Perrier, S. Smart hybrid materials by conjugation of responsive polymers to biomacromolecules, Nature Mat. 2015, 14 (2), 143-159

Gody, G.; Danial, M.; Barbey, R.; Perrier, S. Ultrafast RAFT Polymerization: Multiblock Copolymers within Minutes, Polym. Chem., 2015, 6, 1502-1511

Moraes, J.; Ohno, K.; Maschmeyer, T.; Perrier, S., Selective Patterning of Gold Surfaces by Core-Shell, Semi-Soft Hybrid Nanoparticles, Small 2015, 11 (4), 482-488

Danial, M.; My-Nhi Tran, C.; Jolliffe, K.A. Perrier, S. Thermal Gating in Lipid Membranes Using Thermoresponsive Cyclic PeptidePolymer Conjugates, J. Am. Chem. Soc. 2014, 136 (22), 8018-8026

Gody, G.; Maschmeyer, T.; Zetterlund, P.B.; Perrier, S. Pushing the Limit of the RAFT Process: Multiblock Copolymers by One-Pot Rapid Multiple Chain Extensions at Full Monomer Conversion, Macromolecules 2014, 47(10), 3451-3460

Janus cyclic peptide–polymer nanotubes, Danial, M.; My-Nhi Tran, C.; Young, P.G.; Perrier, S.; Jolliffe, K.A., Nat. Commun. 2013, DOI:10.1038/ncomms3780

Rapid and Quantitative One-Pot Synthesis of Sequence-Controlled Polymers by Radical Polymerization, Gody, G.; Maschmeyer, T.; Zetterlund, P.B.; Perrier, S., Nat. Commun., 2013, DOI: 10.1038/ncomms3505

Structure elucidation and control of cyclic peptide-derived nanotube assemblies in solution, Chapman, R.; Koh, M.L.; Warr, G.G; Jolliffe, K.A.; Perrier, S. Chem. Sci., 2013, 4 (6), 2581 - 2589

Synthesis of Silica-Polymer Core-Shell Nanoparticles by Reversible Addition-Fragmentation Chain Transfer Polymerization, Moraes, J.; Ohno, K.; Maschmeyer, T.; Perrier, S. Chem. Commun., 2013, 49 (80), 9077 - 9088

Multi-Shell Soft Nanotubes from Cyclic Peptide Templates, Chapman, R.; Jolliffe, K.A.; Perrier, S. Adv. Mater., 2013, 25, 1170–1172

Monodisperse, Charge-Stabilized, Core–Shell Particles via Silica-Supported Reversible Addition–Fragmentation Chain Transfer Polymerization for Cell Imaging, Moraes, J.; Ohno, K.; Maschmeyer, T.; Perrier, S., Chem. Mater., 2013, 25 (17), 3522–3527

Facile Route to Functional Hyperbranched Polymers by Combining Reversible Addition−Fragmentation Chain Transfer Polymerization, Thiol−Yne Chemistry, and Postpolymerization Modification Strategies, Barbey, R.; Perrier, S. ACS Macro Lett., 2013, 2 (5), 366-370

Unexpected Behavior of Polydimethylsiloxane / Poly(2-(dimethylamino)ethyl acrylate) (Charged) Amphiphilic Block Copolymers in Aqueous Solution, Zhao, W.; Fonsny, P.; FitzGerald, P.; Warr, G.G.; Perrier, S. Polym. Chem., 2013, 4(6), 2140-2150

One-pot RAFT/“click” chemistry via isocyanates: Efficient synthesis of α-end-functionalized polymers, Gody, G.; Rossner, C.; Moraes, J.; Vana, P.; Maschmeyer, T. ; Perrier, S., J. Am. Chem. Soc., 2012, 134 (30), 12596–12603

‘Green’ Reversible Addition-Fragmentation Chain-Transfer (RAFT) Polymerization, Semsarilar, M.; Perrier, S. Nature Chem., 2010, 2, 811-820.

Hyperbranched polymers by thiol-yne chemistry, from small molecules to functional polymers, Konkolewicz, D.; Gray-Weale, A.; Perrier, S. J. Am. Chem. Soc., 2009, 131 (50), 18075-18077

Orthogonal “relay” reactions to design functional soft nanoparticles, Kakwere, H.; Perrier, S., J. Am. Chem. Soc. 2009, 131(5), 1889-1895

Successful dispersion polymerization in supercritical CO2 using polyvinylalkylate hydrocarbon surfactants synthesized and anchored via RAFT, Lee, H.; Terry, E.; Zong, M.; Arrowsmith, N.; Perrier, S.; Thurecht, K. J.; Howdle, S. M., J. Am. Chem. Soc. 2008, 130, (37), 12242-12243

Reversible addition-fragmentation chain transfer polymerization: end group modification for functionalized polymers and chain transfer agent recovery, Perrier, S.; Takolpuckdee, P.; Mars, C. A., Macromolecules, 2005, 38, (38), 2033-2036