Dr Philip McTernan

Job Title

Associate Professor (Reader)

Department

WMS - Translational Medicine

Phone

024 7696 8587

P.G.McTernan@warwick.ac.uk_FORMER

Research Interests

Obesity is on the increase worldwide and in the majority of cases this increase will lead to type 2 diabetes. At present, 50% of the UK population is overweight and this percentage is set to increase. Fat accumulation around the abdomen is associated with a higher risk of developing type 2 diabetes (late onset diabetes). Fat is also known to produce a number of factors that are thought to increase this risk. Our team works on several of these factors to examine how they impact on the progression of the disease and its complications, such as hypertension and the risk of heart disease. We perform both clinical and laboratory patient based studies assessing the effects of risk factors on fat, as well as the role of drug treatment on reducing pathogenic factors produced by fat. As such, by researching the processes involved in the increase of the associated risk factors, our studies aim to provide a deeper understanding of how present drug therapy works in the body. In addition, our studies also evaluate novel drug therapeutic agents for future treatment of obesity and type 2 diabetes. Current Research Aspects: The multidisciplinary team consists of 5 basic scientist PhD students, 6 clinical Research Fellows, 4 Postdoctoral research fellows, a Research Council Fellow, Visiting fellows, as well as cross clinical specialists and academic departments (Biology, Chemistry Maths, and Systems Biology). The following highlights key research areas: 1) Sub-clinical inflammation in pre- and post- diabetes 2) Obesity mediated hypertension 3) Appetite Control & its dysregulation in obesity 4) Ectopic fat Research 5) Premature ageing in diabetes. 6) Neuropeptides & Adipose tissue 7) Mitochondria, obesity & Diabetes 8) Adipocytokines 9) The 'Gut-Fat-Brain' Axis

Biography

As a Reader within the Diabetes and Metabolism team based on the University Hospital Coventry and Warwickshire Site within the Clinical Science Research Laboratories my main interest involves understanding causes for type 2 diabetes and potential therapeutic targets. The main aim of the team is to develop translational multidisciplinary medical research into obesity and type 2 diabetes. The current research programmes are exploring the underlying mechanisms that lead to the pathogenesis of obesity mediated type 2 diabetes. As such we have researchers within the team focussed on human metabolism examining several aspects such as: the importance of adipokines on human adipocyte signalling, mediators and mechanisms of inflammation, understanding the importance of diet and cell signalling in response to metabolic endotoxinaemia, the role of ectopic fat in the liver and heart, as well as using mathematical modelling of human adipocyte systems.

