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CENP-F stabilizes kinetochore-microtubule attachments and limits dynein-mediated corona stripping, a key step in accurate chromosome segregation

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Phil Auckland (McAinsh lab) reveals how the human kinetochore protein CENP-F helps hold onto microtubules with one hand, while limiting the motorised stripping of corona components with the other (see figure). We find that over stripping leads to inefficient chromosome biorientation - a key step in accurate chromosome segregation. doi.org/10.1083/jcb.201905018

Tue 31 Mar 2020, 13:34 | Tags: BMS