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Biomedical Sciences

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Our research programme in Translational and Experimental Medicine integrates laboratory-based biologists, chemists, engineers and clinicians with computer-based mathematicians, statisticians and data analysts to exploit knowledge derived from fundamental discovery science to develop novel or innovative drugs, devices, techniques and treatments and to provide public health advice for improving the clinical outcomes for patients. The work of the unit is particularly focused on reproductive medicine, metabolic disease and on novel cancer therapy and delivery systems.
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Biomedical Sciences News

Personalized Chronomodulated 5-Fluorouracil Treatment: A Physiologically Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy

This work is based on the discovery of diurnal variations impacting cancer therapy. Especially, use of chronomodulated treatment with 5-fluorouracil (5-FU) has gained significance. Studies indicate high inter-individual variability in diurnal variations in dihydropyrimidine dehydrogenase (DPD) activity – a key enzyme for 5-FU metabolism. However, the influence of individual chronotypes on chronomodulated therapy was unclear but is needed to optimize precision dosing of chronomodulated 5‑FU. Lead by the Thorsten Lehr's PKPD group at the University of Saarland, this collaborative paper is taking a treasure trove of patient 5-FU PK data amalgamated with DPD enzyme activity data from health people to establish a novel PKPD model of 5-FU that captures the extent of diurnal variations in DPD activity and can help investigate individualized chronomodulated 5-FU therapy through testing alternative personalized dosing strategies. Read the paper here.

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Dr Erin Greaves explains her lab's research into endometriosis and how she hopes her work could help millions of women worldwide.