Publications
A complete up-to-date list of publications of Robert can be found on Google Scholar and full-texts might be available from the Warwick Research Active Portal (WRAP).
TafkaTT: The algorithm first known as TimeTeller - now out in PLoS Computational Biology
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Very long time in the making and already online as a preprint, now finally out as peer-reviewed paper with contributions from 2 MRC DTP students from the lab (Laura Usselmann and Vadim Vasilyev) and in collaboration with David Rand as well as Sascha Ott, Francis Lévi and George Bjarnasson. |
Tuning the photoactivated anticancer activity of Pt(IV) compounds via distant ferrocene conjugation
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Led by Huayun Shi from the Sadler lab we discover and characterise novel photoactive prodrugs for cancer treatment that offer potential for spatially-selective anti-tumour activity with minimal effects on normal tissues.Photoactive metal complexes in particular, have a rich and relatively unexplored photochemistry, especially an ability to undergo facile intersystem crossing and populate triplet states. Here, the photoactive octahedral Pt(IV) complex trans,trans,trans-[Pt(N3)2(OH)2(py)2] was conjugated to ferrocene to introduce novel features into a candidate photochemotherapeutic drug. Visible light irradiation gives rise to micromolar activity for these compounds in ovarian, lung, prostate and bladder cancer cells |
5-FU PKPD model suggest patient chronotypes!
Lead by the Thorsten Lehr's PKPD group at the University of Saarland, this paper is taking a treasure trove of patient 5-FU PK data amalgamated with DPD activity data from health people to establish a novel PKPD model of 5-FU that captures the extent of diurnal variations in DPD activity and can help investigate individualized chronomodulated 5-FU therapy through testing alternative personalized dosing strategies. This work is based on the the discovery of diurnal variations impacting cancer therapy. Especially, use of chronomodulated treatment with 5-fluorouracil (5-FU) has gained significance. Studies indicate high inter-individual variability in diurnal variations in dihydropyrimidine dehydrogenase (DPD) activity – a key enzyme for 5-FU metabolism. However, the influence of individual chronotypes on chronomodulated therapy was unclear but is needed to optimize precision dosing of chronomodulated 5‑FU.