Jackisch, Laura, Kumsaiyai, W., Moore, Jonathan D., Al-Daghri, N. M., Kyrou, Ioannis, Barber, T. M., Randeva, Harpal S., Kumar, Sudhesh, Tripathi, Gyanendra, McTernan, P. G., 2018. Differential expression of Lp-PLA2 in obesity, type 2 diabetes and the influence of lipids. Diabetologia, 61, pp. 1155-1166
Reddy, Narendra Lakshmana, Peng, C., Carreira, C., Halder, L., Hattersley, John G., Piya, Milan K., Tripathi, Gyanendra, Randeva, Harpal S., Casanueva, F. F, McTernan, P. G., Kumar, Sudhesh, Barber, T. M., 2015. Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly. Clinical Endocrinology, 82 (6), pp. 831-837
Bradnova, Olga, Kyrou, Ioannis, Hainer, Vojtech, Vcelak, Josef, Halkova, Tereza, Sramkova, Petra, Dolezalova, Karin, Fried, Martin, McTernan, P. G. (Philip G.), Kumar, Sudhesh, Hill, Martin, Kunesova, Marie, Bendlova, Bela, Vrbikova, Jana, 2013. Laparoscopic greater curvature plication in morbidly obese women with type 2 diabetes : effects on glucose homeostasis, postprandial triglyceridemia and selected gut hormones. Obesity Surgery, 24 (5), pp. 718-726
Alokail, Majed S., Sabico, Shaun, Al-Saleh, Yousef, Al-Daghri, Nasser M., Alkharfy, Khalid M., Vanhoutte, Paul M., McTernan, P. G. (Philip G.), 2013. Effects of probiotics in patients with diabetes mellitus type 2 : study protocol for a randomized, double-blind, placebo-controlled trial. Trials, 14 (1)
Harte, A. L., Tripathi, G. N., Piya, Milan K., Barber, Thomas, Clapham, J. C., Al-Daghari, N., Al-Disi, Dara, Kumsaiyai, Warunee, Saravanan, Ponnusamy, Fowler, Anne E., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G., 2013. NFêB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status and TNFá. Obesity, 21 (11), pp. 2322-2330
Chan, Winnie M. F., Bosch, Jos A., Jones, David, Kaur, Okdeep, Inston, N., Moore, S., McLean, A., McTernan, P. G., Harper, L., Phillips, Anna C., Borrows, Richard, 2013. Predictors and consequences of fatigue in prevalent kidney transplant recipients. Transplantation, 96 (11), pp. 987-994
Harte, A. L. (Alison L.), McTernan, P. G. (Philip G.), 2013. Response to comment on : Harte et al. High fat intake leads to acute postprandial exposure to circulating endotoxin in Type 2 diabetic subjects. Diabetes Care 2012;35:375-382. Diabetes Care, 36 (3), pp. e43-e43
Saboor Aftab, S. A., Reddy, Narendra Lakshmana, Owen, N. L., Pollitt, R., Harte, A. L., McTernan, P. G., Tripathi, Gyanendra, Barber, T. M., 2013. Identification of a novel heterozygous mutation in exon 50 of the COL1A1 gene manifesting clinically as osteogenesis imperfecta. Endocrinology, Diabetes & Metabolism Case Reports
Chan, W., G. Ward, Douglas, McClean, Andrew, A. Bosch, Jos, Jones, David, Kaur, Okdeed, Drayson, Mark, Whitelegg, Alison, Iqbal, Tariq, McTernan, P. G. (Philip G.), Tselepis, Chris, Borrows, Richard, 2013. The role of hepcidin-25 in kidney transplantation. Transplantation Journal, 95 (11), pp. 1390-1395
Al-Daghri, Nasser M., Al-Attas, Omar S., Bindahman, Lotfi S., Alokail, Majed S., Alkharfy, Khalid M., Draz, Hossam M., Yakout, Sobhy M., McTernan, P. G. (Philip G.), Sabico, Shaun, Chrousos, George P., 2012. Soluble CD163 is associated with body mass index and blood pressure in hypertensive obese Saudi patients. European Journal of Clinical Investigation, Vol.42 (No.11), pp. 1221-1226
Anveden, Åsa, Sjoholm, Kajsa, Jacobson, Peter, Palsdottir, Vilborg, Walley, Andrew, Froguel, Philippe, Al-Daghri, Nasser M., McTernan, P. G. (Philip G.), Mejhert, Niklas, Arner, Peter, Sjostrom, Lars, Carlsson, Lena M. S., Svensson, Per-Arne, 2012. ITIH-5 Expression in human adipose tissue is increased in obesity. Obesity, Vol.20 (No.4), pp. 708-714
Al-Daghri, Nasser M., Bindahman, Lotfi S., Al-Attas, Omar S., Saleem, Tahia H., Alokail, Majed S., Alkharfy, Khalid M., Draz, Hossam M., Yakout, Sobhy M., Mohamed, Amany O., Harte, Alison L., McTernan, P. G. (Philip G.), 2012. Increased circulating ANG II and TNF-a represents important risk factors in obese Saudi adults with hypertension irrespective of diabetic status and BMI. PLoS One, Vol.7 (No.12)
Al-Attas, Omar S., Al-Daghri, Nasser M., Alokail, Majed S., Alkharfy, Khalid M., Alfadda, Assim, McTernan, P. G. (Philip G.), Gibson, Greg, Sabico, Shaun, Chrousos, George P., 2012. Circulating leukocyte telomere length is highly heritable among families of Arab descent. BMC Medical Genetics, Vol.13 (No.1)
