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Warwick Medical School

Olivetti Study Selected Publications

  1. Barba G, Cappuccio F P, Russo L, Stinga F, Iacone R, Strazzullo P (1996) Renal function and blood pressure response to dietary salt restriction in normotensive men. Hypertension; 27: 1160-1164
  2. Barba G, Strazzullo P, Cappuccio F P (1996) Salt intake and hyperfiltration, Hypertension; 28: 1101-1102
  3. Barba G, Russo O, Siani A, Iacone R, Farinaro E, Gerardi M C, Russo P, Della Valle E, Strazzullo P (2003) Plasma leptin and blood pressure in men: graded association independent of body mass and fat pattern, Obesity Research; 11(1): 160-6
  4. Barba G, Galletti F, Cappuccio F P, Siani A, Venezia A, Versiero M, Della Valle E, Sorrentino P, Tarantino G, Farinaro E, Strazzullo P (2007) Incidence of hypertension in individuals with different salt-sensitivity of blood pressure. Results of a 15-year follow-up study, J Hypertens; 25: 1465-1471
  5. Barbato A, Galletti F, Iacone R, Cappuccio FP, Rossi G, Ippolito R, Venezia A, Farinaro E, Strazzullo P on behalf of The Olivetti Heart Study Research Group (2012). Predictors of resistant hypertension in an unselected sample of adult male population in Italy. Internal & Emergency Medicine;7(4): 343-51
  6. Bland S H, O'Leary E S, Farinaro E, Jossa F, Trevisan M (1996) Long-term psychological effects of natural disasters, Psychosomatic Med; 58: 18-24
  7. Bland S H, O'Leary E S, Farinaro E, Jossa F, Krogh V, Violanti J M, Trevisan M (1997) Social network disturbances and psychological distress following earthquake evacuation, J Nervous Mental Dis; 185: 188-194
  8. Bland S H, Farinaro E, Krogh V, Jossa F, Scottoni A, Trevisan M (2000) Long term relations between earthquake experiences and coronary disease risk factors, Am J Epidemiol; 151: 1086-1090
  9. Bland S H, Valoroso L, Stranges S, Strazzullo P, Farinaro E, Trevisan M (2005) Long-term follow-up of psychological distress following earthquake experiences among working Italian males: a cross-sectional analysis, J Nerv Mental Dis; 193(6): 420-3
  10. Cappuccio F P, Strazzullo P, Trevisan M, Siani A, Soda P R A, Mancini M (1983) Relationship of blood pressure to urinary sodium and potassium excretion in a sample of Neapolitan working population, In: Zanchetti A, ed. Excerpta Medica: 1-2
  11. Cappuccio F P, Strazzullo P, Barba G, Iacone R, Buckley M G, Sugden A L, Miller M, Sagnella G A, MacGregor G A, Mancini M (1989) Atrial natriuretic peptides and tubular sodium handling during normal daily life in men, J Hypertens; 7: S228-S229
  12. Cappuccio F P, MacGregor G A, Strazzullo P, Sagnella G A, Iacoviello L, Buckley M G, Farinaro E, Mancini M (1989) Plasma levels of atrial natriuretic peptide and its correlates in a male working population, In: Brenner BH, Laragh JH, eds. Progress in Atrial Peptide Research, New York: Raven Press: 480-483
  13. Cappuccio F P, MacGregor G A, Strazzullo P, Sagnella G A, Iacoviello L, Buckley M G, Farinaro E, Mancini M (1989) Characteristics of the distribution of plasma atrial natriuretic peptides in a cross-sectional study of middle-aged untreated male workers, J Cardiovasc Pharmacol; 13: S51-S54
  14. Cappuccio F P, Strazzullo P, Mancini M (1990) Kidney stones and hypertension: population based study of an independent clinical association, Br Med J; 300: 1234-1236
  15. Cappuccio F P, Strazzullo P, Giorgione N, Iacone R, Farinaro E, Buckley M G, Miller M A, Sagnella G A, MacGregor G A, Mancini M (1991) Renal tubular sodium handling and plasma atrial natriuretic peptide, renin activity and aldosterone in untreated men under normal living conditions, Eur J Clin Invest; 21: 40-46
