Obesity is on the increase worldwide and in the majority of cases this increase will lead to type 2 diabetes. At present, 50% of the UK population is overweight and this percentage is set to increase. Fat accumulation around the abdomen is associated with a higher risk of developing type 2 diabetes (late onset diabetes). Fat is also known to produce a number of factors that are thought to increase this risk. Our team works on several of these factors to examine how they impact on the progression of the disease and its complications, such as hypertension and the risk of heart disease. We perform both clinical and laboratory patient based studies assessing the effects of risk factors on fat, as well as the role of drug treatment on reducing pathogenic factors produced by fat. As such, by researching the processes involved in the increase of the associated risk factors, our studies aim to provide a deeper understanding of how present drug therapy works in the body. In addition, our studies also evaluate novel drug therapeutic agents for future treatment of obesity and type 2 diabetes. Current Research Aspects: The multidisciplinary team consists of 5 basic scientist PhD students, 6 clinical Research Fellows, 4 Postdoctoral research fellows, a Research Council Fellow, Visiting fellows, as well as cross clinical specialists and academic departments (Biology, Chemistry Maths, and Systems Biology). The following highlights key research areas: 1) Sub-clinical inflammation in pre- and post- diabetes 2) Obesity mediated hypertension 3) Appetite Control & its dysregulation in obesity 4) Ectopic fat Research 5) Premature ageing in diabetes. 6) Neuropeptides & Adipose tissue 7) Mitochondria, obesity & Diabetes 8) Adipocytokines 9) The 'Gut-Fat-Brain' Axis
As a Reader within the Diabetes and Metabolism team based on the University Hospital Coventry and Warwickshire Site within the Clinical Science Research Laboratories my main interest involves understanding causes for type 2 diabetes and potential therapeutic targets. The main aim of the team is to develop translational multidisciplinary medical research into obesity and type 2 diabetes. The current research programmes are exploring the underlying mechanisms that lead to the pathogenesis of obesity mediated type 2 diabetes. As such we have researchers within the team focussed on human metabolism examining several aspects such as: the importance of adipokines on human adipocyte signalling, mediators and mechanisms of inflammation, understanding the importance of diet and cell signalling in response to metabolic endotoxinaemia, the role of ectopic fat in the liver and heart, as well as using mathematical modelling of human adipocyte systems.
- Jackisch, Laura, Kumsaiyai, W., Moore, Jonathan D., Al-Daghri, N. M., Kyrou, Ioannis, Barber, T. M., Randeva, Harpal S., Kumar, Sudhesh, Tripathi, Gyanendra, McTernan, P. G., 2018. Differential expression of Lp-PLA2 in obesity, type 2 diabetes and the influence of lipids. Diabetologia, 61, pp. 1155-1166
- Reddy, Narendra Lakshmana, Peng, C., Carreira, C., Halder, L., Hattersley, John G., Piya, Milan K., Tripathi, Gyanendra, Randeva, Harpal S., Casanueva, F. F, McTernan, P. G., Kumar, Sudhesh, Barber, T. M., 2015. Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly. Clinical Endocrinology, 82 (6), pp. 831-837
- Bradnova, Olga, Kyrou, Ioannis, Hainer, Vojtech, Vcelak, Josef, Halkova, Tereza, Sramkova, Petra, Dolezalova, Karin, Fried, Martin, McTernan, P. G. (Philip G.), Kumar, Sudhesh, Hill, Martin, Kunesova, Marie, Bendlova, Bela, Vrbikova, Jana, 2013. Laparoscopic greater curvature plication in morbidly obese women with type 2 diabetes : effects on glucose homeostasis, postprandial triglyceridemia and selected gut hormones. Obesity Surgery, 24 (5), pp. 718-726
- Alokail, Majed S., Sabico, Shaun, Al-Saleh, Yousef, Al-Daghri, Nasser M., Alkharfy, Khalid M., Vanhoutte, Paul M., McTernan, P. G. (Philip G.), 2013. Effects of probiotics in patients with diabetes mellitus type 2 : study protocol for a randomized, double-blind, placebo-controlled trial. Trials, 14 (1)
- Harte, A. L., Tripathi, G. N., Piya, Milan K., Barber, Thomas, Clapham, J. C., Al-Daghari, N., Al-Disi, Dara, Kumsaiyai, Warunee, Saravanan, Ponnusamy, Fowler, Anne E., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G., 2013. NFêB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status and TNFá. Obesity, 21 (11), pp. 2322-2330
