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Analysis available as Service Contract/Collaboration

  • Markers of protein damage (adduct residues of proteins or free adducts)
    • Protein oxidation – methionine sulfoxide (MetSO), o,o’-dityrosine (DT) and N-formylkynurenine (NFK), glutamic semialdehyde (GSA) and aminoadipic semialdehyde (AASA)
    • Protein nitration - 3-nitrotyosine (3-NT)
    • Protein glycation – early glycation adduct - Nε-fructosyl-lysine; advanced glycation endproducts (AGEs) – Nε-carboxymethyl-lysine (CML), Nε-carboxyethyl-lysine (CEL), pyrraline, hydroimidazolones MG-H1, G-H1, 3DG-H, imidazolium crosslinks GOLD and MOLD, argpyrimidine, pentosidine, glucosepane
    • Non-thiol protein crosslinks - Nε-(γ-Glutamyl)lysine (GEEK)
    • Other protein markers and amino acids – ornithine, citrulline, hydroxyproline and physiological amino acids
  • Markers of nucleotide damage (adduct residues of DNA or free adducts)
    • Nucleotide oxidation - 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-OxodG)
    • Nucleotide glycation - 3-(2’-deoxyribosyl)-6,7- dihydro-6,7-dihydroxyimidazo[2,3-b]purin-9(8)one (GdG), and 3-(2’ -deoxyribosyl)-6,7-dihydro-6,7-dihydroxy-6/7-methylimidazo-[2,3-b]purine-9(8)one (MGdG), N2 -(1,R/S-carboxyethyl)-deoxyguanosine (CEdG)
  • Markers of lipid damage
    • F2-Isoprostanes*
  • Dietary bioactives and related precursors
    • Glucosinolates and isothiocyanates
    • Polyphenols*
    • Flavanols*
    • Triterpenoids*
  • Other
    • Physiological dicarbonyls – glyoxal, methylglyoxal and 3-deoxyglucosone
    • Reduced and oxidized glutathione (GSH and GSSG)
    • Thiamine
    • Pyridoxine and other B6 vitamers (by HPLC method)
    • Homocystine
    • Methylmalonic acid
    • Creatinine

 

*Methods in development