Deepak's research interests span from PURE MATHEMATICS to MEDICAL STATISTICS to CANCER RESEARCH.
On the mathematical front, his research has been focused on algebraic and differential geometric aspects of Quantum Groups (mathematical structures arising from symmetry of quantum inverse scattering methods), quantum calculus, and non-commutative geometry, where order of mathematical and logical operators matters; organised international conference and co-edited a book.
In medical statistics , Deepak has been involved in the design and analyses of oncology trials, retrospective analyses and prospective design of cancer studies; has been the lead statistician on several cancer clinical trials responsible for study design, sample size, statistical analysis plans, and providing statistical expertise on a range of cutting-edge cancer research projects. His statistical methodology research interests are in the area of Stratified Medicine, a hugely important realm of healthcare where the right patient gets the right treatment at the right time. Particular focus is on development of biomarker-stratified clinical trial designs used to establish the effectiveness of a new drug or targeted therapy in specific populations with patients stratified by their biomarker signature assumed to be predictive of treatment response. These designs then lead onto the more general 'master protocols' incorporating multiple tumour types, mutations and drugs where a number of data science aspects are investigated.
Besides, Deepak is interested in Machine Learning, Geometric Data Science, and university mathematics education.
PhD Students
Ben Lanza
Statistical Design and Analysis of Clinical Studies using Personalised Healthcare under Biomarker Uncertainty
(MRC iCASE Award, Industrial Partner: Roche Pharmaceuticals)
Amelia Thompson
Quantitative Decision-Making in Clinical Drug Development Incorporating Biomarkers
(MRC iCASE Award, Industrial Partner: AstraZeneca)
Omar Abdullah
Venous-thromboembolism in muscle invasive, locally advanced or metastatic bladder cancer: Scope of the problem and patients' experiences
(CARA Fellowship)
Prospective PhD Projects
BIOMARKER DATA ANALYTICS FOR STRATIFIED MEDICINE IN CANCER
MRC Data Science Warwick DTP Studentship.
If interested, please get in touch.
Deepak studied for BSc (Honours) and MSc Physics from University of Delhi, Master of Advanced Study in Mathematics from Cambridge, and obtained a PhD in Mathematics in 2000 from Aberdeen, worked as postdoctoral research fellow in Leipzig (under fellowship of Max Planck Society), Swansea (under fellowship of the Royal Commission for the Exhibition of 1851), Rome (under a EU programme and a fellowship of the European Science Foundation), as an Assistant Professor in Mathematics Department at University of Warwick (2 years), visiting scientist at Max Planck Institute fur Mathematik in Bonn, as Senior Statistician at the University of Cambridge (Cancer Trials Centre / MRC Biostatistics Unit / CRUK Cambridge Institute) for 5 years before returning to University of Warwick at the Medical School in 2014 where he is currently an Associate Professor in Systems Biology and Oncology.
Deepak is also a Turing Fellow at the Alan Turing Institute for Data Science and AI based in London.
- Lanza, Ben, Parashar, D.. Do support vector machines play a role in stratifying patient population based on cancer biomarkers?. Archives of Proteomics and Bioinformatics, 2 (1), pp. 20-38
- Parashar, Deepak, 2023. Unlocking multidimensional cancer therapeutics using geometric data science. Scientific Reports, 13 (1)
- 'He, Linchen, 'Ren, Yuru, 'Chen, Han, 'Guinn, Daphne, 'Parashar, Deepak, 'Chen, Cong, 'Yuan, Shuai Sammy, 'Korostyshevskiy, Valeriy, 'Beckman, Robert A., 2022. 'Efficiency of a randomized confirmatory basket trial design constrained to control the family wise error rate by indication. Statistical Methods in Medical Research
- Abdullah, Omar, Parashar, Deepak, Mustafa, Israa J., Young, Annie M., 2022. Venous thromboembolism rate in patients with bladder cancer according to the type of treatment: a systematic review. Cureus, 14 (3)
- Clarke, Amy L., Roscoe, Julia, Appleton, Rebecca, Parashar, Deepak, Muthuswamy, Radha, Khan, Omar, Dale, Jeremy, Nanton, Veronica, 2020. Promoting integrated care in prostate cancer through online prostate cancer-specific holistic needs assessment : a feasibility study in primary care. Supportive Care In Cancer, 28, pp. 1817-1827
