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BMS Seminar: Dr John James - Reconstituting the trafficking and signalling of the preTCR: ghost receptor; Dr Erin Greaves - Exploiting the immune system to solve endometriosis

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Location: IBRB Lecture Theatre

Reconstituting the trafficking and signalling of the preTCR: ghost receptor
Dr John James, Associate Professor, Biomedical Sciences Directorate

Short abstract: Reconstitution of pre-T cell receptor (preTCR) expression in non-immune cells demonstrated that signalling is not required for its rapid internalization and degradation observed during T-cell development, and that the preTCR can drive tonic signalling in T cells.

Exploiting the immune system to solve endometriosis
Dr Erin Greaves, Associate Professor, Biomedical Sciences Directorate

Short abstract: Immune dysfunction is central to the pathobiology of endometriosis. By unravelling the phenotype and role of immune cells, we are finding new ways to potentially diagnose and treat the disorder.

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