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Recent Developments in the Patho-Physiological Molecular Clocks Lab

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Soraia Silva has been awarded a BSN Research Visit Grant by the British Society for Neuroendocrinology.

Soraia Silva

Depression is a common mental disorder, affecting more than 300 million people of all ages and about twice as many women as men worldwide. Less than 50% of depressed patients achieve remission following several pharmacological interventions. For this reason, it becomes pivotal to better understand the underlying disease aetiology and explore approaches that improve the effectiveness of antidepressant drugs. This will reduce suicide and mortality rates, and promote mental health and well-being at all ages. Many depressed patients often have disrupted neuroendocrine rhythms. For example, cortisol loses its daily rhythm, which might in turn disrupt other peripheral clocks; a vicious cycle, which is understudied. Soraia will address this issue by combining expertise from her current lab in Coimbra on a bona fide model of depression with a novel method to analyse circadian function from single tissue samples developed at Warwick. This will allow to answer two main questions, relevant to understand depression: (1) Does a depression-like state shift peripheral clocks? (2) Do selective serotonin re-uptake inhibitors effect the circadian clock?


In addition to the £5000 for consumables for this collaborative project with the Chrono Lab at Warwick, she has also won support from her home institution the University of Coimbra, Portugal, for travel expenses during her time at Warwick, which will start in October 2023.

Fri 28 Apr 2023, 17:16 | Tags: Student, 2023, Funding

UK Clock Club Travel Award at Surrey 2023

James and Award Congratulations to James for receiving a Travel Award at the Spring UK Clock Club at the University of Surrey for his poster presentation.
Wed 19 Apr 2023, 13:42 | Tags: Award, Conference, 2023

Metformin chronopharmacokinetics paper highlighted in Nature Reviews Endocrinology

Claire Greenhill used our metformin chronopharmacokinetics modeling paper (see hereLink opens in a new window) to highlight time-of-day variation in the use of this important diabetes drug.

Mon 17 Apr 2023, 15:15 | Tags: News, 2023

Welcome to our summer URSS student

Congratulations and welcome to Rithvik who has secured funding for a summer lab project in the Chrono Group!

Mon 03 Apr 2023, 15:27 | Tags: Student, 2023, URSS

Resonating Science on the Hill on Metals in Biology

What a pleasure to restart "Science on the Hill" and as part of the Resonate festival talk about Metals in Medicine and beyond. From environmental science to neuroscience and chemotherapy. Metals might not be a magic bullet, but surely have an impressive range of action and implications from global climate to human health.

Thu 09 Mar 2023, 10:53 | Tags: Outreach, 2023

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