Early recognition of type 2 diabetes in primary care
Dynamical models of glycaemic control in diabetes
Health informatics and cardiovascular disease
Tim qualified from St George's Hospital Medical School in 1987 and then trained in hospital medicine at Teesside and Gwent before entering general practice.
As a house officer in 1988 he co-authored a high-impact paper about the new cattle disease Bovine Spongiform Encephalopathy, which helped trigger changes to British food industry policy. As a general practitioner he worked initially in rural North Yorkshire and developed an interest in complexity theory applied to diabetes care and health informatics.
Having moved to Warwick in 2004, he developed his interest in the use of primary care data to identify individuals at risk of cardiovascular disease. As part of this research he recently completed the e-Nudge trial, a RCT of a software tool designed to facilitate cardiovascular disease prevention in primary care. This work led on to other projects involving the detection of undiagnosed diabetes using health care data. Tim is currently working on the problem of detecting abdominal aortic aneurysm in primary care.
- Zhang, Yan, Holt, Tim A., Khovanova, N. A., 2015. A data driven nonlinear stochastic model for blood glucose dynamics. Computer Methods and Programs in Biomedicine, 125, pp. 18-25
- Warren, Fiona C., Stych, Kate, Thorogood, Margaret, Sharp, D. J. (Deborah Jane Lister), Murphy, Marie, Turner, Katrina M., Holt, Tim A., Searle, Aidan, Bryant, Susan, Huxley, Caroline J., Campbell, John L., Hillsdon, Melvyn, Taylor, Rod (Rod S.), 2014. Evaluation of different recruitment and randomisation methods in a trial of general practitioner-led interventions to increase physical activity : a randomised controlled feasibility study with factorial design. Trials, 15 (1)
- Campbell, John L., Fletcher, Emily, Britten, Nicky, Green, Colin, Holt, Tim A., Lattimer, Valerie Ann, Richards, Dave A., Richards, Suzanne H., Salisbury, Chris, Calitri, Raff, Bowyer, V., Chaplin, Katherine, Kandiyali, Rebecca, Murdoch, Jamie, Roscoe, Julia, Varley, Anna, Warren, Fiona C., Taylor, Rod, 2014. Telephone triage for management of same-day consultation requests in general practice (the ESTEEM trial) : a cluster-randomised controlled trial and cost-consequence analysis. The Lancet, 384 (9957), pp. 1859-1868
- Robinson, Louise E., Holt, Tim A., Rees, Karen, Randeva, Harpal S., O'Hare, J. Paul, 2013. Effects of exenatide and liraglutide on heart rate, blood pressure and body weight : systematic review and meta-analysis. BMJ Open, Vol.3 (No.1)
- Khovanova, N. A., Khovanov, I. A., Sbano, L., Griffiths, Frances, Holt, Tim A., 2013. Characterisation of linear predictability and non-stationarity of subcutaneous glucose profiles. Computer Methods and Programs in Biomedicine, 110 (3), pp. 260-267
- Holt, Tim A., Thorogood, Margaret, Griffiths, Frances, 2012. Changing clinical practice through patient specific reminders available at the time of the clinical encounter : systematic review and meta-analysis. Journal of General Internal Medicine, 27 (8), pp. 974-984
- Holt, Tim A., Thorogood, Margaret, Griffiths, Frances, 2012. Changing clinical practice through patient specific reminders available at the time of the clinical encounter : systematic review and meta-analysis. Journal of General Internal Medicine, 27 (8), pp. 974-984
- Holt, Tim A., Thorogood, Margaret, Griffiths, Frances, Munday, Stephen, Friede, Tim, Stables, David, 2010. Automated electronic reminders to facilitate primary cardiovascular disease prevention : randomised controlled trial. British Journal of General Practice, Vol.60 (No.573), pp. e137-e143
- Holt, Tim A., Thorogood, Margaret, Griffiths, Frances, Munday, Stephen, Stables, David, 2008. Identifying individuals for primary cardiovascular disease prevention in UK general practice : priorities and resource implications. British Journal of General Practice, Vol.58 (No.552), pp. 495-498
- Holt, Tim A., Thorogood, Margaret, Griffiths, Frances, Munday, Stephen, 2006. Protocol for the 'e-Nudge trial' : a randomised controlled trial of electronic feedback to reduce the cardiovascular risk of individuals in general practice [ISRCTN64828380]. Trials, Vol.28, pp. 7-11
- Holt, Tim A., Kumar, Sudhesh, 2010. ABC of diabetes. Chichester ; Hoboken, NJ, Wiley-Blackwell/BMJ
- Zhang, Yan, Khovanova, N. A., Holt, Tim A., 2014. Inference of stochastic nonlinear equations for characterisation and prediction of prandial blood glucose levels. 8th European Nonlinear Dynamics Conference (ENOC 2014), Vienna, Austria, 6-11 Jul 2014, Published in ENOC 2014 : Proceedings of 8th European Nonlinear Dynamics Conference
- Khovanova, N. A., Zhang, Yan, Holt, Tim A., 2014. Generalised stochastic model for characterisation of subcutaneous glucose time series. 2014 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI), Valencia, Spain, 1-4 Jun 2014, Published in 2014 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI), pp. 484-487
- Zhang, Yan, Holt, Tim A., Khovanova, N. A., 2015. Data for A data driven nonlinear stochastic model for blood glucose dynamics. University of Warwick, School of Engineering
- Greenhalgh, Trisha, Plsek, Paul, Wilson, Tim, Fraser, Sarah, Holt, Tim A., 2010. Response to 'The appropriation of complexity theory in health care'. Journal of Health Services Research & Policy, Royal Society of Medicine Press Ltd, pp. 115-117
- Holt, Tim A., Holt, Claire J., 2008. Raised blood glucose concentration. British Medical Journal, BMJ Group
- Holt, Tim A., Thorogood, Margaret, Griffiths, Frances, 2006. The use of cardiovascular risk factor information in practice databases. BRITISH JOURNAL OF GENERAL PRACTICE, ROYAL COLL GENERAL PRACTITIONERS, pp. 883-884
Title | Funder | Award start | Award end |
---|---|---|---|
The effectiveness and cost effectiveness of telephone triage of patients requesting same day appointments in general practice: a cluster randomised controlled trial comparing nurse-led and GP-led management systems | National Institute for Health Research (DoH) | 01 Nov 2009 | 31 Jul 2013 |
Use of the V scan for detection of abdominal aortic aneurysm - Regional Innovation Fund | University Hospitals Coventry and Warwickshire NHS Trust | 01 Oct 2010 | 31 Mar 2012 |
The feasibility of a simple low cost general practitioner delivered intervention to promote physical activity | MRC | 01 Oct 2009 | 31 Mar 2011 |