Analysis available as Service Contract/Collaboration
- Markers of protein damage (adduct residues of proteins or free adducts)
- Protein oxidation – methionine sulfoxide (MetSO), o,o’-dityrosine (DT) and N-formylkynurenine (NFK), glutamic semialdehyde (GSA) and aminoadipic semialdehyde (AASA)
- Protein nitration - 3-nitrotyosine (3-NT)
- Protein glycation – early glycation adduct - Nε-fructosyl-lysine; advanced glycation endproducts (AGEs) – Nε-carboxymethyl-lysine (CML), Nε-carboxyethyl-lysine (CEL), pyrraline, hydroimidazolones MG-H1, G-H1, 3DG-H, imidazolium crosslinks GOLD and MOLD, argpyrimidine, pentosidine, glucosepane
- Non-thiol protein crosslinks - Nε-(γ-Glutamyl)lysine (GEEK)
- Other protein markers and amino acids – ornithine, citrulline, hydroxyproline and physiological amino acids
- Markers of nucleotide damage (adduct residues of DNA or free adducts)
- Nucleotide oxidation - 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-OxodG)
- Nucleotide glycation - 3-(2’-deoxyribosyl)-6,7- dihydro-6,7-dihydroxyimidazo[2,3-b]purin-9(8)one (GdG), and 3-(2’ -deoxyribosyl)-6,7-dihydro-6,7-dihydroxy-6/7-methylimidazo-[2,3-b]purine-9(8)one (MGdG), N2 -(1,R/S-carboxyethyl)-deoxyguanosine (CEdG)
- Markers of lipid damage
- F2-Isoprostanes*
- Dietary bioactives and related precursors
- Glucosinolates and isothiocyanates
- Polyphenols*
- Flavanols*
- Triterpenoids*
- Other
- Physiological dicarbonyls – glyoxal, methylglyoxal and 3-deoxyglucosone
- Reduced and oxidized glutathione (GSH and GSSG)
- Thiamine
- Pyridoxine and other B6 vitamers (by HPLC method)
- Homocystine
- Methylmalonic acid
- Creatinine
*Methods in development