Gene regulation is a complex multi-step process required throughout all kingdoms of life to ensure the correct spatiotemporal dosage and distribution of gene products, and response to environmental stimuli. Errors in gene regulation can lead to a diversity of catastrophic errors including developmental malformations, metabolic defects, and a failure of environmental adaptation. However, gene expression is controlled at many levels including (but not limited to) chromatin organisation, transcription initiation, and post-transcriptional control of mRNA localisation, stability and translation. This inaugural annual one-day meeting will bring together researchers from the Universities of Warwick, Birmingham and Leicester working across scales, model systems and disciplines to discuss a broad range of topics related to gene regulation.