- Taylor, Kathryn, Parashar, Deepak, Bouverat, George, Poulos, Ann, Gullien, Randi, Stewart, Elizabeth, Aarre, Randi, Crystal, Pavel, Wallis, Matthew, 2017. Mammographic image quality in relation to positioning of the breast : a multicentre international evaluation of the assessment systems currently used, to provide an evidence base for establishing a standardised method of assessment. Radiography, 23 (4), pp. 343-349
- Parashar, D., 2017. Mortality among men with advanced prostate cancer excluded from the ProtecT Trial. European Urology, 71 (3), pp. 381-388
- Nanton, Veronica, Appleton, Rebecca, Dale, Jeremy, Roscoe, Julia, Hamborg, Thomas, Ahmedzai, Sam H., Arvanitis, Theodoros N., Badger, Douglas, James, Nicholas, Mendelsohn, Richard, Khan, Mohammed Omar, Parashar, Deepak, Patel, Prashant, 2017. Integrated care in prostate cancer (ICARE-P) : nonrandomized controlled feasibility study of online holistic needs assessment, linking the patient and the health care team. JMIR Research Protocols, 6 (7)
- Wadhwa, Karan, Carmona-Echeveria, Lina, Kuru, Timur, Gaziev, Gabriele, Serrao, Eva, Parashar, D., Frey, Julia, Dimov, Ivailo, Seidenader, Jonas, Acher, Pete, Muir, Gordon, Doble, Andrew, Gnanapragasam, Vincent J., Hadaschik, Boris, Kastner, Christof, 2016. Transperineal prostate biopsies for diagnosis of prostate cancer are well tolerated : a prospective study using patient reported outcome measures. Asian Journal of Andrology, 19 (1), pp. 62-66
- Kuo, Joe Chin-Hun, Ibrahim, Ashraf E. K., Dawson, Sarah, Parashar, Deepak, Howat, William J., Guttula, Kiran, Miller, Richard, Fearnhead, Nicola S., Winton, Douglas J., Neves, André A., Brindle, Kevin M., 2016. Detection of colorectal dysplasia using fluorescently labelled lectins. Scientific Reports, 6
- Parashar, D., Bowden, Jack, Starr, Colin, Wernisch, Lorenz, Mander, Adrian, 2016. An optimal stratified Simon two-stage design. Pharmaceutical Statistics, 15 (4), pp. 333-340
- Vivekanandan, Sindu, Breene, Richard, Ramanujachar, Ramya, Traunecker, Heidi, Pizer, Barry, Gaze, Mark N., Saran, Frank, Thorp, Nicky, English, Martin, Wheeler, Kate AH, Michalski, Antony, Walker, David A., Saunders, Daniel, Cowie, Fiona, Cameron, Alison, Picton, Susan V, Parashar, D., Horan, Gail, Williams, Michael V., 2015. The UK experience of a treatment strategy for pediatric metastatic medulloblastoma comprising intensive induction chemotherapy, hyperfractionated accelerated radiotherapy and response directed high dose myeloablative chemotherapy or maintenance chemotherapy (Milan Strategy). Pediatric Blood & Cancer, 62 (12), pp. 2132-2139
- Connolly, Stephen S., Raja, Aditya, Stunell, Helen, Parashar, D., Upponi, Sara, Warren, Anne Y., Gnanapragasam, Vincent J., Eisen, Tim, 2015. Diagnostic accuracy of preoperative computed tomography used alone to detect lymph-node involvement at radical nephrectomy. Scandinavian Journal of Urology, 49 (2), pp. 142-148
- Panagiotopoulou, Ioanna G., Parashar, D., Qasem, Eyas, Mezher-Sikafi, Rasha, Parmar, Jitesh, Wells, Alan D., Bajwa, Farrukh M., Menon, Madhav, Jephcott, Catherine R., 2015. Neoadjuvant long-course chemoradiotherapy for rectal cancer : does time to surgery matter?. International Surgery, 100 (6), pp. 968-973
- Serrao, Eva M, Barrett, Tristan, Wadhwa, Karan, Parashar, D., Frey, Julia, Koo, Brendan C, Warren, Anne Y., Doble, Andrew, Kastner, Christof, Gallagher, Ferdia A, 2015. Investigating the ability of multiparametric MRI to exclude significant prostate cancer prior to transperineal biopsy. Canadian Urological Association Journal, 9 (11-12)
- Dev, Harveer S., Wiklund, Peter, Patel, Vipul, Parashar, D., Palmer, Kenneth, Nyberg, Tommy, Skarecky, Doug, Neal, David E., Ahlering, Tom, Sooriakumaran, Prasanna, 2015. Surgical margin length and location affect recurrence rates after robotic prostatectomy. Urologic Oncology: Seminars and Original Investigations, 33 (3), pp. 109.e7-109.e13
- Connolly, Stephen S., Raja, Aditya, Stunell, Helen, Parashar, D., Upponi, Sara, Warren, Anne Y., Gnanapragasam, Vincent J., Eisen, Tim, 2015. Diagnostic accuracy of preoperative computed tomography used alone to detect lymph-node involvement at radical nephrectomy. Scandinavian Journal of Urology, 49 (2), pp. 142-148
- Boyce, M., Gullien, R., Parashar, D., Taylor, K., 2015. Comparing the use and interpretation of PGMI scoring to assess the technical quality of screening mammograms in the UK and Norway. Radiographics, 21 (4), pp. 342-347
