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Dr Jane Warwick

 

Title   

Professor
 

Contact   

WMS - Warwick Clinical Trials Unit
University of Warwick
Coventry
CV4 7AL
Email: J.Warwick@warwick.ac.uk
WebLink: http://www2.warwick.ac.uk/fac/med/staff/jwarwick/

Research Interests

Jane's current research is largely focused on trials in mental health, surgery, emergency medicine and critical care, and on the use of frailty indices as a measure of general health, biological ageing and prognosis in the very elderly. Previously, her research focused on the evaluation of breast screening programmes, breast cancer aetiology, breast cancer prevention, models to predict breast cancer risk and clinical trials in gynaecological oncology and she maintains an interest in these areas.

Biography

Jane Warwick is Professor in Clinical Trials Statistics, Warwick Clinical Trials Unit (WCTU), Warwick Medical School, University of Warwick, where she works to further develop Warwick CTU's portfolio of pragmatic clinical trials and related statistical research studies. She has over 25 years' experience in medical statistics, epidemiology and clinical trials. She obtained a BSc in Statistics (2.1) from the University of Birmingham (1987) and a PhD (thesis entitled "Selecting tuning parameters in minimum distance estimators", funded by an Open University Studentship, supervisor Professor M.C. Jones) from the Department of Mathematics and Statistics at the Open University (2002). Her first post in medical statistics was at the Cancer Research Campaign Clinical Trials Unit at the University of Birmingham where she specialised in gynaecological oncology and developed a particular interest in ovarian cancer. After completing her PhD she joined the Cancer Research UK Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London where for ten years she worked with Professor Stephen Duffy on the evaluation of breast screening programmes and breast cancer aetiology and with Professor Jack Cuzick on breast cancer prevention and models to predict breast cancer risk. In 2011, in order to broaden her experience and develop her leadership skills, she moved to Imperial Clinical Trials Unit, Imperial College London, where for 3 years she led the statistics team and gained experience of Phase II and III trials in a variety of clinical areas, including cancer, HIV, mental health, vascular surgery and critical care, and of Bayesian methods for adaptive trial designs. She joined Warwick CTU in 2014. She maintains her interest in cancer research through membership of external oversight committees (as independent statistician) and has for many years been a reviewer for the NIHR EME and HTA programmes, and for Cancer Research UK's Science Committee. In 2014 she was awarded the Translational Cancer Research Prize for her contribution to the IBIS team (led by Prof Jack Cuzick QMUL), specifically the design and analysis of the mammographic density sub-studies and the development of the methodology for incorporating mammographic density into the IBIS breast cancer risk evaluation model.