Sung, E. Z. H., Silva, N. F., Goodyear, S. J., McTernan, P. G. (Philip G.), Arasaradnam, Ramesh P., Nwokolo, Chuka U., 2011. Ghrelin promotes nuclear factor kappa-B activation in a human B-lymphocyte cell line. Molecular Biology Reports, Vol.38 (No.8), pp. 4833-4838
Chittari, Madhu Varma, McTernan, P. G. (Philip G.), Bawazeer, Nahla M., Constantinides, K., Ciotola, M., O'Hare, J. Paul, Kumar, Sudhesh, Ceriello, Antonio, 2011. Impact of acute hyperglycaemia on endothelial function and retinal vascular reactivity in patients with Type 2 diabetes. Diabetic Medicine, 28 (4), pp. 450-454
Harte, A. L., da Silva, Nancy F., Creely, Steven J., McGee, K. C., Billyard, Thomas, Youssef-Elabd, Elham M., Tripathi, Gyanendra, Ashour, Esmat, Abdalla, Mohga S., Sharada, Hayat M., Amin, Ashraf I., Burt, Alastair D., Kumar, Sudhesh, Day, Christopher Paul, McTernan, P. G., 2010. Elevated endotoxin levels in non-alcoholic fatty liver disease. Journal of Inflammation, Vol.7
Goodyear, Stephen J., Mottershead, Marcus, Sung, E. Z. H., Wong, Ling S., McTernan, P. G. (Philip G.), Kumar, Sudhesh, Nwokolo, Chuka U., 2010. Dysregulation of plasma ghrelin in alcoholic cirrhosis. Clinical Endocrinology, Vol.73 (No.3), pp. 323-329
Al-Attas, Omar S., Al-Daghri, Nasser M., Bamakhramah, A., Sabico, Shaun, McTernan, P. G. (Philip G.), Huang, T. T-K, 2010. Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth. Acta Paediatrica, Vol.99 (No.6), pp. 896-899
Hill, M. J., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2009. Adipokines and the clinical laboratory : what to measure, when and how?. Journal of Clinical Pathology, Vol.62 (No.3), pp. 206-211
Kos, K., Harte, A. L., O'Hare, J. Paul, Kumar, S., McTernan, P. G. (Philip G.), 2009. Ghrelin and the differential regulation of des-acyl (DSG) and oct-anoyl ghrelin (OTG) in human adipose tissue (AT). Clinical Endocrinology, Vol.70 (No.3), pp. 383-389
Saiki, Atsuhito, Olsson, Maja, Jernas, Margareta, Gummesson, Anders, McTernan, P. G. (Philip G.), Andersson, Johanna, Jacobson, Peter, Sjoholm, Kajsa, Olsson, Bob, Yamamura, Shigeo, Walley, Andrew, Froguel, Philippe, Carlsson, Bjorn, Sjostrom, Lars, Svensson, Per-Arne, Carlsson, Lena M. S., 2009. Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. Journal of Clinical Endocrinology & Metabolism, Vol.94 (No.10), pp. 3987-3994
Baker, Adam R., Harte, A. L. (Alison L.), Howell, N., Pritlove, D. C., Ranasinghe, A. M., da Silva, N. F., Youssef, E. M., Khunti, Kamlesh, Davies, M. J., Bonser, R. S., Kumar, Sudhesh, Pagano, D., McTernan, P. G. (Philip G.), 2009. Epicardial adipose tissue as a source of nuclear factor-kappa B and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease. Journal of Clinical Endocrinology & Metabolism, Vol.94 (No.1), pp. 261-267
Jernas, Margareta, Olsson, Bob, Arner, Peter, Jacobson, Peter, Sjostrom, Lars, Walley, Andrew, Froguel, Philippe, McTernan, P. G. (Philip G.), Hoffstedt, Johan, Carlsson, Lena M. S., 2009. Regulation of carboxylesterase 1 (CES1) in human adipose tissue. Biochemical and Biophysical Research Communications, Vol.383 (No.1), pp. 63-67
Al-Attas, Omar S., Al-Daghri, Nasser M., Al-Rubeaan, Khalid, da Silva, Nancy F., Sabico, Shaun, Kumar, Sudhesh, McTernan, P. G. (Philip G.), Harte, A. L. (Alison L.), 2009. Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies. Cardiovascular Diabetology, Vol.8 (No.20)
Boothby, Meg, McGee, K. C. (Kirsty Claire), Tomlinson, Jeremy W., Gathercole, Laura L., McTernan, P. G. (Philip G.), Shojaee-Moradie, Fariba, Umpleby, A. Margot, Nightingale, Peter, Shahmanesh, Mohsen, 2009. Adipocyte differentiation, mitochondrial gene expression and fat distribution : differences between zidovudine and tenofovir after 6 months. Antiviral Therapy, Vol.14 (No.8), pp. 1089-1100
Sung, E. Z. H., da Silva, N. F., Goodyear, S. J., McTernan, P. G. (Philip G.), Sanger, G. J., Nwokolo, Chuka U., 2009. Increased plasma ghrelin following infliximab in Crohn's disease. Alimentary Pharmacology and Therapeutic, Vol.29 (No.1), pp. 83-89
