Matthew Jenner
UKRI Future Leaders Fellow
Assistant Professor of Biological Mass Spectrometry
Research Interests:
The application of mass spectrometry to solve complex biological problems. These include:
- Mapping protein-protein interactions in biosynthetic systems.
- Mechanisms and engineering of biosynthetic enzymes.
- Genomics-driven natural product discovery from bacteria and fungi
m dot jenner at warwick dot ac dot uk
+44 (024)76 572970
Office C519
Groups at Warwick
- Jenner Group
- Midlands Integrative Biosciences Training Partnership (BBSRC DTP)
- Interdisciplinary Biomedical Research Doctoral Training Partnership (MRC DTP)
Affiliations
- Chemical, Structural and Synthetic Biology (CSSB) ClusterLink opens in a new window
- Warwick Integrative Synthetic Biology Centre (WISB)Link opens in a new window
- Royal Society of Chemistry (MRSC)Link opens in a new window
Biography
- UKRI Future Leaders Fellow, (2022 - present)
- Assistant Professor of Biological Mass Spectrometry, (2021 - present)
- BBSRC Discovery Fellow, University of Warwick, (2018 - 2021).
- Leverhulme ECF, University of Warwick, (2017 - 2018).
- Post Doctoral Research Fellow, University of Warwick (Prof. G.L. Challis), (2014 - 2017).
- DPhil, University of Nottingham (Prof. N.J. Oldham), (2010 - 2014).
- BSc (Hons), University of Nottingham, (2007-2010).
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Application of mass spectrometry to solve complex biological problems. These include:
- Mapping protein-protein interactions in biosynthetic systems.
- Mechanisms and engineering of biosynthetic enzymes.
- Genomics-driven natural product discovery from Burkholderia sp.
I teach on the following modules:
- CH161 - Introduction to Organic Chemistry (Biological Chemistry Lectures, Workshops & Tutorials)
- CH3F2 - Advanced Analytical Chemistry (Lectures & Workshops)
- CH3G0 - Extended Labs (O3 Lab)
I am supervising the following PhD students:
- Munro Passmore (with G. ChallisLink opens in a new window) - 'Exploiting Protein-Protein Interactions in Biosynthetic Systems'
- Mia Foran - 'Fungal Megasynth(et)ases'
I am supervising the following MRes students:
- Karolina Kowalska
I am supervising the following MChem students:
- Madeleine Summers
S. Wang, W.D.G. Brittain, Q. Zhang, Z. Lu, M.H. Tong, K. Wu, K. Kyeremeh, M. Jenner, Y. Yu, S.L. Cobb and H. Deng. Aminoacyl chain translocation by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase.Link opens in a new window
Nat. Commun., 2022, 13, e62.
Nat. Commun., 2022, 13, e62.
M. Passmore, A. Gallo, J.R. Lewandowski and M. Jenner. Molecular basis for acyl carrier protein-ketoreductase interaction in trans-acyltransferase polyketide synthasesLink opens in a new window
Chem. Sci., 2021, 12, 13676–13685.
* Highlighted on the inside coverLink opens in a new window.
C.D. Fage, S. Kosol, M. Jenner, C. Öster, A. Gallo, M. Kaniusaite, R. Steinbach, M. Staniforth, V. Stavros, M. Marahiel, M. Cryle and J.R. Lewandowski. Communication breakdown: dissecting the COM interfaces between the subunits of nonribosomal peptide synthetases.Link opens in a new window
ACS Catal., 2021, 11, 10802–10813.
Y. Hai, M. Jenner and Y. Tang. Fungal siderophore biosynthesis catalysed by an iterative nonribosomal peptide synthetaseLink opens in a new window.
Chem. Sci., 2020, 11, 11525-11530.
I.T. Nakou, M. Jenner, Y. Dashti, I. Romero-Canelón, J. Masschelein, E. Mahenthiralingam and G.L. Challis. Genomics‐driven discovery of a novel glutarimide antibiotic from Burkholderia gladioli reveals an unusual polyketide synthase chain release mechanism.Link opens in a new window
Angew. Chem. Int. Ed., 2020, 59, 23145-23153.
