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GibsonGroup and Cryologyx Demonstrate ‘Assay-Ready’ Cells.
Much cell biology, biomaterials and associated research is conducted on cells attached to tissue culture plastic in multiwell plates - such as high throughput drug discovery and toxicity, to viral plaque assays. However, there is a disconnect that the cells are stored frozen in suspension, not in the format ‘ready to use’. This is because conventional cryoprotectants do not protect the cells when in monolayer format. The GibsonGroup, and UoW Spin-Out Cryologyx have worked together to solve this problem using macromolecular cryoprotectants. In this later paper, the team demonstrate reproducilble and robust recovery of cell monolayers out of the freezer. This is shown for common cell lines, including HepG2 and Caco-2, commonly used in drug screening. This is a revolutionary technology as it shows researchers could stop wasting time culturing cells, and just order them, remove from freezer and within 24 hours begin data collection with no of the traditional culturing steps. Cryologyx are deploying these findings to commercialise assay ready cells, and trial plates are available!
Read the paper here.