Dixon, A. N., Valsamakis, Georgios, Hanif, M. W., Field, A., Boutsiadis, A., Harte, A. L., McTernan, P. G., Barnett, A. H., Kumar, Sudhesh, 2008. Effect of the orlistat on serum endotoxin lipopolysaccharide and adipocytokines in South Asian individuals with impaired glucose tolerance. International Journal of Clinical Practice, 62 (7), pp. 1124-1129
Valsamakis, Georgios, Jones, A., Chetty, R., McTernan, P. G. (Philip G.), Boutsiadis, A., Barnett, A. H., Banerjee, A. K., Kumar, Sudhesh, 2008. MRI total sagittal abdominal diameter as a predictor of metabolic syndrome compared to visceral fat at L4-L5 level. Current Medical Research and Opinion, Vol.24 (No.7), pp. 1853-1860
Gupta, P., Harte, A., Sturdee, D. W., Sharma, A., Barnett, A. H., Kumar, S., McTernan, P. G. (Philip G.), 2008. Effects of menopausal status on circulating calcitonin gene-related peptide and adipokines : implications for insulin resistance and cardiovascular risks. Climacteric, Vol.11 (No.5), pp. 364-372
McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2007. RPB4 and pathogenesis of diabetes. Journal of Clinical Endocrinology & Metabolism, Vol.92 (No.7), pp. 2430-2432
Kusminski, C. M., McTernan, P. G. (Philip G.), Schraw, T., Kos, Katarina, O'Hare, J. Paul, Ahima, R., Kumar, Sudhesh, Scherer, P. E., 2007. Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. Diabetologia, Vol.50 (No.3), pp. 634-642
McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2007. Retinol binding protein 4 and pathogenesis of diabetes. The Journal of Clinical Endocrinology & Metabolism, 92 (7), pp. 2430-2432
Gupta, Pratima, Harte, Alison L., da Silva, Nancy F., Khan, Hassan, Barnett, Anthony H., Kumar, Sudhesh, Sturdee, David W., McTernan, P. G. (Philip G.), 2007. Expression of calcitonin gene-related peptide, adrenomedullin, and receptor modifying proteins in human adipose tissue and alteration in their expression with menopause status. Menopause, 14 (6), pp. 1031-1038
Palin, S. L., McTernan, P. G., McGee, K. C., Sturdee, D. W., Barnett, A. H., Kumar, Sudhesh, 2007. Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones-sensitive lipase in human subcutaneous abdominal adipocytes. Diabetes, Obesity and Metabolism, Vol.9 (No.4), pp. 585-590
Kusminski, C. M., Fernandez da Silva, Nancy, Creely, Steven J., Fisher, Ffolliott M., Harte, A. L. (Alison L.), Baker, Adam R., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2007. The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes. Journal of Clinical Endocrinology & Metabolism, Vol.92 (No.1), pp. 270-276
Gilardini, Luisa, McTernan, P. G. (Philip G.), Girola, Andrea, da Silva, Nancy F., Alberti, Luisella, Kumar, Sudhesh, Invitti, Cecilia, 2006. Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis, 189 (2), pp. 401-407
Creely, Steven J., McTernan, P. G. (Philip G.), Kusminski, C. M., Fisher, Ffolliott M., Fernandez da Silva, Nancy, Khanolkar, M., Evans, M., Harte, A. L. (Alison L.), Kumar, Sudhesh, 2006. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. American Journal of Endocrinology and Metabolism, Vol.297 (No.3), pp. 740-747
McTernan, P. G. (Philip G.), Kusminski, Christine M., Kumar, Sudhesh, 2006. Resistin. Current Opinion in Lipidology, 17 (2), pp. 170-175
Baker, Adam R., Fernandez da Silva, Nancy, Quinn, David W., Harte, A. L. (Alison L.), Pagano, Domenico, Bonser, Robert S., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2006. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovascular Diabetology, Vol.5 (No.1)
Wasim, Hanif, Al-Daghri, Nasser M., Chetty, Raja, McTernan, P. G., Barnett, A. H., Kumar, Sudhesh, 2006. Relationship of serum adiponectin and resistin to glucose intolerance and fat topography in south-Asians. Cardiovascular Diabetology, Vol.5 (No.10)
McTernan, P. G. (Philip G.), Kusminski, Christine M., Kumar, Sudhesh, 2005. Role of resistin in obesity, insulin resistance and Type II diabetes. Clinical Science, 109 (3), pp. 243-256
Al-Daghri, Nasser M., Chetty, R., McTernan, P. G. (Philip G.), Al-Rubean , K., Al-Attas, Omar S., Jones, A. F., Kumar, Sudhesh, 2005. Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population. Cardiovascular Diabetology, Vol.4 (No.10)
Fisher, Ffolliott M., Trujillo, M. E., Hanif, W., Barnett, A. H., McTernan, P. G. (Philip G.), Scherer, P. E., Kumar, Sudhesh, 2005. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia, 48 (6), pp. 1084-1087
