Dr. Gyanendra Tripathi graduated with MSc in Biotechnology from Indian Institute of Technology, Mumbai, India (1993) and completed his PhD on, Regulation of genes involved in the synthesis of biodegradable biolpolymer, polyhydroxy butyrate, in 1998 from National Chemical Laboratory, India on a Council of Scientific and Industrial Research Fellowship. In 1999 he moved to University of Aberdeen, and did his first postdoctoral training on, transcriptional regulation of Gcn4 in Candida albicans. Later in 2002 he moved to Babraham Institute, Cambridge to work on mouse transgenics and IGF signalling. He was appointed as RCUK academic fellow at University of Warwick in 2005. Currently he holds the position of Associate Professor at Warwick Medical School, University of Warwick and is part of Diabetes and Metabolism research theme.
- Pushpakom, S. P., Adaikalakoteswari, Antonysunil, Owen, A., Back, D. J., Tripathi, Gyanendra, Kumar, Sudhesh, McTernan, P. G., Pirmohamed, M., 2018. Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro. Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease, 15 (3), pp. 233-242
- Jackisch, Laura, Kumsaiyai, W., Moore, Jonathan D., Al-Daghri, N. M., Kyrou, Ioannis, Barber, T. M., Randeva, Harpal S., Kumar, Sudhesh, Tripathi, Gyanendra, McTernan, P. G., 2018. Differential expression of Lp-PLA2 in obesity, type 2 diabetes and the influence of lipids. Diabetologia, 61, pp. 1155-1166
- Martinez de la Escalera Clapp, Lucia, Kyrou, Ioannis, Vrbikova, Jana, Hainer, Voitech, Sramkova, Petra, Fried, Martin, Piya, Milan K., Kumar, Sudhesh, Tripathi, Gyanendra, McTernan, P. G., 2017. Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery. BMC Medicine, 15 (1)
- Hu, Jiamiao, Kyrou, Ioannis, Tan, Bee K., Dimitriadis, Georgios K., Ramanjaneya, Manjunath, Tripathi, Gyanendra, Patel, Vanlata H., James, Sean G., Kawan, Mohamed, Chen, Jing, Randeva, Harpal S., 2016. Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes. Endocrinology, 157 (5), pp. 1881-1894
- Perry, David, Paulose Nadappuram, Binoy, Momotenko, Dmitry, Voyias, Philip D., Page, Ashley M., Tripathi, Gyanendra, Frenguelli, Bruno G., Unwin, Patrick R., 2016. Surface charge visualization at viable living cells. Journal of the American Chemical Society, 138 (9), pp. 3152-3160
- Adaikalakoteswari, Antonysunil, Finer, Sarah, Voyias, Philip D., McCarthy, Ciara M., Vatish, Manu, Moore, Jonathan D., Smart-Halajko, Melissa, Bawazeer, Nahla M., Al-Daghri, Nasser M., McTernan, P. G., Kumar, Sudhesh, Hitman, Graham A., Saravanan, Ponnusamy, Tripathi, Gyanendra, 2015. Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes. Clinical Epigenetics, 7 (1), pp. 1-14
- Al-Disi, Dara, Al-Daghri, Nasser, Khan, Nasiruddin, Alfadda, Assim, Sallam, Reem, Alsaif, Mohammed, Sabico, Shaun, Tripathi, Gyanendra, McTernan, P. G., 2015. Postprandial effect of a high-fat meal on endotoxemia in Arab women with and without insulin-resistance-related diseases. Nutrients, 7 (8), pp. 6375-6389
- Antonysunil, Adaikalakoteswari, Vatish, Manu, Lawson, Alexander, Wood, Catherine, Sivakumar, Kavitha, McTernan, P. G., Webster, Craig, Anderson, Neil, Yajnik, Chittaranjan S., Tripathi, Gyanendra, Saravanan, Ponnusamy, 2015. Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white caucasians living in the UK. Nutrients, 7 (4), pp. 2401-2414
- Reddy, Narendra Lakshmana, Peng, C., Carreira, C., Halder, L., Hattersley, John G., Piya, Milan K., Tripathi, Gyanendra, Randeva, Harpal S., Casanueva, F. F, McTernan, P. G., Kumar, Sudhesh, Barber, T. M., 2015. Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly. Clinical Endocrinology, 82 (6), pp. 831-837