- Chan, Winnie M. F., Bosch, Jos A., Jones, David, Kaur, Okdeep, Inston, N., Moore, S., McLean, A., McTernan, P. G., Harper, L., Phillips, Anna C., Borrows, Richard, 2013. Predictors and consequences of fatigue in prevalent kidney transplant recipients. Transplantation, 96 (11), pp. 987-994
- Harte, A. L. (Alison L.), McTernan, P. G. (Philip G.), 2013. Response to comment on : Harte et al. High fat intake leads to acute postprandial exposure to circulating endotoxin in Type 2 diabetic subjects. Diabetes Care 2012;35:375-382. Diabetes Care, 36 (3), pp. e43-e43
- Saboor Aftab, S. A., Reddy, Narendra Lakshmana, Owen, N. L., Pollitt, R., Harte, A. L., McTernan, P. G., Tripathi, Gyanendra, Barber, T. M., 2013. Identification of a novel heterozygous mutation in exon 50 of the COL1A1 gene manifesting clinically as osteogenesis imperfecta. Endocrinology, Diabetes & Metabolism Case Reports
- Chan, W., G. Ward, Douglas, McClean, Andrew, A. Bosch, Jos, Jones, David, Kaur, Okdeed, Drayson, Mark, Whitelegg, Alison, Iqbal, Tariq, McTernan, P. G. (Philip G.), Tselepis, Chris, Borrows, Richard, 2013. The role of hepcidin-25 in kidney transplantation. Transplantation Journal, 95 (11), pp. 1390-1395
- Al-Daghri, Nasser M., Al-Attas, Omar S., Bindahman, Lotfi S., Alokail, Majed S., Alkharfy, Khalid M., Draz, Hossam M., Yakout, Sobhy M., McTernan, P. G. (Philip G.), Sabico, Shaun, Chrousos, George P., 2012. Soluble CD163 is associated with body mass index and blood pressure in hypertensive obese Saudi patients. European Journal of Clinical Investigation, Vol.42 (No.11), pp. 1221-1226
- Anveden, Åsa, Sjoholm, Kajsa, Jacobson, Peter, Palsdottir, Vilborg, Walley, Andrew, Froguel, Philippe, Al-Daghri, Nasser M., McTernan, P. G. (Philip G.), Mejhert, Niklas, Arner, Peter, Sjostrom, Lars, Carlsson, Lena M. S., Svensson, Per-Arne, 2012. ITIH-5 Expression in human adipose tissue is increased in obesity. Obesity, Vol.20 (No.4), pp. 708-714
- Al-Daghri, Nasser M., Bindahman, Lotfi S., Al-Attas, Omar S., Saleem, Tahia H., Alokail, Majed S., Alkharfy, Khalid M., Draz, Hossam M., Yakout, Sobhy M., Mohamed, Amany O., Harte, Alison L., McTernan, P. G. (Philip G.), 2012. Increased circulating ANG II and TNF-a represents important risk factors in obese Saudi adults with hypertension irrespective of diabetic status and BMI. PLoS One, Vol.7 (No.12)
- Al-Attas, Omar S., Al-Daghri, Nasser M., Alokail, Majed S., Alkharfy, Khalid M., Alfadda, Assim, McTernan, P. G. (Philip G.), Gibson, Greg, Sabico, Shaun, Chrousos, George P., 2012. Circulating leukocyte telomere length is highly heritable among families of Arab descent. BMC Medical Genetics, Vol.13 (No.1)
- Sung, E. Z. H., Silva, N. F., Goodyear, S. J., McTernan, P. G. (Philip G.), Arasaradnam, Ramesh P., Nwokolo, Chuka U., 2011. Ghrelin promotes nuclear factor kappa-B activation in a human B-lymphocyte cell line. Molecular Biology Reports, Vol.38 (No.8), pp. 4833-4838
- Chittari, Madhu Varma, McTernan, P. G. (Philip G.), Bawazeer, Nahla M., Constantinides, K., Ciotola, M., O'Hare, J. Paul, Kumar, Sudhesh, Ceriello, Antonio, 2011. Impact of acute hyperglycaemia on endothelial function and retinal vascular reactivity in patients with Type 2 diabetes. Diabetic Medicine, 28 (4), pp. 450-454
- Harte, A. L., da Silva, Nancy F., Creely, Steven J., McGee, K. C., Billyard, Thomas, Youssef-Elabd, Elham M., Tripathi, Gyanendra, Ashour, Esmat, Abdalla, Mohga S., Sharada, Hayat M., Amin, Ashraf I., Burt, Alastair D., Kumar, Sudhesh, Day, Christopher Paul, McTernan, P. G., 2010. Elevated endotoxin levels in non-alcoholic fatty liver disease. Journal of Inflammation, Vol.7
- Goodyear, Stephen J., Mottershead, Marcus, Sung, E. Z. H., Wong, Ling S., McTernan, P. G. (Philip G.), Kumar, Sudhesh, Nwokolo, Chuka U., 2010. Dysregulation of plasma ghrelin in alcoholic cirrhosis. Clinical Endocrinology, Vol.73 (No.3), pp. 323-329
- Al-Attas, Omar S., Al-Daghri, Nasser M., Bamakhramah, A., Sabico, Shaun, McTernan, P. G. (Philip G.), Huang, T. T-K, 2010. Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth. Acta Paediatrica, Vol.99 (No.6), pp. 896-899
- Hill, M. J., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2009. Adipokines and the clinical laboratory : what to measure, when and how?. Journal of Clinical Pathology, Vol.62 (No.3), pp. 206-211
