PURE Study flaws
In this section, we present compelling experimental evidence and authoritative methodological critiques demonstrating that:
Invalid methodology
The principal findings of the PURE-Salt sub-study are methodologically invalid, as they are driven by biased exposure measurement rather than true physiological relationships.
Critique persistently ignored or dismissed
Despite clear, repeated, and unequivocal warnings from the scientific community, these fundamental flaws have been persistently ignored or dismissed. Consequently, studies employing the same discredited methodology continue to be conducted and published, often without adequate acknowledgment of their limitations, thereby propagating misleading conclusions within the literature.
System failure on rigour and oversight
This pattern represents a systemic failure of methodological rigour and editorial oversight, with significant implications for scientific integrity and public health policy. By allowing flawed exposure assessment methods to underpin influential conclusions about sodium intake and CVD risk, the literature risks misinforming guidelines, undermining decades of high-quality experimental evidence, and confusing both clinicians and policymakers.