Job Title
Professor of Molecular Neurosciences
Department
WMS - Biomedical Sciences
Phone
024 765 74868
Web Link
Research Interests
Main areas of research interests are broadly three-fold and relate to: Neuronal electrical synapses in health and disease. Central autonomic control of organ, body and cardiovascular homeostasis in health and disease at the level of the hypothalamus. These interests are related in that electrotonic coupling is an important feature of autonomic sympathetic preganglionic neurones (SPN) and the SPN are the model for health and disease that research within the group has previously focused on. Future research aims are to build upon and develop already on-going projects relating to these general themes. The work involves combined electrophysiological, anatomical and molecular approaches in collaboration with colleagues both overseas and within the UK.
- 'Reichenbach, Alex, 'Clarke, Rachel E., 'Stark, Romana, 'Lockie, Sarah Haas, 'Mequinion, Mathieu, 'Dempsey, Harry, 'Rawlinson, Sasha, 'Reed, Felicia, 'Sepehrizadeh, Tara, 'DeVeer, Michael, 'Munder, Astrid C., 'Nunez-Iglesias, Juan, 'Spanswick, David C., 'Mynatt, Randall, 'Kravitz, Alexxai V., 'Dayas, Christopher V., 'Brown, Robyn, 'Andrews, Zane B., 2022. 'Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum. eLife, 11
- Wall, Mark J., Hill, Emily, Huckstepp, Robert T. R., Barkan, Kerry, Deganutti, Giuseppe, Leuenberger, Michele, Preti, Barbara, Winfield, Ian, Carvalho, Sabrina, Suchankova, Anna, Wei, Haifeng, Safitri, Dewi, Huang, Xianglin, Imlach, Wendy, La Mache, Circe, Dean, Eve, Hume, Cherise, Hayward, Stephanie, Oliver, Jess, Zhao, Fei-Yue et al (Select to open full list), 2022. Selective activation of G?ob by an adenosine A 1 receptor agonist elicits analgesia without cardiorespiratory depression. Nature Communications, 13 (1)
- Milton, Laura K., Mirabella, Paul N., Greaves, Erika, Spanswick, David, van den Buuse, Maarten, Oldfield, Brian J., Foldi, Claire J., 2021. Suppression of corticostriatal circuit activity improves cognitive flexibility and prevents body weight loss in activity-based anorexia in rats. Biological Psychiatry, 90 (12), pp. 819-828
- Milton, Laura K., Mirabella, Paul N., Greaves, Erika, Spanswick, David, van den Buuse, Maarten, Oldfield, Brian J., Foldi, Claire J., Milton, Laura K., Mirabella, Paul N., Greaves, Erika, Spanswick, David, van den Buuse, Maarten, Oldfield, Brian J., Foldi, Claire J., 2021. Suppression of corticostriatal circuit activity improves cognitive flexibility and prevents body weight loss in activity-based anorexia in rats. Biological Psychiatry, 90 (12), pp. 819-828
- Haynes, Vanessa R., Michael, Natalie J., van den Top, Marco, Zhao, Fei-Yue, Brown, Russell D., De Souza, David, Dodd, Garron T., Spanswick, David, Watt, Matthew J., 2020. A Neural basis for Octanoic acid regulation of energy balance. Molecular Metabolism, 34, pp. 54-71
- Michael, Natalie Jane, Simonds, Stephanie Elise, van den Top, Marco, Cowley, Michael Alexander, Spanswick, David, 2017. Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss. Molecular Metabolism, 6 (10), pp. 1103-1112
- van den Top, M., Zhao, F.-Y., Viriyapong, R., Michael, N. J., Munder, A. C., Pryor, J. T., Renaud, L. P., Spanswick, D., 2017. The impact of ageing, fasting and high-fat diet on central and peripheral glucose tolerance and glucose-sensing neural networks in the arcuate nucleus. Journal of Neuroendocrinology, 29 (10)
- Hebeisen, Simon, Pires, Nuno, Loureiro, Ana I., Bonifácio, Maria João, Palma, Nuno, Whyment, Andrew, Spanswick, David, Soares-da-Silva, Patrício, 2015. Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: A comparison with carbamazepine, oxcarbazepine and lacosamide. Neuropharmacology, 89, pp. 122-135