- Kos, K., Harte, A. L., O'Hare, J. Paul, Kumar, S., McTernan, P. G. (Philip G.), 2009. Ghrelin and the differential regulation of des-acyl (DSG) and oct-anoyl ghrelin (OTG) in human adipose tissue (AT). Clinical Endocrinology, Vol.70 (No.3), pp. 383-389
- Saiki, Atsuhito, Olsson, Maja, Jernas, Margareta, Gummesson, Anders, McTernan, P. G. (Philip G.), Andersson, Johanna, Jacobson, Peter, Sjoholm, Kajsa, Olsson, Bob, Yamamura, Shigeo, Walley, Andrew, Froguel, Philippe, Carlsson, Bjorn, Sjostrom, Lars, Svensson, Per-Arne, Carlsson, Lena M. S., 2009. Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. Journal of Clinical Endocrinology & Metabolism, Vol.94 (No.10), pp. 3987-3994
- Baker, Adam R., Harte, A. L. (Alison L.), Howell, N., Pritlove, D. C., Ranasinghe, A. M., da Silva, N. F., Youssef, E. M., Khunti, Kamlesh, Davies, M. J., Bonser, R. S., Kumar, Sudhesh, Pagano, D., McTernan, P. G. (Philip G.), 2009. Epicardial adipose tissue as a source of nuclear factor-kappa B and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease. Journal of Clinical Endocrinology & Metabolism, Vol.94 (No.1), pp. 261-267
- Jernas, Margareta, Olsson, Bob, Arner, Peter, Jacobson, Peter, Sjostrom, Lars, Walley, Andrew, Froguel, Philippe, McTernan, P. G. (Philip G.), Hoffstedt, Johan, Carlsson, Lena M. S., 2009. Regulation of carboxylesterase 1 (CES1) in human adipose tissue. Biochemical and Biophysical Research Communications, Vol.383 (No.1), pp. 63-67
- Al-Attas, Omar S., Al-Daghri, Nasser M., Al-Rubeaan, Khalid, da Silva, Nancy F., Sabico, Shaun, Kumar, Sudhesh, McTernan, P. G. (Philip G.), Harte, A. L. (Alison L.), 2009. Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies. Cardiovascular Diabetology, Vol.8 (No.20)
- Boothby, Meg, McGee, K. C. (Kirsty Claire), Tomlinson, Jeremy W., Gathercole, Laura L., McTernan, P. G. (Philip G.), Shojaee-Moradie, Fariba, Umpleby, A. Margot, Nightingale, Peter, Shahmanesh, Mohsen, 2009. Adipocyte differentiation, mitochondrial gene expression and fat distribution : differences between zidovudine and tenofovir after 6 months. Antiviral Therapy, Vol.14 (No.8), pp. 1089-1100
- Sung, E. Z. H., da Silva, N. F., Goodyear, S. J., McTernan, P. G. (Philip G.), Sanger, G. J., Nwokolo, Chuka U., 2009. Increased plasma ghrelin following infliximab in Crohn's disease. Alimentary Pharmacology and Therapeutic, Vol.29 (No.1), pp. 83-89
- Dixon, A. N., Valsamakis, Georgios, Hanif, M. W., Field, A., Boutsiadis, A., Harte, A. L., McTernan, P. G., Barnett, A. H., Kumar, Sudhesh, 2008. Effect of the orlistat on serum endotoxin lipopolysaccharide and adipocytokines in South Asian individuals with impaired glucose tolerance. International Journal of Clinical Practice, 62 (7), pp. 1124-1129
- Valsamakis, Georgios, Jones, A., Chetty, R., McTernan, P. G. (Philip G.), Boutsiadis, A., Barnett, A. H., Banerjee, A. K., Kumar, Sudhesh, 2008. MRI total sagittal abdominal diameter as a predictor of metabolic syndrome compared to visceral fat at L4-L5 level. Current Medical Research and Opinion, Vol.24 (No.7), pp. 1853-1860
- Gupta, P., Harte, A., Sturdee, D. W., Sharma, A., Barnett, A. H., Kumar, S., McTernan, P. G. (Philip G.), 2008. Effects of menopausal status on circulating calcitonin gene-related peptide and adipokines : implications for insulin resistance and cardiovascular risks. Climacteric, Vol.11 (No.5), pp. 364-372
- McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2007. RPB4 and pathogenesis of diabetes. Journal of Clinical Endocrinology & Metabolism, Vol.92 (No.7), pp. 2430-2432
- Kusminski, C. M., McTernan, P. G. (Philip G.), Schraw, T., Kos, Katarina, O'Hare, J. Paul, Ahima, R., Kumar, Sudhesh, Scherer, P. E., 2007. Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. Diabetologia, Vol.50 (No.3), pp. 634-642
- McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2007. Retinol binding protein 4 and pathogenesis of diabetes. The Journal of Clinical Endocrinology & Metabolism, 92 (7), pp. 2430-2432
- Gupta, Pratima, Harte, Alison L., da Silva, Nancy F., Khan, Hassan, Barnett, Anthony H., Kumar, Sudhesh, Sturdee, David W., McTernan, P. G. (Philip G.), 2007. Expression of calcitonin gene-related peptide, adrenomedullin, and receptor modifying proteins in human adipose tissue and alteration in their expression with menopause status. Menopause, 14 (6), pp. 1031-1038