- Mukesh, Mukesh B., Duke, Simon, Parashar, D., Wishart, Gordon, Coles, Charlotte E., Wilson, Charles, 2014. The Cambridge post-mastectomy radiotherapy (C-PMRT) index : a practical tool for patient selection. Radiotherapy and Oncology, 110 (3), pp. 461-466
- Parashar, D., 2014. Challenges in mathematics and statistics teaching underpinned bystudent ? lecturer expectations. European Journal of Science and Mathematics Education, 2 (4), pp. 202-219
- Parashar, D., Bowden, Jack, Starr, Colin, Wernisch, Lorenz, Mander, Adrian, 2013. Adaptive enrichment in biomarker-stratified clinical trial design. Trials, 14 (Suppl 1)
- Panagiotopoulou, I. G., Parashar, D., Lin, R., Antonowicz, S., Wells, A. D., Bajwa, F. M., Krijgsman, B., 2013. The diagnostic value of white cell count, C-reactive protein and bilirubin in acute appendicitis and its complications. The Annals of The Royal College of Surgeons of England, 95 (3), pp. 215-221
- Nichita, Florin F., Parashar, D., Zielinski, Bartosz, 2013. Semientwining structures and their applications. ISRN Algebra, 2013, pp. 1-9
- Vivekanandan, S., Whitfield, G.A., Parashar, D., Jephcott, C.R., Wilson, C.B., 2012. Split-course chemoradiation therapy : an effective alternative treatment of anal cancer in elderly patients. International Journal of Radiation Oncology*Biology*Physics, 84 (3)
- Panagiotopoulou, I.G., Parashar, D., Mezher-Sikafi, R., Parmar, J., Wells, A.D., Menon, M., Jephcott, C.R., 2012. Timing of surgery after neoadjuvant long-course chemoradiotherapy in the management of locally advanced rectal cancer. Clinical Oncology, 24 (10)
- Corrie, Pippa G., Bulusu, R., Wilson, C. B., Armstrong, G., Bond, S., Hardy, R., Lao-Sirieix, S., Parashar, D., Ahmad, A., Daniel, F., Hill, M., Wilson, G., Blesing, C., Moody, A. M., McAdam, K., Osborne, M., 2012. A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications. British Journal of Cancer, 107 (4), pp. 585-587
- Taylor, K., O'Keeffe, S., Britton, P. D., Wallis, M. G., Treece, G. M., Housden, J., Parashar, D., Bond, S., Sinnatamby, R., 2011. Ultrasound elastography as an adjuvant to conventional ultrasound in the preoperative assessment of axillary lymph nodes in suspected breast cancer : a pilot study. Clinical Radiology, 66 (11), pp. 1064-1071
- Rimmer, Yvonne, Chester, John, Joffe, Johnathan, Stark, Daniel, Shamash, Jonathan, Powles, Thomas, White, J., Wason, James, Parashar, D., Armstrong, G. (Georgina), Mazhar, Danish, Williams, M. V., 2011. Accelerated BEP : a phase I trial of dose-dense BEP for intermediate and poor prognosis metastatic germ cell tumour. British Journal of Cancer, 105 (6), pp. 766-772
- Nichita, Florin F., Parashar, Deepak, 2006. Spectral-parameter dependent Yang-Baxter operators and Yang-Baxter systems from algebra structures. COMMUNICATIONS IN ALGEBRA, 34 (8), pp. 2713-2726
- Parashar, D., McDermott, Roger J., 2000. Realisations of Quantum GL_p,q(2) and Jordanian GL_h,h'(2). Czechoslovak Journal of Physics, 50 (1), pp. 157-162
- Parashar, D., Bowden, Jack, Starr, Colin, Wernisch, Lorenz, Mander, Adrian, 2015. Type I error control in biomarker-stratified clinical trials. 3rd International Clinical Trials Methodology Conference, Glasgow SECC, UK, 16-17 Nov 2015, Published in Trials
- Nichita, Florin F., Parashar, D., 2009. Coloured bialgebras and nonlinear equations. 6th CONGRESS OF ROMANIAN MATHEMATICIANS, Bucharest, Romania, 18 Jun - 04 Jul 2007, Published in Proceedings of the 6th Congress of Romanian Mathematicians, pp. 65-70
- Beri, Nidhi, Kapoor, Lekha, Parashar, Deepak, Mundada, Vivek, 2023. Effect on maximal mouth opening in children with spinal muscular atrophy treated with onasemnogene abeparvovec. Archives of Disease in Childhood, BMJ, pp. 866-867
| Title | Funder | Award start | Award end |
|---|---|---|---|
| Royal Society.NOVEL TRIAL DESIGNS FOR DYNAMIC PRECISION MEDICINE IN CANCER | Royal Society | 15 Mar 2019 | 14 Mar 2024 |
| NIHR i4i via Imperial College London - Detection of metastatic axillary sentinel lymph nodes using ultrafast, super-resolution, dual-contrast enhanced ultrasound imaging in patients with breast cancer. | National Institute for Health Research (DoH) | 01 Oct 2020 | 30 Sept 2023 |
| QUANTITATIVE DECISION-MAKING IN CLINICAL DRUG DEVELOPMENT INCORPORATING BIOMARKERS MRC iCASE | AstraZeneca | 01 Oct 2019 | 30 Sept 2022 |
| MRC iCASE Collaboration Agreement Roche Lanza | Roche Products Ltd | 01 Oct 2018 | 30 Sept 2022 |
| Turing Fellowship | Alan Turing Institute | 01 Oct 2018 | 30 Sept 2020 |