- Simonds, Stephanie E., Pryor, Jack T., Ravussin, Eric, Greenway, Frank L., Dileone, Ralph, Allen, Andrew M., Bassi, Jaspreet, Elmquist, Joel K., Keogh, Julia M., Henning, Elana, Myer, Martin G., Licinio, Julio, Brown, Russell D., Enriori, Pablo J., O'Rahilly, S. (Stephen), Sternson, Scott M., Grove, Kevin L., Spanswick, David C., Farooqi, I. Sadaf, Cowley, Michael A., 2014. Leptin mediates the increase in blood pressure associated with obesity. Cell, 159 (6), pp. 1404-1416
- O'Hare, Eugene, Scopes, David I. C., Kim, Eun-Mee, Palmer, P. (Philip), Spanswick, David, McMahon, Bridgeen, Amijee, Hozefa, Nerou, Edmund, Treherne, J. Mark, Jeggo, Ross, 2014. Novel 5-aryloxypyrimidine SEN1576 as a candidate for the treatment of Alzheimer's disease. The International Journal of Neuropsychopharmacology, 17 (1), pp. 117-126
- Hopkins, Seth C., Campbell, Una C., Heffernan, Michele L. R., Spear, Kerry L., Jeggo, Ross D., Spanswick, David C., Varney, Mark A., Large, Thomas H., 2013. Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo. Pharmacology Research & Perspectives, 1 (1)
- Hopkins, Seth C., Zhao, Fei-Yue, Bowen, C. A, Fang, Xin, Dr., Weiss, Howard, Heffernan, Michele L. R., Spear, Kerry L., Spanswick, David, Varney, Mark A., Large, Thomas H., 2013. Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain. Journal of Pharmacology and Experimental Therapeutics, 345 (3), pp. 502-511
- Scopes, D. I. C., O'Hare, E., Jeggo, R., Whyment, A. D., Spanswick, David, Kim, E. -M., Gannon, J., Amijee, H., Treherne, J. M., 2012. Aß oligomer toxicity inhibitor protects memory in models of synaptic toxicity. British Journal of Pharmacology, 167 (2), pp. 383-392
- O'Hare, Eugene, Scopes, David I.C., Kim, Eun-Mee, Palmer, Philip, Jones, Martyn, Whyment, Andrew D., Spanswick, David C., Amijee, Hozefa, Nerou, Edmund, McMahon, Bridgeen, Treherne, J. Mark, Jeggo, Ross, 2012. Orally bioavailable small molecule drug protects memory in Alzheimer's disease models. Neurobiology of Aging
- Whyment, Andrew D., Coderre, E., Wilson, J. M. M., Renaud, Leo, O'Hare, Eugene, Spanswick, David C., 2011. Electrophysiological, pharmacological and molecular profile of the transient outward rectifying conductance in rat sympathetic preganglionic neurons in vitro. Neuroscience, Vol.178, pp. 68-81
- Bursi, Roberta, Erdemli, Gul, Campbell, Robert, Hutmacher, Matthew M., Kerbusch, Thomas, Spanswick, David, Jeggo, Ross, Nations, Kari R., Dogterom, Peter, Schipper, Jacques, Shahid, Mohammed, 2011. Translational PK?PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576. Psychopharmacology, Vol.218 (No.4), pp. 713-724
- O'Hare, Eugene, Scopes, David I. C., Treherne, J. Mark, Norwood, Kelly, Spanswick, David, Kim, Eun-Mee, 2010. RS-0406 arrests amyloid-beta oligomer-induced behavioural deterioration in vivo. Behavioural Brain Research, Vol.210 (No.1), pp. 32-37
- Jiang, Lu-Yang, Li, Shu-Ren, Zhao, Fei-Yue, Spanswick, David, Lin, Mao-Tsun, 2010. Norepinephrine can act via alpha(2)-adrenoceptors to reduce the hyper-excitability of spinal dorsal horn neurons following chronic nerve injury. Journal of the Formosan Medical Association, Vol.109 (No.6), pp. 438-445
- O'Hare, Eugene, Elliott, Jennifer J., Hobson, Peter, O'Mara, Shane M., Spanswick, David, Kim, Eun-Mee, 2010. Bilateral intrahippocampal NAC(61-95) effects on behavior and moderation with L-NAME treatment. Neuroscience Research, Vol.66 (No.2), pp. 213-218
- O?Hare, Eugene, Elliott, Jennifer J., Hobson, Peter, Spanswick, David, Kim, Eun-Mee, 2010. Behavioural deterioration induced by intrahippocampal NAC61?95 injections and attenuation with ibuprofen. Behavioural Brain Research, Vol.208 (No.1), pp. 274-277
- Kim, Eun-Mee, Quinn, Joseph G., Spanswick, David, O'Hare, Eugene, 2009. Feeding association between the nucleus of the solitary tract and the ventral tegmental area. Appetite, Vol.53 (No.3), pp. 457-460