- Palin, S. L., McTernan, P. G., McGee, K. C., Sturdee, D. W., Barnett, A. H., Kumar, Sudhesh, 2007. Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones-sensitive lipase in human subcutaneous abdominal adipocytes. Diabetes, Obesity and Metabolism, Vol.9 (No.4), pp. 585-590
- Kusminski, C. M., Fernandez da Silva, Nancy, Creely, Steven J., Fisher, Ffolliott M., Harte, A. L. (Alison L.), Baker, Adam R., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2007. The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes. Journal of Clinical Endocrinology & Metabolism, Vol.92 (No.1), pp. 270-276
- Gilardini, Luisa, McTernan, P. G. (Philip G.), Girola, Andrea, da Silva, Nancy F., Alberti, Luisella, Kumar, Sudhesh, Invitti, Cecilia, 2006. Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis, 189 (2), pp. 401-407
- Creely, Steven J., McTernan, P. G. (Philip G.), Kusminski, C. M., Fisher, Ffolliott M., Fernandez da Silva, Nancy, Khanolkar, M., Evans, M., Harte, A. L. (Alison L.), Kumar, Sudhesh, 2006. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. American Journal of Endocrinology and Metabolism, Vol.297 (No.3), pp. 740-747
- McTernan, P. G. (Philip G.), Kusminski, Christine M., Kumar, Sudhesh, 2006. Resistin. Current Opinion in Lipidology, 17 (2), pp. 170-175
- Baker, Adam R., Fernandez da Silva, Nancy, Quinn, David W., Harte, A. L. (Alison L.), Pagano, Domenico, Bonser, Robert S., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2006. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovascular Diabetology, Vol.5 (No.1)
- Wasim, Hanif, Al-Daghri, Nasser M., Chetty, Raja, McTernan, P. G., Barnett, A. H., Kumar, Sudhesh, 2006. Relationship of serum adiponectin and resistin to glucose intolerance and fat topography in south-Asians. Cardiovascular Diabetology, Vol.5 (No.10)
- McTernan, P. G. (Philip G.), Kusminski, Christine M., Kumar, Sudhesh, 2005. Role of resistin in obesity, insulin resistance and Type II diabetes. Clinical Science, 109 (3), pp. 243-256
- Al-Daghri, Nasser M., Chetty, R., McTernan, P. G. (Philip G.), Al-Rubean , K., Al-Attas, Omar S., Jones, A. F., Kumar, Sudhesh, 2005. Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population. Cardiovascular Diabetology, Vol.4 (No.10)
- Fisher, Ffolliott M., Trujillo, M. E., Hanif, W., Barnett, A. H., McTernan, P. G. (Philip G.), Scherer, P. E., Kumar, Sudhesh, 2005. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia, 48 (6), pp. 1084-1087
- Harte, A. L. (Alison L.), McTernan, P. G. (Philip G.), Chetty, Rajkumar, Coppack, Simon, Katz, Jonathan, Smith, Stephen, Kumar, Sudhesh, 2005. Insulin mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by Rosiglitazone. Circulation, Vol.111, pp. 1654-1961
- Valsamakis, Georgios, Anwar, A., Tomlinson, J. W., Shackleton, C. H. L., McTernan, P. G. (Philip G.), Chetty, R., Wood, P. J., Banerjee, A. K., Holder, G., Barnett, A. H., Stewart, P. M., Kumar, Sudhesh, 2004. 11ß-Hydroxysteroid dehydrogenase Type 1 activity in lean and obese males with Type 2 diabetes mellitus. The Journal of Clinical Endocrinology & Metabolism, 89 (9), pp. 4755-4761
- Valsamakis, Georgios, McTernan, P. G. (Philip G.), Chetty, R., Al-Daghri, Nasser M., Field, A., Hanif, W., Barnett, A. H., Kumar, Sudhesh, 2004. Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines. Metabolism, 53 (4), pp. 430-434
- Valsamakis, Georgios, Chetty, R., McTernan, P. G. (Philip G.), Al-Daghri, Nasser M., Barnett, A. H., Kumar, Sudhesh, 2003. Fasting serum adiponectin concentration is reduced in Indo-Asian subjects and is related to HDL cholesterol. Diabetes, Obesity and Metabolism, 5 (2), pp. 131-135
- McTernan, P. G. (Philip G.), Fisher, Ffolliott M., Valsamakis, Georgios, Chetty, Rajkumar, Harte, Alison L., McTernan, Claire L., Clark, Penny, Smith, Stephen A., Barnett, Anthony H., Kumar, Sudhesh, 2003. Resistin and type 2 diabetes : regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes. Journal of Clinical Endocrinology & Metabolism, 88 (12), pp. 6098-6106
- Palin, S. L., McTernan, P. G. (Philip G.), Anderson, L. A., Sturdee, D. W., Barnett, A. H., Kumar, Sudhesh, 2003. 17ß-estradiol and anti-estrogen ICI :compound 182,780 regulate expression of lipoprotein lipase and hormone-sensitive lipase in isolated subcutaneous abdominal adipocytes. Metabolism, 52 (4), pp. 383-388
- McTernan, P. G. (Philip G.), McTernan, Claire L., Chetty, Rajkumar, Jenner, Keely, Fisher, Ffolliott M., Lauer, Michelle N., Crocker, John, Barnett, Anthony H., Kumar, Sudhesh, 2002. Increased resistin gene and protein expression in human abdominal adipose tissue. Journal of Clinical Endocrinology and Metabolism, 87 (5), pp. 2407-2410
