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SLS/WMS Dev Biol and Stem Cell Seminar Series: Modelling remodelling: Investigating genetic control of blood vessel formation and function using lightsheet imaging in zebrafish, Dr Robert Wilkinson, University of Nottingham

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Location: BSR1, School of Life Sciences

Abstract: The cardiovascular system is the first organ system to form during vertebrate embryonic development. Blood vessels are essential for tissue growth and homeostasis, primarily by facilitating gaseous exchange and excretion of waste products alongside transport of nutrients and signalling molecules. Unsurprisingly, defects in the structure and function of blood vessels underlie two of the largest causes of mortality worldwide; cardiovascular disease and cancer. We use the translucent zebrafish embryo to study the signals and mechanisms which regulate vessel formation and permeability and identify how these are dysregulated during disease. We employ live imaging approaches to interrogate the cell types involved and determine how a complex vascular network is formed and subsequently maintained throughout life.

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