Research Projects

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Publications

Journals
  • Astley, Susan M., Harkness, Elaine F., Sergeant, Jamie C., Warwick, Jane, Stavrinos, Paula, Warren, Ruth, Wilson, Mary, Beetles, Ursula, Gadde, Soujanya, Lim, Yit, Jain, Anil, Bundred, Sara, Barr, Nicola, Reece, Valerie, Brentnall, Adam R., Cuzick, Jack, Howell, Tony, Evans, D. Gareth, 2018. A comparison of five methods of measuring mammographic density : a case-control study. Breast cancer research : BCR, 20 (1), View
  • Gohel, Manjit S., Heatley, Francine, Liu, Xinxue, Bradbury, Andrew, Bulbulia, Richard, Cullum, Nicky, Epstein, David M., Nyamekye, Isaac, Poskitt, Keith R., Renton, Sophie, Warwick, Jane, Davies, Alun H., 2018. A randomized trial of early endovenous ablation in venous ulceration. New England Journal Of Medicine, View
  • Signorini, Giulia, Singh, Swaran P., Boricevic-Marsanic, Vlatka, Dieleman, Gwen, Dodig-Curkovic, Katarina, Franic, Tomislav, Gerritsen, Suzanne E, Griffin, James, Maras, Athanasios, McNicholas, Fiona, O'Hara, Lesley, Purper-Ouakil, Diane, Paul, Moli, Schulze, Ulrike, Street, Catherine, Tremmery, Sabine, Tuomainen, Helena, Verhulst, Frank, Warwick, Jane, de Girolamo, Giovanni, 2017. Architecture and functioning of child and adolescent mental health services : a 28-country survey in Europe. The Lancet Psychiatry, View
  • Warwick, Jane, Falaschetti, Emanuela, Rockwood, Kenneth, Mitnitski, Arnold, Thijs, Lutgarde, Beckett, Nigel, Bulpitt, Christopher, Peters, Ruth, 2015. No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people : an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over. BMC Medicine, Volume 13 (Number 1), View
  • Kyrgiou, Maria, Swart, Anne-Marie, Qian, Wendi, Warwick, Jane, 2015. A comparison of outcomes following laparoscopic and open hysterectomy with or without lymphadenectomy for presumed early-stage endometrial cancer. International Journal of Gynecological Cancer, 25 (8), pp. 1424-1436, View
  • Moore, Kate M., Thomas, Gareth J., Duffy, Stephen W., Warwick, Jane, Gabe, Rhian, Chou, Patrick, Ellis, Ian, Green, Andrew R., Haider, Syed, Brouilette, Kellie, Saha, Antonio, Vallath, Sabari, Bowen, Rebecca, Chelala, Claude, Eccles, Diana, Tapper, Will, Thompson, Alastair M., Quinlan, Phillip, Jordan, Lee, Gillett, Cheryl, Brentnall, Adam, Violette, Sheila, Weinreb, Paul H., Kendrew, Jane, Barry, Simon T., Hart, I. R. (Ian R.), Jones, J. Louise, Marshall, John F., 2014. Therapeutic targeting of integrin avß6 in breast cancer. JNCI Journal of the National Cancer Institute, Volume 106 (Number 8), View
  • Assi, Valentina, Massat, Nathalie J., Thomas, Susan, MacKay, James, Warwick, Jane, Kataoka, Masako, Warsi, Iqbal, Brentnall, Adam, Warren, Ruth, Duffy, Stephen W., 2014. A case-control study to assess the impact of mammographic density on breast cancer risk in women aged 40-49 at intermediate familial risk. International Journal of Cancer, View
  • Warwick, Jane, Birke, Hanna, Stone, Jennifer, Warren, Ruth, Pinney, Elizabeth, Brentnall, Adam R., Duffy, Stephen W., Howell, Anthony, Cuzick, Jack, 2014. Mammographic breast density refines Tyrer-Cuzick estimates of breast cancer risk in high-risk women: findings from the placebo arm of the International Breast Cancer Intervention Study I. Breast Cancer Research, Volume 16 (Number 5), View
  • Ingham, S. L., Warwick, Jane, Byers, H., Lalloo, F., Newman, W. G., Evans, D.G. R., 2013. Is multiple SNP testing inBRCA2andBRCA1female carriers ready for use in clinical practice? Results from a large genetic centre in the UK. Clinical Genetics, Volume 84 (Number 1), pp. 37-42, View
