Ramesh Arasaradnam

Professor Arasaradnam is a consultant Gastroenterologist and was former chair of the Research Committee of the British Society of Gastroenterology until 2021 before taking position as Academic Vice President at the Royal College of Physicians London.

His research interest is in colon cancer biomarker and diagnostic research, bile acid pathophysiology and artiificial intelligence where he leads on several NIHR studies. He has an interest in volatile organic compound (VOC) in cancer diagnosis and is part of an European VOC interest group.

He received an OBE as part of the Queen's birthday Honours in 2020 for his services to the NHS during COVID-19.

http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=8459

http://www2.warwick.ac.uk/fac/sci/eng/research/famished

His clinical interest lies in GI physiology and development of small bowel Enteroscopy service at University Hospital Coventry & Warwickshire (UHCW).

Selected recent publications

Changing Gastrointestinal Transit Time Alters Microbiome Composition and Bile Acid Metabolism: A Cross-Over Study in Healthy Volunteers.

Hillman EBM, Baumgartner M, Carson D, Amos GCA, Wazir I, Khan HA, Khan MA, Rijpkema S, Walters JRF, Wellington EMH, Arasaradnam R, Lewis SJ.Neurogastroenterol Motil. 2025 May 20:e70075. doi: 10.1111/nmo.70075. Online ahead of print.PMID: 40394972

Single-use versus multiple-use accessories in gastrointestinal endoscopy: a systematic review of economic evaluations.

Zanganeh M, Jiang Y, Brown A, Chen YF, Arasaradnam RP, Andronis L; SUMU-Endo project group; SUMU Endo project group.BMJ Open Gastroenterol. 2025 May 14;12(1):e001712. doi: 10.1136/bmjgast-2024-001712.PMID: 40374189

Efficacy and Safety of Ustekinumab for Ulcerative Colitis Through 4 Years: Final Results of the UNIFI Long-Term Maintenance Study.

Afif W, Arasaradnam RP, Abreu MT, Danese S, Sandborn WJ, Miao Y, Zhang H, Panaccione R, Hisamatsu T, Scherl EJ, Leong RW, Rowbotham DS, Peyrin-Biroulet L, Sands BE, Marano C.Am J Gastroenterol. 2024 May 1;119(5):910-921. doi: 10.14309/ajg.0000000000002621. Epub 2023 Dec 14.PMID: 38095692

Gut microbiota signatures in inflammatory bowel disease.

Vestergaard MV, Allin KH, Eriksen C, Zakerska-Banaszak O, Arasaradnam RP, Alam MT, Kristiansen K, Brix S, Jess T.United European Gastroenterol J. 2024 Feb;12(1):22-33. doi: 10.1002/ueg2.12485. Epub 2023 Dec 2.PMID: 38041519

Urine as a biological modality for colorectal cancer detection.

A hybrid machine learning feature selection model-HMLFSM to enhance gene classification applied to multiple colon cancers dataset.

Al-Rajab M, Lu J, Xu Q, Kentour M, Sawsa A, Shuweikeh E, Joy M, Arasaradnam R.PLoS One. 2023 Nov 2;18(11):e0286791. doi: 10.1371/journal.pone.0286791. eCollection 2023.PMID: 37917732v

Faecal haemoglobin for colorectal cancer detection: is the evidence base complete enough for use as a triage tool?

Chandrapalan S, Arasaradnam RP.Lancet Gastroenterol Hepatol. 2023 Nov;8(11):970. doi: 10.1016/S2468-1253(23)00320-5.PMID: 37837973

Utility of volatile organic compounds as a diagnostic tool in preterm infants.

Wright H, Bannaga AS, Iriarte R, Mahmoud M, Arasaradnam RP.

Pediatr Res. 2020 Mar 2. doi: 10.1038/s41390-020-0828-3. [Epub ahead of print] Review.

Microbial imbalance in inflammatory bowel disease patients at different taxonomic levels.

Alam MT, Amos GCA, Murphy ARJ, Murch S, Wellington EMH, Arasaradnam RP.

Gut Pathog. 2020 Jan 4;12:1. doi: 10.1186/s13099-019-0341-6. eCollection 2020.

Stool for fecal microbiota transplantation should be classified as a transplant product and not as a drug.