- McTernan, P. G. (Philip G.), Harte, A. L., Anderson, L. A., Green, A., Smith, S. A., Holder, J. C., Barnett, A. H., Eggo, M. C., Kumar, Sudhesh, 2002. Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro. Diabetes, 51 (5), pp. 1493-1498
- McTernan, P. G. (Philip G.), Anderson, Leah A., Anwar, Aresh J., Eggo, Margaret C., Crocker, John, Barnett, Anthony H., Stewart, Paul M., Kumar, Sudhesh, 2002. Glucocorticoid regulation of P450 aromatase activity in human adipose tissue : gender and site differences. Journal of Clinical Endocrinology and Metabolism, 4 (3), pp. 209-213
- Fisher, F. M., McTernan, P. G. (Philip G.), Valsamakis, Georgios, Chetty, R., Harte, A. L., Anwar, A. J., Starcynski, J., Crocker, J., Barnett, A. H., McTernan, Claire L., Kumar, Sudhesh, 2002. Differences in adiponectin protein expression : effect of fat depots and Type 2 diabetic status. Hormone and Metabolic Research, 34 (11/12), pp. 650-654
- McTernan, Claire L., McTernan, P. G. (Philip G.), Harte, A. L. (Alison L.), Levick, P. L., Barnett, A. H., Kumar, Sudhesh, 2002. Resistin, central obesity, and type 2 diabetes. The Lancet, 359 (9300), pp. 46-47
- Anderson, L. A., McTernan, P. G. (Philip G.), Harte, A. L, Barnett, A. H., Kumar, Sudhesh, 2002. The regulation of HSL and LPL expression by DHT and flutamide in human subcutaneous adipose tissue. Diabetes, Obesity and Metabolism, 4 (3), pp. 209-213
- Anwar, A., McTernan, P. G. (Philip G.), Anderson, L. A., Askaa, J., Moody, C. G., Barnett, A. H., Eggo, M. C., Kumar, Sudhesh, 2001. Site-specific regulation of oestrogen receptor-a and -ß by oestradiol in human adipose tissue. Diabetes, Obesity and Metabolism, 3 (5), pp. 338-349
- Anderson, Leah A., McTernan, P. G. (Philip G.), Barnett, Anthony H., Kumar, Sudhesh, 2001. The effects of androgens and estrogens on preadipocyte proliferation in human adipose tissue : influence of gender and site. Journal of Clinical Endocrinology and Metabolism, 86 (10), pp. 5045-5051
- McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2004. The link between obesity and diabetes. Barnett, A. H.; 1951- ;, (Anthony H.); Kumar, Sudhesh (eds.), Obesity and diabetes, Chichester, West Sussex, England ; Hoboken, NJ, Wiley-Blackwell Publishing Ltd
- Shahmanesh, M., Das, S. (Satyajit), Boothby, M., McGee, K. C. (Kirsty Claire), Gathercole, L. L., Harte, A. L. (Alison L.), Higgins, P., Kusminski, C. M., McTernan, P. G. (Philip G.), Ross, Joshua V., Tomlinson, J. W., 2010. Complications of HIV disease or treatment. Second Joint Conference of the British HIV Association and the British Association for Sexual Health and HIV, Manchester, UK, April 20-23l 2010, Published in HIV Medicine, pp. 10-10
- Al-Attas, Omar S., Al-Daghri, Nasser M., Alokail, Majed S., Bamakhramah, Ahmed, Sabico, Shaun, Huang, Terry, McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2010. Telomere length and childhood obesity among Arab youth. 14th International Congress of Endocrinology, Kyoto, Japan, March 26-30, 2010, Published in Endocrine Journal, pp. S619-S619
- Gathercole, L. L., Tomlinson, J. W., Boothby, M., McGee, K. C. (Kirsty Claire), Harre, A. L., McTernan, P. G. (Philip G.), Das, S., Shahmanesh, M., 2009. Changes in the adipocyte (lipid and glucose metabolism) gene expression following 18-24 months treatment with ZDV or TDF-containing ART; and adipocyte mitochondrial gene expression. 11th International Workshop on AdverseDrug Reactions and Co-Morbidities in HIV, Philadelphia, PA, October 26-28, 2009, Published in Antiviral Therapy, pp. A9-A10
- McGee, K. C. (Kirsty Claire), Boothby, M., Tomlinson, J. W., Gathercole, L. L., Harte, A. L. (Alison L.), McTernan, P. G. (Philip G.), Das, S., Shahmanesh, M., 2009. Adipocyte mitochondrial gene expression following 18-24 months treatment with zidovidine or tenofovir-containing antiretroviral therapy. 11th International Workshop on Adverse Drug Reactions and Co-Morbidities in HIV, Philadelphia, PA, October 26-28, 2009, Published in Antiviral Therapy, pp. A10-A10
- Harte, A. L. (Alison L.), Youssef, E. M., Wahba, E. A., Hussen, A. A., Cerellio, A., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2009. Hyperlipidaemic conditions induce 'metabolic memory' within human abdominal subcutaneous adipose tissue and isolated adipocytes, in vivo. 45th General Assembly of the European Association for the Study of Diabetes, Vienna, Austria, September 30-October 02, 2009, Published in Diabetologia, pp. S278-S279