  16. Cappuccio F P, Iacone R, Strazzullo P (1991) Serum uric acid and proximal sodium excretion: an independent association in man (the Olivetti study), J Hypertens; 6: S280-S281
  17. Cappuccio F P, Strazzullo P, Farinaro E, Trevisan M (1993) Uric acid metabolism and tubular sodium handling. Results from a population-based study, JAMA; 270: 354-359
  18. Cappuccio F P, Strazzullo P (1993) Determinants of the renal clearance of exogenous lithium in a large sample of a white male working population, Clin Sci; 85: 479-485
  19. Cappuccio F P, Strazzullo P, Siani A, Trevisan M (1996) Increased proximal sodium reabsorption is associated with increased cardiovascular risk in men, J Hypertens; 14: 909-914
  20. Cappuccio F P, Strazzullo P (1997) Altered renal tubular sodium handling: a new feature of the insulin resistance syndrome? Nutr Metab Cardiovasc Dis; 7: 142-145
  21. Cappuccio F P, Siani A, Barba G, Mellone M C, Russo L, Farinaro E, Trevisan M, Mancini M, Strazzullo P (1999) A prospective study of hypertension and the incidence of kidney stones in men, J Hypertens; 17: 1017-1022
  22. Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, Doblado M, Evans S, Eyheramendy S, Onipinla A, Howard P, Shaw-Hawkins S, Dobson RJ, Wallace C, Newhouse SJ, Brown M, Connell JM, Dominiczak A, Farrall M, Lathrop GM, Samani NJ, Kumari M, Marmot M, Brunner E, Chambers J, Elliott P, Kooner J, Laan M, Org E, Veldre G, Viigimaa M, Cappuccio FP, Ji C, Iacone R, Strazzullo P, Moley KH, Cheeseman C. (2008) SLC2A9 is a high capacity urate transporter in humans. PLoS Med 5(10): e197 (1509-23)
  23. D'Elia L, De Palma D, Rossi G, Strazzullo P, Russo O, Iacone R, et al. (2014) Not smoking is associated with lower risk of hypertension: results of the Olivetti Heart Study. Eur J Public Health 24(2): 226-30
  24. D'Elia L, Manfredi M, Sabino P, Strazzullo P, Galletti F. (2016) The Olivetti Heart Study: predicitve value of a new adiposity index on risk of hypertension, blood pressure, and subclinical organ damage. Nutr Metab Cardiovasc Dis 26(7), 630-6
  25. D’Elia L, Cappuccio FP, Iacone R, Russo O, Galletti F, Strazzullo P. (2017) Altered renal sodium handling and risk of incident hypertension: results of the Olivetti Heart Study. PLoS ONE; 12(2): e0171973.
  26. D'Elia L, Giaquinto A, Cappuccio FP, Iacone R, Russo O, Strazzullo P, Galletti F. (2019) Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men. J Endocrinol Invest ; on-line 5 Nov.
  27. della Valle E, Stranges S, Trevisan M, Strazzullo P, Siani A, Farinaro E (2004) Self-rated measures of physical activity and cardiovascular risk in a sample of Southern Italian male workers: the Olivetti heart study, Nutr Metab Cardiovasc Dis; 14(3): 143-9
  28. Farinaro E, Panico S, Oriente P, Mancini M (1979) The Olivetti survey: asymptomatic hyperglycemia and ECG abnormalities at baseline, J Chron Dis; 32: 773-777
  29. Galletti F, Iacone R, Ragone E, Russo O, Della Valle E, Siani A, Barba G, Farinaro E, Strazzullo V, Strazzullo P (2004) Lack of association between polymorphism in the beta2-adrenergic receptor gene, hypertension, and obesity in the Olivetti heart study, Am J Hypertens; 17(8): 718-20
  30. Galletti F, Barbato A, Versiero M, Iacone R, Russo O, Barba G, Siani A, Cappuccio F P, Farinaro E, della Valle E, Strazzullo P (2007) Circulating leptin levels predict the development of metabolic syndrome in middle-aged men: an 8-year follow-up study, J Hypertens; 25: 1671-7
  31. Galletti F, D'Elia L, Barba G, Cappuccio FP, Farinaro E, Iacone R, Russo O, De Palma D, Ippolito R, Strazzullo P. (2008) High-Circulating Leptin Levels Are Associated with Greater Risk of Hypertension in Men Independently of Body Mass and Insulin Resistance: Results of an Eight-Year Follow-Up Study. J. Clin. Endocrinol.Metab. 93(10):3922-3926.