Keller JJ, Vehreschild MJ, Hvas CL, Jørgensen SM, Kupciskas J, Link A, Mulder CJ, Goldenberg SD, Arasaradnam R, Sokol H, Gasbarrini A, Hoegenauer C, Terveer EM, Kuijper EJ, Arkkila P; UEG working group of the Standards and Guidelines initiative Stool banking for FMT.

United European Gastroenterol J. 2019 Dec;7(10):1408-1410. doi: 10.1177/2050640619887579. Epub 2019 Nov 14.

Diagnosing Inflammatory bowel disease using noninvasive applications of volatile organic compounds: a systematic review.

Bannaga AS, Farrugia A, Arasaradnam RP.

Expert Rev Gastroenterol Hepatol. 2019 Nov;13(11):1113-1122. doi: 10.1080/17474124.2019.1685873. Epub 2019 Nov 8.

Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis.

UNIFI Study Group.

N Engl J Med. 2019 Sep 26;381(13):1201-1214. doi: 10.1056/NEJMoa1900750.

Systematic review and meta-analysis : diagnostic accuracy of faecal immunochemical testing for haemoglobin (FIT) in detecting colorectal cancer for both symptomatic and screening population.

Stonestreet J, Chandrapalan S, Woolley D, Uthman U, Arasaradnam RP.

Acta Gastroenterol Belg. 2019 Apr-Jun;82(2):291-299.

Systematic review with meta-analysis of over 90 000 patients. Does fast-track review diagnose colorectal cancer earlier?

Mozdiak E, Weldeselassie Y, McFarlane M, Tabuso M, Widlak MM, Dunlop A, Tsertsvadze A, Arasaradnam RP.

Aliment Pharmacol Ther. 2019 Aug;50(4):348-372. doi: 10.1111/apt.15378. Epub 2019 Jul 8. Review.

Urinary volatile organic compounds and faecal microbiome profiles in colorectal cancer.

McFarlane M, Millard A, Hall H, Savage R, Constantinidou C, Arasaradnam R, Nwokolo C.

Colorectal Dis. 2019 Nov;21(11):1259-1269. doi: 10.1111/codi.14739. Epub 2019 Jul 10.

Fibroblast growth factor 7 signalling is disrupted in colorectal cancer and is a potential marker of field cancerisation.

Patel A, Tripathi G, McTernan P, Gopalakrishnan K, Ali O, Spector E, Williams N, Arasaradnam RP.

J Gastrointest Oncol. 2019 Jun;10(3):429-436. doi: 10.21037/jgo.2019.02.11.

Enterosgel for the treatment of adults with acute diarrhoea in a primary care setting: a randomised controlled trial.

Howell CA, Markaryan E, Allgar V, Kemppinen A, Khovanov A, Pandya P, Arasaradnam R.

BMJ Open Gastroenterol. 2019 Apr 15;6(1):e000287. doi: 10.1136/bmjgast-2019-000287. eCollection 2019.

Letter: improving detection of colorectal cancer using two-stage investigation process-faecal immunochemical test and urinary volatile organic compounds.

Widlak MM, Neal M, Arasaradnam RP.

Aliment Pharmacol Ther. 2019 Jun;49(11):1459-1460. doi: 10.1111/apt.15278. No abstract available.

Arasaradnam RP, Brown S, Forbes A, Fox MR, Hungin P, Kelman L, Major G, O'Connor M, Sanders DS, Sinha R, Smith SC, Thomas P, Walters JRF.

Gut. 2018 Aug;67(8):1380-1399. doi: 10.1136/gutjnl-2017-315909. Epub 2018 Apr 13.

Book Chapters

Arasaradnam & Bardhan. Cancer Treatment and Prevention; Francis Taylor 2010

Arasaradnam & Nwokolo. Ulcerative Colitis - Molecular determinants of pathogenesis of UC; Impegna 2011

Patents:

'A Diagnostic Device'; PCT/GB2011/052063

'Bile Acid Diarrhoea'; 1316188.0

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Weblinks

Electronic Nose - http://www2.warwick.ac.uk/fac/cross_fac/ias/programmes/2009-10/incubation/smelltechnology/ Link opens in a new window
BBC Science update: http://news.bbc.co.uk/1/hi/health/8367872.stm
Warwick 50 forward - http://www2.warwick.ac.uk/giving/news/healthengineering/