Prof Matthew Gibson

Prof Matt Gibson

Professor of Chemistry and Warwick Medical School

M.I.Gibson@warwick.ac.uk
+44 (0) 24 7652 4803

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About me

Matt holds a professorship joint between the Department of Chemistry and Warwick Medical School and is a Royal Society Industry Research Fellow. Matt also holds an ERC Consolidator Grant. Matt leads the industry (iCASE) Scheme in the MRC-funded Doctoral Training Center. Matt is co-founder, director and chief technical officer of CryoLogyx Ltd.

Matt's research has been supported by BBSRC, EPSRC, MRC, Leverhulme Trust, EU, industry partners, and philanthropic donations. In recognition of his research, Matt has been awarded prizes including the McBain Medal, Biomacromolecules/Macromolecules Young Investigator Prize, RSC Dextra Medal, MacroGroupUK Young Researcher's Medal and an RSC Emerging Technology Prize.

Groups at Warwick

Professor Matt Gibson Research GroupLink opens in a new windowLink opens in a new windowLink opens in a new window

Biography

2003, MChem, 1st Class honours, University of Durham, UK
2007, Ph.D in Macromolecular Chemistry, University of Durham UK with Prof Neil Cameron
2007 - 2009, Postdoc in the group of Prof. Harm-Anton Klok EPFL, Switzerland.
2009 - 2012, University of Warwick, Department of Chemistry, SCIRA Research Fellow
2012 - 2015, Assistant Professor,
2015 - 2016, Associate Professor
Full Professor 2016 - Personal chair between chemistry and Warwick Medical School

Current Projects

The group's research is supported by EU, UKRI, Industry and Charitable bodies. Each project is not listed here, but current funding includes;

Nanocarb Project - large EU consortium investigating how glycosylated nanomaterials can be applied in biomedical areas
Specialty Glycans Project. Large UK consortium using enzymes and chemistry to generate new carbohydrate derivatives
Royal Society Industry Fellow with GE Healthcare
ERC Starter Grant. CRYO_MAT. Investigating how we can use polymer chemistry to mimic antifreeze glycoprotein function
ERC Consolidator Grant. ICE_PACK. Developing new tools and methods for the transport of biologic therapies
Leverhulme Trust Project grants

Research interests

The Gibsongroup's research interests span the use of chemical tools to address challenges in glycosciences and biomaterials science. This work is mutli-disciplinary, and the group has dedicated facilities for synthesis, tissue culture, microbiology, and analytical science enabling us to tackle challenging problems. The group has made particular contributions in developing new biomaterials for cell storage and freezing, new glycosylated sensors for the detection and investigation of infection, and methods to covalently modify cell surfaces.

Teaching and supervision

I teach on 2nd Year Polymers (in CH272 Materials Modules) and the Polymer Masters program on CH967 (living polymerisation), CH971 (Polymer Labs) and CH972 (group research project). I also undertake tutorials (organic). I also teach an introduction to glycoscience in Warwick Medical Schools Integrated Science UG program

I am (co)supervising the following PhD students:

Alexander Baker. Point of Care Diagnostics based upon glyconanomaterials
Alexander Murray. New macromolecular cryoprotectants for cell-based therapies
Amy Godfrey. Bio-enginnering of Photorhabdus Virulence Cassettes (PI Nick Waterfield)
Charlotte Fletcher. Magnetic and responsive nanomaterials
Huba Marton. New chemical tools for the biologic cold chain
Iain Galpin. New materials and molecules inspired by antifreeze proteins
Ioanna Kontopoulou. Polymeric and Colloidal Materials for industry applications
Matthew Warren. Computational and experimental studies of ice recrystallisation inhibitors
Melissa Ligoria. Mono-disperse glycosylated co-ordination cages for infection detection
Panagiotis Georgiou. New glycosylated nanomaterials
Ashfaq Ahmed. Expression and investigation of immune-lectins with glycomaterials
Nina Kinney. Environmental ice nucleators
Ola Alkosti. Re-engineering immune cell function
Qiao Tang. Covalent capture of macromolecules to cell surfaces
Erin Thompson. Polymer-protein conjugates
Natalia Gonzalez-Martinez. Cryopreservation of immune cells
Douglas Soutar. Design and synthesis of cryoprotective polymers
Yanan Gau (visiting PhD for 2 years). Cryopreservation of multi-cellular systems

We have several vacancies for PhD's each year funded by industry, charity, UKRI and the EU. Get in touch with Prof Gibson if interested

Publications

Selected Publications

Richards, S.J., Gibson, M.I., JACS Au,2021, 'Towards glycomaterials with selectivity as well as affinity'. DOI. 10.1021/jacsau.1c00352

Georgiou, P., Marton, H.L., ; Baker, AN., Congdon, TR., Whale, T., Gibson, M.I., Journal of the American Chemical Society, 2021. 143, 7449 - 7461, Polymer Self-Assembly Induced Enhancement of Ice Recrystallization Inhibition

Stevens, C.A., Bachtiger, F., Kong, X-D., Abriata, L.A., Sosso, G.C., Gibson, M.I., Klok, H.-A., Nature Communications, 2021, 12, 2675, A Minimalistic Cyclic Ice-Binding Peptide from Phage Display,

Tomas, RMF., Gibson, M.I.,Chemical Science, 2021, 12, 4557-4569, Covalent Cell Surface recruitment of Chemotherapeutic Polymers Enhances Selectivity and Activity,

Bachtiger, F., Congdon, TR., Stubbs, C., Gibson, M.I., Sosso, G.C, Nature Communications, 2021, 12, 1323 The atomisic details of the ice recrystallisation inhibition activity of PVA

Richards, S-J.,Keenan, T., Vendeveille,J-B., Wheatley, D.E., Chidwick, H., Budhadev, D., Council, C.E., Webster, C.S, Ledru, H., Baker, A.N., Walker, M., Galan, MC., Linclau, B., Fascione, MA., Gibson, M.I., Chemical Science, 2021, 12, 905 - 910, Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands

Mitchell, DE., Deller, RC., Fayter, A.E.R., Hasan, M., Gutierrez-Marcos, J., Gibson, M.I., Materials Horizons, 2019, 6, 364 - 368. Ice-Recrystallization Inhibiting Polymers Protect Proteins Against Freeze-Stress and Enable Glycerol-Free Cryostorage

Biggs, C.I., Bailey, T.L., Graham, B., Stubbs, C., Fayter, A., Gibson, M. I., Nature Communications, 2017, 1546., Polymer Mimics of Biomacromolecular Antifreezes.

Graham, B., Bailey, T.L., Healey, J.R., Marcellini, M., Deville, S., Gibson, M. I., Angewandte Chemie, 2017.56, 15941–15944 ;Polyproline is a minimal antifreeze protein mimetic and enhances the cryopreservation of cell monolayers'

Full Publication ListLink opens in a new window