- McGee, K. C. (Kirsty Claire), Harte, A. L. (Alison L.), Hill, M. J., Burt, A. D., Kumar, Sudhesh, Day, C. P., McTernan, P. G. (Philip G.), 2009. Circulating visfatin levels reduced in patients with non-alcoholic fatty liver disease irrespective of type 2 diabetes mellitus status. 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, AUSTRIA, September 30-OCT 02, 2009, Published in Diabetologia, pp. S20-S21
- Harte, A. L. (Alison L.), Youssef, E. M., Abdalla, M. S., Sharada, H. M., Ashour, E., Amin, A. I., Cerellio, A., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2009. Hyperlipidaemic conditions induce 'metabolic memory' within human abdominal subcutaneous adipose tissue and isolated adipocytes, in vitro. International Journal of Molecular Medicine, pp. S51-S51
- Radford, C. R., Schisano, B., McTernan, P. G. (Philip G.), Ceriello, Antonio, 2008. The impact of oscillating glucose and the metabolic memory effect on oxidative stress in human endothelial cells. 43rd Annual Meeting of the European Association for the Study of Diabetes, Amsterdam, Netherlands, Sep 18-21, 2007, Published in Diabetologia, pp. S29-S30
- Harte, A. L., Hill, M. J., da Silva, N. F., McGee, K. C., Baker, Adam R., Clapham, J. C., Kumar, Sudhesh, McTernan, P. G., 2008. Depot specific activity of the 15-lipoxygenase pathway in adipose tissue : the inflammatory response and metabolic disease. 44th Annual Meeting of the European Association for the Study of Diabetes, Rome, Italy, 7 - 11 September 2008, Published in Diabetologia, pp. S329-S329
- McGee, K. C. (Kirsty Claire), Harte, A. L. (Alison L.), Hill, M., Boothby, M., Tomlinson, J., Gathercole, L. L., Kumar, Sudhesh, Shahmanesh, Mohsen, McTernan, P. G. (Philip G.), 2008. The differential impact of antiretroviral (ARV) therapies on mitochondrial and lipid metabolism genes in human adipose tissue. 44th Annual Meeting of the European Association for the Study of Diabetes, Rome, Italy, 7 - 11 September 2008, Published in Diabetologia, pp. S304-S305
- Schisano, B., Radford, C. R., Harte, A. L. (Alison L.), McGee, K. C. (Kirsty Claire), McTernan, P. G. (Philip G.), Ceriello, Antonio, 2008. Effects of hyperglycaemia on Nrf2 and p53 antioxidant transcriptional activity in HUVECS. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, Sep 18-21, 2007, Published in Diabetologia, pp. S94-S94
- McGee, K. C. (Kirsty Claire), Da Silva, N. E., Harte, A. L. (Alison L.), Creely, S. J., Hill, M. J., Khanolkar, M., Evans, M., Chittari, M. V., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2007. Visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by NF-kappa B and JNK in human abdominal subcutaneous adipocytes. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, 18-21 Sep 2007, Published in Diabetologia, pp. S58-S59
- Harte, A. L. (Alison L.), Al-Daghri, Nasser M., Al-Rubeaan, Khalid, Al-Attas, Omar S., da Silva, N. F., Sabico, Shaun, Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2007. Rosiglitazone as a therapeutic agent to reduce inflammatory risk in type 2 diabetic patients. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, September 18-21, 2007, Published in Diabetologia, pp. S272-S273
- Boothby, M., Tomlinson, J. W., McGee, K. C. (Kirsty Claire), Das, S., Gathercole, L. L., Harte, A. L. (Alison L.), Higgins, P., Kusminski, C. M., McTernan, P. G. (Philip G.), Shahmanesh, M., 2007. The effect of antiretroviral therapy on genes involved with mitochondrial function. 9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, Sydney, Australia, 19-21 Jul 2007, Published in Antiviral Therapy, pp. L23-L23
- Kos, Katarina, Baker, A., Harte, A. L. (Alison L.), O'Hare, J. P., McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2007. DPP IV in human adipose tissue may regulate adipose tissue mass through modulation of NPY. Diabetes UK Annual Professional Conference, Scottish Exhibition and Conference Centre, Glasgow, UK, 14-16 March 2007, Published in Diabetic Medicine, pp. 35-35
- Kusminski, C. M., da Silva, N. F., Fowler, A. E., Creely, S. J., Harte, A. L. (Alison L.), Baker, A. R., Billyard, T. S., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2007. The effects adiposity, diabetic status and depot-specificity on the activation of NFKB on JNK in human abdominal adipose tissue. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, September 18-21, 2007, Published in Diabetologia, pp. S69-S69