  • Ingham, S. L., Warwick, Jane, Buchan, I., Sahin, S., O'Hara, C., Moran, A., Howell, A., Evans, D. G., 2013. Ovarian cancer among 8005 women from a breast cancer family history clinic: no increased risk of invasive ovarian cancer in families testing negative for BRCA1 and BRCA2. Journal of Medical Genetics, Volume 50 (Number 6), pp. 368-372, View
  • Warwick, Jane, Will, O., Allgood, P. C., Miller, R., Duffy, Stephen W., Greenberg, D., 2013. Variation in colorectal cancer treatment and survival : a cohort study covering the East Anglia region. Colorectal Disease, Volume 15 (Number 10), pp. 1243-1252, View
  • Evans, D. G. R., Warwick, Jane, Astley, S. M., Stavrinos, P., Sahin, S., Ingham, S., McBurney, H., Eckersley, B., Harvie, M., Wilson, M., Beetles, U., Warren, R. M. L., Hufton, A., Sergeant, J. C., Newman, W. G., Buchan, I., Cuzick, J., Howell, A., 2012. Assessing individual breast cancer risk within the U.K. national health service breast screening program : a new paradigm for cancer prevention. Cancer Prevention Research, Volume 5 (Number 7), pp. 943-951, View
  • Howell, A., Astley, S., Warwick, Jane, Stavrinos, P., Sahin, S., Ingham, S., McBurney, H., Eckersley, B., Harvie, M., Wilson, M., Beetles, U., Warren, R. M. L., Hufton, A., Sergeant, J., Newman, W., Buchan, I., Cuzick, J., Evans, D. G., 2012. Prevention of breast cancer in the context of a national breast screening programme. Journal of Internal Medicine, Volume 271 (Number 4), pp. 321-330, View
  • Assi, Valentina, Warwick, Jane, Cuzick, Jack, Duffy, Stephen W., 2012. Clinical and epidemiological issues in mammographic density. Nature Reviews Clinical Oncology, Volume 9 (Number 1), pp. 33-40, View
  • Britton, P., Warwick, Jane, Wallis, M. G., O'Keeffe, S., Taylor, K., Sinnatamby, R., Barter, S., Gaskarth, M., Duffy, Stephen W., Wishart, G. C., 2012. Measuring the accuracy of diagnostic imaging in symptomatic breast patients : team and individual performance. The British Journal of Radiology, Volume 85 (Number 1012), pp. 415-422, View
  • Clark, S. E., Warwick, Jane, Carpenter, R., Bowen, Rebecca, Duffy, Stephen W., Jones, J. Louise, 2011. Molecular subtyping of DCIS : heterogeneity of breast cancer reflected in pre-invasive disease. British Journal of Cancer, Volume 104 (Number 1), pp. 120-127, View
  • Wishart, G. C., Warwick, Jane, Pitsinis, V., Duffy, Stephen W., Britton, P. D., 2010. Measuring performance in clinical breast examination. British Journal of Surgery, Volume 97 (Number 8), pp. 1246-1252, View
  • Warwick, Jane, Vardaki, E., Fattizzi, N., McNeish, I., Jeyarajah, A., Oram, D., Hassan, L., Covens, A., Duffy, Stephen W., Reynolds, K., 2009. Defining the surgical management of suspected early-stage ovarian cancer by estimating patient numbers through alternative management strategies. BJOG: An International Journal of Obstetrics & Gynaecology, Volume 116 (Number 9), pp. 1225-1241, View
  • Cuzick, J., Warwick, Jane, Pinney, L., Warren, R., Cawthorn, S., Howell, A., Duffy, S., 2009. Change in breast density as a biomarker of breast cancer risk reduction; results from IBIS-1. Cancer Research, Volume 69 (Number 2), pp. 61-0, View
  • Warwick, Jane, Duffy, Stephen W., 2005. A review of cancer screening evaluation techniques, with some particular examples in breast cancer screening. Journal of the Royal Statistical Society: Series A (Statistics in Society), Volume 168 (Numb er 4), pp. 657-677, View
  • Cuzick, J., Warwick, Jane, Pinney, E., Warren, R. M. L., Duffy, S. W., 2004. Tamoxifen and breast density in women at increased risk of breast cancer. JNCI Journal of the National Cancer Institute, Volume 96 (Number 8), pp. 621-628, View
  • Warwick, Jane, Tabar, L., Vitak, B., Duffy, S. W., 2004. Long-term survival with breast cancer: evidence from the Swedish Two County Study (1977-98). American Journal of Oncology Review, Volume 3 (Number 7), pp. 376-383, View

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