(1). Applying epidemiological principles to health technology assessments (2). Evidence synthesis in diagnostic testing (3). Evaluation of public health interventions using natural experiments. (4) Non-communicable disease epidemiology in high-risk populations
After my undergraduate studies in Medicine and Surgery (MBBS) and a few years practicing as a physician, I went on to study for a Masters in Public Health (MPH) at the University of Warwick, achieving both a distinction and the University of Warwick Chancellor's Scholarship award to commence doctoral (PhD) studies. For my doctoral thesis, I investigated a plausible causal link between antiretroviral therapy and high blood pressure in HIV-positive Africans using observational data. The project entailed specialist methods used in evidence synthesis (including network meta-analysis and meta-regression analyses) and other statistical methods such as propensity score matching and mediation analysis. The findings have had sufficient impact, being invited to present them at international scientific meetings as invited lecturer. Parts of my work have also been adapted as training resource for continuing medical education credit offered to physicians and allied health professionals. I joined the University of Warwick in August 2016, where I work on health technology assessments for NICE as part of the Warwick Evidence Review Group (ERG). My role entails appraising the clinical effectiveness of novel health technologies developed by pharmaceutical companies, potentially influencing NHS policy and practice. My knowledge of clinical medicine and epidemiology allows for a comprehensive understanding of the natural history of the disease in question and to assess the health status of the target population at baseline, such as when comparing disease stages and prognostic markers across cancer drug trials. I provide methodological support including network meta-analysis and matched indirect treatment comparisons; oversee clarification questions on clinical effectiveness; liaise with clinical advisors; coordinate appraisal reports; and represent the Warwick ERG at NICE appraisal committee meetings.
- 'Abba, Mustapha S., 'Nduka, Chidozie U., 'Anjorin, Seun S., 'Mohamed, Shukri F., 'Agogo, Emmanuel, 'Uthman, Olalekan A., 2022. 'One hundred years of hypertension research : a topic modelling study. JMIR Formative Research, 6 (5)
- 'Abba, Mustapha S., 'Nduka, Chidozie U., 'Anjorin, Seun S., 'Uthman, Olalekan A., 2022. 'Household air pollution and high blood pressure : a secondary analysis of the 2016 Albania Demographic Health and Survey dataset. International Journal of Environmental Research and Public Health, 19 (5)
- Uthman, Olalekan A., Court, Rachel, Enderby, Jodie, Al-Khudairy, Lena, Nduka, Chidozie, Mistry, Hema, Melendez-Torres, G. J., Taylor-Phillips, Sian, Clarke, Aileen, 2022. Increasing comprehensiveness and reducing workload in a systematic review of complex interventions using automated machine learning. Health Technology Assessment
- Mottram, Rebecca, Knerr, Wendy Lynn, Gallacher, Daniel C., Fraser, Hannah, Al-Khudairy, Lena, Ayorinde, Abimbola, Williamson, Sian, Nduka, Chidozie U., Uthman, Olalekan A., Johnson, Samantha Ann, Tsertsvadze, Alexander, Stinton, Christopher, Taylor-Phillips, Sian, Clarke, Aileen, 2021. Factors associated with attendance at screening for breast cancer : a systematic review and meta-analysis. BMJ Open, 11 (11)
- Fraser, Hannah, Gallacher, Daniel C., Achana, Felix A., Court, Rachel A., Taylor-Phillips, Sian, Nduka, Chidozie U., Stinton, Chris, Willans, Rebecca, Gill, Paramjit, Mistry, Hema, 2020. Rapid antigen detection and molecular tests for group A streptococcal infections for acute sore throat : systematic reviews and economic evaluation. Health Technology Assessment, 24 (31), pp. 1-232
- Uthman, Olalekan A., Al-Khudairy, Lena, Nduka, Chidozie U., Court, Rachel A., Mistry, Hema, Melendez-Torres, G. J., Taylor-Phillips, Sian, Clarke, Aileen, 2020. Determining optimal strategies for primary prevention of cardiovascular disease : systematic review, cost-effectiveness review and network meta-analysis protocol. Systematic Reviews, 9 (1)
