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Cellular Interfaces Seminar: Lipid-protein interactions hold the key to understand cell signalling, Professor Ünal Coskun and Dr Obada Bahra, Center of Membrane Biochemistry and Lipid Research, School of Medicine TU Dresden

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Location: A151, Medical School Building

The overarching theme of the research group is "Membrane Biochemistry of Cell Signalling". The group addresses the interdependence of lipid-protein interactions through an interdisciplinary approach combining cell and synthetic biology, protein biochemistry, structure biology and biophysics. Their strong expertise allows them to study molecular mechanisms based on lipid-protein interactions at different scales, from organ and cellular systems down to minimal synthetic systems in which they can control both the proteins and the lipid, for example to monitor the allosteric effects of specific lipids on fundamental receptors such as the EGF receptor and the insulin receptor. They will present data on how lipid-protein interactions directly regulate the structure/function of the EGF and insulin receptors, as well as essential lipid-binding intracellular signalling proteins, such as AKT 1.

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