- Boothby, M., Tomlinson, J. W., McGee, K. C. (Kirsty Claire), Das, S., Gathercole, L. L., Harte, A. L. (Alison L.), Higgins, P., Kusminski, C. M., McTernan, P. G. (Philip G.), Shahmanesh, M., 2007. The effect of antiretroviral therapy on genes involved with glucose and lipid metabolism. 9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, Sydney, Australia, 19-21 Jul 2007, Published in Antiviral Therapy, pp. L12-L13
- da Silva, N. F., Harte, A. L. (Alison L.), Hill, M. J., Billyard, T. S., Kumar, Sudhesh, Day, C. P., McTernan, P. G. (Philip G.), 2007. Long-term orlistat treatment reduces endotoxinaemia in fatty liver disease patients. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, September 18-21, 2007, Published in Diabetologia, pp. S296-S297
- Kos, Katarina, Baker, A. R., Harte, A. L. (Alison L.), O'Hare, J. Paul, McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2007. DPP-IV inhibitors influence fat metabolism through modulation of NPY's paracrine antilipolytic action in adipose tissue. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, September 18-21, 2007, Published in Diabetologia, pp. S51-S51
- Kusminski, C. M., Creely, S. J., da Silva, N. F., Harte, A. L. (Alison L.), Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2006. The in vitro effects of JNK of NF-kappa B inhibitor on resistin secretion from isolated human abdominal subcutaneous adipocytes. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen, Denmark, 14-17 Sep 2006, Published in Diabetologia, pp. 79-80
- Harte, A. L. (Alison L.), Kusminski, C. M., Hill, M. J., Gilardini, L., Girola, A., Da Silva, N. F., Alberti, L., Invitti, C., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2006. LPS as a mediator of sub-clinical inflammation in obese children and its' association with vascular injury and atherogenesis biomarkers. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen, Denmark, 14-17 Sep 2006, Published in Diabetologia, pp. 692-693
- Creely, S. J., Fisher, F. M., Harte, A. L. (Alison L.), McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2006. Sub-clinical inflammation in T2DM : the role of Toll like receptors in the activation of NF kappa B and cJun Kinase in the innate immune pathway in human abdominal isolated adipocytes and explants. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen, Denmark, 14-17 Sep 2006, Published in Diabetologia
- McGee, K. C. (Kirsty Claire), Harte, A. L. (Alison L.), da Silva, N. F., Chittari, M. V., Khanolkar, M., Creely, S. J., Evans, M., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2006. The role of visfatin in type 2 diabetes meltitus : the in vivo and in vitro effects of rosiglitazone, TNF alpha and IL-6 on visfatin expression in human abdominal subcutaneous adipocytes. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen, Denmark, 14-17 Sep 2006, Published in Diabetologia, pp. 423-424
- Day, Chris P., Leathart, Julian B., McTernan, P. G. (Philip G.), Mathew, Christopher, Daly, Ann K., 2006. Genetic evidence for a role for gut flora in the pathogenesis of NASH in humans. 57th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Boston, MA, OCT 27-31, 2006, Published in HEPATOLOGY, pp. 261A-261A
- Baker, A. R., Ranasinghe, A., Howei, N., Pagano, D., Bonser, R., Kumar, Sudhesh, McTernan, P. G. (Philip G.), 2006. Inflammation in epicardial adipose tissue: comparison of inflammatory mechanisms for production of adipocytokines in human epicardial and gluteo-femoral adipose tissue in CABG patients. 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Copenhagen, Denmark; Malmoe, Sweden, Sep 14-17, 2006, Published in Diabetologia, pp. 54-55
- Billyard, Tom, McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2007. Potential therapies based on antidiabetic peptides. Best Practice & Research Clinical Endocrinology & Metabolism, Bailliere Tindall, pp. 641-655
- McTernan, P. G. (Philip G.), Kumar, Sudhesh, 2007. Editorial: retinol binding protein 4 and pathogenesis of diabetes. Journal of Clinical Endocrinology & Metabolism, Endocrine Society, pp. 2430-2432
Title | Funder | Award start | Award end |
---|---|---|---|
