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Greg Challis

Monash Warwick Alliance Professor of Sustainable Chemistry (Chemical and Synthetic Biology)


We work on the discovery, biosynthesis, bioengineering, and mechanism of action of antibiotics and other bioactive metabolites produced by bacteria.

g dot l dot challis at warwick dot ac dot uk

02476 5 22355

Office A1.04

Challis Group

Groups at Warwick


Affiliations


Biography

  • Monash Warwick Alliance Professor of Sustainable Chemistry (Chemical and Synthetic Biology), Department of Chemistry, University of Warwick and Department of Biochemistry and Molecular Biology Monash University (2016-)
  • Professor of Chemical Biology, Department of Chemistry, University of Warwick (2006-2016)
  • Senior Lecturer/Reader in Chemical Biology, Department of Chemistry, University of Warwick (2003-2006)
  • Lecturer in Chemical Biology, Department of Chemistry, University of Warwick (2001-2003)
  • Wellcome Trust research fellow, Department of Genetics, John Innes Centre (2000-2001)
  • Wellcome Trust research fellow, Department of Chemistry, Johns Hopkins University (1998-2000)
  • DPhil in Organic Chemistry, University of Oxford (1998)
  • BSc in Chemistry, Imperial College London (1994)

My research focuses on the chemistry and biology of microbial natural products. This encompasses natural product discovery, elucidation of biosynthetic pathways, creation of natural product analogues and novel molecular scaffolds via synthetic biology, and the mechanism of action and biological function of natural products.

Our approach is highly interdisciplinary and employs numerous complementary techniques, including chemical synthesis and analysis, molecular genetic manipulation, enzymology, protein mass spectrometry, structural biology (X-ray crystallography, protein NMR spectroscopy and single particle cryo-electron microscopy), bioinformatics, molecular modelling, and bioactivity assays.

I teach Bioorganic Chemistry (CH3F5 - year 3) and Organic Chemistry (tutorials and workshops in years 1 and 2)

 


I am supervising the following Postdoctoral Research Fellows:

  • Lona Alkhalaf (Senior Research Fellow)
  • Doug Roberts (Research Fellow)
  • Angelo Gallo (Research Fellow)
  • Chuan Huang (Research Fellow)
  • Shanshan Zhou (Research Fellow)
  • Chris Fage (Research Fellow)
  • Arun Gupta (Research Fellow)
  • Xinyun Jian (Research Fellow)
  • Jinlian Zhao (Research Fellow)

 

I am supervising the following PhD students:

  • Matthew Beech (4th year PhD student)
  • Ioanna Nakou (3rd year PhD student)
  • Jacob Sargeant (3rd year PhD student)
  • Helen Smith (3rd year PhD student)
  • Fang Pang (3rd year PhD student)
  • Rebecca Clayton (2nd year PhD student)
  • Marlene Rothe (2nd year PhD student)
  • Munro Passmore (1st year PhD student)

 

I am supervising the following MChem students:

  • Alexis Juteau
  • Stan Green
  • Christina Ramming

Selected recent publications:

 

Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal. P. G. Becher, V. Verschut, M.J. Bibb, M.J. Bush, B.P. Molnár, E. Barane, M.M. Al-Bassam, G. Chandra, L. Song, G.L. Challis, M.J. Buttner, and K. Flärdh. Nat. Microbiol. 2020, 5, DOI: 10.1038/s41564-020-0697-x

 

A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis. J. Masschelein, P.K. Sydor, C. Hobson, R. Howe, C. Jones, D.M. Roberts, Z.L. Yap, J. Parkhill, E. Mahenthiralingam and G.L. Challis. Nat. Chem. 2019, 11, 906-912.

 

Structural basis for chain release from the enacyloxin polyketide synthase. S. Kosol, A. Gallo, D. Griffiths, T.R. Valentic, J. Masschelein, M. Jenner, E.L. de los Santos, L. Manzi, P.K. Sydor, D. Rea, S. Zhou, V. Fülöp, N.J. Oldham, S.-C. Tsai, G.L. Challis, and J.R. Lewandowski. Nat. Chem. 2019, 11, 913-923.

 

Genome mining identifies cepacin as a key plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria. A.J. Mullins, J.A.H. Murray, M.J. Bull, M. Jenner, C. Jones, G. Webster, T.R. Connor, J. Parkhill, G.L. Challis and E. Mahenthiralingam.  Nat. Microbiol. 2019, 4, 996-1005.

 

Binding of distinct substrate conformations enables hydroxylation of remote sites in thaxtomin D by cytochrome P450 TxtC. L.M. Alkhalaf, S.M. Barry, D. Rea, A. Gallo, D. Griffths, J.R. Lewandoswki, V. Fulop and G.L. Challis. J. Am. Chem. Soc. 2019, 141, 216-222.

 

Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases. M. Jenner, S. Kosol , D. Griffiths, P. Prasongpholchai, L. Manzi, A.S. Barrow, J.E. Moses, N.J. Oldham, J.R. Lewandowski  and G.L. Challis. Nat. Chem. Biol. 2018, 14, 270-275.

 

Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis. L. Song, M. Jenner, J. Masschelein, C. Jones, M. Bull, S. Harris, R. Hartkoorn, A. Vocat, I. Romero-Canelón, P. Coupland, Paul, G. Webster, M. Dunn, R. Weiser, C. Paisey, S. Cole, J. Parkhill, E. Mahenthiralingam and G.L. Challis. J. Am. Chem. Soc. 2017, 139, 7974-7981.