Harte, A. L. (Alison L.), McTernan, P. G. (Philip G.), Chetty, Rajkumar, Coppack, Simon, Katz, Jonathan, Smith, Stephen, Kumar, Sudhesh, 2005. Insulin mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by Rosiglitazone. Circulation, Vol.111, pp. 1654-1961
Valsamakis, Georgios, Anwar, A., Tomlinson, J. W., Shackleton, C. H. L., McTernan, P. G. (Philip G.), Chetty, R., Wood, P. J., Banerjee, A. K., Holder, G., Barnett, A. H., Stewart, P. M., Kumar, Sudhesh, 2004. 11ß-Hydroxysteroid dehydrogenase Type 1 activity in lean and obese males with Type 2 diabetes mellitus. The Journal of Clinical Endocrinology & Metabolism, 89 (9), pp. 4755-4761
Valsamakis, Georgios, McTernan, P. G. (Philip G.), Chetty, R., Al-Daghri, Nasser M., Field, A., Hanif, W., Barnett, A. H., Kumar, Sudhesh, 2004. Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines. Metabolism, 53 (4), pp. 430-434
Valsamakis, Georgios, Chetty, R., McTernan, P. G. (Philip G.), Al-Daghri, Nasser M., Barnett, A. H., Kumar, Sudhesh, 2003. Fasting serum adiponectin concentration is reduced in Indo-Asian subjects and is related to HDL cholesterol. Diabetes, Obesity and Metabolism, 5 (2), pp. 131-135
McTernan, P. G. (Philip G.), Fisher, Ffolliott M., Valsamakis, Georgios, Chetty, Rajkumar, Harte, Alison L., McTernan, Claire L., Clark, Penny, Smith, Stephen A., Barnett, Anthony H., Kumar, Sudhesh, 2003. Resistin and type 2 diabetes : regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes. Journal of Clinical Endocrinology & Metabolism, 88 (12), pp. 6098-6106
Palin, S. L., McTernan, P. G. (Philip G.), Anderson, L. A., Sturdee, D. W., Barnett, A. H., Kumar, Sudhesh, 2003. 17ß-estradiol and anti-estrogen ICI :compound 182,780 regulate expression of lipoprotein lipase and hormone-sensitive lipase in isolated subcutaneous abdominal adipocytes. Metabolism, 52 (4), pp. 383-388
McTernan, P. G. (Philip G.), McTernan, Claire L., Chetty, Rajkumar, Jenner, Keely, Fisher, Ffolliott M., Lauer, Michelle N., Crocker, John, Barnett, Anthony H., Kumar, Sudhesh, 2002. Increased resistin gene and protein expression in human abdominal adipose tissue. Journal of Clinical Endocrinology and Metabolism, 87 (5), pp. 2407-2410
McTernan, P. G. (Philip G.), Harte, A. L., Anderson, L. A., Green, A., Smith, S. A., Holder, J. C., Barnett, A. H., Eggo, M. C., Kumar, Sudhesh, 2002. Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro. Diabetes, 51 (5), pp. 1493-1498
McTernan, P. G. (Philip G.), Anderson, Leah A., Anwar, Aresh J., Eggo, Margaret C., Crocker, John, Barnett, Anthony H., Stewart, Paul M., Kumar, Sudhesh, 2002. Glucocorticoid regulation of P450 aromatase activity in human adipose tissue : gender and site differences. Journal of Clinical Endocrinology and Metabolism, 4 (3), pp. 209-213
Fisher, F. M., McTernan, P. G. (Philip G.), Valsamakis, Georgios, Chetty, R., Harte, A. L., Anwar, A. J., Starcynski, J., Crocker, J., Barnett, A. H., McTernan, Claire L., Kumar, Sudhesh, 2002. Differences in adiponectin protein expression : effect of fat depots and Type 2 diabetic status. Hormone and Metabolic Research, 34 (11/12), pp. 650-654
McTernan, Claire L., McTernan, P. G. (Philip G.), Harte, A. L. (Alison L.), Levick, P. L., Barnett, A. H., Kumar, Sudhesh, 2002. Resistin, central obesity, and type 2 diabetes. The Lancet, 359 (9300), pp. 46-47
Anderson, L. A., McTernan, P. G. (Philip G.), Harte, A. L, Barnett, A. H., Kumar, Sudhesh, 2002. The regulation of HSL and LPL expression by DHT and flutamide in human subcutaneous adipose tissue. Diabetes, Obesity and Metabolism, 4 (3), pp. 209-213
Anwar, A., McTernan, P. G. (Philip G.), Anderson, L. A., Askaa, J., Moody, C. G., Barnett, A. H., Eggo, M. C., Kumar, Sudhesh, 2001. Site-specific regulation of oestrogen receptor-a and -ß by oestradiol in human adipose tissue. Diabetes, Obesity and Metabolism, 3 (5), pp. 338-349
Anderson, Leah A., McTernan, P. G. (Philip G.), Barnett, Anthony H., Kumar, Sudhesh, 2001. The effects of androgens and estrogens on preadipocyte proliferation in human adipose tissue : influence of gender and site. Journal of Clinical Endocrinology and Metabolism, 86 (10), pp. 5045-5051

McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2004. The link between obesity and diabetes. Barnett, A. H.; 1951- ;, (Anthony H.); Kumar, Sudhesh (eds.), Obesity and diabetes, Chichester, West Sussex, England ; Hoboken, NJ, Wiley-Blackwell Publishing Ltd

Shahmanesh, M., Das, S. (Satyajit), Boothby, M., McGee, K. C. (Kirsty Claire), Gathercole, L. L., Harte, A. L. (Alison L.), Higgins, P., Kusminski, C. M., McTernan, P. G. (Philip G.), Ross, Joshua V., Tomlinson, J. W., 2010. Complications of HIV disease or treatment. Second Joint Conference of the British HIV Association and the British Association for Sexual Health and HIV, Manchester, UK, April 20-23l 2010, Published in HIV Medicine, pp. 10-10
Al-Attas, Omar S., Al-Daghri, Nasser M., Alokail, Majed S., Bamakhramah, Ahmed, Sabico, Shaun, Huang, Terry, McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2010. Telomere length and childhood obesity among Arab youth. 14th International Congress of Endocrinology, Kyoto, Japan, March 26-30, 2010, Published in Endocrine Journal, pp. S619-S619
Gathercole, L. L., Tomlinson, J. W., Boothby, M., McGee, K. C. (Kirsty Claire), Harre, A. L., McTernan, P. G. (Philip G.), Das, S., Shahmanesh, M., 2009. Changes in the adipocyte (lipid and glucose metabolism) gene expression following 18-24 months treatment with ZDV or TDF-containing ART; and adipocyte mitochondrial gene expression. 11th International Workshop on AdverseDrug Reactions and Co-Morbidities in HIV, Philadelphia, PA, October 26-28, 2009, Published in Antiviral Therapy, pp. A9-A10
McGee, K. C. (Kirsty Claire), Boothby, M., Tomlinson, J. W., Gathercole, L. L., Harte, A. L. (Alison L.), McTernan, P. G. (Philip G.), Das, S., Shahmanesh, M., 2009. Adipocyte mitochondrial gene expression following 18-24 months treatment with zidovidine or tenofovir-containing antiretroviral therapy. 11th International Workshop on Adverse Drug Reactions and Co-Morbidities in HIV, Philadelphia, PA, October 26-28, 2009, Published in Antiviral Therapy, pp. A10-A10
Harte, A. L. (Alison L.), Youssef, E. M., Wahba, E. A., Hussen, A. A., Cerellio, A., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2009. Hyperlipidaemic conditions induce 'metabolic memory' within human abdominal subcutaneous adipose tissue and isolated adipocytes, in vivo. 45th General Assembly of the European Association for the Study of Diabetes, Vienna, Austria, September 30-October 02, 2009, Published in Diabetologia, pp. S278-S279
McGee, K. C. (Kirsty Claire), Harte, A. L. (Alison L.), Hill, M. J., Burt, A. D., Kumar, Sudhesh, Day, C. P., McTernan, P. G. (Philip G.), 2009. Circulating visfatin levels reduced in patients with non-alcoholic fatty liver disease irrespective of type 2 diabetes mellitus status. 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, AUSTRIA, September 30-OCT 02, 2009, Published in Diabetologia, pp. S20-S21
Harte, A. L. (Alison L.), Youssef, E. M., Abdalla, M. S., Sharada, H. M., Ashour, E., Amin, A. I., Cerellio, A., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2009. Hyperlipidaemic conditions induce 'metabolic memory' within human abdominal subcutaneous adipose tissue and isolated adipocytes, in vitro. International Journal of Molecular Medicine, pp. S51-S51
Radford, C. R., Schisano, B., McTernan, P. G. (Philip G.), Ceriello, Antonio, 2008. The impact of oscillating glucose and the metabolic memory effect on oxidative stress in human endothelial cells. 43rd Annual Meeting of the European Association for the Study of Diabetes, Amsterdam, Netherlands, Sep 18-21, 2007, Published in Diabetologia, pp. S29-S30
Harte, A. L., Hill, M. J., da Silva, N. F., McGee, K. C., Baker, Adam R., Clapham, J. C., Kumar, Sudhesh, McTernan, P. G., 2008. Depot specific activity of the 15-lipoxygenase pathway in adipose tissue : the inflammatory response and metabolic disease. 44th Annual Meeting of the European Association for the Study of Diabetes, Rome, Italy, 7 - 11 September 2008, Published in Diabetologia, pp. S329-S329
McGee, K. C. (Kirsty Claire), Harte, A. L. (Alison L.), Hill, M., Boothby, M., Tomlinson, J., Gathercole, L. L., Kumar, Sudhesh, Shahmanesh, Mohsen, McTernan, P. G. (Philip G.), 2008. The differential impact of antiretroviral (ARV) therapies on mitochondrial and lipid metabolism genes in human adipose tissue. 44th Annual Meeting of the European Association for the Study of Diabetes, Rome, Italy, 7 - 11 September 2008, Published in Diabetologia, pp. S304-S305
Schisano, B., Radford, C. R., Harte, A. L. (Alison L.), McGee, K. C. (Kirsty Claire), McTernan, P. G. (Philip G.), Ceriello, Antonio, 2008. Effects of hyperglycaemia on Nrf2 and p53 antioxidant transcriptional activity in HUVECS. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, Sep 18-21, 2007, Published in Diabetologia, pp. S94-S94
McGee, K. C. (Kirsty Claire), Da Silva, N. E., Harte, A. L. (Alison L.), Creely, S. J., Hill, M. J., Khanolkar, M., Evans, M., Chittari, M. V., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2007. Visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by NF-kappa B and JNK in human abdominal subcutaneous adipocytes. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, 18-21 Sep 2007, Published in Diabetologia, pp. S58-S59