- Al-Daghri, Nasser M., Al-Attas, Omar S., Alokail, Majed S., Alkharfy, Khalid M., Yousef, Mansour, Vinodson, Benjamin, Amer, Osama E., Alnaami, Abdullah M., Sabico, Shaun, Tripathi, Gyanendra, Piya, Milan K., McTernan, P. G., Chrousos, George P., 2014. Maternal inheritance of circulating irisin in humans. Clinical Science, 126 (12), pp. 837-844
- Antonysunil, Adaikalakoteswari, Jayashri, Ramamurthy, Sukumar, Nithya, Venkataraman, Hema, Pradeepa, Rajendra, Gokulakrishnan, Kuppan, Anjana, Ranjit, McTernan, P. G., Tripathi, Gyanendra, Patel, Vinod, Kumar, Sudhesh, Mohan, Viswanathan, Saravanan, Ponnusamy, 2014. Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovascular Diabetology, 13 (1), pp. 1-7
- Reddy, Narendra Lakshmana, Jones, Terence A., Wayte, Sarah C., Adesanya, Oludolapo, Sankar, Sailesh, Yeo, Yen C., Tripathi, Gyanendra, McTernan, P. G., Randeva, Harpal S., Kumar, Sudhesh, Hutchinson, Charles E., Barber, T. M., 2014. Identification of brown adipose tissue using MR imaging in a human adult with histological and immunohistochemical confirmation. The Journal of Clinical Endocrinology & Metabolism, 99 (1), pp. E117-E121
- Piya, Milan K., Harte, A. L., Sivakumar, Kavitha, Tripathi, Gyanendra, Voyias, Philip D., James, S., Sabico, Shaun, Al-Daghri, Nasser M., Saravanan, Ponnusamy, Barber, T. M., Kumar, Sudhesh, Vatish, Manu, McTernan, P. G., 2014. The identification of irisin in human cerebrospinal fluid : influence of adiposity, metabolic markers, and gestational diabetes. AJP : Endocrinology and Metabolism, 306 (5), pp. E512-E518
- Harte, A. L., Tripathi, G. N., Piya, Milan K., Barber, Thomas, Clapham, J. C., Al-Daghari, N., Al-Disi, Dara, Kumsaiyai, Warunee, Saravanan, Ponnusamy, Fowler, Anne E., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G., 2013. NFêB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status and TNFá. Obesity, 21 (11), pp. 2322-2330
- Harte, A. L., Tripathi, Gyanendra, Piya, Milan K., Barber, T. M., Clapham, John C., Al-Daghri, Nasser, Al-Disi, Dara, Kumsaiyai, Warunee, Saravanan, Ponnusamy, Fowler, Anne E., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G., 2013. NF?B as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status, and TNFa. Obesity research, 21 (11), pp. 2322-23300
- Saboor Aftab, S. A., Reddy, Narendra Lakshmana, Owen, N. L., Pollitt, R., Harte, A. L., McTernan, P. G., Tripathi, Gyanendra, Barber, T. M., 2013. Identification of a novel heterozygous mutation in exon 50 of the COL1A1 gene manifesting clinically as osteogenesis imperfecta. Endocrinology, Diabetes & Metabolism Case Reports
- Youssef-Elabd, Elham M., McGee, Kirsty C., Tripathi, Gyanendra, Al-Daghri, Nasser M., Abdalla, Mohga S., Sharada, Hayat M., Ashour, Esmat, Amin, Ashraf I., Ceriello, Antonio, O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G., Harte, Alison L., 2012. Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro. Journal of Nutritional Biochemistry, Vol.23 (No.1), pp. 39-50
- Harte, A. L., Varma, Madhusudhan C., Tripathi, Gyanendra, McGee, K. C., Al-Daghri, Nasser M., Al-Attas, Omar S., Sabico, Shaun, O'Hare, J. Paul, Ceriello, Antonio, Saravanan, Ponnusamy, Kumar, Sudhesh, McTernan, P. G., 2012. High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects. Diabetes Care, Vol.35 (No.2), pp. 375-382
- Metcalfe, David, Harte, Alison L., Aletrari, Mina Olga, Al Daghri, Nasser M., Al Disi, Dara, Tripathi, Gyanendra, McTernan, P. G., 2012. Does endotoxaemia contribute to osteoarthritis in obese patients?. Clinical science, Volulme 123 (11), pp. 627-34
- Schisano, Bruno, Harte, Alison L., Lois, Konstantinos, Saravanan, Ponnusamy, Al-Daghri, Nasser M., Al-Attas, Omar S., Knudsen, Lotte B., McTernan, P. G., Ceriello, Antonio, Tripathi, Gyanendra, 2012. GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress. Regulatory Peptides, Vol.174 (No.1-3), pp. 46-52