- Barrett, Perry, van den Top, Marco, Wilson, D., Mercer, Julian G., Song, C. K., Bartness, Timothy J., Morgan, Peter J., Spanswick, David C., 2009. Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian Hamster. Endocrinology, Vol.150 (No.8), pp. 3655-3663
- Pattaranit, Ratchada, Berg, Hugo van den, Spanswick, David, 2008. The development of insulin resistance in Type 2 diabetes : insights from knockout studies. Science Progress, Vol.91 (No.3), pp. 285-316
- Van den Top, M., Lyons, D. J., Lee, K., Coderre, E., Renaud, L. P., Spanswick, D., 2007. Pharmacological and molecular characterization of ATP-sensitive K+ conductances in CART and NPY/AgRP expressing neurons of the hypothalamic arcuate nucleus. Neuroscience, Vol.144 (No.3), pp. 815-824
- Whyment, Andrew D., Blanks, Andrew M., Lee, Kevin, Renaud, L. P., Spanswick, David, 2006. Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H-1 receptors. Journal of Neurophysiology, 95 (4), pp. 2492-2500
- van den Top, Marco, Spanswick, David, 2006. Integration of metabolic stimuli in the hypothalamic arcuate nucleus. 24th International Summer School of Brain Research, Royal Netherlands Acad Arts & Sci, Amsterdam, NETHERLANDS, 29 Aug-01 Sep 2005, Published in Progress in Brain Research, pp. 141-154
- Lee, Kevin, Spanswick, David, 2006. Pain - Introduction. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, pp. 541-543
| Title | Funder | Award start | Award end |
|---|---|---|---|
| MRC iCASE Agreement NeuroSolutions Ltd | NeuroSolutions Limited | 01 Oct 2018 | 30 Sep 2022 |
| Extension to RMRMV0050 An Investigation of the Intrinsic Electrophysiological Properties of Hypothlamic and Spinal Neurone | NeuroSolutions Limited | 01 Dec 2012 | 31 Dec 2014 |
| Warwick Systems Biology Doctoral Training Centre | EPSRC | 01 Oct 2006 | 01 Oct 2013 |
| The functional role of 5-HT and MC4 receptors in the central regulation of appetite: a combined neurophysiological and molecular approach | University of Lubeck | 01 Jan 2009 | 03 Jun 2011 |
| An Investigation of the Intrinsic Electrophysiological Properties of hypothalamic and spinal neurones and their utility as markers of neurol function | NeuroSolutions Limited | 01 Apr 2009 | 31 Dec 2010 |
| CASE - Intrinsic Primary Afferent Neurones of the Human and Guinea Pig Enteric Nervous Systems: Basic Neurophysiology and Effects of Prokinetic Peptides Sukhdav Vairea | GlaxoSmithKline Research and Development Ltd | 01 Oct 2005 | 30 Sep 2008 |
| Adiponectin as a Peripheral and central Metabolic Adipocytokine in Regulating Energy Homeostasis Dysregulated by Obesity and Diabetes | Medical Research Fund of Warwick | 01 Nov 2005 | 31 Oct 2007 |
| Integration of signalling mechanisms in NPY/Agouti related protein (NPY/AgRP) pacemaker neurons in the arcuate nucleus of the hypothalamus | BBSRC | 01 Oct 2004 | 30 Sep 2007 |
| CASE STUDENTSHIP: Louise Saker | NeuroSolutions Limited | 01 Oct 2004 | 30 Sep 2007 |
| Modulation of neuronal activity patterning by electrotonic coupling in the amygdala | Wellcome Trust | 01 Apr 2004 | 31 Mar 2007 |
| Molecular Characterisation of Gap Juntions expressed by electrotonically coupled sympathetic preganglionic neurones. | BBSRC | 15 Feb 2006 | 31 Aug 2006 |
| Understanding the Action of Ghrelin in the Brain: Identification of Novel Treatments for hyperghrelinaemia | The Prader-Willi Syndrome Association (USA) | 01 Dec 2004 | 30 Nov 2005 |
| Understanding the action of ghrelin in the brain: Identification of novel treatments for hyperghrelinaemia | The Prader-Willi Syndrome Association (USA) | 01 Oct 2003 | 31 Aug 2005 |
| Understanding the action of ghrelin in the brain: Identification of novel treatments for hyperghrelinaemia | The Prader-Willi Syndrome Association (USA) | 01 Oct 2003 | 30 Jun 2004 |