  32. Galletti F, D’Elia L, De Palma D, Russo O, Barba G, Siani A, Miller MA, Cappuccio FP, Rossi G, Zampa G & Strazzullo P. (2012) Hyperleptinemia is associated with hypertension, systemic inflammation and insulin resistance in overweight but not in normal weight men. Nutr Metab Cardiovasc Dis 22(3): 300-6

  33. Ji C, Miller MA, Venezia A, Strazzullo P & Cappuccio FP. (2014) Comparisons of spot vs 24-h urine samples for estimating salt intake: validation study in two independent population samples of adults in Britain and Italy. Nutr Metab Cardiovasc Dis; 24: 140-147

  34. Jossa F, Trevisan M, Krogh V, Farinaro E, Giumetti D, Fusco G, Galasso R, Panico S, Frascatore S, Mellone C, et al (1991) Serum selenium and coronary heart disease risk factors in southern Italian men, Atherosclerosis; 87: 129-134
  35. Jossa F, Trevisan M, Krogh V, Farinaro E, Giumetti D, Fusco G, Galasso R, Frascatore S, Mellone C, Mancini M (1991) Correlates of high-density lipoprotein cholesterol in a sample of healthy workers, Prev Med; 20: 700-712
  36. Jossa F, Krogh V, Farinaro E, Panico S, Giumetti D, Galasso R, Celentano E, Mancini M, Trevisan M (1993) Coffee and serum lipids: findings from the Olivetti Heart Study, Ann Epidemiol; 3: 250-255
  37. Jossa F, Farinaro E, Panico S, Krogh V, Celentano E, Galasso R, Mancini M, Trevisan M (1994) Serum uric acid and hypertension: the Olivetti heart study, J Hum Hypert; 8: 677-681
  38. Krogh V, Trevisan M, Jossa F, Bland S, Jalowiec A, Celentano E, Farinaro E, Panico S, Fusco G, Mancini M (1992) Coping and blood pressure, J Hum Hypert; 6: 65-70
  39. Mancini M, Strazzullo P, Contaldo F, Trevisan M, Cappuccio F P (1984) Obesity and hypertension: an up to date on possible pathophysiological links, In: Lenzi S, Descovich GC, eds. Atherosclerosis and Cardiovascular Diseases, MTP Press Ltd: 399-408
  40. Mancini M, Strazzullo P, Cappuccio F P, DeLeo A, Giorgione N (1985) Obesity and hypertension, In: Critelli G, ed. Selected topics in cardiology, Rome: L Pozzi: 189-193
  41. Mancini M, Strazzullo P, Trevisan M, Contaldo F, Vaccaro O, Cappuccio F P (1985) Pathophysiological interrelation of obesity, impaired glucose tolerance and arterial hypertension, Prev Med; 14: 428-435
  42. Newhouse S, Farrall M, Wallace C, Hoti M, Burke B, Howard P, Onipinla A, Lee K, Shaw-Hawkins S, Dobson R, Brown M, Samani NJ, Dominiczak AF, Connell JM, Lathrop GM, Kooner J, Chambers J, Elliott P, Clarke R, Collins R, Laan M, Org E, Juhanson P, Veldre G, Viigimaa M, Eyheramendy S, Cappuccio FP, Ji C, Iacone R, Strazzullo P, Kumari M, Marmot M, Brunner E, Caulfield M, Munroe PB (2009). Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion. PLoS ONE; 4(4): e5003
  43. Russo P, Siani A, Venezia A, Iacone R, Russo O, Barba G, Cappuccio F P, Strazzullo P (2002) Interaction between the C(-344)T polymorphism of CYP11B2 and age in the regulation of blood pressure and plasma aldosterone levels. Cross-sectional and longitudinal findings of the Olivetti Prospective Heart Study, J Hypertens; 20: 1785-1792
  44. Russo P, Venezia A, Lauria F, Strazzullo P, Cappuccio F P, Iacoviello L, Barba G, Siani A (2006) HindIII (+/-) Polymorphism of the Y Chromosome, Blood Pressure, and Serum Lipids: No Evidence of Association in Three White Populations, Am J Hypertens; 19: 331-338
  45. Russo P, Strazzullo P, Cappuccio F P, Tregouet D A, Lauria F, Loguercio M, Barba G, Versiero M, Siani A (2007) Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with central obesity and metabolic syndrome in men, J Clin Endocrinol Metab; 92: 2382-2386
  46. Siani A, Jossa F, Cappuccio F P, Russo L, Farinaro E, Trevisan M, Strazzullo P, Mancini M (1994) Association of metabolic abnormalities and high blood pressure in a sample of male working population, High Blood Press; 3: 7-14
