Recent Developments in the Patho-Physiological Molecular Clocks Lab
It's that time of year again: The Winter Blues, a SAD story
But if you want to hear something on how what to do against low mood in the fall and winter, and also be depressed because of new monkey pox and leaks in Chernobyl, then head over to the Naked ScientistLink opens in a new window.
Morning Immunochemotherapy in Cancer better once more, now in SCLC
Robert and Seline have commented on a new paper in the journal Cancer on chronoimmunochemotherapy in patients with small cell lung cancer showing a beneficial effect of early immunotherapy in this disease (Huang et al. doi: 10.1002/cncr.70126Link opens in a new window) in an article in New Scientist this week.
Rachael's first outputs as a naked scientist: Cool science, accessibly presented
Want to learn something about moss in space or seagulls knowing you are shouting at them? Read Rachael's articles on how mossLink opens in a new window and seagullsLink opens in a new window.
Time to test for late clocks for early detection of gestational diabetes mellitus
Dr Robert DallmannLink opens in a new window and Prof Ponnusamy SaravananLink opens in a new window receive funding from the Gates FoundationLink opens in a new window for a project entitled "Molecular circadian biomarkers for early prediction of gestational diabetes mellitus (GDM)”
The aim of the project is to establish if circadian biomarkers can contribute to GDM risk-stratification in biosamples taken in early pregnancy. For this, we take advantage of a subsample of the well phenotyped PRiDE study, which included pregnant women from diverse ethnic backgrounds with and without GDM and, crucially, the associated clinical history. We will test their plasma, biobanked at George Eliot Hospital, Nuneaton, in a to be established bioassay using human fibroblasts and the TimeTeller algorithm as "circadian sensors”. Furthermore, once stratified by circadian phenotype, we aim to discover further correlative biomarkers that will allow to establish simple bioassays that will be easily available in LMICs, also a key aim of the foundation.
The project brings together the expertise of Warwick’s Chrono group, including the WMS based Dallmann lab and Rand’s group in Maths, as well as the WMS’ Saravanan who is also a clinically active Diabetes and Endocrinology specialist at George Eliot Hospital.