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Warwick Medical School

Lecture by Dr Britta Stordal, Middlesex University

BSTitle: Comparative Selection Strategies for Development of Platinum-Drug Resistant Ovarian Cancer Cell Lines
Date: Monday 21 May, 12.30pm-1.30pm
Venue: Oculus OC0.03

Come and join us for free lunch and an interesting talk from Dr Britta Stordal, Senior Lecturer in Life Sciences at Middlesex University London. Her visit is hosted by Professor Peter Sadler.


Abstract

The development of a drug-resistant cell line in vitro can take from three to 18 months. However, little is published on the methodology of this development process. Clinically relevant drug-resistant cell lines are developed by mimicking the conditions cancer patients experience during chemotherapy. Doses of drug administered are low, and a pulsed treatment strategy is often used where the cells recover in drug-free media. It is common to have difficulty developing stable clinically relevant drug-resistant cell lines. A comparative selection strategy of multiple cell lines or multiple chemotherapeutic agents mitigates this risk and gives insight into which agents or which clinical phenotypes develops resistance easily.

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