  47. Siani A, Trevisan M, Cappuccio F P, Ragone E, Russo L, Noviello F, Jossa F, Frascatore S, Farinaro E, Candura U, Strazzullo P (1997) Does red blood cell sodium/lithium countertransport predict blood pressure changes over time? A seven year follow-up study, Acta Cardiologica; LII: 202-204
  48. Siani A, Iacone R, Russo O, Barba G, Russo P, Cappuccio F P, Galletti F, Strazzullo P (2001) The Gly40Ser polymorphism of the glucagone receptor gene is associated with central adiposity in men. Findings of the Olivetti Heart Study, Obesity Research; 9: 722-726
  49. Siani A, Cappuccio F P, Barba G, Trevisan M, Farinaro E, Iacone R, Russo O, Russo P, Mancini M, Strazzullo P (2002) The relationship of waist circumference to blood pressure: the Olivetti Heart Study, Am J Hypertens; 15: 780-786
  50. Siani A, Russo P, Cappuccio F P, Iacone R, Venezia A, Russo O, Barba G, Iacoviello L, Strazzullo P (2004) Combination of renin-angiotensin system polymorphisms is associated with altered renal sodium handling and hypertension, Hypertension; 43: 598-602  

  51. Stranges S, Galletti F, Farinaro E, D’Elia L, Russo O, Iacone R, Capasso C, Carginale V, De Luca V, Della Valle E, Cappuccio FP & Strazzullo P. (2011) Association of selenium status with cardiometabolic risk factors: an 8-year follow-up analysis of the Olivetti Heart Study. Atherosclerosis; 217(1): 274-8

  52. Strazzullo P, Trevisan M, Farinaro E, Cappuccio F P, Ferrara L A, Mancini M (1983) Characteristics of the association between salt intake and blood pressure in a sample of male working population in Southern Italy, Eur Heart J; 4: 608-613

  53. Strazzullo P, Cappuccio F P, Trevisan M, Ferrara L A, Farinaro E, Cirillo M, Scottoni A, Mancini M (1983) Association between blood pressure, dietary salt intake and family history of hypertension in a five year follow-up study, J Hypertens; 1: 159-161
  54. Strazzullo P, Cappuccio F P, Cirillo M, Pacioni D, Zappia V (1985) The relationship of blood pressure to urinary sodium excretion in men with and without familial predisposition to hypertension, In: Ghione S, ed. Individual susceptibility to salt intake and arterial hypertension: 45-50
  55. Strazzullo P, Cappuccio F P, Contaldo F, Trevisan M, Giorgione N (1986) Obesita' e ipertensione, In: Anonymous. Obesita' e magrezze: studi e ricerche cliniche in Italia. Roma: Societa' Editrice Universo: 213-223
  56. Strazzullo P, Cirillo M, Galletti F, Siani A, Cappuccio F P, Iacoviello L, Mancini M (1986). Altered renal and erithrocyte calcium handling in human primary and rat genetic hypertension, J Hypertens;4: S349-S351
  57. Strazzullo P, Cappuccio F P, Trevisan M, Iacoviello L, Iacone R, Barba G, DeLeo A, Farinaro E, Mancini M (1989) Red blood cell sodium-lithium countertransport, blood pressure, and uric acid metabolism in untreated healthy men, Am J Hypertens; 2: 634-636
  58. Strazzullo P, Cappuccio F P, Trevisan M, Iacoviello L, Iacone R, Jossa F, Giorgione N, Farinaro E, Mancini M (1989) Erythrocyte sodium/lithium countertransport and renal lithium clearance in a random sample of untreated middle-aged men, Clin Sci; 77: 337-342
  59. Strazzullo P, Cappuccio F P, Barba G, Trevisan M, Ciacci C, Iacone R, Russo L (1989) Altered renal tubular function in men with high erythrocyte sodium-lithium countertransport, J Hypertens; 7: S154-S155
  60. Strazzullo P, Cappuccio F P, Iacoviello L, Cipollaro M, Varriale V, Giorgione N, Farinaro E, Mancini M (1990) Erythrocyte volume and blood pressure in a cross-sectional population-based study, J Hypertens; 8: 179-183
  61. Strazzullo P, Cappuccio F P, Trevisan M, Siani A, Barba G, Ragone E, Pagano E, Mancini M (1993) The relationship of erythrocyte sodium-lithium countertransport to blood pressure and metabolic abnormalities in a sample of untreated middle-aged male workers, J Hypertens; 11: 815-822