- Mistry, Hema, Nduka, Chidozie U., Connock, Martin, Colquitt, Jill, Mantopoulos, Theodoros, Loveman, Emma, Walewska, Renata, Mason, James, 2019. Correction to: Venetoclax for Treating Chronic Lymphocytic Leukaemia: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 37 (6), pp. 869-869
- Uthman, Olalekan A., Nduka, Chidozie U., Watson, Samuel I., Mills, Edward, Kengne, Andre, Jaffar, Shabbar, Clarke, Aileen, Moradi, Tahereh, Ekström, Anna Mia, Lilford, Richard, 2018. Statin use and all-cause mortality in people living with HIV : a systematic review and meta-analysis. BMC Infectious Diseases, 18
- Mistry, Hema, Nduka, Chidozie U., Connock, M., Colquitt, Jill, Mantopoulos, Theodoros, Loveman, Emma, Walewska, Renata, Mason, James, 2017. Venetoclax for treating chronic lymphocytic leukaemia : an evidence review group perspective of a NICE single technology appraisal. PharmacoEconomics
- Uthman, Olalekan A., Oladimeji, Olanrewaju, Nduka, Chidozie U., 2017. Adherence to antiretroviral therapy among HIV-infected prisoners : a systematic review and meta-analysis. AIDS Care, 29 (4), pp. 489-497
- McCrary, Andrew W., Nduka, Chidozie U., Stranges, Saverio, Bloomfield, Gerald S., 2017. Features of cardiovascular disease in low-income and middle-income countries in adults and children living with HIV. Current Opinion in HIV and AIDS, 12 (6), pp. 579-584
- Nduka, Chidozie U., Stranges, Saverio, Kimani, Peter K., Sarki, Ahmed M., Uthman, Olalekan A., 2017. Is there sufficient evidence for a causal association between Antiretroviral therapy and Diabetes in HIV-infected patients? A meta-analysis. Diabetes/Metabolism Research and Reviews, 33 (6)
- Nduka, Chidozie U., Stranges, Saverio, Sarki, Ahmed M., Kimani, Peter K., Uthman, Olalekan A., 2016. Evidence of increased blood pressure and hypertension risk among people living with HIV on antiretroviral therapy : a systematic review with meta-analysis. Journal of Human Hypertension, 30 (6), pp. 355-362
- Nduka, Chidozie U., Stranges, Saverio, Sarki, Ahmed M., Kimani, Peter K., Uthman, Olalekan A., 2016. Evidence of increased blood pressure and hypertension risk among people living with HIV on antiretroviral therapy : a systematic review with meta-analysis. Journal of Human Hypertension, 30 (6), pp. 355-362
- Nduka, Chidozie U., Uthman, Olalekan A., Kimani, Peter K., Stranges, Saverio, 2016. Body fat changes in people living with HIV on antiretroviral therapy. AIDS reviews, 18 (4)
- Nduka, Chidozie U., Uthman, Olalekan A., Kimani, Peter K., Malu, Abraham O., Stranges, Saverio, 2016. Impact of body fat changes in mediating the effects of antiretroviral therapy on blood pressure in HIV-infected persons in a sub-Saharan African setting. Infectious Diseases of Poverty, 5 (1)
- Nduka, Chidozie U., Stranges, Saverio, Bloomfield, Gerald S., Kimani, Peter K., Achinge, Godwin, Malu, Abraham O., Uthman, Olalekan A., 2016. A plausible causal link between antiretroviral therapy and increased blood pressure in a sub-Saharan African setting : a propensity score-matched analysis. International Journal of Cardiology, 220, pp. 400-407
- Sarki, Ahmed M., Nduka, Chidozie U., Stranges, Saverio, Kandala, Ngianga-Bakwin, Uthman, Olalekan A., 2015. Prevalence of hypertension in low- and middle-income countries : a systematic review and meta-analysis.. Medicine, 94 (50)
- Nduka, Chidozie U., Sarki, Ahmed M., Uthman, Olalekan A., Stranges, Saverio, 2015. Impact of antiretroviral therapy on serum lipoprotein levels and dyslipidemias : a systematic review and meta-analysis. International Journal of Cardiology, 199, pp. 307-318
Title | Funder | Award start | Award end |
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NIHR HTA 17/148 - Health Technology Assessment Programme researcher-led evidence synthesis: Determining optimal dietary and physical activity interventions for primary prevention of cardiovascular disease: a global data integration and network meta-analysis | National Institute for Health Research (DoH) | 01 Feb 2019 | 31 Jul 2021 |