- Harte, Alison L., da Silva, Nancy F., Miller, Michelle A., Cappuccio, Francesco, Kelly, Ann M., O'Hare, J. Paul, Barnett, Anthony H., Al-Daghri, Nasser M., Al-Attas, Omar S., Alokail, Majed S., Sabico, Shaun, Tripathi, Gyanendra, Bellary, Srikanth, Kumar, Sudhesh, McTernan, P. G., 2012. Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus. Experimental Diabetes Research, Vol.2012
- McGee, K. C., Shahmanesh, Mohsen, Boothby, Meg, Nightingale, Peter, Gathercole, Laura L., Tripathi, Gyanendra, Harte, Alison L., Shojaee-Moradie, Fariba, Umpleby, A Margot, Das, Satyajit, Al-Daghri, Nasser M., McTernan, P. G., Tomlinson, Jeremy W., 2011. Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbones. Antiviral Therapy, 17 (3), pp. 495-507
- Schisano, B., Tripathi, Gyanendra, McGee, K. C., McTernan, P. G., Ceriello, Antonio, 2011. Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells. Diabetologia, Vol.54 (No.5), pp. 1219-1226
- Shirihai, Orian S., McGee, K. C., Harte, Alison L., da Silva, Nancy F., Al-Daghri, Nasser M., Creely, Steven J., Kusminski, Christine M., Tripathi, Gyanendra, Levick, Paul L., Khanolkar, Manish, Evans, Marc, Chittari, Madhu V., Patel, Vinod, Kumar, Sudhesh, McTernan, P. G., 2011. Visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by NF?B and JNK in human abdominal subcutaneous adipocytes. PLoS One, Vol.6 (No.6)
- Alhusaini, S., McGee, K. C., Harte, A. L., McTernan, P. G., Kumar, Sudhesh, Tripathi, Gyanendra, 2010. Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress. Biochemical and Biophysical Research Communications, Vol.397 (No.3), pp. 472-478
- Ramanjaneya, Manjunath, Chen, Jing, Brown, James E. P., Tripathi, Gyanendra, Hallschmid, Manfred, Patel, Suketu, Kern, Werner, Hillhouse, Edward W., Lehnert, Hendrik, Tan, Bee K., Randeva, Harpal S., 2010. Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinology, Vol.151 (No.7), pp. 3169-3180
- Harte, A. L., da Silva, Nancy F., Creely, Steven J., McGee, K. C., Billyard, Thomas, Youssef-Elabd, Elham M., Tripathi, Gyanendra, Ashour, Esmat, Abdalla, Mohga S., Sharada, Hayat M., Amin, Ashraf I., Burt, Alastair D., Kumar, Sudhesh, Day, Christopher Paul, McTernan, P. G., 2010. Elevated endotoxin levels in non-alcoholic fatty liver disease. Journal of Inflammation, Vol.7
- Al-Attas, Omar S., Al-Daghri, Nasser M., Alokail, Majed S., Alfadda, Assim, Bamakhramah, Ahmed, Sabico, Shaun, Pritlove, D. C., Harte, A. L., Tripathi, Gyanendra, McTernan, P. G., Kumar, Sudhesh, Chrousos, George P., 2010. Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs : the influence of circulating adiponectin. European Journal of Endocrinology, Vol.163 (No.4), pp. 601-607
- Tripathi, Gyanendra, Salih, D. A. M., Drozd, A. C., Cosgrove, R. A., Cobb, L. J., Pell, J. M., 2009. IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo. The FASEB Journal, Vol.23 (No.8), pp. 2616-2626
- Schisano, B., Tripathi, Gyanendra, Harte, A. L., McTernan, P. G., Knusden, L., Ceriello, Antonio, 2010. Liraglutide down regulates endoplasmic reticulum stress in human endothelial cells exposed to hyperglycaemia. 46th Annual Meeting of the European Association for the Study of Diabetes (EASD), Stockholm, Sweden, September 20-24, 2010, Published in Diabetologia, pp. S518-S518
- Langowska, M., Alhusaini, S., McGee, K. C., Harte, A. L., McTernan, P. G., Kumar, Sudhesh, Tripathi, Gyanendra, 2010. Endoplasmic reticulum stress induced by hyperglycaemia and saturated fatty acids is alleviated by salicylates in cultured primary human adipocytes. 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), Stockholm, Sweden, September 20-24, 2010, Published in Diabetologia
