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Rapid low cost SARS-COV-2 diagnostics using glycosylated nanoparticles

Current diagnostic strategies for SARS-COV-2 rely on centralised infrastructure using PCR (polymerase chain reaction) methods. The GibsonGroup have discovered that the SARS-COV-2 spike protein binds a sialic acids (a type of glycan other respiratory viruses also target) and show this can be used to detect it. The glycan is installed onto gold nanoparticles, which are then used in a hijacked ‘pregnancy test’ allowing quick detection without any infrastructure. This publication proves the principle including detection of a model virus system. https://doi.org/10.1021/acscentsci.0c00855 

Wed 23 Sep 2020, 21:45 | Tags: BMS