  62. Strazzullo P, Cappuccio F P, Miller M A, Buckley M G, Sagnella G A, Trevisan M, Pagano E, MacGregor G A (1994) Erythrocyte sodium-lithium countertransport: relationship with plasma renin activity, aldosterone and atrial natriuretic peptide in a population study, J Hum Hypert; 8: 199-204
  63. Strazzullo P, Cappuccio F P (1995) Hypertension and kidney stones: hypotheses and implications, Sem Nephrol; 15: 519-525
  64. Strazzullo P, Siani A, Cappuccio F P, Trevisan M, Ragone E, Russo L, Iacone R, Farinaro E (1998) Red blood cell sodium-lithium countertransport and risk of future hypertension. The Olivetti Prospective Heart Study, Hypertension; 31: 1284-1289
  65. Strazzullo P, Iacone R, Siani A, Cappuccio F P, Russo O, Barba G, Barbato A, D'Elia L, Trevisan M, Farinaro E (2001) Relationship of the Trp64Arg mutation in the beta3-adrenoceptor gene to central adiposity and high blood pressure: interaction with age. Cross-sectional and longitudinal findings of the Olivetti Heart Study, J Hypertens; 19: 399-406
  66. Strazzullo P, Iacone R, Siani A, Barba G, Russo O, Russo P, D'Elia L, Farinaro E, Cappuccio F P (2001) Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene Gly40Ser polymorphism, J Mol Med; 79: 574-580
  67. Strazzullo P, Barba G, Vuotto P, Farinaro E, Siani A, Nunziata V, Galletti F, Mancini M and Cappuccio F P (2001) Past history of nephrolithiasis and incidence of hypertension in men: a reappraisal based on the results of the Olivetti Prospective Heart Study, Nephrol Dial Transplant; 16; 2232-2235
  68. Strazzullo P, Barba G, Cappuccio F P, Siani A, Trevisan M, Farinaro E, Pagano E, Barbato A, Iacone R (2001) Altered renal sodium handling in men with abdominal adiposity. A link to hypertension, J Hypertens; 19: 2157-2164
  69. Strazzullo P, Iacone R, Iacoviello L, Russo O, Barba G, Russo P, D'Orazio A, Barbato A, Cappuccio F P, Farinaro E, Siani A (2003) Genetic variation in the renin-angiotensin system and the development of obesity in men: the Olivetti Prospective Heart Study, Ann Int Med; 138: 17-23
  70. Strazzullo P, Barbato A, Galletti F, Barba G, Siani A, Iacone R, d'Elia L, Russo O, Versiero M, Farinaro E, Cappuccio F P (2006) Abnormalities of renal sodium handling in the metabolic syndrome. Results of the Olivetti study, J Hypertens; 24: 1633-1639  
  71. Strazzullo P, Barbato A, Siani A, Cappuccio F P, Versiero M, Schiattarella P, Russo O, Avallone S, della Valle E, Farinaro E (2008) Diagnostic criteria for metabolic syndrome: a comparative analysis in an unselected sample of adult male population, Metabolism Clin Exp; 57: 355-61
  72. Trevisan M, Celentano E, Meucci C, Farinaro E, Jossa F, Krogh V, Giumetti D, Panico S, Scottoni A, Mancini M (1986) Short-term effecct of natural disasters on coronary heart disease risk factors, Arteriosclerosis; 6: 491-494
  73. Trevisan M, Strazzullo P, Cappuccio F P, Farinaro E, Jossa F, Krogh V, Iacone R, Mancini M (1992) Sodium-lithium countertransport and body fat distribution, Life Sci; 51: 687-693
  74. Trevisan M, Jossa F, Farinaro E, Krogh V, Panico S, Giumetti D, Mancini M (1992) Earthquake and coronary heart disease risk factors: a longitudinal study, Am J Epidemiol; 135: 632-637
  75. Trevisan M, Farinaro E, Krogh V, Jossa F, Giumetti D, Fusco G, Panico S, Mellone C, Frascatore S, Scottoni A, et al (1993) Baldness and coronary heart disease risk factors, J Clin Epidemiol; 46: 1213-1218
  76. Trevisan M, Strazzullo P, Cappuccio F P, Jossa F, Iacone R, Russo L, Farinaro E (1996) Sodium lithium countertransport and blood pressure. Longitudinal findings, Am J Hypertens; 9: 1132-1135
  77. Venezia A, Barba G, Russo O, Capasso C, De Luca V, Farinaro E, Cappuccio FP, Galletti F, Rossi G & Strazzullo P (2010). Dietary sodium intake in a sample of adult male population in southern Italy: results of the Olivetti Heart Study. Eur J Clin Nutr 64: 518-524