- McGee, K. C., Tripathi, Gyanendra, Creely, S. J., Harte, A. L., Langowska, M., da Silva, N. F., Brown, A., Oscarsson, J., Clapham, J,, Kumar, Sudhesh, McTernan, P. G., 2010. Metabolic endotoxaemia as a mediator of mitochondrial dysfunction in human adipose tissue, alleviated by salicylate. 46th Annual Meeting of the European Association for the Study of Diabetes (EASD), Stockholm, Sweden, September 20-24, 2010, Published in Diabetologia, pp. S285-S285
- Harte, A. L., Youssef-Elabd, E. M., McGee, K. C., Tripathi, Gyanendra, Abdalla, M. S., Sharada, H. M., Ashour, E., Amin, A. I., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G., 2010. Acute and chronic saturated fatty acid treatment as a key instigator of the TLR mediated inflammatory response in human adipose tissue in vitro. 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), Stockholm, Sweden, 20-24 Sep 2010, Published in Diabetologia
- Alhusaini, S., Lois, Konstantinos, McGee, K. C., McTernan, P. G., Kumar, Sudhesh, Tripathi, Gyanendra, 2009. Endoplasmic stress is induced by lipopolysaccharides and high glucose and is alleviated by salicylates in cultured primary human adipocytes. 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, Austria, SEP 30-OCT 02, 2009, Published in Diabetologia, pp. S51-S51
- Schisano, Bruno, Radford, C. R., Harte, A. L., Tripathi, Gyanendra, McTernan, P. G., Ceriello, Antonio, 2009. A novel role for p53 in the regulation of oxidative stress in vascular cells in response to glucose fluctuation. 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, Austria, SEP 30-OCT 02, 2009, Published in Diabetologia, pp. S501-S501
- Tripathi, Gyanendra, Kusminski, C. M., Harte, A. L., McGee, K. C., O'Hare, J. Paul, McTernan, P. G., Kumar, Sudhesh, 2008. Obesity is associated with activation of innate immune pathway and ER stress in human abdominal subcutaneous adipose tissue. 43rd Annual Meeting of the European Association for the Study of Diabetes, Amsterdam, Netherlands, Sep 18-21, 2007, Published in Diabetologia, pp. S315-S315
- Hill, M. J., McGee, K. C., Boothby, M., Higgins, P., Kusminski, C. M., Harte, A. L., Tripathi, Gyanendra, Gathercole, L. L., Kumar, Sudhesh, Shahmanesh, Mohsen, McTernan, P. G., 2007. The effect of HIV status and the impact of ARV therapy on mitochondrial metabolism in human adipose tissue. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, September 18-21, 2007, Published in Diabetologia, pp. S313-S313
- McTernan, P. G., Hardo, F. J., Baker, A. R., McGee, K. C., Tripathi, Gyanendra, Creely, S. J., da Silva, N. F., Kumar, Sudhesh, Clapham, J. C., 2006. Expression of mitochondrial genes related to energy homoeostasis are dysregulated in obesity and type 2 diabetes. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen, Denmark, 14-17 Sep 2006, Published in Diabetologia, pp. 333-334
Title | Funder | Award start | Award end |
---|---|---|---|
The role of vitamin D deficiency in pregnant women and its association with gestational diabetes mellitus and impact on inflammation | King Saud University | 30 Sep 2013 | 30 Sep 2017 |
The origins of inflammation in human adipocytes | King Saud University | 01 Oct 2011 | 30 Sep 2015 |
Role of Endoplasmic Reticulum stress in inflammation, insulin resistance and Diabetes in cultured primary human adipocytes | Astrazeneca AB | 01 Jul 2011 | 30 Jun 2015 |
King Saudi University Grant | King Saud University | 01 Oct 2010 | 30 Sep 2014 |
Summer studentship (Alice Murphy): Regulation of endoplasmic reticulum stress pathways in human adipocytes | Society for Endocrinology | 01 Jul 2013 | 31 Dec 2013 |
Role and regulation of inducible nitric oxide synthase (iNOS or NOS2) in diabetes | AstraZeneca | 01 Feb 2011 | 31 Jan 2012 |
Novo Nordisk Continuation | Novo Nordisk A/S | 01 Mar 2010 | 30 Sep 2010 |