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Indra Napit

Research Title:

Trial of Autologous Blood products to promote ulcer healing in Leprosy (TABLE)

About my research:

Aim: To evaluate a treatment based on autologous blood products – Leukocyte and Platelet-Rich Fibrin (L-PRF), for the treatment of leprosy ulcers.

Design: Single centre, 1:1 individual randomised, single blinded, controlled trial.

Participants: Adults admitted to hospital with leprosy ulcer in the range 2-20 square centimetres.

Intervention: Leukocyte and Platelet-Rich Fibrin (L-PRF) applications at the time of dressing changes to ulcers twice per week. Controls get dressing change but no L-PRF.

Main Outcomes: Rate of healing as assessed by photographs taken in a standardised manner and assessed blind to intervention versus control status. Percentage wounds healed (re-epithelialization) by 70 days, assessed blindly from standardised photographs.

Sample size: One hundred and thirty consenting patients (65 in each arm).

Follow-up: Six months from randomisation.

Supervisors: Professor Paramjit Gill, Professor Richard Lilford

Contact: Dr-Indra.Napit@warwick.ac.uk