Freeze dried broccoli as a dietary intervention to reduce cardiometabolic risk in post-partum GDM women. | Novo Nordisk UK Research Foundation | 01 Nov 2016 | 31 Jan 2020 |
A randomised control trial of the effect of weight loss in patients with and without type 2 diabetes following a 2 week low calorie diet and sleeve gatrectomy on inflammation and metabolic health | Royal Embassy of Saudi Arabia Cultural Bureau London | 02 Feb 2016 | 31 Jan 2020 |
The role of vitamin D deficiency in pregnant women and its association with gestational diabetes mellitus and impact on inflammation | King Saud University | 30 Sep 2013 | 30 Sep 2017 |
Together driving 360 wellbeing Phase 1: A high level review of employee health risks, and associated business impact. | Jaguar Land Rover | 01 Feb 2017 | 31 Aug 2017 |
The origins of inflammation in human adipocytes | King Saud University | 01 Oct 2011 | 30 Sep 2015 |
King Saudi University Grant | King Saud University | 01 Oct 2010 | 30 Sep 2014 |
Investigation of dietary fats and Gut derived endotoxin as post-prandial triggers of systemic chronic low grade inflammation and ER stress | Office of Educational Affairs, The Royal Thai Embassy | 01 Oct 2010 | 30 Sep 2014 |
Philanthropic donation for diabetes research (The role of LP-PLA2 in inflammation ) | Anonymous | 18 Apr 2011 | 17 Apr 2013 |
Matched funding for philanthropic donation for diabetes research (The role of LP-PLA2 in inflammation ) | Higher Education Funding Council for England | 18 Apr 2011 | 17 Apr 2013 |
Role and regulation of inducible nitric oxide synthase (iNOS or NOS2) in diabetes | AstraZeneca | 01 Feb 2011 | 31 Jan 2012 |
Novo Nordisk Continuation | Novo Nordisk A/S | 01 Mar 2010 | 30 Sep 2010 |
Metabolic endotoxinaemia and inflammation in the pathogenesis of obesity associated diabetes | AstraZeneca UK Limited | 01 Oct 2008 | 30 Sep 2010 |
Regulation of RAS by insulin and TNFa in human adipocytes | British Heart Foundation | 01 Oct 2007 | 30 Sep 2010 |
Investigating Liraglutide as an Antioxidant and its Beneficial Effects to Type 2 Diabetic Patients | Novo Nordisk A/S | 01 Dec 2008 | 30 Nov 2009 |
The molecular mechanisms and potential therapeutic treatment for obesity associated cardiovascular disease, hypertension and inflammation | British Medical Association | 01 Sep 2006 | 31 Aug 2008 |
Insulin resistance, adverse metabolic profile and premature ageing in type 2 diabetic patients. | The Novo Nordisk UK Research Foundation | 01 Jun 2006 | 31 May 2008 |
Extension to Clinical Fellow in Gastro-enterology | University Hospitals Coventry and Warwickshire NHS Trust | 08 May 2007 | 07 May 2008 |
Albert Renold Fellowship - Dr Ioannis Kyrou, Travel Grant | European Foundation for the Study of Diabetes (EFSD) | 01 Oct 2007 | 31 Dec 2007 |
Adiponectin as a Peripheral and central Metabolic Adipocytokine in Regulating Energy Homeostasis Dysregulated by Obesity and Diabetes | Medical Research Fund of Warwick | 01 Nov 2005 | 31 Oct 2007 |
Conference Travel Grant : The First Varna Nutrigenomics Meeting (ISAA) | Royal Society | 18 Oct 2007 | 21 Oct 2007 |
Prospective nested case-control study to evaluate sub-clinical inflammatory biomarkers as predictors of diabetes and other cardiovascular risk in the Whitehall II population | The Harold Hyam Wingate Foundation | 01 Apr 2006 | 30 Sep 2007 |
Assessing Premature Ageing and Metabolic Profile Invasion Type 2 Diabetic Patients. | Eli Lilly and Co Limited | 01 Apr 2006 | 31 Mar 2007 |
The potential pathophysical effects of excess adiopose tissue on various systems in human obesity and type 2 diabetes. | AstraZeneca | 01 Jun 2005 | 31 Dec 2006 |
Defining the Molecular Mechanisms for Obesity Associated Hypertension and Inflammatory Disease Leading to Cardiovascular Pathology | British Medical Association | 01 Aug 2005 | 31 May 2006 |
Adiponectin in higher molecular structures in human cerebrospinal fluid: effect of obesity and Type 2 diabetes | European Federation of Diabetes Studies (EFDS) | 01 Oct 2005 | 31 Dec 2005 |
Investigation of Lipid Metabolism in Cardiovascular Disease | Wellcome Trust | 04 Jul 2005 | 26 Aug 2005 |
The Role of Adipocytokines in the Pathogenesis of non-alcoholic steatohepatitis in obesity and type 2 diabetes | Eli Lilly and Co Limited | 01 Apr 2004 | 31 Mar 2005 |
Kirsty McGee - Vacation Studentship - Determining Severe Insulin Resistance Syndromes in Patients with Metabolic Syndrome | Wellcome Trust | 07 Jul 2004 | 01 Sep 2004 |