M. Passmore and M. Jenner. Clicking into place: Interfacing terminal alkyne biosynthesis with polyketide synthases.Link opens in a new window
Trends Biotechnol., 2020, 38, 682-684.
Y. Hai, M. Jenner and Y. Tang. Complete stereoinversion of L-tryptophan by a fungal single module nonribosomal peptide synthetase.Link opens in a new window
J. Am. Chem. Soc., 2019, 141, 8198-8206.
S. Kosol, A. Gallo, D. Griffiths, T.R. Valentic, J. Masschelein, M. Jenner, E.L.C de los Santos, L. Manzi, P.K. Sydor, D. Rea, S. Zhou, V. Fülöp, N.J. Oldham, S-C. Tsai, G.L. Challis and J.R. Lewandowski. Structural basis for chain release from the enacyloxin polyketide synthase.Link opens in a new window
Nat. Chem., 2019, 11, 913-923.
M. Jenner. Predicting the peculiarLink opens in a new window.
Nat. Chem. Biol., 2019, 15, 761-763.
M. Jenner, X. Jian, Y. Dashti, J. Masschelein, C. Hobson, D.M. Roberts, C. Jones, S. Harris, J. Parkhill, H.A. Raja, N.H. Oberlies, C.J. Pearce, E. Mahenthiralingam and G.L. Challis. An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles 'fungal' icosalide antibioticsLink opens in a new window.
Chem. Sci., 2019, 10, 5489-5494.
A.J. Mullins, J.A.H. Murray, M.J. Bull, M. Jenner, C. Jones, G. Webster, A.E. Green, D.R. Neill, T.R. Connor, J. Parkhill, G.L. Challis and E. Mahenthiralingam. Genome mining identifies cepacin as a key plant-protective metabolite of the biopesticidal bacterium Burkholeria ambifariaLink opens in a new window.
Nat. Microbiol., 2019, 4, 996-1005.
S. Kosol, M. Jenner, J.R. Lewandowski and G.L. Challis. Protein-protein interactions in trans-AT polyketide synthases.Link opens in a new window
Nat. Prod. Rep., 2018, 35, 1097-1109.
B. R. K. Menon and M. Jenner. Reprogramming assembly lines.Link opens in a new window
Nat. Chem., 2018, 10, 245-247.
M. Jenner, S. Kosol , D. Griffiths, P. Prasongpholchai, L. Manzi, A.S. Barrow, J.E. Moses, N.J. Oldham, J.R. Lewandowski and G.L. Challis. Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthasesLink opens in a new window.
M. Jenner, S. Kosol , D. Griffiths, P. Prasongpholchai, L. Manzi, A.S. Barrow, J.E. Moses, N.J. Oldham, J.R. Lewandowski and G.L. Challis. Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthasesLink opens in a new window.
Nat. Chem. Biol., 2018, 14, 270-275.
J. Masschelein, M. Jenner and G.L. Challis. Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights.Link opens in a new window
Nat. Prod. Rep., 2017, 34, 712-783.
L. Song, M. Jenner, J. Masschelein, C. Jones, M. Bull, S. Harris, R. Hartkoorn, A. Vocat, I. Romero-Canelón, P. Coupland, Paul, G. Webster, M. Dunn, R. Weiser, C. Paisey, S. Cole, J. Parkhill, E. Mahenthiralingam and G.L. Challis. Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis.Link opens in a new window
J. Am. Chem. Soc., 2017, 138, 7974-7981.
M. Jenner, J. P Afonso, C. Kohlhaas, P. Karbaum, S. Frank, J. Piel and N. J Oldham. Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins.Link opens in a new window
Chem. Comm., 2016, 52, 5262-5265.
M. Jenner, J. P. Afonso, H. R Bailey, S. Frank, A. Kampa, J. Piel and N. J Oldham. Acyl‐Chain Elongation Drives Ketosynthase Substrate Selectivity in trans‐Acyltransferase Polyketide Synthases.Link opens in a new window
Angew. Chem. Intl. Ed., 2015, 54, 1817-1821.