Harte, A. L. (Alison L.), Al-Daghri, Nasser M., Al-Rubeaan, Khalid, Al-Attas, Omar S., da Silva, N. F., Sabico, Shaun, Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2007. Rosiglitazone as a therapeutic agent to reduce inflammatory risk in type 2 diabetic patients. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, September 18-21, 2007, Published in Diabetologia, pp. S272-S273
Boothby, M., Tomlinson, J. W., McGee, K. C. (Kirsty Claire), Das, S., Gathercole, L. L., Harte, A. L. (Alison L.), Higgins, P., Kusminski, C. M., McTernan, P. G. (Philip G.), Shahmanesh, M., 2007. The effect of antiretroviral therapy on genes involved with mitochondrial function. 9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, Sydney, Australia, 19-21 Jul 2007, Published in Antiviral Therapy, pp. L23-L23
Kos, Katarina, Baker, A., Harte, A. L. (Alison L.), O'Hare, J. P., McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2007. DPP IV in human adipose tissue may regulate adipose tissue mass through modulation of NPY. Diabetes UK Annual Professional Conference, Scottish Exhibition and Conference Centre, Glasgow, UK, 14-16 March 2007, Published in Diabetic Medicine, pp. 35-35
Kusminski, C. M., da Silva, N. F., Fowler, A. E., Creely, S. J., Harte, A. L. (Alison L.), Baker, A. R., Billyard, T. S., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2007. The effects adiposity, diabetic status and depot-specificity on the activation of NFKB on JNK in human abdominal adipose tissue. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, September 18-21, 2007, Published in Diabetologia, pp. S69-S69
Boothby, M., Tomlinson, J. W., McGee, K. C. (Kirsty Claire), Das, S., Gathercole, L. L., Harte, A. L. (Alison L.), Higgins, P., Kusminski, C. M., McTernan, P. G. (Philip G.), Shahmanesh, M., 2007. The effect of antiretroviral therapy on genes involved with glucose and lipid metabolism. 9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, Sydney, Australia, 19-21 Jul 2007, Published in Antiviral Therapy, pp. L12-L13
da Silva, N. F., Harte, A. L. (Alison L.), Hill, M. J., Billyard, T. S., Kumar, Sudhesh, Day, C. P., McTernan, P. G. (Philip G.), 2007. Long-term orlistat treatment reduces endotoxinaemia in fatty liver disease patients. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, September 18-21, 2007, Published in Diabetologia, pp. S296-S297
Kos, Katarina, Baker, A. R., Harte, A. L. (Alison L.), O'Hare, J. Paul, McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2007. DPP-IV inhibitors influence fat metabolism through modulation of NPY's paracrine antilipolytic action in adipose tissue. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, September 18-21, 2007, Published in Diabetologia, pp. S51-S51
Kusminski, C. M., Creely, S. J., da Silva, N. F., Harte, A. L. (Alison L.), Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2006. The in vitro effects of JNK of NF-kappa B inhibitor on resistin secretion from isolated human abdominal subcutaneous adipocytes. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen, Denmark, 14-17 Sep 2006, Published in Diabetologia, pp. 79-80
Harte, A. L. (Alison L.), Kusminski, C. M., Hill, M. J., Gilardini, L., Girola, A., Da Silva, N. F., Alberti, L., Invitti, C., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2006. LPS as a mediator of sub-clinical inflammation in obese children and its' association with vascular injury and atherogenesis biomarkers. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen, Denmark, 14-17 Sep 2006, Published in Diabetologia, pp. 692-693
Creely, S. J., Fisher, F. M., Harte, A. L. (Alison L.), McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2006. Sub-clinical inflammation in T2DM : the role of Toll like receptors in the activation of NF kappa B and cJun Kinase in the innate immune pathway in human abdominal isolated adipocytes and explants. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen, Denmark, 14-17 Sep 2006, Published in Diabetologia
McGee, K. C. (Kirsty Claire), Harte, A. L. (Alison L.), da Silva, N. F., Chittari, M. V., Khanolkar, M., Creely, S. J., Evans, M., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2006. The role of visfatin in type 2 diabetes meltitus : the in vivo and in vitro effects of rosiglitazone, TNF alpha and IL-6 on visfatin expression in human abdominal subcutaneous adipocytes. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen, Denmark, 14-17 Sep 2006, Published in Diabetologia, pp. 423-424
Day, Chris P., Leathart, Julian B., McTernan, P. G. (Philip G.), Mathew, Christopher, Daly, Ann K., 2006. Genetic evidence for a role for gut flora in the pathogenesis of NASH in humans. 57th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Boston, MA, OCT 27-31, 2006, Published in HEPATOLOGY, pp. 261A-261A
Baker, A. R., Ranasinghe, A., Howei, N., Pagano, D., Bonser, R., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2006. Inflammation in epicardial adipose tissue: comparison of inflammatory mechanisms for production of adipocytokines in human epicardial and gluteo-femoral adipose tissue in CABG patients. 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Copenhagen, Denmark; Malmoe, Sweden, Sep 14-17, 2006, Published in Diabetologia, pp. 54-55

Billyard, Tom, McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2007. Potential therapies based on antidiabetic peptides. Best Practice & Research Clinical Endocrinology & Metabolism, Bailliere Tindall, pp. 641-655
McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2007. Editorial: retinol binding protein 4 and pathogenesis of diabetes. Journal of Clinical Endocrinology & Metabolism, Endocrine Society, pp. 2430-2432

Title	Funder	Award start	Award end
Freeze dried broccoli as a dietary intervention to reduce cardiometabolic risk in post-partum GDM women.	Novo Nordisk UK Research Foundation	01 Nov 2016	31 Jan 2020
A randomised control trial of the effect of weight loss in patients with and without type 2 diabetes following a 2 week low calorie diet and sleeve gatrectomy on inflammation and metabolic health	Royal Embassy of Saudi Arabia Cultural Bureau London	02 Feb 2016	31 Jan 2020
The role of vitamin D deficiency in pregnant women and its association with gestational diabetes mellitus and impact on inflammation	King Saud University	30 Sept 2013	30 Sept 2017
Together driving 360 wellbeing Phase 1: A high level review of employee health risks, and associated business impact.	Jaguar Land Rover	01 Feb 2017	31 Aug 2017
The origins of inflammation in human adipocytes	King Saud University	01 Oct 2011	30 Sept 2015
King Saudi University Grant	King Saud University	01 Oct 2010	30 Sept 2014
Investigation of dietary fats and Gut derived endotoxin as post-prandial triggers of systemic chronic low grade inflammation and ER stress	Office of Educational Affairs, The Royal Thai Embassy	01 Oct 2010	30 Sept 2014
Philanthropic donation for diabetes research (The role of LP-PLA2 in inflammation )	Anonymous	18 Apr 2011	17 Apr 2013
Matched funding for philanthropic donation for diabetes research (The role of LP-PLA2 in inflammation )	Higher Education Funding Council for England	18 Apr 2011	17 Apr 2013
Role and regulation of inducible nitric oxide synthase (iNOS or NOS2) in diabetes	AstraZeneca	01 Feb 2011	31 Jan 2012
Novo Nordisk Continuation	Novo Nordisk A/S	01 Mar 2010	30 Sept 2010
Metabolic endotoxinaemia and inflammation in the pathogenesis of obesity associated diabetes	AstraZeneca UK Limited	01 Oct 2008	30 Sept 2010
Regulation of RAS by insulin and TNFa in human adipocytes	British Heart Foundation	01 Oct 2007	30 Sept 2010
Investigating Liraglutide as an Antioxidant and its Beneficial Effects to Type 2 Diabetic Patients	Novo Nordisk A/S	01 Dec 2008	30 Nov 2009
The molecular mechanisms and potential therapeutic treatment for obesity associated cardiovascular disease, hypertension and inflammation	British Medical Association	01 Sept 2006	31 Aug 2008
Insulin resistance, adverse metabolic profile and premature ageing in type 2 diabetic patients.	The Novo Nordisk UK Research Foundation	01 Jun 2006	31 May 2008
Extension to Clinical Fellow in Gastro-enterology	University Hospitals Coventry and Warwickshire NHS Trust	08 May 2007	07 May 2008
Albert Renold Fellowship - Dr Ioannis Kyrou, Travel Grant	European Foundation for the Study of Diabetes (EFSD)	01 Oct 2007	31 Dec 2007
Adiponectin as a Peripheral and central Metabolic Adipocytokine in Regulating Energy Homeostasis Dysregulated by Obesity and Diabetes	Medical Research Fund of Warwick	01 Nov 2005	31 Oct 2007
Conference Travel Grant : The First Varna Nutrigenomics Meeting (ISAA)	Royal Society	18 Oct 2007	21 Oct 2007
Prospective nested case-control study to evaluate sub-clinical inflammatory biomarkers as predictors of diabetes and other cardiovascular risk in the Whitehall II population	The Harold Hyam Wingate Foundation	01 Apr 2006	30 Sept 2007
Assessing Premature Ageing and Metabolic Profile Invasion Type 2 Diabetic Patients.	Eli Lilly and Co Limited	01 Apr 2006	31 Mar 2007
The potential pathophysical effects of excess adiopose tissue on various systems in human obesity and type 2 diabetes.	AstraZeneca	01 Jun 2005	31 Dec 2006
Defining the Molecular Mechanisms for Obesity Associated Hypertension and Inflammatory Disease Leading to Cardiovascular Pathology	British Medical Association	01 Aug 2005	31 May 2006
Adiponectin in higher molecular structures in human cerebrospinal fluid: effect of obesity and Type 2 diabetes	European Federation of Diabetes Studies (EFDS)	01 Oct 2005	31 Dec 2005
Investigation of Lipid Metabolism in Cardiovascular Disease	Wellcome Trust	04 Jul 2005	26 Aug 2005
The Role of Adipocytokines in the Pathogenesis of non-alcoholic steatohepatitis in obesity and type 2 diabetes	Eli Lilly and Co Limited	01 Apr 2004	31 Mar 2005
Kirsty McGee - Vacation Studentship - Determining Severe Insulin Resistance Syndromes in Patients with Metabolic Syndrome	Wellcome Trust	07 Jul 2004	01 Sept 2004